CL2019000810A1 - Method for producing a pharmaceutically stable composition presented as an aqueous solution. - Google Patents

Method for producing a pharmaceutically stable composition presented as an aqueous solution.

Info

Publication number
CL2019000810A1
CL2019000810A1 CL2019000810A CL2019000810A CL2019000810A1 CL 2019000810 A1 CL2019000810 A1 CL 2019000810A1 CL 2019000810 A CL2019000810 A CL 2019000810A CL 2019000810 A CL2019000810 A CL 2019000810A CL 2019000810 A1 CL2019000810 A1 CL 2019000810A1
Authority
CL
Chile
Prior art keywords
producing
composition presented
aqueous solution
stable composition
pharmaceutically stable
Prior art date
Application number
CL2019000810A
Other languages
Spanish (es)
Inventor
Alexey Leonidovich Kovalenko
Andrey Yurievich Petrov
Original Assignee
Obschestvo S Ogranichennoi Otvetstvennostyu Nauchno Tekh Farmacevticheskaya Firma Polysan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Obschestvo S Ogranichennoi Otvetstvennostyu Nauchno Tekh Farmacevticheskaya Firma Polysan filed Critical Obschestvo S Ogranichennoi Otvetstvennostyu Nauchno Tekh Farmacevticheskaya Firma Polysan
Publication of CL2019000810A1 publication Critical patent/CL2019000810A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions

Abstract

MÉTODO PARA PRODUCIR UNA COMPOSICIÓN FARMACÉUTICA ESTABILIZADA PRESENTADA COMO UNA SOLUCIÓN ACUOSA QUE CONTIENE ÁCIDO SUCCÍNICO, INOSINA, NICOTINAMIDA, RIBOFLAVINA-MONONUCLEÓTIDO DE SODIO COMO LOS INGREDIENTES ACTIVOS, MEDIANTE LA DISOLUCIÓN DE ESTOS EN AGUA CON LA SUBSIGUIENTE FILTRACIÓN ESTÉRIL, EN DONDE LA COMPOSICIÓN SE SUPLEMENTA CON UNO O VARIOS DE LOS COMPONENTES FARMACÉUTICAMENTE ACEPTABLES COMO EL AGENTE ESTABILIZADOR QUE SE HAN DE SELECCIONAR DEL GRUPO QUE INCLUYE HIDRÓXIDO DE SODIO, TRIS(HIDROXIMETIL)AMINOMETANO (TRIS), ETANOLAMINA, DIETANOLAMINA, CARBONATO DE SODIO, MEGLUMINA, HASTA UNA SOLUCIÓN ESTABLE CON PH ENTRE 6,0 Y 8,0; SIENDO LA PROPORCIÓN DE LOS COMPONENTES, % EN PESO, COMO SIGUE: ÁCIDO SUCCÍNICO 5,00-12,50 INOSINA 1,00-2,40 NICOTINAMIDA 0,50-1,20 RIBOFLAVINA-MONONUCLEÓTIDO DE SODIO 0,10-0,24 AGENTE ESTABILIZANTE 3,21-51,30 AGUA HASTA 100,0%,METHOD FOR PRODUCING A STABILIZED PHARMACEUTICAL COMPOSITION PRESENTED AS A WATER SOLUTION CONTAINING SUCCINIC ACID, INOSINE, NICOTINAMIDE, RIBOFLAVINE-MONONUCLEOTIDE SODIUM AS THE ACTIVE INGREDIENTS, THROUGH THE SUBSTITUTE THROUGH THE SUBSTITUTE. WITH ONE OR MISCELLANEOUS OF THE PHARMACEUTICALLY ACCEPTABLE COMPONENTS AS THE STABILIZING AGENT TO BE SELECTED FROM THE GROUP THAT INCLUDES SODIUM HYDROXIDE, TRIS (HYDROXIMETHYL) AMINOMETHANE (TRIS), ETHANOLAMINE, SETHYLAMINATE HYDROCHLINET PH BETWEEN 6.0 AND 8.0; BEING THE PROPORTION OF THE COMPONENTS,% BY WEIGHT, AS FOLLOWS: SUCCINIC ACID 5.00-12.50 INOSINE 1.00-2.40 NICOTINAMIDE 0.50-1.20 SODIUM RIBOFLAVINE-0.10-0, 24 STABILIZING AGENT 3.21-51.30 WATER UP TO 100.0%,

