ES8404334A1 - Un metodo para preparar productos intermedios para la preparacion de 4-fenil-1,3-benzodiazepinas. - Google Patents

Un metodo para preparar productos intermedios para la preparacion de 4-fenil-1,3-benzodiazepinas.

Info

Publication number
ES8404334A1
ES8404334A1 ES518413A ES518413A ES8404334A1 ES 8404334 A1 ES8404334 A1 ES 8404334A1 ES 518413 A ES518413 A ES 518413A ES 518413 A ES518413 A ES 518413A ES 8404334 A1 ES8404334 A1 ES 8404334A1
Authority
ES
Spain
Prior art keywords
intermediates
benzodiazepins
phenyl
preparing
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES518413A
Other languages
English (en)
Other versions
ES518413A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Roussel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharmaceuticals Inc filed Critical Hoechst Roussel Pharmaceuticals Inc
Publication of ES8404334A1 publication Critical patent/ES8404334A1/es
Publication of ES518413A0 publication Critical patent/ES518413A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/04—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C233/07—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

METODO PARA PREPARAR PRODUCTOS INTERMEDIOS PARA LA OBTENCION DE 4-FENIL-1,3-BENZODIAZEPINAS, DE FORMULA GENERAL (I), EN LA QUE Y ES OH, HALOGENO, -N-CH3 O R1SO3-; R1 ES UN GRUPO ALCOHILO DE CADENA RECTA O RAMIFICADA QUE TIENE DE 1 A 5 ATOMOS DE CARBONO; Y R2 ES -C(CH3)3 O -O-C(CH3)3.COMPRENDE LAS SIGUIENTES OPERACIONES: PRIMERA, SE HACE REACCIONAR UNA O-TOLUIDINA ACILADA EN N, DE FORMULA GENERAL (II) CON N-ALCOHIL-LITIO, PARA OBTENER UN INTERMEDIO DILITIO, DE FORMULA (III); SEGUNDA, SE APAGA EL INTERMEDIO DILITIO CON BENZALDEHIDO; Y POR ULTIMO, SE TRATA LA MEZCLA DE REACCION RESULTANTECON UN MEDIO ACUOSO PARA OBTENER EL COMPUESTO DE FORMULA (I).
ES518413A 1981-12-23 1982-12-21 Un metodo para preparar productos intermedios para la preparacion de 4-fenil-1,3-benzodiazepinas. Granted ES518413A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/333,965 US4374067A (en) 1981-12-23 1981-12-23 Intermediates for the preparation of 4-phenyl-1,3-benzodiazepins and methods for preparing the intermediates

Publications (2)

Publication Number Publication Date
ES8404334A1 true ES8404334A1 (es) 1984-05-01
ES518413A0 ES518413A0 (es) 1984-05-01

Family

ID=23304981

Family Applications (2)

Application Number Title Priority Date Filing Date
ES518413A Granted ES518413A0 (es) 1981-12-23 1982-12-21 Un metodo para preparar productos intermedios para la preparacion de 4-fenil-1,3-benzodiazepinas.
ES524846A Granted ES524846A0 (es) 1981-12-23 1983-08-10 Un metodo para preparar productos intermedios para la obtencion de 4-fenil-1,3-benzodiazepinas

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES524846A Granted ES524846A0 (es) 1981-12-23 1983-08-10 Un metodo para preparar productos intermedios para la obtencion de 4-fenil-1,3-benzodiazepinas

Country Status (7)

Country Link
US (1) US4374067A (es)
EP (1) EP0082523B1 (es)
JP (1) JPS58135843A (es)
AT (1) ATE18901T1 (es)
CA (1) CA1213900A (es)
DE (1) DE3270320D1 (es)
ES (2) ES518413A0 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3148594A1 (de) * 1981-12-09 1983-07-21 Basf Ag, 6700 Ludwigshafen Anilinderivate, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung unerwuenschten pflanzenwuchses
US5510346A (en) * 1987-12-07 1996-04-23 Hoechst Marion Roussel, Inc. 4-heteroaryl-1,3-benzodiazepines and 2-substituted-gamma-(heteroaryl)benzeneethanamines
US4908360A (en) * 1988-11-14 1990-03-13 Hoechst-Roussel Pharmaceuticals Inc. 1-aminoalkyl-3-oxysubstituted-4-aryl-1,3,4,5-tetrahydro-2H-1,3-benzodiazepine-2-ones

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4182760A (en) * 1977-06-16 1980-01-08 E. I. Du Pont De Nemours And Company Benzophenone anti-oximes, diazepin-N-oxides, and their use as pharmaceutical agents and as intermediates for pharmaceutical agents
ES484553A1 (es) * 1978-10-05 1980-05-16 Hoechst Ag Un metodo para preparar 4-fenil-1,3-benzodiazepinas

Also Published As

Publication number Publication date
ES8502675A1 (es) 1985-01-16
JPH0365339B2 (es) 1991-10-11
EP0082523B1 (en) 1986-04-02
CA1213900A (en) 1986-11-12
JPS58135843A (ja) 1983-08-12
EP0082523A2 (en) 1983-06-29
EP0082523A3 (en) 1984-08-22
ATE18901T1 (de) 1986-04-15
DE3270320D1 (en) 1986-05-07
ES524846A0 (es) 1985-01-16
US4374067A (en) 1983-02-15
ES518413A0 (es) 1984-05-01

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