MD411C2 - Procedeu de obţinere a pancreatinei din pancreas - Google Patents
Procedeu de obţinere a pancreatinei din pancreasInfo
- Publication number
- MD411C2 MD411C2 MD95-0074A MD950074A MD411C2 MD 411 C2 MD411 C2 MD 411C2 MD 950074 A MD950074 A MD 950074A MD 411 C2 MD411 C2 MD 411C2
- Authority
- MD
- Moldova
- Prior art keywords
- alcohol
- isoprophylic
- autolysis
- filtrated
- pancreas
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 210000000496 pancreas Anatomy 0.000 title abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 3
- 208000035404 Autolysis Diseases 0.000 abstract 2
- 206010057248 Cell death Diseases 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 238000004062 sedimentation Methods 0.000 abstract 2
- 230000028043 self proteolysis Effects 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 235000013372 meat Nutrition 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/94—Pancreatin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
Invenţia se referă la medicină, în particular la procedeul de obţinere a preparatelor medicamentoase.Scopul invenţiei constă în sporirea randamentului produsului special cu o activitate mai mare. Pentru aceasta pancreasurile congelate de porcină se mărunţesc, trecându-le prin maşina de tocat carne, şi se efectuează autoliza la temperatura de (-2)-(Ş30)°C şi pH 6,5-8,5. Paralel, peste fiecare 15 min. se analizează proba în vederea precipitării în alcool hidric izopropilic de 55-65%. Dacă viteza precipitării autolizei este 3-10 mm timp de 1-3 min., autoliza se suspendă prin adăugarea alcoolului izopropilic până la concentraţia finală de 30-35%, apoi se efectuează filtrarea prin sită. În soluţia obţinută se adaugă alcool izopropilic în concentraţie finală de 55-65% la 20-24°C. Precipitatul obţinut se spală cu alcool izopropilic cu concentraţia de 75-95%. Suspensia se filtrează pe filtrul-nuch cu diametrul de 40 cm şi se sedimentează pentru uscare în vid la 55°C şi presiunea de 5 mbari. Procedeul face posibilă sporirea randamentului produsului special cu o activitate mai mare.Revendicări:1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19823248587 DE3248587A1 (de) | 1982-12-30 | 1982-12-30 | Verfahren zur gewinnung von pankreatin |
| DE19823248588 DE3248588A1 (de) | 1982-12-30 | 1982-12-30 | Verfahren zur gewinnung von pankreatin von hohem schuettgewicht |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MD411C2 true MD411C2 (ro) | 1996-06-30 |
Family
ID=25807022
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD95-0074A MD411C2 (ro) | 1982-12-30 | 1994-12-29 | Procedeu de obţinere a pancreatinei din pancreas |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4623624A (ro) |
| EP (1) | EP0115023B1 (ro) |
| AR (1) | AR232000A1 (ro) |
| BR (1) | BR8307280A (ro) |
| CA (1) | CA1208580A (ro) |
| DD (1) | DD212981A5 (ro) |
| DE (1) | DE3377506D1 (ro) |
| DK (1) | DK173599B1 (ro) |
| ES (1) | ES8407516A1 (ro) |
| HU (1) | HU196435B (ro) |
| MD (1) | MD411C2 (ro) |
| PL (1) | PL141118B1 (ro) |
| SU (1) | SU1644712A3 (ro) |
| UA (1) | UA5996A1 (ro) |