CL2019000810A 2016-09-29 2019-03-27 Method for producing a pharmaceutically stable composition presented as an aqueous solution. CL2019000810A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2016138632A RU2629204C1 (en) 2016-09-29 2016-09-29 Method for obtaining of stabilized pharmaceutical composition as aqueous solution

Publications (1)

Publication Number Publication Date
CL2019000810A1 true CL2019000810A1 (en) 2019-08-02

Family

ID=59744837

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2019000810A CL2019000810A1 (en) 2016-09-29 2019-03-27 Method for producing a pharmaceutically stable composition presented as an aqueous solution.

Country Status (14)

Country Link
CN (1) CN110022858B (en)
AR (1) AR109775A1 (en)
BR (1) BR112019006167A2 (en)
CL (1) CL2019000810A1 (en)
CO (1) CO2019004133A2 (en)
EA (1) EA029693B1 (en)
EC (1) ECSP19030392A (en)
MD (1) MD4774C1 (en)
MY (1) MY193623A (en)
PH (1) PH12019500702A1 (en)
RU (1) RU2629204C1 (en)
UA (1) UA118387C2 (en)
UY (1) UY37426A (en)
WO (1) WO2018063028A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2651047C1 (en) * 2017-05-04 2018-04-18 Общество С Ограниченной Ответственностью "Научно-Технологическая Фармацевтическая Фирма "Полисан" Drug composition of cytoprotective action and method for production thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2059417C1 (en) * 1992-10-01 1996-05-10 Данилевич Василий Николаевич Method for sterilization of nutrient media
KR20010033563A (en) * 1997-12-25 2001-04-25 다카하시 데츠로 Water-base liquid preparation
EA001099B1 (en) * 1999-06-10 2000-10-30 Общество С Ограниченной Ответственностью "Научно-Технологическая Фармацевтическая Фирма "Полисан" Injecting medical preparation "citoflavin" possessing cito-pretecting effect
JP2002161047A (en) * 2000-11-28 2002-06-04 Terumo Corp Hemoglobin solution and hemoglobin-containing liposome
RU2238108C1 (en) * 2003-01-27 2004-10-20 Нестерук Владимир Викторович Method for sterilizing sodium chloride injection solution
CN1679615A (en) * 2005-02-04 2005-10-12 北京阜康仁生物制药科技有限公司 Compound infantile energy mistura soluble vitamin preparation and use thereof
CN101601647B (en) * 2009-07-09 2010-09-15 周晓东 Riboflavine sodium phosphate composition injection and preparation method thereof
RU2536994C1 (en) * 2013-05-17 2014-12-27 Общество С Ограниченной Ответственностью "Нпо "Нефрон" Concentrated acidic component, kit for producing it, concentrated solution of acidic component for producing hemodialysis solution and method for producing it
WO2015113035A1 (en) * 2014-01-27 2015-07-30 Abbott Laboratories Aseptic filtration process
EP3107551B1 (en) * 2014-02-18 2020-10-28 Glenn Abrahmsohn Compositions comprising bicarbonate and calcium salts for pain relief without numbness
US10627407B2 (en) * 2015-03-12 2020-04-21 Mars, Incorporated Ultra high resolution mass spectrometry and methods of using the same

Also Published As

Publication number Publication date
EA201700072A1 (en) 2018-03-30
EA029693B1 (en) 2018-04-30
ECSP19030392A (en) 2019-08-30
PH12019500702A1 (en) 2019-11-25
CO2019004133A2 (en) 2019-09-30
MY193623A (en) 2022-10-20
CN110022858B (en) 2021-12-14
MD4774C1 (en) 2022-06-30
MD20190038A2 (en) 2019-10-31
WO2018063028A1 (en) 2018-04-05
UY37426A (en) 2018-04-30
BR112019006167A2 (en) 2019-06-18
CN110022858A (en) 2019-07-16
AR109775A1 (en) 2019-01-23
RU2629204C1 (en) 2017-08-25
UA118387C2 (en) 2019-01-10
MD4774B1 (en) 2021-11-30

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