ME02602B - Antikoagulantni protivotrovi - Google Patents

Antikoagulantni protivotrovi

Info

Publication number
ME02602B
ME02602B MEP-2017-29A MEP2917A ME02602B ME 02602 B ME02602 B ME 02602B ME P2917 A MEP2917 A ME P2917A ME 02602 B ME02602 B ME 02602B
Authority
ME
Montenegro
Prior art keywords
antidotes
anticoagulant
anticoagulant antidotes
Prior art date
Application number
MEP-2017-29A
Other languages
German (de)
English (en)
French (fr)
Inventor
Ryn Joanne Van
John Edward Park
Norbert Hauel
Ulrich Kunz
Tobias Litzenburger
Keith Canada
Sanjaya Singh
Alisa Waterman
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42061991&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ME02602(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of ME02602B publication Critical patent/ME02602B/me

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39583Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials not provided for elsewhere, e.g. haptens, coenzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/02Antidotes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54F(ab')2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/626Diabody or triabody
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/02Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/10Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
MEP-2017-29A 2010-01-20 2011-01-20 Antikoagulantni protivotrovi ME02602B (me)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP10151239 2010-01-20
US38391410P 2010-09-17 2010-09-17
PCT/EP2011/050749 WO2011089183A2 (en) 2010-01-20 2011-01-20 Anticoagulant antidotes
EP11703410.8A EP2525812B1 (en) 2010-01-20 2011-01-20 Anticoagulant antidotes

Publications (1)

Publication Number Publication Date
ME02602B true ME02602B (me) 2017-06-20

Family

ID=42061991

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2017-29A ME02602B (me) 2010-01-20 2011-01-20 Antikoagulantni protivotrovi

Country Status (43)

Country Link
US (3) US8486398B2 (me)
EP (2) EP2525812B1 (me)
JP (2) JP5575923B2 (me)
KR (1) KR101781787B1 (me)
CN (1) CN102711813B (me)
AP (1) AP2012006242A0 (me)
AR (1) AR079944A1 (me)
AU (1) AU2011208719C1 (me)
BR (1) BR112012018021B1 (me)
CA (1) CA2787566A1 (me)
CO (1) CO6571889A2 (me)
CY (2) CY1118875T1 (me)
DK (1) DK2525812T3 (me)
EA (1) EA028371B1 (me)
EC (1) ECSP12012105A (me)
ES (1) ES2614992T3 (me)
FR (1) FR17C1026I2 (me)
GE (1) GEP20156341B (me)
HK (1) HK1173957A1 (me)
HR (1) HRP20170613T1 (me)
HU (2) HUE032263T2 (me)
IL (1) IL219427B (me)
LT (2) LT2525812T (me)
LU (1) LUC00028I2 (me)
MA (1) MA33936B1 (me)
ME (1) ME02602B (me)
MX (1) MX2012008360A (me)
MY (1) MY162323A (me)
NL (1) NL300882I2 (me)
NO (2) NO2017034I1 (me)
NZ (1) NZ599508A (me)
PE (1) PE20121516A1 (me)
PL (1) PL2525812T3 (me)
PT (1) PT2525812T (me)
RS (1) RS55683B1 (me)
SG (1) SG182552A1 (me)
SI (1) SI2525812T1 (me)
TN (1) TN2012000366A1 (me)
TW (1) TWI513466B (me)
UA (1) UA110470C2 (me)
UY (1) UY33196A (me)
WO (1) WO2011089183A2 (me)
ZA (1) ZA201202876B (me)

