AR247394A1 - Procedimiento para preparar derivados de 9-amino-1,2,3,4-tetrahidroacridin-1-ol, e intermediarios para uso exclusivo en dicho procedimiento - Google Patents

Procedimiento para preparar derivados de 9-amino-1,2,3,4-tetrahidroacridin-1-ol, e intermediarios para uso exclusivo en dicho procedimiento

Info

Publication number
AR247394A1
AR247394A1 AR85302040A AR30204085A AR247394A1 AR 247394 A1 AR247394 A1 AR 247394A1 AR 85302040 A AR85302040 A AR 85302040A AR 30204085 A AR30204085 A AR 30204085A AR 247394 A1 AR247394 A1 AR 247394A1
Authority
AR
Argentina
Prior art keywords
rent
formula
compound
alquilo
nhcor2
Prior art date
Application number
AR85302040A
Other languages
English (en)
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/664,731 external-priority patent/US4631286A/en
Priority claimed from US06/781,155 external-priority patent/US4695573A/en
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Application granted granted Critical
Publication of AR247394A1 publication Critical patent/AR247394A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C07D219/10—Nitrogen atoms attached in position 9
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C07D219/10—Nitrogen atoms attached in position 9
    • C07D219/12—Amino-alkylamino radicals attached in position 9
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

DERIVADOS DE 9-AMINO-1,2,3,4-TETRAHIDROACRIDIN-1-OL DE LA FORMULA I: DONDE N ES 1 O 2, X ES H, ALQUILO, ALCOXI, COH, HALOGENO,-NO2,-CF3, NHCOR2, EN EL CUAL R2 ES ALQUILO, O NR3R4, EN EL CUAL R3 Y R4 ES H O ALQUILO, R1 ES H, DI(ALQUIL)AMINO-ALQUILO, ALQUILO, FENIL-ALQUILO, DIFENIL-ALQUILO, FENIL- ALQUILO SUSTITUIDO CON HALOGENO, ALQUILO, ALCOXI, -CF3; DI(HALOGENFENILO)- ALQUILO, FENIL-ALCOXI, -FENIL-ALQUILO, FENOXI-ALQUILO, TIENIL-ALQUILO, PENTA-HALOGENFENIL-ALQUILO, BIS(HALOGENFENIL)-METOXI-ALQUILO, TIENIL, Y ES >C=O O >CR5-OH, DONDE R5 ES HIDROGENO O ALQUILO, Z ES >CH2 O C=CR6R7EN LA CUAL R6 Y R7 SON HIDROGENO O ALQUILO E Y Y Z JUNTOS FORMAN -CH=CH, QUE COMPRENDE A) CICLIZAR UN COMPUESTO DE LA FORMULA II, DONDE EN PRESENCIA DE UN HALURO METALICO, PARA OBTENER UN COMPUESTO DE LA FORMULA IV:, Y OPCIONALMENTE OBTENER LOS DERIVADOS A PARTIR DE IV PARA OBTENER V Y TAMBIEN A PARTIR DE IV O V OBTENER LOS DERIVADOS DONDE X ES -OH,-NO2,-NHCOR2,- N(R3)COR2,-NH(ALQUILO); H)REDUCIR UN COMPUESTO DE LA FORMULA XII, CON UN COMPUESTO DE LA FORMULA XV, PARA FORMAR UN COMPUESTO DE LA FORMULA XVI,Y DESCOMPONER ULTERIORMENTE EL PRODUCTO INTERMEDIO PARA OBTENER UN COMPUESTO DE LA FORMULA XIV; I)DESHIDRATAR UN COMPUESTO DE LA FORMULA XI/XIII, DONDE R5 ES HIDROGENO O ALQUILO,X NO ES - NHCOR2 NI -NO2, PARA OBTENER UN COMPUESTO DE LA FORMULA XVII; J) HACER REACCIONAR OPCIONALMENTE UN COMPUESTO DE LA FORMULA XIV, DONDE X NO ES NO2 NI -NHCOR2, CON (ISOBUTIL)2 A1H O R5LI, SIENDO R5 ALQUILO C1-C6 PARA OBTENER UN COMPUESTO DE LA FORMULA XVIII.
AR85302040A 1984-10-25 1985-10-23 Procedimiento para preparar derivados de 9-amino-1,2,3,4-tetrahidroacridin-1-ol, e intermediarios para uso exclusivo en dicho procedimiento AR247394A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/664,731 US4631286A (en) 1984-10-25 1984-10-25 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds
US06/781,155 US4695573A (en) 1984-10-25 1985-10-01 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds

