BR112015023568B8 - Composto à base de metal como composto fotodinâmico - Google Patents
Composto à base de metal como composto fotodinâmicoInfo
- Publication number
- BR112015023568B8 BR112015023568B8 BR112015023568A BR112015023568A BR112015023568B8 BR 112015023568 B8 BR112015023568 B8 BR 112015023568B8 BR 112015023568 A BR112015023568 A BR 112015023568A BR 112015023568 A BR112015023568 A BR 112015023568A BR 112015023568 B8 BR112015023568 B8 BR 112015023568B8
- Authority
- BR
- Brazil
- Prior art keywords
- complexes
- compositions
- metal
- compound
- photodynamic
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000002184 metal Substances 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 abstract 4
- 241000894006 Bacteria Species 0.000 abstract 1
- 241000233866 Fungi Species 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000003915 cell function Effects 0.000 abstract 1
- 239000000032 diagnostic agent Substances 0.000 abstract 1
- 229940039227 diagnostic agent Drugs 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000003463 hyperproliferative effect Effects 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System compounds of the platinum group
- C07F15/0046—Ruthenium compounds
- C07F15/0053—Ruthenium compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System compounds of the platinum group
- C07F15/002—Osmium compounds
- C07F15/0026—Osmium compounds without a metal-carbon linkage
Abstract
complexos de coordenação à base de metal como compostos fotodinâmicos e seus usos. a presente invenção se refere a composições que incluem complexos de coordenação à base de metal, que são preferivelmente compostos fotodinâmicos sintonizáveis. as composições e complexos são uteis como agentes terapêuticos e como agentes de diagnóstico in vivo para tratar ou prevenir doenças incluindo aquelas que envolvem células hiperproliferativas em sua etiologia, tais como o câncer. composições e complexos da invenção são ainda capazes de destruir células microbianas, tais como bactérias, fungos e protozoários, e destruir vírus. as composições e complexos também são capazes de modular a função celular de outras maneiras
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361801674P | 2013-03-15 | 2013-03-15 | |
US61/801,674 | 2013-03-15 | ||
PCT/US2014/030194 WO2014145428A2 (en) | 2013-03-15 | 2014-03-17 | Metal-based coordination complexes as photodynamic compounds and their use |
Publications (3)
Publication Number | Publication Date |
---|---|
BR112015023568A2 BR112015023568A2 (pt) | 2017-07-18 |
BR112015023568B1 BR112015023568B1 (pt) | 2023-04-11 |
BR112015023568B8 true BR112015023568B8 (pt) | 2024-01-02 |
Family
ID=50687659
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015023568A BR112015023568B8 (pt) | 2013-03-15 | 2014-03-17 | Composto à base de metal como composto fotodinâmico |
Country Status (7)
Country | Link |
---|---|
US (1) | US10766915B2 (pt) |
EP (1) | EP2976347B1 (pt) |
CN (1) | CN105377862B (pt) |
BR (1) | BR112015023568B8 (pt) |
CA (1) | CA2907356C (pt) |
RU (1) | RU2682674C2 (pt) |
WO (1) | WO2014145428A2 (pt) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10111936B2 (en) | 2015-01-19 | 2018-10-30 | Theralase Technologies, Inc. | Metal-glycoprotein complexes and photodynamic therapy of immune privileged sites with same |
BR112017015499A2 (pt) | 2015-01-19 | 2018-01-30 | Theralase Tech Inc | ?composição, e, métodos para tratar uma condição associada com células hiperprolifereantes, e para destruir uma célula microbiana? |
