AR109775A1 - METHOD FOR PRODUCING A PHARMACEUTICALLY STABLE COMPOSITION PRESENTED AS A WATER SOLUTION - Google Patents
METHOD FOR PRODUCING A PHARMACEUTICALLY STABLE COMPOSITION PRESENTED AS A WATER SOLUTIONInfo
- Publication number
- AR109775A1 AR109775A1 ARP170102733A ARP170102733A AR109775A1 AR 109775 A1 AR109775 A1 AR 109775A1 AR P170102733 A ARP170102733 A AR P170102733A AR P170102733 A ARP170102733 A AR P170102733A AR 109775 A1 AR109775 A1 AR 109775A1
- Authority
- AR
- Argentina
- Prior art keywords
- producing
- composition presented
- aqueous solution
- pharmaceutical composition
- stabilized pharmaceutical
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Se relaciona con la industria química y farmacéutica y, en particular, con un método para producir una composición farmacéutica estabilizada presentada como una solución acuosa que se puede usar para obtener un fármaco intravenoso que contiene ácido succínico, nicotinamida, inosina y riboflavina-mononucleótido como los ingredientes activos y que posee propiedades citoprotectoras. Un método para producir la composición farmacéutica conocida estabilizada presentada como una solución acuosa que permitiría mejorar su seguridad en el uso a través de la aplicación de esterilización térmica. Un método para producir una composición farmacéutica estabilizada presentada como una solución acuosa que contiene ácido succínico, inosina, nicotinamida, riboflavina-mononucleótido de sodio como ingredientes activos, mediante la disolución de estos en agua con la subsiguiente filtración estéril, donde, la composición se suplementa con uno o varios de los componentes farmacéuticamente aceptables como el agente estabilizador que se ha de seleccionar del grupo que incluye hidróxido de sodio, tris(hidroximetil)aminometano (TRIS), etanolamina, dietanolamina, carbonato de sodio, meglumina, hasta una solución estable con pH entre 6,0 y 8,0; siendo la proporción de componentes, % en peso, como sigue: @@@@@@@@@It relates to the chemical and pharmaceutical industry and, in particular, to a method for producing a stabilized pharmaceutical composition presented as an aqueous solution that can be used to obtain an intravenous drug containing succinic acid, nicotinamide, inosine and riboflavin-mononucleotide such as active ingredients and that has cytoprotective properties. A method for producing the known stabilized pharmaceutical composition presented as an aqueous solution that would improve its safety in use through the application of thermal sterilization. A method for producing a stabilized pharmaceutical composition presented as an aqueous solution containing succinic acid, inosine, nicotinamide, riboflavin-sodium mononucleotide as active ingredients, by dissolving these in water with subsequent sterile filtration, where the composition is supplemented with one or more of the pharmaceutically acceptable components as the stabilizing agent to be selected from the group that includes sodium hydroxide, tris (hydroxymethyl) aminomethane (TRIS), ethanolamine, diethanolamine, sodium carbonate, meglumine, to a stable solution with pH between 6.0 and 8.0; being the proportion of components,% by weight, as follows: @@@@@@@@@@
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2016138632A RU2629204C1 (en) | 2016-09-29 | 2016-09-29 | Method for obtaining of stabilized pharmaceutical composition as aqueous solution |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR109775A1 true AR109775A1 (en) | 2019-01-23 |
Family
ID=59744837
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP170102733A AR109775A1 (en) | 2016-09-29 | 2017-09-29 | METHOD FOR PRODUCING A PHARMACEUTICALLY STABLE COMPOSITION PRESENTED AS A WATER SOLUTION |
Country Status (14)
| Country | Link |
|---|---|
| CN (1) | CN110022858B (en) |
| AR (1) | AR109775A1 (en) |
| BR (1) | BR112019006167A2 (en) |
| CL (1) | CL2019000810A1 (en) |
| CO (1) | CO2019004133A2 (en) |
