EA201700072A1 - METHOD FOR OBTAINING A STABILIZED PHARMACEUTICAL COMPOSITION IN THE FORM OF AQUEOUS SOLUTION - Google Patents
METHOD FOR OBTAINING A STABILIZED PHARMACEUTICAL COMPOSITION IN THE FORM OF AQUEOUS SOLUTIONInfo
- Publication number
- EA201700072A1 EA201700072A1 EA201700072A EA201700072A EA201700072A1 EA 201700072 A1 EA201700072 A1 EA 201700072A1 EA 201700072 A EA201700072 A EA 201700072A EA 201700072 A EA201700072 A EA 201700072A EA 201700072 A1 EA201700072 A1 EA 201700072A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- obtaining
- aqueous solution
- pharmaceutical composition
- minutes
- stabilized pharmaceutical
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Изобретение относится к химико-фармацевтической промышленности, в частности к способу получения стабилизированной фармацевтической композиции в виде водного раствора, который может быть использован для получения лекарственного препарата для внутривенного введения, содержащего в качестве активных компонентов янтарную кислоту, никотинамид, инозин и рибофлавина мононуклеотид и обладающего цитопротекторными свойствами. Согласно изобретению в композицию дополнительно вводят в качестве стабилизирующего агента один или несколько фармацевтически приемлемых компонентов, выбранных из группы, включающей натрия гидроксид, трис-оксиметиламинометан, этаноламин, диэтаноламин, натрия карбонат, меглюмин, до получения стабильного раствора со значением рН в диапазоне от 6,0 до 8,0 и дополнительно проводят термическую стерилизацию раствора при температуре от 100°С и времени экспозиции 8 мин до 116°С и времени экспозиции 2 мин.The invention relates to the pharmaceutical industry, in particular to a method for obtaining a stabilized pharmaceutical composition in the form of an aqueous solution, which can be used to obtain a medicinal product for intravenous administration, containing succinic acid, nicotinamide, inosine and riboflavin mononucleotide and possessing cytoprotective as active components properties. According to the invention, one or more pharmaceutically acceptable components selected from the group comprising sodium hydroxide, tris-oxymethylaminomethane, ethanolamine, diethanolamine, sodium carbonate, meglumine are additionally introduced into the composition as a stabilizing agent to obtain a stable solution with a pH value ranging from 6, 0 to 8.0 and additionally carry out thermal sterilization of the solution at a temperature of from 100 ° C and an exposure time of 8 minutes to 116 ° C and an exposure time of 2 minutes.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2016138632A RU2629204C1 (en) | 2016-09-29 | 2016-09-29 | Method for obtaining of stabilized pharmaceutical composition as aqueous solution |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201700072A1 true EA201700072A1 (en) | 2018-03-30 |
| EA029693B1 EA029693B1 (en) | 2018-04-30 |
Family
ID=59744837
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201700072A EA029693B1 (en) | 2016-09-29 | 2017-02-16 | Method for obtaining a stable pharmaceutical composition as an aqueous solution for intravenous administration |
Country Status (14)
| Country | Link |
|---|---|
| CN (1) | CN110022858B (en) |
| AR (1) | AR109775A1 (en) |
| BR (1) | BR112019006167A2 (en) |
| CL (1) | CL2019000810A1 (en) |
| CO (1) | CO2019004133A2 (en) |
| EA (1) | EA029693B1 (en) |
| EC (1) | ECSP19030392A (en) |
| MD (1) | MD4774C1 (en) |
| MY (1) | MY193623A (en) |
| PH (1) | PH12019500702A1 (en) |
| RU (1) | RU2629204C1 (en) |
| UA (1) | UA118387C2 (en) |
| UY (1) | UY37426A (en) |
