MD381C2 - Procedeu de obţinere a aminodiacizilor substituiţi, racematelor sau izomerilor lor optici, sau sărurilor lor farmaceutic admisibile - Google Patents

Procedeu de obţinere a aminodiacizilor substituiţi, racematelor sau izomerilor lor optici, sau sărurilor lor farmaceutic admisibile

Info

Publication number
MD381C2
MD381C2 MD95-0107A MD950107A MD381C2 MD 381 C2 MD381 C2 MD 381C2 MD 950107 A MD950107 A MD 950107A MD 381 C2 MD381 C2 MD 381C2
Authority
MD
Moldova
Prior art keywords
alkyl group
racemates
pharmaceutically acceptable
acceptable salts
optical isomers
Prior art date
Application number
MD95-0107A
Other languages
English (en)
Romanian (ro)
Russian (ru)
Inventor
Vincent Michel
Remond Georges
Laubie Michel
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26222007&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MD381(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from FR8021095A external-priority patent/FR2491469A1/fr
Application filed by Adir filed Critical Adir
Publication of MD381C2 publication Critical patent/MD381C2/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/08—Six-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
MD95-0107A 1980-10-02 1994-12-29 Procedeu de obţinere a aminodiacizilor substituiţi, racematelor sau izomerilor lor optici, sau sărurilor lor farmaceutic admisibile MD381C2 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8021095A FR2491469A1 (fr) 1980-10-02 1980-10-02 Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
FR8106916A FR2503155A2 (fr) 1980-10-02 1981-04-07 Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme

Publications (1)

Publication Number Publication Date
MD381C2 true MD381C2 (ro) 1996-05-31

Family

ID=26222007

Family Applications (1)

Application Number Title Priority Date Filing Date
MD95-0107A MD381C2 (ro) 1980-10-02 1994-12-29 Procedeu de obţinere a aminodiacizilor substituiţi, racematelor sau izomerilor lor optici, sau sărurilor lor farmaceutic admisibile

Country Status (29)

