ES251894A1 - Procedure for the manufacture of tetrahidroisoquinoline derivatives (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the manufacture of tetrahidroisoquinoline derivatives (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES251894A1
ES251894A1 ES0251894A ES251894A ES251894A1 ES 251894 A1 ES251894 A1 ES 251894A1 ES 0251894 A ES0251894 A ES 0251894A ES 251894 A ES251894 A ES 251894A ES 251894 A1 ES251894 A1 ES 251894A1
Authority
ES
Spain
Prior art keywords
derivatives
translation
manufacture
machine
legally binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0251894A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES251894A1 publication Critical patent/ES251894A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Process for the manufacture of tetrahydroisoquinoline derivatives of the formula ** (See formula) ** in which R1 represents halogen, R2 represents hydrogen or alkyl, and n represents an integer from 1 to 3, and acid addition salts of said derivatives, characterized by comprising, condensing a 1-alkanoyl-2- (2-acylamide-ethyl) -4,5-dimethoxy-benzene with a halogenated benzaldehyde, cyclizing the substituted styrylketone which is obtained to convert it to substituted 1-styryl-3,4-dihydroisoquinoline, reducing the latter, N-methylated substituted 1-phenethyl-1,2,3,4-tetrahydroisoquinoline and , if desired, converting the product so obtained into an acid addition salt. (Machine-translation by Google Translate, not legally binding)
ES0251894A 1958-09-04 1959-09-03 Procedure for the manufacture of tetrahidroisoquinoline derivatives (Machine-translation by Google Translate, not legally binding) Expired ES251894A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH6358458A CH377348A (en) 1958-09-04 1958-09-04 Process for the preparation of substituted 1-phenethyl-tetrahydroisoquinolines

Publications (1)

Publication Number Publication Date
ES251894A1 true ES251894A1 (en) 1960-03-16

Family

ID=4525093

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0251894A Expired ES251894A1 (en) 1958-09-04 1959-09-03 Procedure for the manufacture of tetrahidroisoquinoline derivatives (Machine-translation by Google Translate, not legally binding)

Country Status (5)

Country Link
BE (1) BE582044A (en)
CH (1) CH377348A (en)
ES (1) ES251894A1 (en)
FR (2) FR1272493A (en)
OA (1) OA00950A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1199775B (en) * 1960-04-01 1965-09-02 Hoffmann La Roche Process for the production of tetrahydroisoquinoline derivatives with an analgesic, antitussive and antispasmodic effect

Also Published As

Publication number Publication date
FR170M (en) 1961-02-13
CH377348A (en) 1964-05-15
OA00950A (en) 1968-03-22
BE582044A (en) 1960-02-26
FR1272493A (en) 1961-09-29

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