PH12019500702A1 - Method for producing a stabilized pharmaceutical composition in the from of an aqueous solution - Google Patents

Method for producing a stabilized pharmaceutical composition in the from of an aqueous solution

Info

Publication number
PH12019500702A1
PH12019500702A1 PH12019500702A PH12019500702A PH12019500702A1 PH 12019500702 A1 PH12019500702 A1 PH 12019500702A1 PH 12019500702 A PH12019500702 A PH 12019500702A PH 12019500702 A PH12019500702 A PH 12019500702A PH 12019500702 A1 PH12019500702 A1 PH 12019500702A1
Authority
PH
Philippines
Prior art keywords
aqueous solution
producing
pharmaceutical composition
composition
tris
Prior art date
Application number
PH12019500702A
Inventor
Alexey Leonidovich Kovalenko
Andrey Yurievich Petrov
Original Assignee
Obschestvo S Ogranichennoi Otvetstvennostyu Nauchno Tekh Farmacevticheskaya Firma Polysan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Obschestvo S Ogranichennoi Otvetstvennostyu Nauchno Tekh Farmacevticheskaya Firma Polysan filed Critical Obschestvo S Ogranichennoi Otvetstvennostyu Nauchno Tekh Farmacevticheskaya Firma Polysan
Publication of PH12019500702A1 publication Critical patent/PH12019500702A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention relates to the chemical and pharmaceutical industry. A method for producing a stabilized pharmaceutical composition in the form of an aqueous solution comprising active ingredients which include succinic acid, inosine, nicotinamide and riboflavin mononucleotide sodium salt, wherein a stabilizing agent is further introduced into the composition as one or more pharmaceutically acceptable ingredients selected from the group consisting of sodium hydroxide, tris-(oxymethyl)aminomethane (TRIS), ethanolamine, diethanolamine, sodium carbonate and meglumine to obtain a stable aqueous solution having a pH value in the range of 6.0 to 8.0; the method further comprises a sterilizing filtration of the resulting dissolved composition, and an additional thermal sterilization at temperatures from 100øC and an exposure time of 8 minutes to 116øC and an exposure time of 2 minutes.
PH12019500702A 2016-09-29 2019-03-29 Method for producing a stabilized pharmaceutical composition in the from of an aqueous solution PH12019500702A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2016138632A RU2629204C1 (en) 2016-09-29 2016-09-29 Method for obtaining of stabilized pharmaceutical composition as aqueous solution
PCT/RU2017/000658 WO2018063028A1 (en) 2016-09-29 2017-09-07 Method for producing a stabilized pharmaceutical composition in the form of an aqueous solution

Publications (1)

Publication Number Publication Date
PH12019500702A1 true PH12019500702A1 (en) 2019-11-25

Family

ID=59744837

Family Applications (1)

Application Number Title Priority Date Filing Date
PH12019500702A PH12019500702A1 (en) 2016-09-29 2019-03-29 Method for producing a stabilized pharmaceutical composition in the from of an aqueous solution

Country Status (14)

Country Link
CN (1) CN110022858B (en)
AR (1) AR109775A1 (en)
BR (1) BR112019006167A2 (en)
CL (1) CL2019000810A1 (en)
CO (1) CO2019004133A2 (en)
EA (1) EA029693B1 (en)
EC (1) ECSP19030392A (en)
MD (1) MD4774C1 (en)
MY (1) MY193623A (en)
PH (1) PH12019500702A1 (en)
RU (1) RU2629204C1 (en)
UA (1) UA118387C2 (en)
UY (1) UY37426A (en)
WO (1) WO2018063028A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2651047C1 (en) * 2017-05-04 2018-04-18 Общество С Ограниченной Ответственностью "Научно-Технологическая Фармацевтическая Фирма "Полисан" Drug composition of cytoprotective action and method for production thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2059417C1 (en) * 1992-10-01 1996-05-10 Данилевич Василий Николаевич Method for sterilization of nutrient media
KR20010033563A (en) * 1997-12-25 2001-04-25 다카하시 데츠로 Water-base liquid preparation
EA001099B1 (en) * 1999-06-10 2000-10-30 Общество С Ограниченной Ответственностью "Научно-Технологическая Фармацевтическая Фирма "Полисан" Injecting medical preparation "citoflavin" possessing cito-pretecting effect
JP2002161047A (en) * 2000-11-28 2002-06-04 Terumo Corp Hemoglobin solution and hemoglobin-containing liposome
RU2238108C1 (en) * 2003-01-27 2004-10-20 Нестерук Владимир Викторович Method for sterilizing sodium chloride injection solution
CN1679615A (en) * 2005-02-04 2005-10-12 北京阜康仁生物制药科技有限公司 Compound infantile energy mistura soluble vitamin preparation and use thereof
CN101601647B (en) * 2009-07-09 2010-09-15 周晓东 Riboflavine sodium phosphate composition injection and preparation method thereof
RU2536994C1 (en) * 2013-05-17 2014-12-27 Общество С Ограниченной Ответственностью "Нпо "Нефрон" Concentrated acidic component, kit for producing it, concentrated solution of acidic component for producing hemodialysis solution and method for producing it
WO2015113035A1 (en) * 2014-01-27 2015-07-30 Abbott Laboratories Aseptic filtration process
WO2015126942A1 (en) * 2014-02-18 2015-08-27 Glenn Abrahmsohn Compositions and methods for pain relief without numbness
US10627407B2 (en) * 2015-03-12 2020-04-21 Mars, Incorporated Ultra high resolution mass spectrometry and methods of using the same

