MD381C2 - Process for obtaining substituted aminodiacids, racemates thereof or optical isomers, or their pharmaceutically acceptable salts - Google Patents

Process for obtaining substituted aminodiacids, racemates thereof or optical isomers, or their pharmaceutically acceptable salts

Info

Publication number
MD381C2
MD381C2 MD95-0107A MD950107A MD381C2 MD 381 C2 MD381 C2 MD 381C2 MD 950107 A MD950107 A MD 950107A MD 381 C2 MD381 C2 MD 381C2
Authority
MD
Moldova
Prior art keywords
alkyl group
racemates
pharmaceutically acceptable
acceptable salts
optical isomers
Prior art date
Application number
MD95-0107A
Other languages
Romanian (ro)
Russian (ru)
Inventor
Vincent Michel
Remond Georges
Laubie Michel
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26222007&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MD381(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from FR8021095A external-priority patent/FR2491469A1/en
Application filed by Adir filed Critical Adir
Publication of MD381C2 publication Critical patent/MD381C2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/08—Six-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

The invention relates to the process of obtaining substituted aminodiacids, racemates thereof or optical isomers or their pharmaceutically acceptable salts which possess an inhibition activity.The new obtained compounds possess valuable pharmacological properties.The process of obtaining substituted aminodiacids (racemates thereof or optical isomers or their pharmaceutically acceptable salts) is of general formula I:wherein A - is a benzenic cycle, n = 1;A - is a saturated cycle n = 0 or 1;R1 - is a lower alkyl group with 1 - 1 carbon atoms, comprising an aminogroup; R2 - hydrogen atom or alkyl group with 1 - 4 carbon atoms; R3 - linear or ramified alkyl group with 1 - 8 hydrogen atoms, mono- or dicycloalkyl - alkyl group or phenylalkyl group comprising totally 9 hydrogen atoms or substituted alkyl group of the formula:- (CH2)p - y - (CH)(R4)-R5,wherein R4 and R5 is hydrogen, lower alkyl with 1 - 4 hydrogen atoms or cycloalkyl with 3 - 6 hydrogen atoms; or R5 - alcoxycarbonyl, y = S or > N-Q, where Q- is hydrogen, acetyl or benzil - oxecarbonyl, p = 1 or 2, q = 0 or 1, racemates thereof or optical isomers or consisting pharmaceutically acceptable salts, consisting in the fact that the compound is of general formula II:wherein A, n, q have said values R+ +6 - is lower alkylradical or aminoalkyl radical, the aminofunction of which is protected by such radicals as benzil - oxycarbonyl or tretbutyloxycalbonyl, R+ 7 - hydroxy or lower alcoxy radicals, exposes to reaction the reductive alkylation with the compound of general formula III.wherein R2 and R3 have said values with the separation of the special product or removal in case of need of N - protective and ether groups by hydrogenolysis or saponification.
MD95-0107A 1980-10-02 1994-12-29 Process for obtaining substituted aminodiacids, racemates thereof or optical isomers, or their pharmaceutically acceptable salts MD381C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8021095A FR2491469A1 (en) 1980-10-02 1980-10-02 2-Carboxy-per:hydro-indole(s) and per or tetra:hydro-isoquinoline(s) - having a carboxy-substd. amino-acyl N-gp., inhibit carboxy:poly:peptidase(s), and kininase II and control hypertension
FR8106916A FR2503155A2 (en) 1980-10-02 1981-04-07 NOVEL SUBSTITUTED IMINO DIACIDES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS AN ENZYME INHIBITOR

Publications (1)

Publication Number Publication Date
MD381C2 true MD381C2 (en) 1996-05-31

Family

ID=26222007

Family Applications (1)

Application Number Title Priority Date Filing Date
MD95-0107A MD381C2 (en) 1980-10-02 1994-12-29 Process for obtaining substituted aminodiacids, racemates thereof or optical isomers, or their pharmaceutically acceptable salts

Country Status (29)

Country Link
EP (1) EP0049658B1 (en)
JP (1) JPS5791974A (en)
KR (1) KR860001875B1 (en)
AR (1) AR242949A1 (en)
AT (1) ATE7910T1 (en)
AU (1) AU542611B2 (en)
CA (1) CA1341196C (en)
DD (1) DD201783A5 (en)
DE (1) DE3164201D1 (en)
DK (1) DK157011C (en)
EG (1) EG15361A (en)
ES (1) ES505999A0 (en)
FI (1) FI77230C (en)
FR (1) FR2503155A2 (en)
GE (1) GEP19970943B (en)
GR (1) GR75016B (en)
HU (1) HU185147B (en)
IE (1) IE51821B1 (en)
IL (1) IL63940A (en)
LU (1) LU88262I2 (en)
MD (1) MD381C2 (en)
NL (1) NL930046I2 (en)
NO (1) NO160780C (en)
NZ (1) NZ198535A (en)
OA (1) OA06914A (en)
PH (1) PH17516A (en)
PT (1) PT73755B (en)
SU (1) SU1153827A3 (en)
UA (1) UA6308A1 (en)

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US4532342A (en) * 1981-02-20 1985-07-30 Warner-Lambert Company N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
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EP0065301A1 (en) * 1981-05-18 1982-11-24 Merck & Co. Inc. Isoquinoline carboxylic acid derivates, process for preparing and pharmaceutical composition containing the same
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Also Published As

Publication number Publication date
HU185147B (en) 1984-12-28
IE812257L (en) 1983-03-29
KR860001875B1 (en) 1986-10-24
KR830007564A (en) 1983-10-21
FR2503155B2 (en) 1983-07-01
DK157011B (en) 1989-10-30
FI813034L (en) 1982-04-03
NO160780B (en) 1989-02-20
NO813339L (en) 1982-04-05
DK157011C (en) 1990-03-26
ES8305723A1 (en) 1983-04-16
PT73755B (en) 1983-10-11
NZ198535A (en) 1984-09-28
EG15361A (en) 1987-04-30
NO160780C (en) 1989-05-31
SU1153827A3 (en) 1985-04-30
LU88262I2 (en) 1994-02-03
PT73755A (en) 1981-11-01
IL63940A0 (en) 1981-12-31
JPS5791974A (en) 1982-06-08
JPH0132239B2 (en) 1989-06-29
PH17516A (en) 1984-09-13
DD201783A5 (en) 1983-08-10
IL63940A (en) 1985-06-30
CA1341196C (en) 2001-03-06
DE3164201D1 (en) 1984-07-19
FI77230B (en) 1988-10-31
EP0049658B1 (en) 1984-06-13
NL930046I2 (en) 1994-01-03
UA6308A1 (en) 1994-12-29
AU542611B2 (en) 1985-02-28
AU7594981A (en) 1982-04-08
AR242949A1 (en) 1993-06-30
FR2503155A2 (en) 1982-10-08
GEP19970943B (en) 1997-04-18
ES505999A0 (en) 1983-04-16
OA06914A (en) 1983-05-31
DK434381A (en) 1982-04-03
IE51821B1 (en) 1987-04-01
EP0049658A1 (en) 1982-04-14
NL930046I1 (en) 1993-09-01
ATE7910T1 (en) 1984-06-15
FI77230C (en) 1989-02-10
GR75016B (en) 1984-07-12

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