| YU (1) | YU45584B (ro) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100229754B1 (ko) * | 1989-11-24 | 1999-11-15 | 샬러 한스, 하우스 한스 루돌프 | 판크레아틴구형입자, 이의 제조방법 및 이를 함유하는 약제학적 조성물 |
| US5861291A (en) * | 1997-02-24 | 1999-01-19 | Biozymes Inc. | Method for producing pancreatin which contains low amounts of residual organic solvent and product thereof |
| US6632429B1 (en) | 1999-12-17 | 2003-10-14 | Joan M. Fallon | Methods for treating pervasive development disorders |
| KR100367659B1 (ko) * | 2000-05-08 | 2003-01-14 | 주식회사 바이넥스 | 선택적 안정화제의 첨가에 따른 자가분해(autolysis)를 통한 고역가 판크레아틴의 제조방법 |
| US20070053895A1 (en) | 2000-08-14 | 2007-03-08 | Fallon Joan M | Method of treating and diagnosing parkinsons disease and related dysautonomic disorders |
| IT1319655B1 (it) | 2000-11-15 | 2003-10-23 | Eurand Int | Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione. |
| US8030002B2 (en) | 2000-11-16 | 2011-10-04 | Curemark Llc | Methods for diagnosing pervasive development disorders, dysautonomia and other neurological conditions |
| CA2419572A1 (en) * | 2003-02-18 | 2004-08-18 | Axcan Pharma Inc. | High dosage protease formulation |
| AU2004260961B2 (en) * | 2003-07-29 | 2010-05-20 | Abbott Laboratories Gmbh | Analytical method for pancreatin and comparable compositions |
| PT1729797E (pt) * | 2004-03-22 | 2008-12-17 | Solvay Pharm Gmbh | Composições farmacêuticas orais de produtos contendo lipase, em particular de pancreatina, contendo tensioactivos |
| US7153504B2 (en) | 2004-07-30 | 2006-12-26 | Can Technologies, Inc. | Stabilized pancreas product |
| WO2006121803A1 (en) | 2005-05-05 | 2006-11-16 | Sensient Flavors Inc. | Production of beta-glucans and mannans |
| EP1913138B1 (en) | 2005-07-29 | 2016-08-24 | Abbott Laboratories GmbH | Processes for the manufacture of pancreatin powder with low virus content |
| US9198871B2 (en) * | 2005-08-15 | 2015-12-01 | Abbott Products Gmbh | Delayed release pancreatin compositions |
| US11266607B2 (en) * | 2005-08-15 | 2022-03-08 | AbbVie Pharmaceuticals GmbH | Process for the manufacture and use of pancreatin micropellet cores |
| US20080058282A1 (en) | 2005-08-30 | 2008-03-06 | Fallon Joan M | Use of lactulose in the treatment of autism |
| TW200745337A (en) * | 2006-02-24 | 2007-12-16 | Aminotech As | Modified process |
| US10072256B2 (en) * | 2006-05-22 | 2018-09-11 | Abbott Products Gmbh | Process for separating and determining the viral load in a pancreatin sample |
| SG186648A1 (en) | 2007-02-20 | 2013-01-30 | Aptalis Pharma Ltd | Stable digestive enzyme compositions |
| US20090130063A1 (en) * | 2007-11-15 | 2009-05-21 | Solvay Pharmaceuticals Gmbh | Process for separating and determining the viral load in a pancreatin sample |
| US10087493B2 (en) | 2008-03-07 | 2018-10-02 | Aptalis Pharma Canada Ulc | Method for detecting infectious parvovirus in pharmaceutical preparations |
| US8658163B2 (en) | 2008-03-13 | 2014-02-25 | Curemark Llc | Compositions and use thereof for treating symptoms of preeclampsia |
| US8084025B2 (en) | 2008-04-18 | 2011-12-27 | Curemark Llc | Method for the treatment of the symptoms of drug and alcohol addiction |
