MD4774C1 - Metodă de obţinere a unei compoziţii farmaceutice stabilizate sub formă de soluţie apoasă - Google Patents
Metodă de obţinere a unei compoziţii farmaceutice stabilizate sub formă de soluţie apoasăInfo
- Publication number
- MD4774C1 MD4774C1 MDA20190038A MD20190038A MD4774C1 MD 4774 C1 MD4774 C1 MD 4774C1 MD A20190038 A MDA20190038 A MD A20190038A MD 20190038 A MD20190038 A MD 20190038A MD 4774 C1 MD4774 C1 MD 4774C1
- Authority
- MD
- Moldova
- Prior art keywords
- producing
- aqueous solution
- pharmaceutical composition
- stabilized pharmaceutical
- composition
- Prior art date
Links
- 239000007864 aqueous solution Substances 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 abstract 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 abstract 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 230000001954 sterilising effect Effects 0.000 abstract 2
- UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 abstract 1
- 229930010555 Inosine Natural products 0.000 abstract 1
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 abstract 1
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 abstract 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 abstract 1
- 230000001120 cytoprotective effect Effects 0.000 abstract 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 229960003786 inosine Drugs 0.000 abstract 1
- 229960003194 meglumine Drugs 0.000 abstract 1
- 229960003966 nicotinamide Drugs 0.000 abstract 1
- 235000005152 nicotinamide Nutrition 0.000 abstract 1
- 239000011570 nicotinamide Substances 0.000 abstract 1
- -1 riboflavin mononucleotide sodium salt Chemical class 0.000 abstract 1
- 229910000029 sodium carbonate Inorganic materials 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
- 238000004659 sterilization and disinfection Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2016138632A RU2629204C1 (ru) | 2016-09-29 | 2016-09-29 | Способ получения стабилизированной фармацевтической композиции в виде водного раствора |
| PCT/RU2017/000658 WO2018063028A1 (ru) | 2016-09-29 | 2017-09-07 | Способ получения стабилизированной фармацевтической композиции в виде водного раствора |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| MD20190038A2 MD20190038A2 (ro) | 2019-10-31 |
| MD4774B1 MD4774B1 (ro) | 2021-11-30 |
| MD4774C1 true MD4774C1 (ro) | 2022-06-30 |
Family
ID=59744837
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MDA20190038A MD4774C1 (ro) | 2016-09-29 | 2017-09-07 | Metodă de obţinere a unei compoziţii farmaceutice stabilizate sub formă de soluţie apoasă |
Country Status (14)
| Country | Link |
|---|---|
| CN (1) | CN110022858B (es) |
| AR (1) | AR109775A1 (es) |
| BR (1) | BR112019006167A2 (es) |
| CL (1) | CL2019000810A1 (es) |
| CO (1) | CO2019004133A2 (es) |
| EA (1) | EA029693B1 (es) |
| EC (1) | ECSP19030392A (es) |
| MD (1) | MD4774C1 (es) |
| MY (1) | MY193623A (es) |
| PH (1) | PH12019500702A1 (es) |
| RU (1) | RU2629204C1 (es) |
| UA (1) | UA118387C2 (es) |
| UY (1) | UY37426A (es) |
| WO (1) | WO2018063028A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2651047C1 (ru) * | 2017-05-04 | 2018-04-18 | Общество С Ограниченной Ответственностью "Научно-Технологическая Фармацевтическая Фирма "Полисан" | Лекарственная композиция цитопротекторного действия и способ ее получения |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2059417C1 (ru) * | 1992-10-01 | 1996-05-10 | Данилевич Василий Николаевич | Способ стерилизации питательных сред |