Publications (1)

Publication Number Publication Date
AR247394A1 true AR247394A1 (es) 1994-12-29

Family

ID=27099040

Family Applications (1)

Application Number Title Priority Date Filing Date
AR85302040A AR247394A1 (es) 1984-10-25 1985-10-23 Procedimiento para preparar derivados de 9-amino-1,2,3,4-tetrahidroacridin-1-ol, e intermediarios para uso exclusivo en dicho procedimiento

Country Status (20)

Country Link
US (1) US4839364A (es)
EP (1) EP0179383B1 (es)
JP (1) JPH01125362A (es)
KR (1) KR900007624B1 (es)
AR (1) AR247394A1 (es)
AT (1) ATE63903T1 (es)
AU (2) AU589141B2 (es)
CA (1) CA1292744C (es)
DE (1) DE3582995D1 (es)
DK (2) DK167250B1 (es)
ES (3) ES8701165A1 (es)
FI (1) FI86421C (es)
GR (1) GR852555B (es)
HU (1) HU196183B (es)
IE (1) IE58696B1 (es)
IL (3) IL90300A (es)
NO (1) NO172847C (es)
NZ (2) NZ229248A (es)
PH (1) PH22614A (es)
PT (1) PT81362B (es)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0179383B1 (en) * 1984-10-25 1991-05-29 Hoechst-Roussel Pharmaceuticals Incorporated 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds, a process for their preparation and their use as medicaments
US4695573A (en) * 1984-10-25 1987-09-22 Hoechst-Roussel Pharmaceuticals Inc. 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds
GB8610980D0 (en) * 1986-05-06 1986-06-11 Ici America Inc Heterocyclic fused tricyclic compounds
US4789678A (en) * 1986-08-25 1988-12-06 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing α-alkyl-4-amino-3-quinolinemethanols and 1-(4-aralkylamino-3-quinolinyl)alkanones and related compounds
US4816456A (en) * 1986-10-01 1989-03-28 Summers William K Administration of monoamine acridines in cholinergic neuronal deficit states
US4753950A (en) * 1986-11-24 1988-06-28 Hoechst-Roussel Pharmaceuticals, Inc. Fused heterocyclic tetrahydroaminoquinolinols and related compounds
US4897400A (en) * 1987-02-13 1990-01-30 Hoeschst-Roussel Pharmaceuticals, Inc. 9-amino-1,4-ethano-1,2,3,4-tetrahydroacridine and related compounds useful for incresing the cholinergic function in a mammal
EP0282959A3 (en) * 1987-03-17 1989-05-31 Hoechst-Roussel Pharmaceuticals Incorporated Substituted 9-amino-tetrahydro-acridines and related compounds, a process for their preparation and their use as medicaments
US4762841A (en) * 1987-03-30 1988-08-09 Hoechst-Roussel Pharmaceuticals Inc. Substituted 9-amino-spiro(cycloalkyl(b)quinoline-2,1'cycloalkanes)
ATE92046T1 (de) * 1987-04-20 1993-08-15 Hoechst Roussel Pharma 9-hydroxyamino-tetrahydroacridine, verfahren zu ihrer herstellung und ihre verwendung als medikamente.
US6075144A (en) 1987-04-20 2000-06-13 Hoechst Marion Roussel, Inc. 9-hydroxyamino tetrahydroacridine and related compounds
US4843079A (en) * 1987-04-23 1989-06-27 Hoechst-Roussel Pharmaceuticals, Inc. Fused heteroalkylene quinolinamines
US4970316A (en) * 1987-05-07 1990-11-13 American Home Products Corporation Pyrano-, thiopyrano- and cyclohexylquinolines as inhibitors of interleukin 1
US5013741A (en) * 1987-09-08 1991-05-07 Hoechst-Roussel Pharmaceuticals Incorporated N-[substituted alkylidene]-1,2,3,4-tetrahydro-9-acridinamines useful for enhancing the cholinergic function in a mammal
US5037833A (en) * 1988-07-25 1991-08-06 Hoechst-Roussel Pharmaceuticals Inc. N-[substituted alkylidene]fused-bicycloalkylidene quinolinamines useful for enhancing the cholinergic function in a mammal
EP0306826A1 (en) * 1987-09-08 1989-03-15 Hoechst-Roussel Pharmaceuticals Incorporated N-(substituted alkylidene)fused bicycloalkylidene and hetero-alkylidene quinolinamines, a process for their preparation and their use as medicaments
US4800203A (en) * 1987-09-24 1989-01-24 Hoechst-Roussel Pharmaceuticals, Inc. Pyrrolo(1,2-b)cinnolines
US5202440A (en) * 1987-10-05 1993-04-13 Pfizer Inc. Certain 9-amino-2-(or 4)-oxa 1,2,3,4-tetrahydro- or 1,2,3,4,5,6,7,8-octahydro-acridines
IL87861A0 (en) * 1987-10-05 1989-03-31 Pfizer 4-aminopyridine derivatives