| US9320780B2 (en) | 2008-06-26 | 2016-04-26 | Curemark Llc | Methods and compositions for the treatment of symptoms of Williams Syndrome |
| WO2010002972A1 (en) * | 2008-07-01 | 2010-01-07 | Curemark, Llc | Methods and compositions for the treatment of symptoms of neurological and mental health disorders |
| US10776453B2 (en) | 2008-08-04 | 2020-09-15 | Galenagen, Llc | Systems and methods employing remote data gathering and monitoring for diagnosing, staging, and treatment of Parkinsons disease, movement and neurological disorders, and chronic pain |
| EP2165717A1 (de) * | 2008-08-27 | 2010-03-24 | Nordmark Arzneimittel GmbH & Co.KG | Verfahren zur Verringerung der viralen und mikrobiellen Belastung feststoffhaltiger biologischer Extrakte |
| US20100092447A1 (en) | 2008-10-03 | 2010-04-15 | Fallon Joan M | Methods and compositions for the treatment of symptoms of prion diseases |
| KR20170005192A (ko) | 2009-01-06 | 2017-01-11 | 큐어론 엘엘씨 | 스타필로코쿠스 아우레우스 감염의 치료 또는 예방 및 표면 상의 스타필로코쿠스 아우레우스의 박멸 또는 감소를 위한 조성물 및 방법 |
| KR101694931B1 (ko) | 2009-01-06 | 2017-01-10 | 큐어론 엘엘씨 | 이. 콜라이에 의한 구강 감염의 치료 또는 예방을 위한 조성물 및 방법 |
| US9056050B2 (en) | 2009-04-13 | 2015-06-16 | Curemark Llc | Enzyme delivery systems and methods of preparation and use |
| US9511125B2 (en) | 2009-10-21 | 2016-12-06 | Curemark Llc | Methods and compositions for the treatment of influenza |
| UA111726C2 (uk) | 2010-10-01 | 2016-06-10 | Апталіс Фарма Лімітед | Препарат панкреліпази низької сили з кишковорозчинним покриттям |
| CN106310242B (zh) | 2011-04-21 | 2020-02-28 | 柯尔马克有限责任公司 | 用于治疗神经精神障碍的化合物 |
| EP2741766B1 (en) | 2011-08-08 | 2015-10-07 | Aptalis Pharma Limited | Method for dissolution testing of solid compositions containing digestive enzymes |
| US10350278B2 (en) | 2012-05-30 | 2019-07-16 | Curemark, Llc | Methods of treating Celiac disease |
| KR20160055123A (ko) * | 2013-07-22 | 2016-05-17 | 앨러간 파마슈티컬스 인터내셔널 리미티드 | 고효능 판크레아틴 약학적 조성물 |
| US10993996B2 (en) | 2013-08-09 | 2021-05-04 | Allergan Pharmaceuticals International Limited | Digestive enzyme composition suitable for enteral administration |
| BR112016000658A2 (pt) * | 2013-11-05 | 2018-03-20 | Allergan Pharmaceuticals International Limited | pancreatina de alta atividade, processo para a preparação de pancreatina de aa tendo atividade lipásica específica de pelo menos aproximadamente 120 usp iu/mg e método de tratamento de um paciente sujeito a uma condição patológica associada com a insuficiência enzimática pandreática |
| CA2947998A1 (en) | 2014-06-19 | 2015-12-23 | Aptalis Pharma Ltd. | Methods for removing viral contaminants from pancreatic extracts |
| CN107073084B (zh) | 2014-11-05 | 2022-03-25 | 雅培制药股份有限公司 | 用于生产具有改善的安全特性的具有脂肪酶活性的组合物和适用于药物用途的组合物的方法 |
| WO2017172619A1 (en) | 2016-03-28 | 2017-10-05 | Abb Vie Inc. | Enzyme compositions with reduced viral and microbial contamination |
| US11278603B2 (en) | 2016-03-28 | 2022-03-22 | Abbvie Inc. | Enzyme compositions with reduced viral and microbial contamination |
| EP3688153A1 (en) | 2017-09-27 | 2020-08-05 | Abbott Laboratories GmbH | Enzyme compositions with reduced viral and microbial contamination |
