MD411C2 - Procedeu de obţinere a pancreatinei din pancreas - Google Patents
Procedeu de obţinere a pancreatinei din pancreasInfo
- Publication number
- MD411C2 MD411C2 MD95-0074A MD950074A MD411C2 MD 411 C2 MD411 C2 MD 411C2 MD 950074 A MD950074 A MD 950074A MD 411 C2 MD411 C2 MD 411C2
- Authority
- MD
- Moldova
- Prior art keywords
- alcohol
- isoprophylic
- autolysis
- filtrated
- pancreas
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 210000000496 pancreas Anatomy 0.000 title abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 3
- 208000035404 Autolysis Diseases 0.000 abstract 2
- 206010057248 Cell death Diseases 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 238000004062 sedimentation Methods 0.000 abstract 2
- 230000028043 self proteolysis Effects 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 235000013372 meat Nutrition 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/94—Pancreatin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Enzymes And Modification Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
Invenţia se referă la medicină, în particular la procedeul de obţinere a preparatelor medicamentoase.Scopul invenţiei constă în sporirea randamentului produsului special cu o activitate mai mare. Pentru aceasta pancreasurile congelate de porcină se mărunţesc, trecându-le prin maşina de tocat carne, şi se efectuează autoliza la temperatura de (-2)-(Ş30)°C şi pH 6,5-8,5. Paralel, peste fiecare 15 min. se analizează proba în vederea precipitării în alcool hidric izopropilic de 55-65%. Dacă viteza precipitării autolizei este 3-10 mm timp de 1-3 min., autoliza se suspendă prin adăugarea alcoolului izopropilic până la concentraţia finală de 30-35%, apoi se efectuează filtrarea prin sită. În soluţia obţinută se adaugă alcool izopropilic în concentraţie finală de 55-65% la 20-24°C. Precipitatul obţinut se spală cu alcool izopropilic cu concentraţia de 75-95%. Suspensia se filtrează pe filtrul-nuch cu diametrul de 40 cm şi se sedimentează pentru uscare în vid la 55°C şi presiunea de 5 mbari. Procedeul face posibilă sporirea randamentului produsului special cu o activitate mai mare.Revendicări:1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19823248587 DE3248587A1 (de) | 1982-12-30 | 1982-12-30 | Verfahren zur gewinnung von pankreatin |
| DE19823248588 DE3248588A1 (de) | 1982-12-30 | 1982-12-30 | Verfahren zur gewinnung von pankreatin von hohem schuettgewicht |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MD411C2 true MD411C2 (ro) | 1996-06-30 |
Family
ID=25807022
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD95-0074A MD411C2 (ro) | 1982-12-30 | 1994-12-29 | Procedeu de obţinere a pancreatinei din pancreas |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4623624A (ro) |
| EP (1) | EP0115023B1 (ro) |
| AR (1) | AR232000A1 (ro) |
| BR (1) | BR8307280A (ro) |
| CA (1) | CA1208580A (ro) |
| DD (1) | DD212981A5 (ro) |
| DE (1) | DE3377506D1 (ro) |
| DK (1) | DK173599B1 (ro) |
| ES (1) | ES528537A0 (ro) |
| HU (1) | HU196435B (ro) |
| MD (1) | MD411C2 (ro) |
| PL (1) | PL141118B1 (ro) |
| SU (1) | SU1644712A3 (ro) |