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TWI513466B (zh) 2010-01-20 2015-12-21 Boehringer Ingelheim Int 抗凝血劑解毒劑
CA2858350A1 (en) 2011-01-14 2013-07-19 The Regents Of The University Of California Therapeutic antibodies against ror-1 protein and methods for use of same
EP2665751A1 (en) * 2011-01-19 2013-11-27 Bayer Intellectual Property GmbH Binding proteins to inhibitors of coagulation factors
PE20140964A1 (es) * 2011-03-30 2014-08-17 Boehringer Ingelheim Int Antidotos anticoagulantes
PT2785700E (pt) 2011-11-29 2016-06-02 Perosphere Inc Agentes de reversão de anticoagulantes
AR095499A1 (es) 2013-03-14 2015-10-21 Bayer Healthcare Llc ANTICUERPOS MONOCLONALES CONTRA ANTITROMBINA b
EP3060583A1 (en) * 2013-10-25 2016-08-31 Boehringer Ingelheim International GmbH Anticoagulant antidotes
TW201623331A (zh) * 2014-03-12 2016-07-01 普羅帝納生物科學公司 抗黑色素瘤細胞黏著分子(mcam)抗體類及使用彼等之相關方法
CN105223348A (zh) * 2014-05-26 2016-01-06 北京九强生物技术股份有限公司 人抗凝血酶iii的胶乳增强免疫比浊法检测试剂盒
EP2980218A1 (en) 2014-07-30 2016-02-03 Rheinische Friedrich-Wilhelms-Universität Bonn Aptamer thrombin complex for use as an antidote to direct acting thrombin inhibitors
EP3611507B1 (en) * 2014-07-31 2021-11-24 Haemonetics Corporation Detection of reversal of an anticoagulant using ecarin and factor xa clotting assays
US10300154B2 (en) 2014-09-17 2019-05-28 David R Elmaleh Anticoagulant derivatives for cardiovascular imaging
EP4205743A1 (en) 2014-12-31 2023-07-05 Shenzhen Pharmacin Co., Ltd. Pharmaceutical composition and preparation method therefor
US10449195B2 (en) 2016-03-29 2019-10-22 Shenzhen Pharmacin Co., Ltd. Pharmaceutical formulation of palbociclib and a preparation method thereof
US11879014B2 (en) 2017-03-17 2024-01-23 Tusk Therapeutics Ltd. Method of treating cancer or depleting regulatory T cells in a subject by administering a human IGG1 anti-CD25 antibody
SG11202005908WA (en) * 2017-12-24 2020-07-29 Noile Immune Biotech Inc Immunocompetent cell that expresses a cell surface molecule specifically recognizing human mesothelin, il-7 and ccl19
TW202003034A (zh) 2018-03-13 2020-01-16 英商塔斯克療法有限公司 抗-cd25抗體藥劑
CA3099974A1 (en) 2018-05-11 2019-11-14 Halcyon Therapeutics, Inc. Binding proteins and chimeric antigen receptor t cells targeting gasp-1 granules and uses thereof
US20210395299A1 (en) 2018-10-29 2021-12-23 Huahai Us Inc. Novel dipeptide compounds and uses thereof
WO2020180489A1 (en) 2019-03-06 2020-09-10 University Of Rochester Anticoagulant compositions and uses thereof
CN114306245A (zh) 2020-09-29 2022-04-12 深圳市药欣生物科技有限公司 无定形固体分散体的药物组合物及其制备方法
TW202321311A (zh) * 2021-08-02 2023-06-01 日商諾伊爾免疫生物科技股份有限公司 與scFv等之連接子結合的抗體
US11446286B1 (en) * 2022-02-28 2022-09-20 King Faisal University Treatment of fungal infections using dabigatran etexilate

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SI1639011T1 (sl) 2003-06-30 2009-04-30 Domantis Ltd Pegilirana protitelesa z enojno domeno (dAb)
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TWI513466B (zh) 2010-01-20 2015-12-21 Boehringer Ingelheim Int 抗凝血劑解毒劑

Also Published As

Publication number Publication date
CY2017025I2 (el) 2017-11-14
UY33196A (es) 2011-08-31
JP5575923B2 (ja) 2014-08-20
HUS1700030I1 (hu) 2017-08-28
JP2013517317A (ja) 2013-05-16
MA33936B1 (fr) 2013-01-02
HUE032263T2 (en) 2017-09-28
KR101781787B1 (ko) 2017-09-26
HK1173957A1 (en) 2013-05-31
CN102711813B (zh) 2015-03-04
CO6571889A2 (es) 2012-11-30
LUC00028I1 (me) 2017-07-14
US20150210778A1 (en) 2015-07-30
IL219427A0 (en) 2012-06-28
UA110470C2 (ru) 2016-01-12
ECSP12012105A (es) 2012-10-30
SG182552A1 (en) 2012-08-30
CY1118875T1 (el) 2018-01-10
CN102711813A (zh) 2012-10-03
IL219427B (en) 2018-05-31
EP2525812B1 (en) 2017-01-18
LUC00028I2 (me) 2017-09-25
AU2011208719C1 (en) 2017-07-13
LTPA2017021I1 (lt) 2017-07-25
NO2017034I1 (no) 2017-07-11
LTC2525812I2 (lt) 2019-05-10
EA028371B1 (ru) 2017-11-30
AP2012006242A0 (en) 2012-04-30
NZ599508A (en) 2014-05-30
PE20121516A1 (es) 2012-11-24
BR112012018021B1 (pt) 2020-12-08
FR17C1026I1 (fr) 2017-09-08
EA201201016A1 (ru) 2013-02-28
US9034822B2 (en) 2015-05-19
EP2525812A2 (en) 2012-11-28
WO2011089183A3 (en) 2011-11-17
GEP20156341B (en) 2015-08-10
PT2525812T (pt) 2017-04-26
FR17C1026I2 (fr) 2018-07-20
TN2012000366A1 (en) 2014-01-30
BR112012018021A2 (pt) 2017-06-20
WO2011089183A2 (en) 2011-07-28
EP3195876A1 (en) 2017-07-26
US20130289248A1 (en) 2013-10-31
US20120027780A1 (en) 2012-02-02
TWI513466B (zh) 2015-12-21
LT2525812T (lt) 2017-02-27
AU2011208719A1 (en) 2012-05-17
JP2014210794A (ja) 2014-11-13
ES2614992T3 (es) 2017-06-02
MX2012008360A (es) 2012-08-08
CA2787566A1 (en) 2011-07-28
DK2525812T3 (en) 2017-02-27
ZA201202876B (en) 2012-12-27
HRP20170613T1 (hr) 2017-06-30
NL300882I2 (nl) 2017-07-20
US8486398B2 (en) 2013-07-16
PL2525812T3 (pl) 2017-07-31
CY2017025I1 (el) 2017-11-14
AR079944A1 (es) 2012-02-29
TW201136606A (en) 2011-11-01
MY162323A (en) 2017-05-31
NO2022036I1 (no) 2022-08-12
KR20120128126A (ko) 2012-11-26
RS55683B1 (sr) 2017-07-31
SI2525812T1 (sl) 2017-05-31

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