Country Link
EP (1) EP0049658B1 (ja)
JP (1) JPS5791974A (ja)
KR (1) KR860001875B1 (ja)
AR (1) AR242949A1 (ja)
AT (1) ATE7910T1 (ja)
AU (1) AU542611B2 (ja)
CA (1) CA1341196C (ja)
DD (1) DD201783A5 (ja)
DE (1) DE3164201D1 (ja)
DK (1) DK157011C (ja)
EG (1) EG15361A (ja)
ES (1) ES8305723A1 (ja)
FI (1) FI77230C (ja)
FR (1) FR2503155A2 (ja)
GE (1) GEP19970943B (ja)
GR (1) GR75016B (ja)
HU (1) HU185147B (ja)
IE (1) IE51821B1 (ja)
IL (1) IL63940A (ja)
LU (1) LU88262I2 (ja)
MD (1) MD381C2 (ja)
NL (1) NL930046I2 (ja)
NO (1) NO160780C (ja)
NZ (1) NZ198535A (ja)
OA (1) OA06914A (ja)
PH (1) PH17516A (ja)
PT (1) PT73755B (ja)
SU (1) SU1153827A3 (ja)
UA (1) UA6308A1 (ja)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3177311D1 (de) * 1980-08-30 1994-06-09 Hoechst Ag Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung.
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
DE19575012I2 (de) * 1980-10-23 2002-01-24 Schering Corp Carboxyalkyl-Dipeptide Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
ZA817261B (en) * 1980-10-23 1982-09-29 Schering Corp Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them
US4479963A (en) * 1981-02-17 1984-10-30 Ciba-Geigy Corporation 1-Carboxyalkanoylindoline-2-carboxylic acids
US4532342A (en) * 1981-02-20 1985-07-30 Warner-Lambert Company N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
IN156096B (ja) * 1981-03-19 1985-05-11 Usv Pharma Corp
EP0065301A1 (en) * 1981-05-18 1982-11-24 Merck & Co. Inc. Isoquinoline carboxylic acid derivates, process for preparing and pharmaceutical composition containing the same
SU1327787A3 (ru) * 1981-11-05 1987-07-30 Хехст Аг (Фирма) Способ получени цис,эндо-2-азабицикло-/3,3,0/-октан-3-карбоновых кислот или их кислотно-аддитивных солей
DE3226768A1 (de) * 1981-11-05 1983-05-26 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
EP0170775B2 (de) * 1981-12-29 1994-10-12 Hoechst Aktiengesellschaft Derivate bicyclischer Aminosäuren, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung sowie neue bicyclische Aminosäuren als Zwischenstufen und Verfahren zu deren Herstellung
GR78413B (ja) * 1981-12-29 1984-09-27 Hoechst Ag
DE3210496A1 (de) * 1982-03-23 1983-10-06 Hoechst Ag Neue derivate bicyclischer aminsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung
DE3302125A1 (de) * 1983-01-22 1984-07-26 Boehringer Ingelheim KG, 6507 Ingelheim Aminosaeure-derivate, verfahren zu ihrer herstellung und verwendung
HU191120B (en) * 1983-01-31 1987-01-28 Hoechts Ag,De Process for raceme separation of optically active byciclic imino-alpha-carbonic acid esthers
US5175306A (en) * 1983-01-31 1992-12-29 Hoechst Aktiengesellschaft Process for the resolution of racemates of optically active bicyclic imino-α-carboxylic esters
DE3303344A1 (de) 1983-02-02 1984-08-02 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten aminosaeuren und deren estern
DE3333455A1 (de) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung n-alkylierter dipeptide und deren estern
DE3333454A1 (de) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten dipeptiden und deren estern
DE3408923A1 (de) * 1984-03-12 1985-09-26 Hoechst Ag, 6230 Frankfurt Carboxyalkyldipeptidderivate, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung
DE3413710A1 (de) * 1984-04-12 1985-10-24 Hoechst Ag, 6230 Frankfurt Verfahren zur behandlung der herzinsuffizienz
US5684016A (en) * 1984-04-12 1997-11-04 Hoechst Aktiengesellschaft Method of treating cardiac insufficiency
DE3431541A1 (de) * 1984-08-28 1986-03-06 Hoechst Ag, 6230 Frankfurt Cis,endo-2-azabicycloalkan-3-carbonsaeure-derivate, verfahren zu deren herstellung, deren verwendung sowie zwischenprodukte bei deren herstellung
GB8422165D0 (en) * 1984-09-01 1984-10-03 Wellcome Found Compounds
US5231080A (en) * 1985-10-15 1993-07-27 Hoechst Aktiengesellschaft Method for the treatment of atherosclerosis, thrombosis, and peripheral vessel disease
US4693996A (en) * 1985-12-23 1987-09-15 Warner-Lambert Company Method of treating heart failure and medicaments therefor
US5231084A (en) * 1986-03-27 1993-07-27 Hoechst Aktiengesellschaft Compounds having a cognition adjuvant action, agents containing them, and the use thereof for the treatment and prophylaxis of cognitive dysfuncitons
DE3633496A1 (de) * 1986-10-02 1988-04-14 Hoechst Ag Kombination von angiotensin-converting-enzyme-hemmern mit calciumantagonisten sowie deren verwendung in arzneimitteln
DE3639879A1 (de) * 1986-11-21 1988-06-01 Hoechst Ag Verfahren zur herstellung von mono-, bi- und tricyclischen aminosaeuren, zwischenprodukte dieses verfahrens sowie ein verfahren zu deren herstellung
DE3722007A1 (de) * 1987-07-03 1989-01-12 Hoechst Ag Verfahren zur herstellung bicyclischer aminocarbonsaeuren, zwischenprodukte dieses verfahrens und deren verwendung
FR2620703B1 (fr) * 1987-09-17 1991-10-04 Adir Procede de synthese industrielle de l'acide perhydroindole carboxylique - 2(2s, 3as, 7as). application a la synthese de carboxyalkyl dipeptides
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
FR2620699B1 (fr) * 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et de leurs esters. application a la synthese de carboxyalkyl dipeptides
