MD411C2 - Process for obtaining the pancreatic from the pancreas - Google Patents

Process for obtaining the pancreatic from the pancreas

Info

Publication number
MD411C2
MD411C2 MD95-0074A MD950074A MD411C2 MD 411 C2 MD411 C2 MD 411C2 MD 950074 A MD950074 A MD 950074A MD 411 C2 MD411 C2 MD 411C2
Authority
MD
Moldova
Prior art keywords
alcohol
isoprophylic
autolysis
filtrated
pancreas
Prior art date
Application number
MD95-0074A
Other languages
Romanian (ro)
Russian (ru)
Inventor
Schultze Dr.Hans
Original Assignee
Nordmark Arzneimittel Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19823248587 external-priority patent/DE3248587A1/en
Priority claimed from DE19823248588 external-priority patent/DE3248588A1/en
Application filed by Nordmark Arzneimittel Gmbh filed Critical Nordmark Arzneimittel Gmbh
Publication of MD411C2 publication Critical patent/MD411C2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/94—Pancreatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention relates to medicine, namely, to remedies preparation.The aim of the invention - desired high activity products yield increasing.The congelated pig's pancreas are reduced to fragments, grinded with the meat grinder, conducted to autolysis at (-2)-(+30)°C and pH 6,5-8,5.In parallel the sedimentation test is analyzed each 15 min water isoprophylic alcohol solution 55-65%. At achieving the autolysus sedimentation speed of 3-10 mm during 1-3 min the autolysis is broken off by addition of the isoprophylic alcohol up to the final concentration of 30-35%, then it is filtrated through the sieve. In the obtained solution there is added isporopylic alcohol at the concentration of 75-95%. the suspension is filtrated with he nutsch-filter having diameter of 40 cm and is settled for drying in the vacuum at 55°C and pression of 4 mbar. The process allows the high activity desired product yield increasing.
MD95-0074A 1982-12-30 1994-12-29 Process for obtaining the pancreatic from the pancreas MD411C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19823248587 DE3248587A1 (en) 1982-12-30 1982-12-30 Process for obtaining pancreatin
DE19823248588 DE3248588A1 (en) 1982-12-30 1982-12-30 Process for obtaining pancreatin with high apparent density

Publications (1)

Publication Number Publication Date
MD411C2 true MD411C2 (en) 1996-06-30

Family

ID=25807022

Family Applications (1)

Application Number Title Priority Date Filing Date
MD95-0074A MD411C2 (en) 1982-12-30 1994-12-29 Process for obtaining the pancreatic from the pancreas

Country Status (15)

Country Link
US (1) US4623624A (en)
EP (1) EP0115023B1 (en)
AR (1) AR232000A1 (en)
BR (1) BR8307280A (en)
CA (1) CA1208580A (en)
DD (1) DD212981A5 (en)
DE (1) DE3377506D1 (en)
DK (1) DK173599B1 (en)
ES (1) ES8407516A1 (en)
HU (1) HU196435B (en)
MD (1) MD411C2 (en)
PL (1) PL141118B1 (en)
SU (1) SU1644712A3 (en)
UA (1) UA5996A1 (en)
YU (1) YU45584B (en)

