ME03665B - Antitela koja vezuju axl - Google Patents

Antitela koja vezuju axl

Info

Publication number
ME03665B
ME03665B MEP-2020-42A MEP202042A ME03665B ME 03665 B ME03665 B ME 03665B ME P202042 A MEP202042 A ME P202042A ME 03665 B ME03665 B ME 03665B
Authority
ME
Montenegro
Prior art keywords
antibodies binding
binding axl
axl
antibodies
binding
Prior art date
Application number
MEP-2020-42A
Other languages
German (de)
English (en)
French (fr)
Unknown language (me)
Inventor
Esther Breij
David Satijn
Den Brink Edward Norbert Van
Dennis Verzijl
Jong Rob N De
Paul Parren
Dijkhuizen Radersma Riemke Van
Original Assignee
Genmab As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genmab As filed Critical Genmab As
Publication of ME03665B publication Critical patent/ME03665B/me

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
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    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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    • C07K2317/77—Internalization into the cell
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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HUE048667T2 (hu) 2020-08-28
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IL249512A0 (en) 2017-02-28
CN107074948B (zh) 2022-01-28
JP6701162B2 (ja) 2020-05-27
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AU2015286569A1 (en) 2017-02-02
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US10512688B2 (en) 2019-12-24
US20180214549A1 (en) 2018-08-02
EP3169706B1 (en) 2019-12-04
ES2774428T3 (es) 2020-07-21
JP2020141682A (ja) 2020-09-10
JP2017522871A (ja) 2017-08-17
EA201790173A1 (ru) 2017-06-30
HRP20200283T1 (hr) 2020-05-29
AU2021205074B2 (en) 2024-12-12
US20170157250A1 (en) 2017-06-08
SG11201610777VA (en) 2017-01-27
US10765743B2 (en) 2020-09-08
UA127198C2 (uk) 2023-06-07
JP2024026158A (ja) 2024-02-28
LT3169706T (lt) 2020-03-25
RS60012B1 (sr) 2020-04-30
EP3763738A1 (en) 2021-01-13
SMT202000265T1 (it) 2020-07-08
US20200171152A1 (en) 2020-06-04
IL249512B (en) 2022-10-01
AU2015286569B2 (en) 2021-04-15
US10500276B2 (en) 2019-12-10
US20240091352A1 (en) 2024-03-21
US20190275149A1 (en) 2019-09-12
IL249512B2 (en) 2023-02-01
AU2025201717A1 (en) 2025-03-27
PL3169706T3 (pl) 2020-05-18
US20190160170A1 (en) 2019-05-30
BR112017000316A2 (pt) 2017-10-31
US10201607B2 (en) 2019-02-12
CY1122721T1 (el) 2021-03-12
KR20170030585A (ko) 2017-03-17
SI3169706T1 (sl) 2020-04-30
CN107074948A (zh) 2017-08-18
CN114621347A (zh) 2022-06-14
KR20230146665A (ko) 2023-10-19
MX370807B (es) 2020-01-08
SG10202006715SA (en) 2020-08-28
IL296633A (en) 2022-11-01
AU2021205074A1 (en) 2021-08-12

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