CN111701144B (zh) | 2015-07-28 | 2023-03-21 | 诺欧生物有限责任公司 | 用于对一氧化氮的光疗调节的系统和方法 |
US10335608B2 (en) | 2016-04-20 | 2019-07-02 | Theralase Technologies, Inc. | Photodynamic compounds and methods for activating them using ionizing radiation and/or other electromagnetic radiation for therapy and/or diagnostics |
ES2959891T3 (es) | 2017-05-05 | 2024-02-28 | Bold Therapeutics Inc | Producción de trans-[tetraclorobis(1H-indazol)rutenato (III)] y composiciones del mismo |
EP3621629A4 (en) * | 2017-05-11 | 2021-03-17 | Theralase Biotech Inc. | VACCINE CONTAINING CANCER CELLS INACTIVATED BY PHOTODYNAMIC TREATMENT WITH METAL-BASED COORDINATION COMPLEXES, AND IMMUNOTHERAPY METHOD USING THE LATTER |
US11793818B2 (en) | 2018-03-26 | 2023-10-24 | Theralase Technologies, Inc. | Method for treating conditions associated with hyperproliferating cells comprising combined administration of a cannabinoid receptor agonist and radiation therapy |
US11147984B2 (en) | 2020-03-19 | 2021-10-19 | Know Bio, Llc | Illumination devices for inducing biological effects |
CN111939124B (zh) * | 2020-07-13 | 2022-06-28 | 东南大学 | 一种金属聚合物、金属聚合物纳米胶束及其制备方法和应用 |
US11813330B2 (en) * | 2021-03-04 | 2023-11-14 | Theralase Technologies, Inc. | Sonodynamic therapy using sonodynamically activated coordination complexes of transition metals as sensitizing agents |
US11654294B2 (en) | 2021-03-15 | 2023-05-23 | Know Bio, Llc | Intranasal illumination devices |
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JPS6239682A (ja) * | 1985-08-13 | 1987-02-20 | Fuji Photo Film Co Ltd | 赤外線吸収性組成物 |
CA2005039A1 (en) | 1989-12-08 | 1991-06-08 | Randell L. Mills | Pharmaceuticals and apparatus providing diagnosis and selective tissue necrosis |
ES2080313T3 (es) * | 1990-04-17 | 1996-02-01 | Ecole Polytech | Celulas fotovoltaicas. |
US6362175B1 (en) | 1991-09-20 | 2002-03-26 | The Trustees Of The University Of Pennsylvania | Porphyrin compounds for imaging tissue oxygen |
GB9123814D0 (en) | 1991-11-08 | 1992-01-02 | Johnson Matthey Plc | Photosensitizers |
TW235298B (pt) | 1992-02-27 | 1994-12-01 | Ciba Geigy | |
CA2133284A1 (en) | 1994-09-29 | 1996-03-30 | Svetlana Kudrevich | Octacarboxy substituted tetra(2,3-pyrazino)porphyrazines and their derivatives |
US5648485A (en) | 1994-10-26 | 1997-07-15 | University Of British Columbia | β, β-dihydroxy meso-substituted chlorins, isobacteriochlorins, and bacteriochlorins |
RU2089555C1 (ru) * | 1995-05-04 | 1997-09-10 | Новосибирский институт биоорганической химии СО РАН | Бисимидазол-(1,10)-фенантролинплатина (iii) дихлорид, проявляющий цитостатическую противоопухолевую активность |
WO1996039144A1 (en) * | 1995-06-06 | 1996-12-12 | Procyte Corporation | Stable copper(i) complexes as active therapeutic substances |
AU716207B2 (en) | 1995-06-20 | 2000-02-24 | Miravant Pharmaceuticals, Inc. | Efficient functionalization of porphyrin derivatives |
CA2237056C (en) | 1995-11-24 | 2006-10-10 | Avigdor Scherz | Synthetic metal-substituted bacteriochlorophyll derivatives and use thereof |
CA2221912A1 (en) | 1997-11-21 | 1999-05-21 | David Dolphin | Photosensitizers with improved biodistribution and light-absorbing properties |
US6248733B1 (en) | 1998-01-09 | 2001-06-19 | 3M Innovative Properties Company | Method for limiting the growth of microorganisms using metal-containing compounds |
EP1097935B1 (en) | 1998-07-10 | 2003-12-03 | Meiji Seika Kaisha Ltd. | X-ray intercepting metal complexes of chlorin derivatives |
HU228208B1 (en) | 1998-12-09 | 2013-01-28 | Yeda Res & Dev | Palladium-substituted bacteriochlorophyll derivatives and use thereof |
