GB873935A - Improvements in and relating to new isoquinoline phthalides and their process of preparation - Google Patents

Improvements in and relating to new isoquinoline phthalides and their process of preparation

Info

Publication number
GB873935A
GB873935A GB2668759A GB2668759A GB873935A GB 873935 A GB873935 A GB 873935A GB 2668759 A GB2668759 A GB 2668759A GB 2668759 A GB2668759 A GB 2668759A GB 873935 A GB873935 A GB 873935A
Authority
GB
United Kingdom
Prior art keywords
phthalides
nitro group
preparation
phthalide
relating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2668759A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to GB2668759A priority Critical patent/GB873935A/en
Publication of GB873935A publication Critical patent/GB873935A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The invention comprises compounds of the general formula shown in Fig. 1, <FORM:0873935/IV (b)/1> in which R1, R2 and R3 are identical or different alkyl radicals and X is a hydrogen atom or a nitro or amino group; and their acid addition salts, and the preparation thereof by condensing cotarnine with a phthalide of the general formula shown in Fig. 2, preferably wherein the phthalide contains as substituent X a nitro group, said nitro group being converted into an amino group and thereafter being replaced by a hydrogen atom, if isoquindines phthalides are to be obtained in which X is other than a nitro group. The process may be combined with one wherein the phthalide itself is prepared from the corresponding trialkoxybenzoic acid by condensation with formaldehyde, followed preferably by the introduction of the nitro group as substituent X.
GB2668759A 1959-08-05 1959-08-05 Improvements in and relating to new isoquinoline phthalides and their process of preparation Expired GB873935A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB2668759A GB873935A (en) 1959-08-05 1959-08-05 Improvements in and relating to new isoquinoline phthalides and their process of preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2668759A GB873935A (en) 1959-08-05 1959-08-05 Improvements in and relating to new isoquinoline phthalides and their process of preparation

Publications (1)

Publication Number Publication Date
GB873935A true GB873935A (en) 1961-08-02

Family

ID=10247604

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2668759A Expired GB873935A (en) 1959-08-05 1959-08-05 Improvements in and relating to new isoquinoline phthalides and their process of preparation

Country Status (1)

Country Link
GB (1) GB873935A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4302458A (en) 1979-10-24 1981-11-24 Laborec Laboratoire De Recherches Biologiques Phthalidyl-isoquinoline derivatives
JPS5944382A (en) * 1982-09-06 1984-03-12 Mitsubishi Chem Ind Ltd Preparation of phthalide isoquinoline
EP0161499A1 (en) * 1984-04-17 1985-11-21 Mitsubishi Kasei Corporation Process for preparation of aminophthalideisoquinolines
US4684732A (en) * 1985-03-05 1987-08-04 Mitsubishi Chemical Industries Limited Process for preparation of phthalide derivatives
US4704458A (en) * 1984-02-14 1987-11-03 Mitsubishi Chemical Industries Limited Process for the epimerization of aminated phthalideisoquinolines
FR3015977A1 (en) * 2013-12-30 2015-07-03 Patrice Binay TRITOQUALINE HYDROCHLORIDE IN CRYSTALLIZED FORM AND PROCESS FOR OBTAINING THE SAME

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4302458A (en) 1979-10-24 1981-11-24 Laborec Laboratoire De Recherches Biologiques Phthalidyl-isoquinoline derivatives
JPS5944382A (en) * 1982-09-06 1984-03-12 Mitsubishi Chem Ind Ltd Preparation of phthalide isoquinoline
JPS64398B2 (en) * 1982-09-06 1989-01-06 Mitsubishi Kasei Kk
US4704458A (en) * 1984-02-14 1987-11-03 Mitsubishi Chemical Industries Limited Process for the epimerization of aminated phthalideisoquinolines
EP0161499A1 (en) * 1984-04-17 1985-11-21 Mitsubishi Kasei Corporation Process for preparation of aminophthalideisoquinolines
US4684732A (en) * 1985-03-05 1987-08-04 Mitsubishi Chemical Industries Limited Process for preparation of phthalide derivatives
FR3015977A1 (en) * 2013-12-30 2015-07-03 Patrice Binay TRITOQUALINE HYDROCHLORIDE IN CRYSTALLIZED FORM AND PROCESS FOR OBTAINING THE SAME
WO2015101727A1 (en) * 2013-12-30 2015-07-09 Patrice Binay Tritoqualine hydrochloride in crystalline form and a process for obtaining same

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