| CN108316036A (zh) * | 2018-01-25 | 2018-07-24 | 陕西科技大学 | 一种豆渣制备微纤化纤维素的方法 |
| US11541009B2 (en) | 2020-09-10 | 2023-01-03 | Curemark, Llc | Methods of prophylaxis of coronavirus infection and treatment of coronaviruses |
| WO2024105193A1 (en) * | 2022-11-17 | 2024-05-23 | Koptyug Andrey V | Novel compounds and methods |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3223594A (en) * | 1960-10-25 | 1965-12-14 | Philips Corp | Method of producing pancreatin |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1328202A (en) | 1969-06-17 | 1973-08-30 | Union International Co Ltd | Manufacture of pancreatin |
| DE2106706B2 (de) * | 1971-02-12 | 1973-05-10 | Wilson Pharmaceutical & Chemical Corp., Chicago, 111. (V.St.A.) | Verfahren zur herstellung von pankreatin als trockenes pulver mit hoher proteolytischer, amylolytischer und lipolytischer aktivitaet |
| MX4738E (es) | 1976-05-07 | 1982-08-25 | Nattermann A & Cie | Procedimiento para fabricar preparados enzimaticos ricos en lipasa |
| DE2620289C2 (de) * | 1976-05-07 | 1982-05-19 | A. Nattermann & Cie GmbH, 5000 Köln | Herstellung eines lipasereichen Enzympräparates |
-
1983
- 1983-12-20 DE DE8383112809T patent/DE3377506D1/de not_active Expired
- 1983-12-20 EP EP83112809A patent/EP0115023B1/de not_active Expired
- 1983-12-23 US US06/565,220 patent/US4623624A/en not_active Expired - Lifetime
- 1983-12-28 CA CA000444332A patent/CA1208580A/en not_active Expired
- 1983-12-28 AR AR295280A patent/AR232000A1/es active
- 1983-12-28 PL PL1983245381A patent/PL141118B1/pl unknown
- 1983-12-28 YU YU252483A patent/YU45584B/sh unknown
- 1983-12-29 DD DD83258863A patent/DD212981A5/de not_active IP Right Cessation
- 1983-12-29 SU SU833682185A patent/SU1644712A3/ru active
- 1983-12-29 BR BR8307280A patent/BR8307280A/pt not_active IP Right Cessation
- 1983-12-29 DK DK198306055A patent/DK173599B1/da not_active IP Right Cessation
- 1983-12-29 ES ES528537A patent/ES8407516A1/es not_active Expired
- 1983-12-29 UA UA3682185A patent/UA5996A1/uk unknown
- 1983-12-29 HU HU834516A patent/HU196435B/hu not_active IP Right Cessation
-
1994
- 1994-12-29 MD MD95-0074A patent/MD411C2/ro unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3223594A (en) * | 1960-10-25 | 1965-12-14 | Philips Corp | Method of producing pancreatin |
Also Published As
| Publication number | Publication date |
|---|---|
| AR232000A1 (es) | 1985-04-30 |
| UA5996A1 (uk) | 1994-12-29 |
| DD212981A5 (de) | 1984-08-29 |
| HU196435B (en) | 1988-11-28 |
| YU45584B (sh) | 1992-07-20 |
| DE3377506D1 (en) | 1988-09-01 |
| ES528537A0 (es) | 1984-09-16 |
| EP0115023B1 (de) | 1988-07-27 |
| PL141118B1 (en) | 1987-06-30 |
| CA1208580A (en) | 1986-07-29 |
| PL245381A1 (en) | 1984-10-22 |
| DK605583A (da) | 1984-07-01 |
| DK605583D0 (da) | 1983-12-29 |
| SU1644712A3 (ru) | 1991-04-23 |
| EP0115023A3 (en) | 1986-04-09 |
| BR8307280A (pt) | 1984-08-07 |
| EP0115023A2 (de) | 1984-08-08 |
| DK173599B1 (da) | 2001-04-23 |
| YU252483A (en) | 1986-10-31 |
| ES8407516A1 (es) | 1984-09-16 |
| US4623624A (en) | 1986-11-18 |
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