EP0319429B1 (en) * 1987-12-03 1994-04-27 Mitsubishi Kasei Corporation 9-Acylamino-tetrahydroacridine derivatives and memory enhancing agent containing said derivative as active ingredient
KR0156241B1 (ko) * 1988-11-16 1998-11-16 도날드 알.토센 하이드록시-1,2,3,4-테트라하이드로아미노아크리딘, 이의 제조방법 및 이를 함유하는 약제학적 조성물
US4927820A (en) * 1988-11-25 1990-05-22 Hoechst Roussel Pharmaceuticals Inc. Fused heterocyclic derivatives of 1,2,3,4-tetrahydroacridine
GB8827704D0 (en) * 1988-11-28 1988-12-29 Fujisawa Pharmaceutical Co New acridine derivatives & processes for their production
US5280032A (en) * 1989-02-14 1994-01-18 Toyama Chemical Co., Ltd. 1,2-ethanediol derivative and salt thereof, process for producing the same, and cerebral function-improving agent comprising the same
US4916135A (en) * 1989-05-08 1990-04-10 Hoechst Roussel Pharmaceuticals Inc. N-heteroaryl-4-quinolinamines
US5053513A (en) * 1990-03-29 1991-10-01 Hoechst-Roussel Pharmaceuticals Incorporated Method of reducing a carbonyl containing acridine
US5210087A (en) * 1991-02-13 1993-05-11 Hoechst-Roussel Pharmaceuticals Inc. 9-aminotetrahydroacridines and related compounds
RU2024509C1 (ru) * 1991-05-07 1994-12-15 Всероссийский научный центр по безопасности биологически активных веществ Производные 9-аминоакридина или их соли с органическими или неорганическими кислотами, проявляющие психотропную, антиамнестическую и липидрегулирующую активность
GB2264707A (en) * 1991-06-18 1993-09-08 Roger Michael Marchbanks Acridine derivatives for treating alzheimer's disease
US5434165A (en) * 1991-11-18 1995-07-18 Sanawa Kagaku Kenkyusho Company, Ltd. Nootropic agents, compositions of, and method of use thereof
JP2873898B2 (ja) * 1992-04-13 1999-03-24 富山化学工業株式会社 ベンゾ［ｂ］チオフェン−５−イル誘導体もしくはその光学活性体またはそれらの塩並びにそれらの製造法
US5247091A (en) * 1992-07-30 1993-09-21 Hoechst Celanese Corporation Preparation of enamines in aqueous media
US5466696A (en) * 1992-09-10 1995-11-14 Warner Lambert Company Tacrine and cytochrome P450 oxidase inhibitors and methods of use
US5422350A (en) * 1992-09-10 1995-06-06 Warner-Lambert Company Nitrogen substituted acridine and cytochrome P450 inhibitors and methods of use
ES2059263B1 (es) * 1992-10-27 1995-10-01 Vita Invest Sa Procedimiento para la obtencion del (+)-9-amino-1,2,3,4-tetrahidroacridin-1-ol.
WO1995003052A1 (en) * 1993-07-22 1995-02-02 Warner-Lambert Company Controlled release tacrine drug delivery systems and methods for preparing same
US5434170A (en) * 1993-12-23 1995-07-18 Andrulis Pharmaceuticals Corp. Method for treating neurocognitive disorders
US20100210590A1 (en) * 1995-09-27 2010-08-19 Northwestern University Compositions and treatments for seizure-related disorders
ES2144353B1 (es) * 1997-12-26 2001-01-01 Consejo Superior Investigacion Nuevos analogos de tacrina: potenciales agentes neuroprotectores para las enfermedades de alzheimer y parkinson. su procedimiento de obtencion.
KR100381716B1 (ko) * 2000-10-09 2003-04-26 한국화학연구원 항암활성을 가지는 아크리딘 유도체
WO2005072713A2 (en) 2004-01-27 2005-08-11 The Feinstein Institute For Medical Research Cholinesterase inhibitors for treating inflammation
WO2006004201A1 (ja) * 2004-07-01 2006-01-12 Eisai R & D Management Co., Ltd. 神経再生促進剤
ATE523199T1 (de) * 2004-11-02 2011-09-15 Univ Northwestern Pyridazinverbindungen und verfahren
BRPI0517790A (pt) * 2004-11-12 2008-10-21 Neurochem Int Ltd métodos e composições fluoradas para tratar doenças relacionadas à amilóide
US20080188510A1 (en) * 2005-05-23 2008-08-07 Eisai R & D Management Co., Ltd. Novel methods using zonisamide
CA2650711A1 (en) * 2006-04-28 2007-11-08 Northwestern University Compositions and treatments using pyridazine compounds and cholinesterase inhibitors
AU2015205995A1 (en) * 2014-01-15 2016-07-28 Centre National De La Recherche Scientifique (Cnrs) Water soluble 4-azapodophyllotoxin analogs
KR101586473B1 (ko) * 2014-04-30 2016-01-19 (주)이컴프 스크롤 압축기
RU2567388C1 (ru) * 2014-12-10 2015-11-10 Открытое акционерное общество "Нижегородский химико-фармацевтический завод" Способ получения 9-бутиламино-3,3-диметил-3,4-дигидроакридин-1(2н)-она гидрохлорида

