MX168612B - Procedimiento para la preparacion del acido (piridil-3)-3 pirrolotiazol carboxilico dextrogiro - Google Patents

Procedimiento para la preparacion del acido (piridil-3)-3 pirrolotiazol carboxilico dextrogiro

Info

Publication number
MX168612B
MX168612B MX012118A MX1211888A MX168612B MX 168612 B MX168612 B MX 168612B MX 012118 A MX012118 A MX 012118A MX 1211888 A MX1211888 A MX 1211888A MX 168612 B MX168612 B MX 168612B
Authority
MX
Mexico
Prior art keywords
acid
ester
formula
general formula
pirrolotiazol
Prior art date
Application number
MX012118A
Other languages
English (en)
Inventor
Marivelo Gerard Rajoharison
Original Assignee
Rhone Poulenc Sante
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Sante filed Critical Rhone Poulenc Sante
Publication of MX168612B publication Critical patent/MX168612B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención se refiere a procedimiento de preparación del ácido (piridil-3)-3 1H,3H-pirrolo [1,2-c] tiazolcarboxílico-7 dextrógiro de la fórmula: (I) caracterizada porque se hace reacciona un ester del ácido cloro-2 acrílico de la fórmula general: (V) en la cual R representa un grupo alquilo con de 1 a 4 átomos de carbono en cadena reta o ramificada o un grupo bencilo o arilo sobre una sal orgánica del ácido formil-3 (piridil-3)-2 tiazolidincarboxilíco-4 cis o en su mayor parte cis de la fórmula: (VI) en presencia de un cloruro de ácido y de trietilamina para obtener un ester de la formula general: (VII) en la cual R se define como anteriormente en el ester de la formula (V), y después se saponifica el citado ester de fórmula general (VII) en condiones suaves no racemisantes, y se aisla el producto obtenido.
MX012118A 1987-07-02 1988-06-30 Procedimiento para la preparacion del acido (piridil-3)-3 pirrolotiazol carboxilico dextrogiro MX168612B (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8709376A FR2617484B1 (fr) 1987-07-02 1987-07-02 Procede de preparation de l'acide (pyridyl-3)-3 1h-3h-pyrrolo (1,2-c) thiazolecarboxylique-7 dextrogyre

Publications (1)

Publication Number Publication Date
MX168612B true MX168612B (es) 1993-06-01

Family

ID=9352790

Family Applications (1)

Application Number Title Priority Date Filing Date
MX012118A MX168612B (es) 1987-07-02 1988-06-30 Procedimiento para la preparacion del acido (piridil-3)-3 pirrolotiazol carboxilico dextrogiro

Country Status (24)

Country Link
US (1) US4906757A (es)
EP (1) EP0297987A1 (es)
JP (1) JP2571828B2 (es)
KR (1) KR890002193A (es)
AU (1) AU600838B2 (es)
BG (1) BG48810A3 (es)
CA (1) CA1298839C (es)
CS (1) CS272240B2 (es)
DD (1) DD271330A5 (es)
DK (1) DK367388A (es)
FI (1) FI95801C (es)
FR (1) FR2617484B1 (es)
HU (1) HU198073B (es)
IE (1) IE65279B1 (es)
IL (1) IL86919A (es)
MA (1) MA21305A1 (es)
MX (1) MX168612B (es)
NO (1) NO882959L (es)
NZ (1) NZ225261A (es)
PL (1) PL157527B1 (es)
PT (1) PT87907B (es)
SU (1) SU1579463A3 (es)
TN (1) TNSN88070A1 (es)
ZA (1) ZA884746B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260451A (en) * 1989-05-11 1993-11-09 Merckle Gmbh Substituted pyrrole compounds and use thereof in pharmaceutical compositions
DE3915450A1 (de) * 1989-05-11 1990-11-15 Gerd Prof Dr Dannhardt Substituierte pyrrolverbindungen und deren anwendung in der pharmazie
IL102494A0 (en) * 1991-07-17 1993-01-14 Abbott Lab Platelet activating factor antagonists
DE10004157A1 (de) 2000-02-01 2001-08-02 Merckle Gmbh Chem Pharm Fabrik 4-Pyridyl-und 2,4-Pyrimidinyl-substituierte Pyrrolderivate und ihre Anwendung in der Pharmazie
CN106543204A (zh) * 2016-11-08 2017-03-29 清华大学 一种合成多取代吡咯并[1,2‑c]噻唑衍生物的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2541280B1 (fr) * 1983-01-13 1985-06-21 Rhone Poulenc Sante Nouveaux derives du 1h, 3h-pyrrolo (1,2c) thiazolecarboxamide-7, leur preparation et les medicaments qui les contiennent
FR2601015B1 (fr) * 1986-07-04 1988-08-05 Rhone Poulenc Sante Nouveaux derives du 1h,3h-pyrrolo (1,2-c) thiazole, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2601016B1 (fr) * 1986-07-04 1988-10-07 Rhone Poulenc Sante Nouveaux derives du 1h,3h-pyrrolo (1,2-c) thiazole, leur preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
FI95801B (fi) 1995-12-15
JPS6429382A (en) 1989-01-31
BG48810A3 (en) 1991-05-15
PL273372A1 (en) 1989-03-06
IE65279B1 (en) 1995-10-18
FI95801C (fi) 1996-03-25
TNSN88070A1 (fr) 1990-07-10
IE882015L (en) 1989-01-02
DD271330A5 (de) 1989-08-30
NZ225261A (en) 1989-12-21
IL86919A0 (en) 1988-11-30
AU600838B2 (en) 1990-08-23
ZA884746B (en) 1989-03-29
FI883167A (fi) 1989-01-03
KR890002193A (ko) 1989-04-08
DK367388D0 (da) 1988-07-01
JP2571828B2 (ja) 1997-01-16
SU1579463A3 (ru) 1990-07-15
HU198073B (en) 1989-07-28
FR2617484B1 (fr) 1989-10-20
CA1298839C (fr) 1992-04-14
CS476288A2 (en) 1990-03-14
CS272240B2 (en) 1991-01-15
MA21305A1 (fr) 1988-12-31
AU1851288A (en) 1989-01-05
IL86919A (en) 1992-02-16
EP0297987A1 (fr) 1989-01-04
PT87907A (pt) 1989-06-30
FI883167A0 (fi) 1988-07-01
NO882959D0 (no) 1988-07-01
PL157527B1 (pl) 1992-06-30
HUT47588A (en) 1989-03-28
DK367388A (da) 1989-01-03
NO882959L (no) 1989-01-03
FR2617484A1 (fr) 1989-01-06
US4906757A (en) 1990-03-06
PT87907B (pt) 1995-06-30

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