| WO (1) | WO2018063028A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2651047C1 (en) * | 2017-05-04 | 2018-04-18 | Общество С Ограниченной Ответственностью "Научно-Технологическая Фармацевтическая Фирма "Полисан" | Drug composition of cytoprotective action and method for production thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2059417C1 (en) * | 1992-10-01 | 1996-05-10 | Данилевич Василий Николаевич | Method for sterilization of nutrient media |
| KR20010033563A (en) * | 1997-12-25 | 2001-04-25 | 다카하시 데츠로 | Water-base liquid preparation |
| EA001099B1 (en) * | 1999-06-10 | 2000-10-30 | Общество С Ограниченной Ответственностью "Научно-Технологическая Фармацевтическая Фирма "Полисан" | Injecting medical preparation "citoflavin" possessing cito-pretecting effect |
| JP2002161047A (en) * | 2000-11-28 | 2002-06-04 | Terumo Corp | Hemoglobin solution and hemoglobin-containing liposome |
| RU2238108C1 (en) * | 2003-01-27 | 2004-10-20 | Нестерук Владимир Викторович | Method for sterilizing sodium chloride injection solution |
| CN1679615A (en) * | 2005-02-04 | 2005-10-12 | 北京阜康仁生物制药科技有限公司 | Compound infantile energy mistura soluble vitamin preparation and use thereof |
| CN101601647B (en) * | 2009-07-09 | 2010-09-15 | 周晓东 | Riboflavine sodium phosphate composition injection and preparation method thereof |
| RU2536994C1 (en) * | 2013-05-17 | 2014-12-27 | Общество С Ограниченной Ответственностью "Нпо "Нефрон" | Concentrated acidic component, kit for producing it, concentrated solution of acidic component for producing hemodialysis solution and method for producing it |
| WO2015113035A1 (en) * | 2014-01-27 | 2015-07-30 | Abbott Laboratories | Aseptic filtration process |
| CA2939916A1 (en) * | 2014-02-18 | 2015-08-27 | Glenn Abrahmsohn | Compositions and methods for pain relief without numbness |
| US10627407B2 (en) * | 2015-03-12 | 2020-04-21 | Mars, Incorporated | Ultra high resolution mass spectrometry and methods of using the same |
-
2016
- 2016-09-29 RU RU2016138632A patent/RU2629204C1/en active IP Right Revival
-
2017
- 2017-02-16 EA EA201700072A patent/EA029693B1/en unknown
- 2017-02-23 UA UAA201701703A patent/UA118387C2/en unknown
- 2017-09-07 CN CN201780073686.9A patent/CN110022858B/en active Active
- 2017-09-07 BR BR112019006167A patent/BR112019006167A2/en not_active Application Discontinuation
- 2017-09-07 WO PCT/RU2017/000658 patent/WO2018063028A1/en active Application Filing
- 2017-09-07 MY MYPI2019001541A patent/MY193623A/en unknown
- 2017-09-07 MD MDA20190038A patent/MD4774C1/en not_active IP Right Cessation
- 2017-09-29 UY UY0001037426A patent/UY37426A/en not_active Application Discontinuation
- 2017-09-29 AR ARP170102733A patent/AR109775A1/en unknown
-
2019
- 2019-03-27 CL CL2019000810A patent/CL2019000810A1/en unknown
- 2019-03-29 PH PH12019500702A patent/PH12019500702A1/en unknown
- 2019-04-26 CO CONC2019/0004133A patent/CO2019004133A2/en unknown
- 2019-04-29 EC ECSENADI201930392A patent/ECSP19030392A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MD4774C1 (en) | 2022-06-30 |
| RU2629204C1 (en) | 2017-08-25 |
| CN110022858B (en) | 2021-12-14 |
| CL2019000810A1 (en) | 2019-08-02 |
| CN110022858A (en) | 2019-07-16 |
| AR109775A1 (en) | 2019-01-23 |
| PH12019500702A1 (en) | 2019-11-25 |
| BR112019006167A2 (en) | 2019-06-18 |
| MD20190038A2 (en) | 2019-10-31 |
| UY37426A (en) | 2018-04-30 |
| UA118387C2 (en) | 2019-01-10 |
| CO2019004133A2 (en) | 2019-09-30 |
| ECSP19030392A (en) | 2019-08-30 |
| MY193623A (en) | 2022-10-20 |
| WO2018063028A1 (en) | 2018-04-05 |
| EA029693B1 (en) | 2018-04-30 |
| MD4774B1 (en) | 2021-11-30 |
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