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE532397C (de) * 1929-04-23 1931-08-27 J D Riedel E De Haeen Akt Ges Verfahren zur Darstellung polycyclischer Basen
US3122553A (en) * 1959-08-20 1964-02-25 Bansen Inc 4-alkyl resorcinolates of aminoacridines
US3033866A (en) * 1960-02-17 1962-05-08 Smith Kline French Lab Novel 9-acridanemethanol derivatives
US3232945A (en) * 1962-08-13 1966-02-01 S E Massengill Company 7,8,9,10-tetrahalo-6h-cyclohepta-(b)-quinolines
US3318896A (en) * 1963-12-05 1967-05-09 Squibb & Sons Inc Production of 12-substituted-6, 7, 8, 9, 10, 11-hexahydrocycloocta[b]quinolines
DE2337474C2 (de) * 1973-07-24 1982-01-21 Hoechst Ag, 6000 Frankfurt Chemotherapeutisch wirksame Tetrahydroacridone, Verfahren zu ihrer Herstellung und sie enthaltende Mittel
PL101032B1 (pl) * 1976-04-06 1978-11-30 Sposob otrzymywania 1-nitro-9-dwualkilo-aminoizoalkiloamiroakrydyn lub ich soli
DE2748333A1 (de) * 1977-10-28 1979-05-03 Hoechst Ag Mittel gegen malaria
US4550113A (en) * 1982-08-19 1985-10-29 Nauchno-Issledovatelsky Institut Po Biologicheskikm Ispytaniyam Khimicheskikh Soedineny 9-Amino-2,3,5,6,7,8-hexahydro-1H-cyclopenta(b)quinoline monohydrate hydrochloride as stimulant of neuro-muscular transmission of smooth muscles
US4631286A (en) * 1984-10-25 1986-12-23 Hoechst-Roussel Pharmaceuticals Inc. 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds
US4695573A (en) * 1984-10-25 1987-09-22 Hoechst-Roussel Pharmaceuticals Inc. 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds
EP0179383B1 (en) * 1984-10-25 1991-05-29 Hoechst-Roussel Pharmaceuticals Incorporated 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds, a process for their preparation and their use as medicaments
EP0268871A1 (en) * 1986-10-31 1988-06-01 Sumitomo Pharmaceuticals Company, Limited Quinoline derivatives