FR2620700B1 (fr) * 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et leurs esters. application a la synthese de carboxyalkyl dipeptides
US4902695A (en) * 1989-02-13 1990-02-20 Eli Lilly And Company Excitatory amino acid receptor antagonists
TW197945B (ja) * 1990-11-27 1993-01-11 Hoechst Ag
LT3872B (en) 1993-12-06 1996-04-25 Hoechst Ag Novel peptides and pharmaceutical compositions containing them
PT796855E (pt) 1996-03-20 2002-07-31 Hoechst Ag Inibicao da reabsorcao nos ossos e antagonistas de vitronectina
FR2746394B1 (fr) 1996-03-20 1998-05-29 Roussel Uclaf Nouveaux composes tricycliques, leur procede de preparation, et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
DE19653647A1 (de) 1996-12-20 1998-06-25 Hoechst Ag Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung
DE19741873A1 (de) * 1997-09-23 1999-03-25 Hoechst Marion Roussel De Gmbh Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19751251A1 (de) 1997-11-19 1999-05-20 Hoechst Marion Roussel De Gmbh Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate
DE19821483A1 (de) 1998-05-14 1999-11-18 Hoechst Marion Roussel De Gmbh Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
FR2807431B1 (fr) * 2000-04-06 2002-07-19 Adir Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
FR2807430B1 (fr) * 2000-04-11 2002-05-17 Adir Nouveau procede de synthese des esters de la n-[(s)-1- carboxybutyl]-(s)-alanine et application a la synthese du perindopril
FR2811320B1 (fr) * 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline alpha du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2811318B1 (fr) * 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline gamma du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
AU2007203451B2 (en) * 2000-07-06 2010-09-02 Les Laboratoires Servier Pharmaceutical composition containing a crystalline form of perindopril tert-butylamine salt
FR2827860B1 (fr) * 2001-07-24 2004-12-10 Servier Lab Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril
ES2289060T3 (es) * 2002-01-30 2008-02-01 Les Laboratoires Servier Proceso para la preparacion de perindopril de alta pureza y de intermedios utiles en su sintesis.
FR2838648B1 (fr) * 2002-04-18 2004-05-21 Servier Lab Nouveau sel de perindopril et les compositions pharmaceutiques qui le contiennent
GB2395195A (en) * 2002-11-18 2004-05-19 Cipla Ltd Preparation of perindopril from carboxy-protected precursor, & perindopril monohydrates for use as angiotensin converting enzyme (ACE) inhibitors
CN100395235C (zh) 2003-06-24 2008-06-18 瑟维尔实验室 培哚普利特丁胺的新晶形
DK1367061T3 (da) * 2003-06-30 2006-05-15 Servier Lab Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
ES2272922T3 (es) * 2003-08-29 2007-05-01 Les Laboratoires Servier Nuevo procedimiento de sintesis de perindopril y de sus sales farmaceuticamente aceptables.
EP1362845B1 (fr) * 2003-09-01 2009-10-14 Les Laboratoires Servier Nouveau procédé de synthèse des esters de la N-((S)-1-carboxybutyl)-(S)-alanine et application à la synthèse du perindopril
SI21703A (en) 2004-01-14 2005-08-31 Lek Farmacevtska Druzba Dd Inclusion complexes of perindopril, procedure of their preparation, pharmaceutical compositions containing these complexes and their application in treatment of hypertensia
GB2413128A (en) * 2004-04-13 2005-10-19 Neopharma Ltd Process for the preparation of perindopril
SI21800A (sl) 2004-05-14 2005-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek sinteze perindoprila
SI21881A (sl) 2004-10-15 2006-04-30 Diagen, Smartno Pri Ljubljani, D.O.O. Nove kristalne oblike perindopril erbumin hidratov, postopek za njihovo pripravo in farmacevtske oblike, ki vsebujejo te spojine
ES2314583T4 (es) 2005-01-06 2009-05-18 Ipca Laboratories Limited Proceso para sintesis de los derivados del acido (2s,3as,7as)-1-(s)-alanil-octahidro-1h-indol-2-carboxilico y su utilizacion en la sintesis de perindropil.
EP1815857A1 (en) 2006-02-02 2007-08-08 LEK Pharmaceuticals D.D. A pharmaceutical composition comprising perindopril
FR2897866B1 (fr) * 2006-02-28 2008-04-18 Servier Lab Forme cristalline alpha du sel d'arginine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
SI22543A (sl) 2007-06-27 2008-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nove soli perindoprila
GB0910692D0 (en) 2009-06-20 2009-08-05 Teva Pharma Compound
PT105315B (pt) 2010-09-29 2013-01-16 Inst Superior Tecnico Uma nova forma cristalina hidratada de erbumina de perindopril, métodos para a sua preparação e sua utilização em preparações farmacêuticas
FR2985511B1 (fr) 2012-01-05 2014-01-03 Servier Lab Forme cristalline delta du sel d'arginine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2985512B1 (fr) * 2012-01-05 2014-06-20 Servier Lab Procede de preparation du sel de l-arginine du perindopril
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
FR3050380B1 (fr) 2016-04-20 2020-07-10 Les Laboratoires Servier Composition pharmaceutique comprenant un betabloquant, un inhibiteur de l'enzyme de conversion et un antihypertenseur ou un ains.
EP3842035A1 (en) 2019-12-23 2021-06-30 KRKA, d.d., Novo mesto Composition for the preparation of perindopril arginine granules, a method for their preparation and pharmaceutical composition comprising the granules