Also Published As

Publication number Publication date
MY193623A (en) 2022-10-20
WO2018063028A1 (en) 2018-04-05
MD4774B1 (en) 2021-11-30
MD4774C1 (en) 2022-06-30
EA029693B1 (en) 2018-04-30
MD20190038A2 (en) 2019-10-31
CN110022858B (en) 2021-12-14
UY37426A (en) 2018-04-30
CO2019004133A2 (en) 2019-09-30
EA201700072A1 (en) 2018-03-30
AR109775A1 (en) 2019-01-23
CN110022858A (en) 2019-07-16
BR112019006167A2 (en) 2019-06-18
ECSP19030392A (en) 2019-08-30
UA118387C2 (en) 2019-01-10
CL2019000810A1 (en) 2019-08-02
RU2629204C1 (en) 2017-08-25

Similar Documents

Publication Publication Date Title
CY1121782T1 (en) PROCEDURE FOR DRYING BIBW2992, ITS SALTS AND SOLID PHARMACEUTICAL FORMULATIONS CONTAINING THIS ACTIVE INGREDIENT
CN103704264B (en) A kind of disinfectant detergent
PH12020551692A1 (en) 2-amino-pyrimidine derivatives as cyclin dependent kinase inhibitors
MX2019011785A (en) Process for preparing chiral 2,3-dihydrothiazolo[3,2-a]pyrimidin- 4-ium compounds.
EA202192783A1 (en) MODULATOR OF THE REGULATOR OF TRANSMEMBRANE CONDUCTIVITY IN CYSTIC FISSIDOSIS, PHARMACEUTICAL COMPOSITIONS, METHODS OF TREATMENT AND METHOD OF OBTAINING THE SPECIFIED MODULATOR
NO20076635L (en) Crystalline and other forms of 4-amino-5-fluoro-3- [6- (4-methylpiperazin-1-yl) -1H-benzimidazol-2-yl] -1H-quinolin-2-one lactic acid salts
MY189761A (en) Quinazoline derivatives used to treat hiv
WO2009139576A3 (en) Pyridine derivatives substituted with novel benzoxazoles or pharmaceutically acceptable salts thereof, preparation method thereof and pharmaceutical compositions containing the same as active ingredients for prevention and treatment of abnormal cell growth disease
MY148375A (en) Delta and epsilon crystal forms of imatinib mesylate
EA201792224A1 (en) COMPOSITIONS CONTAINING IBRUTINIB
EA201491674A1 (en) NEW PHARMACEUTICAL COMPOSITIONS
FI75492C (en) Process for the preparation of a sterile, injectable, physiologically removable solution of an X-ray contrast agent and a solution used as a starting material for an X-ray contrast agent and a physiologically acceptable buffer system.
AR036248A1 (en) DERIVATIVES OF 2H-PIRIDAZIN-3-ONA, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND A PROCESS FOR THE PREPARATION OF SUCH DERIVATIVES AND THE USE OF SUCH DERIVATIVES FOR THE PREPARATION OF A PHARMACEUTICAL COMPOSITION
PH12014501711A1 (en) Benzyl sulfonamide derivatives useful as mogat-2 inhibitors
PH12016501175B1 (en) Formulations of deoxycholic acid and salts thereof
PH12019500394A1 (en) Bicyclic nitrogenated heterocyclic compound
PH12019500702A1 (en) Method for producing a stabilized pharmaceutical composition in the from of an aqueous solution
MX2018010177A (en) 6,7-dihydro-5h-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds.
SG11201907472QA (en) Composition for inhibiting myofibrosis
PH12021550439A1 (en) O-glycoprotein-2-acetamido-2-deoxy-3-d-glucopyranosidase inhibitors
PH12020551154A1 (en) Method for suppressing discoloration of external composition containing adenosine phosphate and tranexamic acid
EA202290215A1 (en) COMPOUNDS AND METHODS OF THEIR APPLICATION AS ANTIBACTERIAL AGENTS
PH12018501138A1 (en) Pest control composition including iminopyridine derivative
CR8097A (en) AGROCHEMICAL COMPOSITION IN WATERPROOF SUSPENSION
BR112022022264A2 (en) TABLET FOR FORMING A LIQUID DISHWASHING COMPOSITION AND METHOD FOR FORMING A HAND DISHWASHING LIQUID