JPS6447754A - Novel process for producing alpha-(1-carboxyethyl)amino-gamma-phenylbutyric acid ethyl esters - Google Patents

Novel process for producing alpha-(1-carboxyethyl)amino-gamma-phenylbutyric acid ethyl esters

Info

Publication number
JPS6447754A
JPS6447754A JP20486087A JP20486087A JPS6447754A JP S6447754 A JPS6447754 A JP S6447754A JP 20486087 A JP20486087 A JP 20486087A JP 20486087 A JP20486087 A JP 20486087A JP S6447754 A JPS6447754 A JP S6447754A
Authority
JP
Japan
Prior art keywords
compound
carboxyethyl
gamma
amino
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP20486087A
Other languages
Japanese (ja)
Inventor
Kenji Inoue
Mitsunori Matsumoto
Satomi Takahashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanegafuchi Chemical Industry Co Ltd
Original Assignee
Kanegafuchi Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanegafuchi Chemical Industry Co Ltd filed Critical Kanegafuchi Chemical Industry Co Ltd
Priority to JP20486087A priority Critical patent/JPS6447754A/en
Publication of JPS6447754A publication Critical patent/JPS6447754A/en
Pending legal-status Critical Current

Links

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE:To easily and economically obtain the titled compound useful as an intermediate for hypotensor, in high efficiency, by converting a nitrile group of an easily synthesizable inexpensive novel intermediate compound into an ethoxycarbonyl group. CONSTITUTION:The objective alpha-(1-carboxyethyl)amino-gamma-phenylbutyric acid ethyl esters can be produced by converting nitrile group of alpha-(1-carboxyethyl) amino-gamma-butyronitriles of formula I (R is H, alkyl, aralkyl, aryl or their substituted derivative group) or its mineral acid salt into ethoxycarbonyl group. The conversion of the nitrile group is carried out e.g. by treating the compound with HCl at a low temperature in the presence of ethanol to convert the compound into an imidate and subjecting the product to hydrolysis, etc. The compound of formula I can be easily produced from phenylpropionaldehyde, L- alanine (ester) and a hydrocyanic acid compound.
JP20486087A 1987-08-18 1987-08-18 Novel process for producing alpha-(1-carboxyethyl)amino-gamma-phenylbutyric acid ethyl esters Pending JPS6447754A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP20486087A JPS6447754A (en) 1987-08-18 1987-08-18 Novel process for producing alpha-(1-carboxyethyl)amino-gamma-phenylbutyric acid ethyl esters

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP20486087A JPS6447754A (en) 1987-08-18 1987-08-18 Novel process for producing alpha-(1-carboxyethyl)amino-gamma-phenylbutyric acid ethyl esters

Publications (1)

Publication Number Publication Date
JPS6447754A true JPS6447754A (en) 1989-02-22

Family

ID=16497592

Family Applications (1)

Application Number Title Priority Date Filing Date
JP20486087A Pending JPS6447754A (en) 1987-08-18 1987-08-18 Novel process for producing alpha-(1-carboxyethyl)amino-gamma-phenylbutyric acid ethyl esters

Country Status (1)

Country Link
JP (1) JPS6447754A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991017141A2 (en) * 1990-04-26 1991-11-14 Schering Corporation Diastereoselective process for preparing n-substituted amino acids and derivatives
WO2000066104A3 (en) * 1999-04-30 2001-06-28 Millennium Pharm Inc Ace-2 inhibiting compounds and methods of use thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991017141A2 (en) * 1990-04-26 1991-11-14 Schering Corporation Diastereoselective process for preparing n-substituted amino acids and derivatives
WO1991017141A3 (en) * 1990-04-26 1991-12-26 Schering Corp Diastereoselective process for preparing n-substituted amino acids and derivatives
WO2000066104A3 (en) * 1999-04-30 2001-06-28 Millennium Pharm Inc Ace-2 inhibiting compounds and methods of use thereof

Similar Documents

Publication Publication Date Title
DE69221777D1 (en) Fermentation process for the production of 2-keto-L-gulonic acid
Hirama et al. Enantiospecific syntheses of trifunctional (R)-3-hydroxy esters by baker's yeast reduction
HUT63947A (en) Method for producing foodstuffs and nutriment
ATE125544T1 (en) METHOD FOR PRODUCING AMIKACIN.
JPS6447754A (en) Novel process for producing alpha-(1-carboxyethyl)amino-gamma-phenylbutyric acid ethyl esters
NO903732L (en) PROCEDURE FOR THE PREPARATION OF CYCLIC AMINO ACID COMPOUNDS AGAINST CRAMPS.
DE69027084D1 (en) Process for the preparation of purine compounds
ID26888A (en) CEPHALOSPORIN FERMENTATION PRODUCTION PROCESS
AU8309591A (en) Process for producing aminomethanephosphonic acid and aminomethylphosphinic acids
ID22148A (en) VINILESTER MAKING PROCESS
JPS6479149A (en) Production of unsaturated dicarboxylic acid imide compound
HUT56346A (en) Process for producing alkyl esters having long carbon chain of 2-pyridyloxyalkane carboxylic acids
MX168612B (en) PROCEDURE FOR THE PREPARATION OF ACID (PIRIDIL-3) -3 PIRROLOTIAZOL CARBOXILICO DEXTROGIRO
FI932697A (en) FOERFARANDE FOER FRAMSTAELLNING AV TETRONSYRAALKYLESTRAR
ES8707174A1 (en) Process for preparing trans-beta-benzoylacrylic acid ester.
DE3782566D1 (en) EFFICIENT STEREO-CONSERVATIVE SYNTHESIS OF 1-SUBSTITUTED (S) - AND (R) -2-AMINOMETHYLPYRROLIDINES AND INTERMEDIATE PRODUCTS THEREOF.
JPS6452739A (en) Selective production of omega-hydroxyfatty acid ester
JPS57144252A (en) Preparation of aminoalkylthiol
ES8707167A1 (en) Process for optically active threo-3-(3,4-methylenedioxyphenyl) serine.
JPS6445348A (en) Production of n-substituted-l-amino acid derivative
JPS6431775A (en) Production of (r)-(+)-gamma-butyrolactone-gamma-3-propionic acid
JPS54157560A (en) Preparation of n-substituted imidazole derivative
JPS57118547A (en) Preparation of glutamic acid and its derivative
JPS5782345A (en) Preparation of lactic ester
OWEN et al. Studies on the Chemistry of Heterocyclics. X. Syntheses of Thenal-and Thenyl-Barbituric Acids