JPS6447754A - Novel process for producing alpha-(1-carboxyethyl)amino-gamma-phenylbutyric acid ethyl esters - Google Patents
Novel process for producing alpha-(1-carboxyethyl)amino-gamma-phenylbutyric acid ethyl estersInfo
- Publication number
- JPS6447754A JPS6447754A JP20486087A JP20486087A JPS6447754A JP S6447754 A JPS6447754 A JP S6447754A JP 20486087 A JP20486087 A JP 20486087A JP 20486087 A JP20486087 A JP 20486087A JP S6447754 A JPS6447754 A JP S6447754A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- carboxyethyl
- gamma
- amino
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE:To easily and economically obtain the titled compound useful as an intermediate for hypotensor, in high efficiency, by converting a nitrile group of an easily synthesizable inexpensive novel intermediate compound into an ethoxycarbonyl group. CONSTITUTION:The objective alpha-(1-carboxyethyl)amino-gamma-phenylbutyric acid ethyl esters can be produced by converting nitrile group of alpha-(1-carboxyethyl) amino-gamma-butyronitriles of formula I (R is H, alkyl, aralkyl, aryl or their substituted derivative group) or its mineral acid salt into ethoxycarbonyl group. The conversion of the nitrile group is carried out e.g. by treating the compound with HCl at a low temperature in the presence of ethanol to convert the compound into an imidate and subjecting the product to hydrolysis, etc. The compound of formula I can be easily produced from phenylpropionaldehyde, L- alanine (ester) and a hydrocyanic acid compound.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP20486087A JPS6447754A (en) | 1987-08-18 | 1987-08-18 | Novel process for producing alpha-(1-carboxyethyl)amino-gamma-phenylbutyric acid ethyl esters |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP20486087A JPS6447754A (en) | 1987-08-18 | 1987-08-18 | Novel process for producing alpha-(1-carboxyethyl)amino-gamma-phenylbutyric acid ethyl esters |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS6447754A true JPS6447754A (en) | 1989-02-22 |
Family
ID=16497592
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP20486087A Pending JPS6447754A (en) | 1987-08-18 | 1987-08-18 | Novel process for producing alpha-(1-carboxyethyl)amino-gamma-phenylbutyric acid ethyl esters |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6447754A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991017141A2 (en) * | 1990-04-26 | 1991-11-14 | Schering Corporation | Diastereoselective process for preparing n-substituted amino acids and derivatives |
WO2000066104A3 (en) * | 1999-04-30 | 2001-06-28 | Millennium Pharm Inc | Ace-2 inhibiting compounds and methods of use thereof |
-
1987
- 1987-08-18 JP JP20486087A patent/JPS6447754A/en active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991017141A2 (en) * | 1990-04-26 | 1991-11-14 | Schering Corporation | Diastereoselective process for preparing n-substituted amino acids and derivatives |
WO1991017141A3 (en) * | 1990-04-26 | 1991-12-26 | Schering Corp | Diastereoselective process for preparing n-substituted amino acids and derivatives |
WO2000066104A3 (en) * | 1999-04-30 | 2001-06-28 | Millennium Pharm Inc | Ace-2 inhibiting compounds and methods of use thereof |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69221777D1 (en) | Fermentation process for the production of 2-keto-L-gulonic acid | |
Hirama et al. | Enantiospecific syntheses of trifunctional (R)-3-hydroxy esters by baker's yeast reduction | |
HUT63947A (en) | Method for producing foodstuffs and nutriment | |
ATE125544T1 (en) | METHOD FOR PRODUCING AMIKACIN. | |
JPS6447754A (en) | Novel process for producing alpha-(1-carboxyethyl)amino-gamma-phenylbutyric acid ethyl esters | |
NO903732L (en) | PROCEDURE FOR THE PREPARATION OF CYCLIC AMINO ACID COMPOUNDS AGAINST CRAMPS. | |
DE69027084D1 (en) | Process for the preparation of purine compounds | |
ID26888A (en) | CEPHALOSPORIN FERMENTATION PRODUCTION PROCESS | |
AU8309591A (en) | Process for producing aminomethanephosphonic acid and aminomethylphosphinic acids | |
ID22148A (en) | VINILESTER MAKING PROCESS | |
JPS6479149A (en) | Production of unsaturated dicarboxylic acid imide compound | |
HUT56346A (en) | Process for producing alkyl esters having long carbon chain of 2-pyridyloxyalkane carboxylic acids | |
MX168612B (en) | PROCEDURE FOR THE PREPARATION OF ACID (PIRIDIL-3) -3 PIRROLOTIAZOL CARBOXILICO DEXTROGIRO | |
FI932697A (en) | FOERFARANDE FOER FRAMSTAELLNING AV TETRONSYRAALKYLESTRAR | |
ES8707174A1 (en) | Process for preparing trans-beta-benzoylacrylic acid ester. | |
DE3782566D1 (en) | EFFICIENT STEREO-CONSERVATIVE SYNTHESIS OF 1-SUBSTITUTED (S) - AND (R) -2-AMINOMETHYLPYRROLIDINES AND INTERMEDIATE PRODUCTS THEREOF. | |
JPS6452739A (en) | Selective production of omega-hydroxyfatty acid ester | |
JPS57144252A (en) | Preparation of aminoalkylthiol | |
ES8707167A1 (en) | Process for optically active threo-3-(3,4-methylenedioxyphenyl) serine. | |
JPS6445348A (en) | Production of n-substituted-l-amino acid derivative | |
JPS6431775A (en) | Production of (r)-(+)-gamma-butyrolactone-gamma-3-propionic acid | |
JPS54157560A (en) | Preparation of n-substituted imidazole derivative | |
JPS57118547A (en) | Preparation of glutamic acid and its derivative | |
JPS5782345A (en) | Preparation of lactic ester | |
OWEN et al. | Studies on the Chemistry of Heterocyclics. X. Syntheses of Thenal-and Thenyl-Barbituric Acids |