Also Published As

Publication number Publication date
FI86421C (fi) 1992-08-25
ES548137A0 (es) 1986-11-16
FI86421B (fi) 1992-05-15
FI854156A0 (fi) 1985-10-23
NO172847C (no) 1993-09-15
HUT41009A (en) 1987-03-30
IL90300A (en) 1990-11-29
KR860003227A (ko) 1986-05-21
EP0179383A2 (en) 1986-04-30
PT81362A (en) 1985-11-01
ES8801213A1 (es) 1988-01-01
IE852632L (en) 1986-04-25
AU4903885A (en) 1986-05-01
IL76796A (en) 1990-03-19
DK141992D0 (da) 1992-11-26
DK141992A (da) 1992-11-26
IL76796A0 (en) 1986-02-28
KR900007624B1 (ko) 1990-10-17
US4839364A (en) 1989-06-13
ES8701165A1 (es) 1986-11-16
ES554568A0 (es) 1988-05-16
PH22614A (en) 1988-10-17
DK488885A (da) 1986-04-26
NO172847B (no) 1993-06-07
IL90300A0 (en) 1989-12-15
AU589141B2 (en) 1989-10-05
EP0179383A3 (en) 1987-01-28
EP0179383B1 (en) 1991-05-29
JPH01125362A (ja) 1989-05-17
JPH0584306B2 (es) 1993-12-01
CA1292744C (en) 1991-12-03
GR852555B (es) 1986-02-24
DK168704B1 (da) 1994-05-24
ES8802383A1 (es) 1988-05-16
ES554569A0 (es) 1988-01-01
DE3582995D1 (de) 1991-07-04
ATE63903T1 (de) 1991-06-15
AU3823489A (en) 1989-10-26
NZ229248A (en) 1990-12-21
AU615768B2 (en) 1991-10-10
FI854156L (fi) 1986-04-26
DK167250B1 (da) 1993-09-27
NO904711D0 (no) 1990-10-30
NZ213932A (en) 1990-12-21
PT81362B (pt) 1987-11-30
IE58696B1 (en) 1993-11-03
NO904711L (no) 1986-04-28
DK488885D0 (da) 1985-10-24
HU196183B (en) 1988-10-28

Similar Documents

Publication Publication Date Title
AR247394A1 (es) Procedimiento para preparar derivados de 9-amino-1,2,3,4-tetrahidroacridin-1-ol, e intermediarios para uso exclusivo en dicho procedimiento
CO4520226A1 (es) Compuestos carbociclicos
AR247402A1 (es) Un procedimiento para preparar antibioticos macrolidos c-20 aminosustituidos
ES2056150T3 (es) Derivados del acido dietilentriamino-pentaacetico.
HU9400246D0 (en) Modified oligodeoxyribonucleotides, process for producing them, and pharmaceutical compositions containing them
PT75494B (en) Process for the preparation of dibenzymidazoazepine dibenzymidazoxazepine and dibenzymidazothiazepine compounds
FR2358141A1 (fr) Nouveaux anesthesiques locaux
FR2383931A1 (fr) Derives d'oxadiazolopyrimidine
US2635982A (en) Mercurated allylurea derivatives and diuretics containing the same
ES8106729A1 (es) Un procedimiento para preparar benzoxazepinas
ES8707972A1 (es) Un procedimiento para la preparacion de nuevos esteroides 11-b-sustituidos.
ES8400743A1 (es) "procedimiento para la preparacion de compuestos de 1-fenilindazol-3-ona".
ES448629A1 (es) Procedimiento para la preparacion de nuevos derivados de 1,4-bis-(carboxil-alcohil-benzoxazolil)-naftaleno.
FI882874A0 (fi) Tiofenderivat och foerfarande foer dess framstaellning.
ES8301931A1 (es) Un procedimiento para la preparacion de nuevos imidazoles.
KR860003204A (ko) 디페닐메틸이민 유도체의 제조방법
ES520486A0 (es) Procedimiento para la preparacion de fenoleteres biciclicos.
TAKAMIzAwA et al. Studies on Pyrimidine Derivatives and Related Compounds. LXX. A Novel Reaction of Thiamine Anhydride
FR2377378A1 (fr) Nouvelles amidines
ES8703457A1 (es) Un procedimiento para la preparacion de nuevos derivados de tiacetona.
GB1032269A (en) Process for the preparation of water-soluble alkane sulphonic acid salts of isoquinoline bases of the papaverine series
ES8605241A1 (es) Procedimiento de preparacion de ftalidoisoquinolinas amina- das
ES8505656A1 (es) Procedimiento para la preparacion de quinolinonas-4
KR840003637A (ko) 3-[2-(모노- 및 디알킬아미노) 프로일] -1,2,3,4- 테드라하이드로- 5h-[1] 벤조피라노 [3,4-c] 피리딘 -5-온의 제조방법
GB1545077A (en) Process for purifying water using bis-isothiouronium salts