| UA (1) | UA5996A1 (ro) |
| YU (1) | YU45584B (ro) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100229754B1 (ko) * | 1989-11-24 | 1999-11-15 | 샬러 한스, 하우스 한스 루돌프 | 판크레아틴구형입자, 이의 제조방법 및 이를 함유하는 약제학적 조성물 |
| US5861291A (en) * | 1997-02-24 | 1999-01-19 | Biozymes Inc. | Method for producing pancreatin which contains low amounts of residual organic solvent and product thereof |
| US6632429B1 (en) | 1999-12-17 | 2003-10-14 | Joan M. Fallon | Methods for treating pervasive development disorders |
| KR100367659B1 (ko) * | 2000-05-08 | 2003-01-14 | 주식회사 바이넥스 | 선택적 안정화제의 첨가에 따른 자가분해(autolysis)를 통한 고역가 판크레아틴의 제조방법 |
| US20070053895A1 (en) | 2000-08-14 | 2007-03-08 | Fallon Joan M | Method of treating and diagnosing parkinsons disease and related dysautonomic disorders |
| IT1319655B1 (it) | 2000-11-15 | 2003-10-23 | Eurand Int | Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione. |
| US8030002B2 (en) | 2000-11-16 | 2011-10-04 | Curemark Llc | Methods for diagnosing pervasive development disorders, dysautonomia and other neurological conditions |
| CA2419572A1 (en) * | 2003-02-18 | 2004-08-18 | Axcan Pharma Inc. | High dosage protease formulation |
| CN1809753B (zh) * | 2003-07-29 | 2010-10-20 | 索尔瓦药物有限公司 | 通过二维凝胶电泳分析包含生理可接受消化酶混合物的方法 |
| RU2381813C2 (ru) * | 2004-03-22 | 2010-02-20 | Зольвай Фармасьютиклз Гмбх | Пероральные фармацевтические композиции на основе продуктов, содержащих липазы, прежде всего панкреатин, и пав |
| US7153504B2 (en) * | 2004-07-30 | 2006-12-26 | Can Technologies, Inc. | Stabilized pancreas product |
| JP5296531B2 (ja) | 2005-05-05 | 2013-09-25 | センシエント フレイバーズ エルエルシー | βグルカン及びマンナンの製造 |
| JP5140586B2 (ja) * | 2005-07-29 | 2013-02-06 | アボット プロダクツ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 滅菌パンクレアチン粉末の製法 |
| US11266607B2 (en) * | 2005-08-15 | 2022-03-08 | AbbVie Pharmaceuticals GmbH | Process for the manufacture and use of pancreatin micropellet cores |
| US9198871B2 (en) * | 2005-08-15 | 2015-12-01 | Abbott Products Gmbh | Delayed release pancreatin compositions |
| US20080058282A1 (en) | 2005-08-30 | 2008-03-06 | Fallon Joan M | Use of lactulose in the treatment of autism |
| TW200745337A (en) * | 2006-02-24 | 2007-12-16 | Aminotech As | Modified process |
| US10072256B2 (en) * | 2006-05-22 | 2018-09-11 | Abbott Products Gmbh | Process for separating and determining the viral load in a pancreatin sample |
| US8221747B2 (en) | 2007-02-20 | 2012-07-17 | Aptalis Pharma Limited | Stable pancreatic enzyme compositions |
| US20090130063A1 (en) * | 2007-11-15 | 2009-05-21 | Solvay Pharmaceuticals Gmbh | Process for separating and determining the viral load in a pancreatin sample |
| US10087493B2 (en) | 2008-03-07 | 2018-10-02 | Aptalis Pharma Canada Ulc | Method for detecting infectious parvovirus in pharmaceutical preparations |
| US8658163B2 (en) | 2008-03-13 | 2014-02-25 | Curemark Llc | Compositions and use thereof for treating symptoms of preeclampsia |
| US8084025B2 (en) | 2008-04-18 | 2011-12-27 | Curemark Llc | Method for the treatment of the symptoms of drug and alcohol addiction |
| US9320780B2 (en) | 2008-06-26 | 2016-04-26 | Curemark Llc | Methods and compositions for the treatment of symptoms of Williams Syndrome |
