ME03452B - Disupstituisani oktahi-dropirolo[3,4-c]piroli kao modulatori oreksin receptora - Google Patents

Disupstituisani oktahi-dropirolo[3,4-c]piroli kao modulatori oreksin receptora

Info

Publication number
ME03452B
ME03452B MEP-2019-199A MEP2019199A ME03452B ME 03452 B ME03452 B ME 03452B ME P2019199 A MEP2019199 A ME P2019199A ME 03452 B ME03452 B ME 03452B
Authority
ME
Montenegro
Prior art keywords
dropyrrolo
octahy
disubstituted
pyrrole
receptor modulators
Prior art date
Application number
MEP-2019-199A
Other languages
German (de)
English (en)
French (fr)
Unknown language (me)
Inventor
Wenying Chai
Michael A Letavic
Kiev S Ly
Daniel J Pippel
Dale A Rudolph
Kathleen C Strother
Brad M Savall
Chandravadan R Shah
Brock T Shireman
Akinola Soyode-Johnson
Emily M Stocking
Devin M Swanson
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of ME03452B publication Critical patent/ME03452B/me

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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  • Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Reproductive Health (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
MEP-2019-199A 2009-10-23 2010-10-21 Disupstituisani oktahi-dropirolo[3,4-c]piroli kao modulatori oreksin receptora ME03452B (me)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25450909P 2009-10-23 2009-10-23
EP16163733.5A EP3093291B1 (en) 2009-10-23 2010-10-21 Disubstituted octahy - dropyrrolo [3,4-c]pyrroles as orexin receptor modulators

Publications (1)

Publication Number Publication Date
ME03452B true ME03452B (me) 2020-01-20

Family

ID=43385633

Family Applications (2)

Application Number Title Priority Date Filing Date
MEP-2019-199A ME03452B (me) 2009-10-23 2010-10-21 Disupstituisani oktahi-dropirolo[3,4-c]piroli kao modulatori oreksin receptora
MEP-2016-135A ME02437B (me) 2009-10-23 2010-10-21 Disupstituirani oktahidropirolo[3,4-c]piroli kao modulatori oreksin receptora

Family Applications After (1)

Application Number Title Priority Date Filing Date
MEP-2016-135A ME02437B (me) 2009-10-23 2010-10-21 Disupstituirani oktahidropirolo[3,4-c]piroli kao modulatori oreksin receptora

Country Status (38)

Country Link
US (8) US8653263B2 (2)
EP (3) EP2491038B1 (2)
JP (1) JP5759470B2 (2)
KR (3) KR101859409B1 (2)
CN (1) CN102781942B (2)
AR (2) AR078731A1 (2)
AU (2) AU2010310595B2 (2)
BR (1) BR112012010820B1 (2)
CA (1) CA2778484C (2)
CL (1) CL2010001162A1 (2)
CO (1) CO6541572A2 (2)
CR (1) CR20120273A (2)
CY (2) CY1117743T1 (2)
DK (2) DK3093291T3 (2)
EA (1) EA022766B1 (2)
EC (1) ECSP12011908A (2)
ES (2) ES2735411T3 (2)
HR (2) HRP20160781T1 (2)
HU (2) HUE028650T2 (2)
IL (1) IL219234A (2)
JO (2) JO3267B1 (2)
LT (1) LT3093291T (2)
ME (2) ME03452B (2)
MX (1) MX2012004753A (2)
NI (1) NI201200062A (2)
NZ (1) NZ599629A (2)
PE (1) PE20110404A1 (2)
PH (1) PH12012500796A1 (2)
PL (2) PL3093291T3 (2)
PT (2) PT3093291T (2)
RS (2) RS59004B1 (2)
SI (2) SI3093291T1 (2)
SM (2) SMT201900392T1 (2)
TR (1) TR201910327T4 (2)
TW (1) TWI481613B (2)
UA (1) UA107812C2 (2)
UY (1) UY32966A (2)
WO (1) WO2011050198A1 (2)

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ME03452B (me) 2009-10-23 2020-01-20 Janssen Pharmaceutica Nv Disupstituisani oktahi-dropirolo[3,4-c]piroli kao modulatori oreksin receptora
WO2012145581A1 (en) 2011-04-20 2012-10-26 Janssen Pharmaceutica Nv Disubstituted octahy-dropyrrolo [3,4-c] pyrroles as orexin receptor modulators
US8501768B2 (en) * 2011-05-17 2013-08-06 Hoffmann-La Roche Inc. Hexahydrocyclopentapyrrolone, hexahydropyrrolopyrrolone, octahydropyrrolopyridinone and octahydropyridinone compounds
ES2572703T3 (es) 2011-11-08 2016-06-01 Actelion Pharmaceuticals Ltd. Derivados de 2-(1,2,3-triazol-2-il)benzamida y 3-(1,2,3-triazol-2-il)picolinamida como antagonistas del receptor de orexina
CA2863413A1 (en) 2012-02-07 2013-08-15 Eolas Therapeutics, Inc. Substituted prolines / piperidines as orexin receptor antagonists
US9440982B2 (en) 2012-02-07 2016-09-13 Eolas Therapeutics, Inc. Substituted prolines/piperidines as orexin receptor antagonists
ES2617863T3 (es) 2012-06-04 2017-06-20 Actelion Pharmaceuticals Ltd. Derivados de bencimidazol-prolina
WO2014028829A1 (en) * 2012-08-16 2014-02-20 The Scripps Research Institute Novel kappa opioid ligands
EA201500399A1 (ru) 2012-10-10 2015-09-30 Актелион Фармасьютиклз Лтд. Антагонисты рецептора орексина, которые представляют собой производные [орто-би-(гетеро)арил]-[2-(мета-би-(гетеро)арил)пирролидин-1-ил]метанона
CN103012293A (zh) * 2012-12-13 2013-04-03 同济大学 一种抗失眠药物mk-4305中间体的合成方法
CA2902135A1 (en) 2013-03-12 2014-09-18 Actelion Pharmaceuticals Ltd Azetidine amide derivatives as orexin receptor antagonists
TW201444849A (zh) 2013-03-13 2014-12-01 Janssen Pharmaceutica Nv 經取代的7-氮雜雙環類及其作為食慾激素受體調節劑之用途
TWI621618B (zh) 2013-03-13 2018-04-21 比利時商健生藥品公司 經取代２－氮雜雙環類及其作為食慾素受體調控劑之用途
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