RU2310447C2 (ru) | 2001-06-06 | 2007-11-20 | Брукхейвен Сайенс Ассошиэйтс | Новые металлопорфирины и их применение в качестве радиосенсибилизаторов в лучевой терапии |
GB0120618D0 (en) | 2001-08-24 | 2001-10-17 | Univerity Court Of The Univers | Photoreactive compounds and compositions |
US7087214B2 (en) | 2002-02-01 | 2006-08-08 | Zentaris Gmbh | Water-soluble porphyrin platinum compounds with high tumor selectivity and their use for the treatment of benign and malignant tumor diseases |
CA2498231A1 (en) | 2002-08-01 | 2004-02-12 | Purdue Research Foundation | Photoactivated anti-viral and anti-cancer agent |
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EP1664070B1 (en) | 2003-08-13 | 2008-08-13 | University Of South Florida | Methods for inhibiting tumor cell proliferation involving platinum complexes |
PL197232B1 (pl) * | 2004-06-03 | 2008-03-31 | Univ Wroclawski | Nowe kompleksy kationowe żelaza(II) i kobaltu(II) z 2,2'-bipirydyną, z 2,2'-bichinoliną i 1,10-fenantroliną oraz ich pochodnymi, sposób wytwarzania tych kompleksów i zastosowanie |
GB0418643D0 (en) | 2004-08-20 | 2004-09-22 | Univ Edinburgh | Ruthenium (II) compounds |
EP1798222B1 (en) * | 2004-10-01 | 2011-09-21 | Ube Industries, Ltd. | Binuclear metal complex, metal complex dye, photoelectric transducer and photochemical battery |
GB0610062D0 (en) | 2006-05-19 | 2006-06-28 | Univ Edinburgh | Ruthenium (ll) compounds |
US20110021483A1 (en) | 2007-06-18 | 2011-01-27 | Platco Technologies (Proprietary) Limited | Platinum (IV) Complexes |
GB201006762D0 (en) | 2010-04-22 | 2010-06-09 | Univ Warwick | Osmium (II) arene AZO anti-cancer complexes |
GB201008584D0 (en) | 2010-05-22 | 2010-07-07 | Univ Warwick | Novel iridium anti-cancer compounds |
US9345769B2 (en) | 2012-04-15 | 2016-05-24 | Sherri Ann McFARLAND | Metal-based thiophene photodynamic compounds and their use |
PT108082B (pt) | 2014-12-06 | 2020-12-15 | Faculdade De Ciências Da Universidade De Lisboa | Complexos macromoleculares de metais de transição para o tratamento do cancro e seu processo de preparação |
JP2018535250A (ja) | 2015-10-01 | 2018-11-29 | フォトダイナミック インコーポレイテッド | 新規なイタドリ(polygonum cuspidatum)抽出物及び光力学的不活化剤としてのそれらの使用 |
-
2014
- 2014-03-17 RU RU2015144121A patent/RU2682674C2/ru active
- 2014-03-17 CA CA2907356A patent/CA2907356C/en active Active
- 2014-03-17 BR BR112015023568A patent/BR112015023568B8/pt active IP Right Grant
- 2014-03-17 CN CN201480027613.2A patent/CN105377862B/zh active Active
- 2014-03-17 US US14/777,169 patent/US10766915B2/en active Active
- 2014-03-17 EP EP14723201.1A patent/EP2976347B1/en active Active
- 2014-03-17 WO PCT/US2014/030194 patent/WO2014145428A2/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
RU2682674C2 (ru) | 2019-03-20 |
CA2907356C (en) | 2022-07-12 |
RU2015144121A (ru) | 2017-04-21 |
US10766915B2 (en) | 2020-09-08 |
US20160039854A1 (en) | 2016-02-11 |
EP2976347B1 (en) | 2022-01-19 |
BR112015023568A2 (pt) | 2017-07-18 |
CN105377862B (zh) | 2019-09-13 |
CA2907356A1 (en) | 2014-09-18 |
EP2976347A2 (en) | 2016-01-27 |
WO2014145428A2 (en) | 2014-09-18 |
CN105377862A (zh) | 2016-03-02 |
WO2014145428A3 (en) | 2015-01-15 |
BR112015023568B1 (pt) | 2023-04-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B25G | Requested change of headquarter approved |
Owner name: SHERRI ANN MCFARLAND (US) |
|
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 17/03/2014, OBSERVADAS AS CONDICOES LEGAIS |
|
B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: REFERENTE A RPI 2727 DE 11/04/2023, QUANTO AO ITEM (54) TITULO. |