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5572169A (en) * 1978-11-27 1980-05-30 Tanabe Seiyaku Co Ltd Isoquinoline derivative and its preparation
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
US4461896A (en) * 1979-02-07 1984-07-24 Norwich Eaton Pharmaceuticals, Inc. 1-[Acylthio) and (mercapto)-1-oxoalkyl]-1,2,3,4-tetrahydroquinoline-2-carboxylic acids
EP0018104B1 (en) * 1979-03-26 1983-05-25 Takeda Chemical Industries, Ltd. Tetrahydroisoquinolines, their production and the compounds and pharmaceutical compositions containing them for use in the prevention or treatment of hypertension
US4294832A (en) * 1979-04-28 1981-10-13 Tanabe Seiyaku Co., Ltd. Tetrahydroisoquinoline compounds and a pharmaceutical composition thereof
GB2048863B (en) * 1979-05-16 1983-06-15 Morton Norwich Products Inc Tetrahydroisoquinoline-3-carboxylic acids
US4303583A (en) * 1979-08-13 1981-12-01 American Home Products Corporation 1H,5H-[1,4]Thiazepino[4,3-a]indole-1,5-diones
FR2470767A1 (fr) * 1979-12-07 1981-06-12 Science Union & Cie Nouveaux iminoacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzymes
FR2487829A2 (fr) * 1979-12-07 1982-02-05 Science Union & Cie Nouveaux imino acides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
ZA811493B (en) * 1980-04-02 1982-03-31 Warner Lambert Co Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids
US4251444A (en) * 1980-04-07 1981-02-17 American Home Products Corporation Thiazepino-[4,3-b]-isoquinoline-1,5-dione derivatives and precursors
DE3177311D1 (de) * 1980-08-30 1994-06-09 Hoechst Ag Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung.
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Вейганд-Хильгетаг. Методы эксперимента в органической химии. М.,"Химия", 1968, p. 378. *