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CA2030581C (en) * 1989-11-24 2000-06-27 Gunther Atzl Pancreatin preparations
US5861291A (en) * 1997-02-24 1999-01-19 Biozymes Inc. Method for producing pancreatin which contains low amounts of residual organic solvent and product thereof
US6632429B1 (en) 1999-12-17 2003-10-14 Joan M. Fallon Methods for treating pervasive development disorders
KR100367659B1 (en) * 2000-05-08 2003-01-14 주식회사 바이넥스 The method of preparing pancreatin by adding selective stabilizers
US20070053895A1 (en) 2000-08-14 2007-03-08 Fallon Joan M Method of treating and diagnosing parkinsons disease and related dysautonomic disorders
IT1319655B1 (en) 2000-11-15 2003-10-23 Eurand Int PANCREATIC ENZYME MICROSPHERES WITH HIGH STABILITY AND RELATIVE PREPARATION METHOD.
US8030002B2 (en) 2000-11-16 2011-10-04 Curemark Llc Methods for diagnosing pervasive development disorders, dysautonomia and other neurological conditions
CA2419572A1 (en) * 2003-02-18 2004-08-18 Axcan Pharma Inc. High dosage protease formulation
MXPA06001173A (en) * 2003-07-29 2006-04-11 Solvay Pharm Gmbh Analytical method for pancreatin and comparable compositions.
CA2560613C (en) * 2004-03-22 2015-11-24 Solvay Pharmaceuticals Gmbh Oral pharmaceutical compositions of lipase-containing products, in particular of pancreatin, containing surfactants
US7153504B2 (en) * 2004-07-30 2006-12-26 Can Technologies, Inc. Stabilized pancreas product
JP5296531B2 (en) 2005-05-05 2013-09-25 センシエント フレイバーズ エルエルシー Production of β-glucan and mannan
KR101555058B1 (en) * 2005-07-29 2015-09-22 애보트 래버러토리즈 게엠베하 Process for producing sterilized pancreatin powder
US11266607B2 (en) * 2005-08-15 2022-03-08 AbbVie Pharmaceuticals GmbH Process for the manufacture and use of pancreatin micropellet cores
US9198871B2 (en) * 2005-08-15 2015-12-01 Abbott Products Gmbh Delayed release pancreatin compositions
US20080058282A1 (en) 2005-08-30 2008-03-06 Fallon Joan M Use of lactulose in the treatment of autism
TW200745337A (en) * 2006-02-24 2007-12-16 Aminotech As Modified process
US10072256B2 (en) * 2006-05-22 2018-09-11 Abbott Products Gmbh Process for separating and determining the viral load in a pancreatin sample
JP5966202B2 (en) 2007-02-20 2016-08-10 アラガン ファーマシューティカルズ インターナショナル リミテッド Stable digestive enzyme composition
US20090130063A1 (en) * 2007-11-15 2009-05-21 Solvay Pharmaceuticals Gmbh Process for separating and determining the viral load in a pancreatin sample
US10087493B2 (en) 2008-03-07 2018-10-02 Aptalis Pharma Canada Ulc Method for detecting infectious parvovirus in pharmaceutical preparations
US8658163B2 (en) 2008-03-13 2014-02-25 Curemark Llc Compositions and use thereof for treating symptoms of preeclampsia
US8084025B2 (en) 2008-04-18 2011-12-27 Curemark Llc Method for the treatment of the symptoms of drug and alcohol addiction
US9320780B2 (en) 2008-06-26 2016-04-26 Curemark Llc Methods and compositions for the treatment of symptoms of Williams Syndrome
PL2318035T3 (en) * 2008-07-01 2019-10-31 Curemark Llc Methods and compositions for treating the symptoms of neurological disorders and mental health disorders
US10776453B2 (en) 2008-08-04 2020-09-15 Galenagen, Llc Systems and methods employing remote data gathering and monitoring for diagnosing, staging, and treatment of Parkinsons disease, movement and neurological disorders, and chronic pain
EP2165717A1 (en) * 2008-08-27 2010-03-24 Nordmark Arzneimittel GmbH & Co.KG Method for reducing viral and microbial load on biological extracts containing solids
US20100092447A1 (en) 2008-10-03 2010-04-15 Fallon Joan M Methods and compositions for the treatment of symptoms of prion diseases
CN102300989B (en) 2009-01-06 2015-12-09 柯尔朗恩有限责任公司 Compositions and methods for treating or preventing staphylococcus aureus infection and for eradicating or reducing staphylococcus aureus on surfaces
KR20170005191A (en) 2009-01-06 2017-01-11 큐어론 엘엘씨 Compositions and methods for the treatment or the prevention oral infections by e. coli
US9056050B2 (en) 2009-04-13 2015-06-16 Curemark Llc Enzyme delivery systems and methods of preparation and use
US9511125B2 (en) 2009-10-21 2016-12-06 Curemark Llc Methods and compositions for the treatment of influenza
ES2657673T3 (en) 2010-10-01 2018-03-06 Aptalis Pharma Limited Enteric coated pancrelipase formulations, low intensity
US8980252B2 (en) 2011-04-21 2015-03-17 Curemark Llc Methods of treatment of schizophrenia
CA2843556A1 (en) 2011-08-08 2013-02-14 Aptalis Pharma Ltd. Method for dissolution testing of solid compositions containing digestive enzymes
US10350278B2 (en) 2012-05-30 2019-07-16 Curemark, Llc Methods of treating Celiac disease
US10184121B2 (en) 2013-06-28 2019-01-22 Allergan Pharmaceuticals International Limited Methods for removing viral contaminants from pancreatic extracts
US20160108389A1 (en) * 2013-07-22 2016-04-21 Aptalis Pharma Ltd. High potency pancreatin pharmaceutical compositions
MX2016000794A (en) * 2013-07-22 2016-12-02 Allergan Pharmaceuticals Int Ltd High potency pancreatin pharmaceutical compositions.
CA2920844A1 (en) 2013-08-09 2015-02-12 Allergan Pharmaceuticals International Limited Digestive enzyme composition suitable for enteral administration
EP3003360B1 (en) * 2013-11-05 2020-10-07 Allergan Pharmaceuticals International Limited High potency pancreatin pharmaceutical compositions
EP3215181B1 (en) 2014-11-05 2024-12-18 Abbott Laboratories GmbH Processes for producing compositions with improved safety profile comprising pancreatin and compositions suitable for pharmaceutical use
US11278603B2 (en) 2016-03-28 2022-03-22 Abbvie Inc. Enzyme compositions with reduced viral and microbial contamination
ES2970869T3 (en) 2016-03-28 2024-05-31 Abbott Laboratories Gmbh Enzymatic compositions with reduced viral and microbial contamination
AU2018250823A1 (en) 2017-04-10 2019-10-17 Curemark, Llc Compositions for treating addiction
BR112020006211A2 (en) 2017-09-27 2020-10-13 Abbott Laboratories Gmbh enzyme preparation produced by a method, enzyme preparation, method for producing a pancreatin product, pharmaceutical composition and method for treating exocrine pancreatic insufficiency
CN108316036A (en) * 2018-01-25 2018-07-24 陕西科技大学 A kind of method that bean dregs prepare fento cellulose
US11541009B2 (en) 2020-09-10 2023-01-03 Curemark, Llc Methods of prophylaxis of coronavirus infection and treatment of coronaviruses
WO2024105193A1 (en) * 2022-11-17 2024-05-23 Koptyug Andrey V Novel compounds and methods