| US11016104B2 (en) * | 2008-07-01 | 2021-05-25 | Curemark, Llc | Methods and compositions for the treatment of symptoms of neurological and mental health disorders |
| US10776453B2 (en) | 2008-08-04 | 2020-09-15 | Galenagen, Llc | Systems and methods employing remote data gathering and monitoring for diagnosing, staging, and treatment of Parkinsons disease, movement and neurological disorders, and chronic pain |
| EP2165717A1 (de) | 2008-08-27 | 2010-03-24 | Nordmark Arzneimittel GmbH & Co.KG | Verfahren zur Verringerung der viralen und mikrobiellen Belastung feststoffhaltiger biologischer Extrakte |
| US20100092447A1 (en) | 2008-10-03 | 2010-04-15 | Fallon Joan M | Methods and compositions for the treatment of symptoms of prion diseases |
| EP2373693A4 (en) | 2009-01-06 | 2012-04-25 | Curelon Llc | COMPOSITIONS AND METHODS FOR THE TREATMENT OR PREVENTION OF ORAL INFECTIONS BY E. COLI |
| DK3064217T3 (en) | 2009-01-06 | 2018-05-28 | Galenagen Llc | COMPOSITIONS COMPREHENSIVE PROTEASE, AMYLASE AND LIPASE FOR USE IN TREATMENT OF STAPHYLOCOCCUS AUREUS INFECTIONS |
| US9056050B2 (en) | 2009-04-13 | 2015-06-16 | Curemark Llc | Enzyme delivery systems and methods of preparation and use |
| US9511125B2 (en) | 2009-10-21 | 2016-12-06 | Curemark Llc | Methods and compositions for the treatment of influenza |
| EA029101B1 (ru) | 2010-10-01 | 2018-02-28 | Апталис Фарма Лимитид | Составы с низкой дозой панкрелипазы и кишечнорастворимым покрытием |
| ES2726978T3 (es) | 2011-04-21 | 2019-10-11 | Curemark Llc | Compuestos para el tratamiento de trastornos neuropsiquiátricos |
| US9976171B2 (en) | 2011-08-08 | 2018-05-22 | Allergan Pharmaceuticals International Limited | Method for dissolution testing of solid compositions containing digestive enzymes |
| US10350278B2 (en) | 2012-05-30 | 2019-07-16 | Curemark, Llc | Methods of treating Celiac disease |
| JP2016527247A (ja) * | 2013-07-22 | 2016-09-08 | アラガン ファーマシューティカルズ インターナショナル リミテッド | 高力価パンクレアチン医薬組成物 |
| ES2784227T3 (es) | 2013-08-09 | 2020-09-23 | Allergan Pharmaceuticals Int Ltd | Composición de enzimas digestivos adecuada para la administración entérica |
| CA2915671A1 (en) * | 2013-11-05 | 2015-05-14 | Aptalis Pharma Ltd. | High potency pancreatin pharmaceutical compositions |
| AU2015275860A1 (en) | 2014-06-19 | 2016-11-03 | Aptalis Pharma Ltd. | Methods for removing viral contaminants from pancreatic extracts |
| US20160120964A1 (en) | 2014-11-05 | 2016-05-05 | George Shlieout | Processes for producing compositions with improved safety profile having lipase activity and compositions suitable for pharmaceutical use |
| BR112018070033A2 (pt) | 2016-03-28 | 2019-02-05 | Abbott Gmbh & Co Kg | preparação enzimática, método para produzir um produto de pancreatina, composição farmacêutica e método para tratar insuficiência pancreática exócrina |
| US11278603B2 (en) | 2016-03-28 | 2022-03-22 | Abbvie Inc. | Enzyme compositions with reduced viral and microbial contamination |
| WO2019067743A1 (en) | 2017-09-27 | 2019-04-04 | Abbvie Inc. | ENZYME COMPOSITIONS HAVING MICROBIAL CONTAMINATION AND REDUCED VIRAL |