Also Published As

Publication number Publication date
SU1153827A3 (ru) 1985-04-30
GEP19970943B (en) 1997-04-18
NL930046I2 (nl) 1994-01-03
OA06914A (fr) 1983-05-31
NO813339L (no) 1982-04-05
EG15361A (en) 1987-04-30
GR75016B (ja) 1984-07-12
NO160780B (no) 1989-02-20
PT73755B (fr) 1983-10-11
ES505999A0 (es) 1983-04-16
IE812257L (en) 1983-03-29
PH17516A (en) 1984-09-13
IE51821B1 (en) 1987-04-01
EP0049658A1 (fr) 1982-04-14
DK434381A (da) 1982-04-03
AR242949A1 (es) 1993-06-30
EP0049658B1 (fr) 1984-06-13
FR2503155A2 (fr) 1982-10-08
AU542611B2 (en) 1985-02-28
CA1341196C (fr) 2001-03-06
NZ198535A (en) 1984-09-28
FI77230C (fi) 1989-02-10
PT73755A (fr) 1981-11-01
JPH0132239B2 (ja) 1989-06-29
UA6308A1 (uk) 1994-12-29
FI77230B (fi) 1988-10-31
IL63940A0 (en) 1981-12-31
NO160780C (no) 1989-05-31
JPS5791974A (en) 1982-06-08
HU185147B (en) 1984-12-28
KR860001875B1 (ko) 1986-10-24
LU88262I2 (ja) 1994-02-03
FI813034L (fi) 1982-04-03
IL63940A (en) 1985-06-30
DK157011B (da) 1989-10-30
ES8305723A1 (es) 1983-04-16
KR830007564A (ko) 1983-10-21
NL930046I1 (nl) 1993-09-01
DK157011C (da) 1990-03-26
DD201783A5 (de) 1983-08-10
ATE7910T1 (de) 1984-06-15
FR2503155B2 (ja) 1983-07-01
AU7594981A (en) 1982-04-08
DE3164201D1 (en) 1984-07-19

Similar Documents

Publication Publication Date Title
MD381C2 (ro) Procedeu de obţinere a aminodiacizilor substituiţi, racematelor sau izomerilor lor optici, sau sărurilor lor farmaceutic admisibile
AR002986A1 (es) Nuevos derivados de piperazina sustituida particularmente utiles como antagonistas de receptores de taquiquinina, composiciones farmaceuticas, usosde dichos derivados y procedimiento de preparacion de los mismos.
ES448263A1 (es) Procedimiento para la obtencion de materiales sinteticos de poliuretano.
FR2354986A1 (fr) Procede pour separer les hydrocarbures aromatiques de melanges de composes organiques
ES8300699A1 (es) Procedimiento para la preparacion de derivados del indol.
GB1307315A (en) Fire retardant polyurethanes
GB1448414A (en) Prostaglandin intermediates
ES448549A1 (es) Procedimiento para la obtencion de azometinas.
YU43089B (en) Process for preparing new 3-iminodibenzimidazo-azepines-oxazepines
FR2430942A1 (fr) Preparation de derives o-methyliques d'hydroxyaporphines
ES8300695A1 (es) Un procedimiento para obtener halohidratos de 2-mercaptoe- tilamina
ES475587A1 (es) Procedimiento para preparar derivados de isoquinolina
BG48694A3 (en) Method for preparing alkandiol- dicarboxilates
ES440723A1 (es) Procedimiento para la produccion de nuevos compuestos orga- nicos.
FR2546515B1 (fr) Procede de preparation de composes carbonyles adpdiethytleniques
ES8401059A1 (es) Procedimiento para la preparacion de fenoleteres biciclicos.
ES378034A1 (es) Un metodo para la produccion de un compuesto herbicida.
DE3160968D1 (en) Cardenolide-bis-digitoxoside derivatives, process for their preparation and their utilization as medicines
FI811424L (fi) Cykliska amider
ES425591A1 (es) Un procedimiento para la preparacion de secoprostaglandi- nas.
ES8404334A1 (es) Un metodo para preparar productos intermedios para la preparacion de 4-fenil-1,3-benzodiazepinas.
ES8204981A1 (es) Procedimiento de desalquilacion de una amina terciaria
ES8506570A1 (es) Un procedimiento para producir un acetal
ES469883A1 (es) Procedimiento para la obtencion de derivados de la hidroxi-4tiazolidinationa-2
ATE4049T1 (de) Verfahren zum herstellen von chlorphenolen.