| KR20010033563A (ko) * | 1997-12-25 | 2001-04-25 | 다카하시 데츠로 | 수성 액제 |
| EA001099B1 (ru) * | 1999-06-10 | 2000-10-30 | Общество С Ограниченной Ответственностью "Научно-Технологическая Фармацевтическая Фирма "Полисан" | Инъекционное лекарственое средство "цитофлавин", обладающее цитопротекторным действием |
| JP2002161047A (ja) * | 2000-11-28 | 2002-06-04 | Terumo Corp | ヘモグロビン溶液およびヘモグロビン含有リポソーム |
| RU2238108C1 (ru) * | 2003-01-27 | 2004-10-20 | Нестерук Владимир Викторович | Способ стерилизации инъекционного раствора натрия хлорида |
| CN1679615A (zh) * | 2005-02-04 | 2005-10-12 | 北京阜康仁生物制药科技有限公司 | 复方小儿能量合剂水溶性维生素制剂及其应用 |
| CN101601647B (zh) * | 2009-07-09 | 2010-09-15 | 周晓东 | 一种核黄素磷酸钠组合物注射液及制备方法 |
| RU2536994C1 (ru) * | 2013-05-17 | 2014-12-27 | Общество С Ограниченной Ответственностью "Нпо "Нефрон" | Концентрированный кислотный компонент, набор для его получения, концентрированный раствор кислотного компонента для получения гемодиализирующего раствора и способ его получения |
| WO2015113035A1 (en) * | 2014-01-27 | 2015-07-30 | Abbott Laboratories | Aseptic filtration process |
| US20170224726A1 (en) * | 2014-02-18 | 2017-08-10 | Glenn Abrahmsohn | Compositions and methods for pain relief without numbness |
| WO2016145390A1 (en) * | 2015-03-12 | 2016-09-15 | Mars, Incorporated | Ultra high resolution mass spectrometry and methods of using the same |
-
2016
- 2016-09-29 RU RU2016138632A patent/RU2629204C1/ru active IP Right Revival
-
2017
- 2017-02-16 EA EA201700072A patent/EA029693B1/ru unknown
- 2017-02-23 UA UAA201701703A patent/UA118387C2/uk unknown
- 2017-09-07 MD MDA20190038A patent/MD4774C1/ro not_active IP Right Cessation
- 2017-09-07 CN CN201780073686.9A patent/CN110022858B/zh active Active
- 2017-09-07 WO PCT/RU2017/000658 patent/WO2018063028A1/ru active Application Filing
- 2017-09-07 MY MYPI2019001541A patent/MY193623A/en unknown
- 2017-09-07 BR BR112019006167A patent/BR112019006167A2/pt active Search and Examination
- 2017-09-29 AR ARP170102733A patent/AR109775A1/es unknown
- 2017-09-29 UY UY0001037426A patent/UY37426A/es not_active Application Discontinuation
-
2019
- 2019-03-27 CL CL2019000810A patent/CL2019000810A1/es unknown
- 2019-03-29 PH PH12019500702A patent/PH12019500702A1/en unknown
- 2019-04-26 CO CONC2019/0004133A patent/CO2019004133A2/es unknown
- 2019-04-29 EC ECSENADI201930392A patent/ECSP19030392A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN110022858A (zh) | 2019-07-16 |
| UA118387C2 (uk) | 2019-01-10 |
| CL2019000810A1 (es) | 2019-08-02 |
| ECSP19030392A (es) | 2019-08-30 |
| WO2018063028A1 (ru) | 2018-04-05 |
| EA201700072A1 (ru) | 2018-03-30 |
| PH12019500702A1 (en) | 2019-11-25 |
| MD4774B1 (ro) | 2021-11-30 |
| UY37426A (es) | 2018-04-30 |
| AR109775A1 (es) | 2019-01-23 |
| MY193623A (en) | 2022-10-20 |
| CO2019004133A2 (es) | 2019-09-30 |
| CN110022858B (zh) | 2021-12-14 |
| EA029693B1 (ru) | 2018-04-30 |
| BR112019006167A2 (pt) | 2019-06-18 |
| MD20190038A2 (ro) | 2019-10-31 |
| RU2629204C1 (ru) | 2017-08-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG4A | Patent for invention issued | ||
| KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) |