| EA (1) | EA029693B1 (en) |
| EC (1) | ECSP19030392A (en) |
| MD (1) | MD4774C1 (en) |
| MY (1) | MY193623A (en) |
| PH (1) | PH12019500702A1 (en) |
| RU (1) | RU2629204C1 (en) |
| UA (1) | UA118387C2 (en) |
| UY (1) | UY37426A (en) |
| WO (1) | WO2018063028A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2651047C1 (en) * | 2017-05-04 | 2018-04-18 | Общество С Ограниченной Ответственностью "Научно-Технологическая Фармацевтическая Фирма "Полисан" | Drug composition of cytoprotective action and method for production thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2059417C1 (en) * | 1992-10-01 | 1996-05-10 | Данилевич Василий Николаевич | Method for sterilization of nutrient media |
| CA2316986A1 (en) * | 1997-12-25 | 1999-07-08 | Toshihiro Baba | Aqueous liquid preparation |
| EA001099B1 (en) * | 1999-06-10 | 2000-10-30 | Общество С Ограниченной Ответственностью "Научно-Технологическая Фармацевтическая Фирма "Полисан" | Injecting medical preparation "citoflavin" possessing cito-pretecting effect |
| JP2002161047A (en) * | 2000-11-28 | 2002-06-04 | Terumo Corp | Hemoglobin solution and hemoglobin-containing liposome |
| RU2238108C1 (en) * | 2003-01-27 | 2004-10-20 | Нестерук Владимир Викторович | Method for sterilizing sodium chloride injection solution |
| CN1679615A (en) * | 2005-02-04 | 2005-10-12 | 北京阜康仁生物制药科技有限公司 | Compound infantile energy mistura soluble vitamin preparation and use thereof |
| CN101601647B (en) * | 2009-07-09 | 2010-09-15 | 周晓东 | Riboflavine sodium phosphate composition injection and preparation method thereof |
| RU2536994C1 (en) * | 2013-05-17 | 2014-12-27 | Общество С Ограниченной Ответственностью "Нпо "Нефрон" | Concentrated acidic component, kit for producing it, concentrated solution of acidic component for producing hemodialysis solution and method for producing it |
| WO2015113035A1 (en) * | 2014-01-27 | 2015-07-30 | Abbott Laboratories | Aseptic filtration process |
| PL3107551T3 (en) * | 2014-02-18 | 2021-05-04 | Glenn Abrahmsohn | Compositions comprising bicarbonate and calcium salts for pain relief without numbness |
| WO2016145390A1 (en) * | 2015-03-12 | 2016-09-15 | Mars, Incorporated | Ultra high resolution mass spectrometry and methods of using the same |
-
2016
- 2016-09-29 RU RU2016138632A patent/RU2629204C1/en active IP Right Revival
-
2017
- 2017-02-16 EA EA201700072A patent/EA029693B1/en unknown
- 2017-02-23 UA UAA201701703A patent/UA118387C2/en unknown
- 2017-09-07 BR BR112019006167A patent/BR112019006167A2/en active Search and Examination
- 2017-09-07 MD MDA20190038A patent/MD4774C1/en not_active IP Right Cessation
- 2017-09-07 CN CN201780073686.9A patent/CN110022858B/en active Active
- 2017-09-07 MY MYPI2019001541A patent/MY193623A/en unknown
- 2017-09-07 WO PCT/RU2017/000658 patent/WO2018063028A1/en active Application Filing
- 2017-09-29 UY UY0001037426A patent/UY37426A/en not_active Application Discontinuation
- 2017-09-29 AR ARP170102733A patent/AR109775A1/en unknown
-
2019
- 2019-03-27 CL CL2019000810A patent/CL2019000810A1/en unknown
- 2019-03-29 PH PH12019500702A patent/PH12019500702A1/en unknown
- 2019-04-26 CO CONC2019/0004133A patent/CO2019004133A2/en unknown
- 2019-04-29 EC ECSENADI201930392A patent/ECSP19030392A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MD4774B1 (en) | 2021-11-30 |
| RU2629204C1 (en) | 2017-08-25 |
| WO2018063028A1 (en) | 2018-04-05 |
| MD4774C1 (en) | 2022-06-30 |
| CL2019000810A1 (en) | 2019-08-02 |
| EA029693B1 (en) | 2018-04-30 |
| UA118387C2 (en) | 2019-01-10 |
| CN110022858B (en) | 2021-12-14 |
| EA201700072A1 (en) | 2018-03-30 |
| BR112019006167A2 (en) | 2019-06-18 |
| PH12019500702A1 (en) | 2019-11-25 |
| UY37426A (en) | 2018-04-30 |
| CN110022858A (en) | 2019-07-16 |
| CO2019004133A2 (en) | 2019-09-30 |
| ECSP19030392A (en) | 2019-08-30 |
| MY193623A (en) | 2022-10-20 |
| MD20190038A2 (en) | 2019-10-31 |
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