ES8605241A1 - Procedimiento de preparacion de ftalidoisoquinolinas amina- das - Google Patents

Procedimiento de preparacion de ftalidoisoquinolinas amina- das

Info

Publication number
ES8605241A1
ES8605241A1 ES540235A ES540235A ES8605241A1 ES 8605241 A1 ES8605241 A1 ES 8605241A1 ES 540235 A ES540235 A ES 540235A ES 540235 A ES540235 A ES 540235A ES 8605241 A1 ES8605241 A1 ES 8605241A1
Authority
ES
Spain
Prior art keywords
group
amino
epimer
phthalideisoquinolines
aminated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES540235A
Other languages
English (en)
Other versions
ES540235A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Kasei Corp
Original Assignee
Mitsubishi Kasei Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Kasei Corp filed Critical Mitsubishi Kasei Corp
Publication of ES8605241A1 publication Critical patent/ES8605241A1/es
Publication of ES540235A0 publication Critical patent/ES540235A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE FTALIDOISOQUINOLINAS AMINADAS. COMPRENDE: A) CONDENSAR A UN C.D.F. (III) CON UN C.D.F. (IV) EN METANOL O BUTANOL, ENTRE 20 Y 100JC, DURANTE LAS 3 HORAS, PARA PRODUCIR UNA MEZCLA DE NITROS DE (A-MERO) Y (B-MERO) D.F. (II); B) REDUCIR A LAS MEZCLAS D.F. (II) CON NOROHIDRURO SODICO, EN PRESENCIA DE UN CATALIZADOR ELEGIDO ENTRE LOS METALES DE LOS GRUPOS IV Y VIII, ENTRE 10 Y 60JC, PARA DAR UN B-MERO D.F. (I); Y C) EPIMERIZAR AL B-MERO D.F. (I), EN PRESENCIA DE UN ALCALI COMONAOH, O BACOHL2, EN METANOL O BUTANOL Y ENTRE 20 Y 100JC, PARA OBTENER UN (A-MERO) D.F. (I). SIENDO: R1 Y R2, H O ALCOXI INFERIOR; R3, R4, R5 Y R6, H, AMINO, ALCOXI INFERIOR; R7, ALQUILO INFERIOR; R3, R4, R5 Y R6, H, NITRO O ALCOXI INFERIOR; C.D.F. COMPUESTO D.F.; D.F. DE FORMULA; (B-MERO), 1RS-3SR; Y A-MERO, 1RS-3RS. SE UTILIZAN PARA TRATAR ENFERMEDADES HEPATICAS O ALERGICAS.
ES540235A 1984-02-14 1985-02-08 Procedimiento de preparacion de ftalidoisoquinolinas amina- das Expired ES8605241A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59025639A JPS60169482A (ja) 1984-02-14 1984-02-14 アミノ化フタライド−イソキノリン類の製法

Publications (2)

Publication Number Publication Date
ES8605241A1 true ES8605241A1 (es) 1986-04-01
ES540235A0 ES540235A0 (es) 1986-04-01

Family

ID=12171413

Family Applications (1)

Application Number Title Priority Date Filing Date
ES540235A Expired ES8605241A1 (es) 1984-02-14 1985-02-08 Procedimiento de preparacion de ftalidoisoquinolinas amina- das

Country Status (6)

Country Link
US (1) US4704458A (es)
EP (1) EP0152090B1 (es)
JP (1) JPS60169482A (es)
DE (1) DE3579830D1 (es)
ES (1) ES8605241A1 (es)
HU (1) HU199478B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69207539T2 (de) * 1991-10-01 1996-05-30 Zeneca Ltd Benzofuranone
US20070238750A1 (en) * 2006-04-07 2007-10-11 Michalis Nicolaou Pure isomers of tritoqualine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1295310A (fr) * 1958-02-13 1962-06-08 Rech S Biolog Laborec Lab De Phtalides isoquinoléiniques nouveaux et procédé pour leur préparation
GB873935A (en) * 1959-08-05 1961-08-02 Maurice Jeanson Improvements in and relating to new isoquinoline phthalides and their process of preparation
JPS6058919B2 (ja) * 1979-10-23 1985-12-23 ラボレツク ソシエテ アノニム フタリジル−イソキノリン誘導体、その製造法及びそれを含有する医薬
JPS5921841B2 (ja) * 1982-09-01 1984-05-22 工業技術院長 繊維害虫忌避剤

Also Published As

Publication number Publication date
JPH0436157B2 (es) 1992-06-15
EP0152090A2 (en) 1985-08-21
HUT36461A (en) 1985-09-30
US4704458A (en) 1987-11-03
DE3579830D1 (de) 1990-10-31
ES540235A0 (es) 1986-04-01
JPS60169482A (ja) 1985-09-02
EP0152090A3 (en) 1986-08-13
EP0152090B1 (en) 1990-09-26
HU199478B (en) 1990-02-28

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970203