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3223594A (en) * 1960-10-25 1965-12-14 Philips Corp Method of producing pancreatin

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1328202A (en) 1969-06-17 1973-08-30 Union International Co Ltd Manufacture of pancreatin
DE2106706B2 (en) * 1971-02-12 1973-05-10 Wilson Pharmaceutical & Chemical Corp., Chicago, 111. (V.St.A.) METHOD FOR MANUFACTURING PANCREATIN AS A DRY POWDER WITH HIGH PROTEOLYTIC, AMYLOLYTIC AND LIPOLYTIC ACTIVITY
DE2620289C2 (en) * 1976-05-07 1982-05-19 A. Nattermann & Cie GmbH, 5000 Köln Production of a lipase-rich enzyme preparation
US4088539A (en) 1976-05-07 1978-05-09 A. Nattermann & Cie Gmbh Process of manufacturing enzyme preparation rich in lipase

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3223594A (en) * 1960-10-25 1965-12-14 Philips Corp Method of producing pancreatin

Also Published As

Publication number Publication date
DE3377506D1 (en) 1988-09-01
DK173599B1 (en) 2001-04-23
ES528537A0 (en) 1984-09-16
EP0115023A3 (en) 1986-04-09
PL245381A1 (en) 1984-10-22
CA1208580A (en) 1986-07-29
PL141118B1 (en) 1987-06-30
DK605583A (en) 1984-07-01
YU252483A (en) 1986-10-31
US4623624A (en) 1986-11-18
DD212981A5 (en) 1984-08-29
DK605583D0 (en) 1983-12-29
BR8307280A (en) 1984-08-07
ES8407516A1 (en) 1984-09-16
AR232000A1 (en) 1985-04-30
HU196435B (en) 1988-11-28
EP0115023A2 (en) 1984-08-08
YU45584B (en) 1992-07-20
EP0115023B1 (en) 1988-07-27
UA5996A1 (en) 1994-12-29
SU1644712A3 (en) 1991-04-23

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