| CN108316036A (zh) * | 2018-01-25 | 2018-07-24 | 陕西科技大学 | 一种豆渣制备微纤化纤维素的方法 |
| US11541009B2 (en) | 2020-09-10 | 2023-01-03 | Curemark, Llc | Methods of prophylaxis of coronavirus infection and treatment of coronaviruses |
| WO2024105193A1 (en) * | 2022-11-17 | 2024-05-23 | Koptyug Andrey V | Novel compounds and methods |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3223594A (en) * | 1960-10-25 | 1965-12-14 | Philips Corp | Method of producing pancreatin |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1328202A (en) | 1969-06-17 | 1973-08-30 | Union International Co Ltd | Manufacture of pancreatin |
| DE2106706B2 (de) * | 1971-02-12 | 1973-05-10 | Wilson Pharmaceutical & Chemical Corp., Chicago, 111. (V.St.A.) | Verfahren zur herstellung von pankreatin als trockenes pulver mit hoher proteolytischer, amylolytischer und lipolytischer aktivitaet |
| MX4738E (es) | 1976-05-07 | 1982-08-25 | Nattermann A & Cie | Procedimiento para fabricar preparados enzimaticos ricos en lipasa |
| DE2620289C2 (de) * | 1976-05-07 | 1982-05-19 | A. Nattermann & Cie GmbH, 5000 Köln | Herstellung eines lipasereichen Enzympräparates |
-
1983
- 1983-12-20 DE DE8383112809T patent/DE3377506D1/de not_active Expired
- 1983-12-20 EP EP83112809A patent/EP0115023B1/de not_active Expired
- 1983-12-23 US US06/565,220 patent/US4623624A/en not_active Expired - Lifetime
- 1983-12-28 CA CA000444332A patent/CA1208580A/en not_active Expired
- 1983-12-28 AR AR295280A patent/AR232000A1/es active
- 1983-12-28 PL PL1983245381A patent/PL141118B1/pl unknown
- 1983-12-28 YU YU252483A patent/YU45584B/sh unknown
- 1983-12-29 DD DD83258863A patent/DD212981A5/de not_active IP Right Cessation
- 1983-12-29 UA UA3682185A patent/UA5996A1/uk unknown
- 1983-12-29 HU HU834516A patent/HU196435B/hu not_active IP Right Cessation
- 1983-12-29 DK DK198306055A patent/DK173599B1/da not_active IP Right Cessation
- 1983-12-29 ES ES528537A patent/ES528537A0/es active Granted
- 1983-12-29 SU SU833682185A patent/SU1644712A3/ru active
- 1983-12-29 BR BR8307280A patent/BR8307280A/pt not_active IP Right Cessation
-
1994
- 1994-12-29 MD MD95-0074A patent/MD411C2/ro unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3223594A (en) * | 1960-10-25 | 1965-12-14 | Philips Corp | Method of producing pancreatin |
Also Published As
| Publication number | Publication date |
|---|---|
| DE3377506D1 (en) | 1988-09-01 |
| EP0115023A2 (de) | 1984-08-08 |
| ES8407516A1 (es) | 1984-09-16 |
| CA1208580A (en) | 1986-07-29 |
| EP0115023B1 (de) | 1988-07-27 |
| DK605583A (da) | 1984-07-01 |
| PL245381A1 (en) | 1984-10-22 |
| UA5996A1 (uk) | 1994-12-29 |
| ES528537A0 (es) | 1984-09-16 |
| DD212981A5 (de) | 1984-08-29 |
| YU45584B (sh) | 1992-07-20 |
| SU1644712A3 (ru) | 1991-04-23 |
| DK605583D0 (da) | 1983-12-29 |
| US4623624A (en) | 1986-11-18 |
| DK173599B1 (da) | 2001-04-23 |
| HU196435B (en) | 1988-11-28 |
| PL141118B1 (en) | 1987-06-30 |
| YU252483A (en) | 1986-10-31 |
| BR8307280A (pt) | 1984-08-07 |
| EP0115023A3 (en) | 1986-04-09 |
| AR232000A1 (es) | 1985-04-30 |
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