IE812257L - Substituted imino-diacids - Google Patents

Substituted imino-diacids

Info

Publication number
IE812257L
IE812257L IE812257A IE225781A IE812257L IE 812257 L IE812257 L IE 812257L IE 812257 A IE812257 A IE 812257A IE 225781 A IE225781 A IE 225781A IE 812257 L IE812257 L IE 812257L
Authority
IE
Ireland
Prior art keywords
diacids
substituted imino
imino
substituted
Prior art date
Application number
IE812257A
Other versions
IE51821B1 (en
Original Assignee
Science Union & Cie
Medicale
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
Priority to FR8021095A priority Critical patent/FR2491469B1/fr
Priority to FR8106916A priority patent/FR2503155B2/fr
Application filed by Science Union & Cie, Medicale filed Critical Science Union & Cie
Publication of IE812257L publication Critical patent/IE812257L/en
Publication of IE51821B1 publication Critical patent/IE51821B1/en
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26222007&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IE812257(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44Iso-indoles; Hydrogenated iso-indoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D339/00Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/08Six-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
IE2257/81A 1980-10-02 1981-09-29 Substituted imino-diacids,their preparation and pharmaceutical compositions containing them IE51821B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FR8021095A FR2491469B1 (en) 1980-10-02 1980-10-02
FR8106916A FR2503155B2 (en) 1980-10-02 1981-04-07

Publications (2)

Publication Number Publication Date
IE812257L true IE812257L (en) 1983-03-29
IE51821B1 IE51821B1 (en) 1987-04-01

Family

ID=26222007

Family Applications (1)

Application Number Title Priority Date Filing Date
IE2257/81A IE51821B1 (en) 1980-10-02 1981-09-29 Substituted imino-diacids,their preparation and pharmaceutical compositions containing them

Country Status (27)

Country Link
EP (1) EP0049658B1 (en)
JP (1) JPH0132239B2 (en)
KR (1) KR860001875B1 (en)
AR (1) AR242949A1 (en)
AT (1) AT7910T (en)
AU (1) AU542611B2 (en)
CA (1) CA1341196C (en)
DD (1) DD201783A5 (en)
DE (1) DE3164201D1 (en)
DK (1) DK157011C (en)
EG (1) EG15361A (en)
ES (1) ES505999A0 (en)
FI (1) FI77230C (en)
FR (1) FR2503155B2 (en)
GR (1) GR75016B (en)
HU (1) HU185147B (en)
IE (1) IE51821B1 (en)
IL (1) IL63940A (en)
LU (1) LU88262I2 (en)
MD (1) MD381C2 (en)
NL (1) NL930046I2 (en)
NO (1) NO160780C (en)
NZ (1) NZ198535A (en)
OA (1) OA6914A (en)
PH (1) PH17516A (en)
PT (1) PT73755B (en)
SU (1) SU1153827A3 (en)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
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EP0046953B1 (en) * 1980-08-30 1989-12-06 Hoechst Aktiengesellschaft Amino acid derivatives, processes for their preparation, compositions containing them and their use
US4532342A (en) * 1981-02-20 1985-07-30 Warner-Lambert Company N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
ZA8107261B (en) * 1980-10-23 1982-09-29 Schering Corp Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them
DE3174844D1 (en) * 1980-10-23 1986-07-24 Schering Corp Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them
US4479963A (en) * 1981-02-17 1984-10-30 Ciba-Geigy Corporation 1-Carboxyalkanoylindoline-2-carboxylic acids
IN156096B (en) * 1981-03-19 1985-05-11 Usv Pharma Corp
EP0065301A1 (en) * 1981-05-18 1982-11-24 Merck & Co., Inc. Isoquinoline carboxylic acid derivates, process for preparing and pharmaceutical composition containing the same
SU1327787A3 (en) * 1981-11-05 1987-07-30 Хехст Аг (Фирма) Method of producing cis,endo-2-azabicyclo-(3,3,0)-octane-3-carboxylic acids or acid-additive salts thereof
DE3226768A1 (en) * 1981-11-05 1983-05-26 Hoechst Ag Derivatives of cis, endo-2-azabicyclo (3.3.0) octane-3-carboxylic acid, process for their preparation, agents containing them and their use
EP0170775B2 (en) * 1981-12-29 1994-10-12 Hoechst Aktiengesellschaft Derivatives of bicyclic amino acids, processes for their preparation, agents containing them and their use as well as bicyclic amino acids as intermediates and process for their preparation
NZ202903A (en) * 1981-12-29 1988-01-08 Hoechst Ag 1-- pe pyrrol-2-yl-carboxylic acid derivatives and pharmaceutical compositions
DE3210496A1 (en) * 1982-03-23 1983-10-06 Hoechst Ag New derivatives of bicyclic aminsaeuren, methods for their manufacture, containing these agents and their use as well as novel bicyclic amino acids as between stages and processes for their preparation
DE3302125A1 (en) * 1983-01-22 1984-07-26 Boehringer Ingelheim Kg An amino acid, derivatives, methods for their manufacture and use
US5175306A (en) * 1983-01-31 1992-12-29 Hoechst Aktiengesellschaft Process for the resolution of racemates of optically active bicyclic imino-α-carboxylic esters
HU191120B (en) * 1983-01-31 1987-01-28 Hoechts Ag,De Process for raceme separation of optically active byciclic imino-alpha-carbonic acid esthers
DE3303344A1 (en) 1983-02-02 1984-08-02 Hoechst Ag Amino acids A process for the preparation of N-alkylated and esters thereof
DE3333455A1 (en) * 1983-09-16 1985-04-11 Hoechst Ag A process for the production of N-alkylated dipeptide esters and their
DE3333454A1 (en) * 1983-09-16 1985-04-11 Hoechst Ag A process for the preparation of N-alkylated dipeptides and esters thereof
DE3408923A1 (en) * 1984-03-12 1985-09-26 Hoechst Ag Carboxyalkyldipeptidderivate process, for their preparation containing them and their use
DE3413710A1 (en) * 1984-04-12 1985-10-24 Hoechst Ag A process for the treatment of heart failure
US5684016A (en) * 1984-04-12 1997-11-04 Hoechst Aktiengesellschaft Method of treating cardiac insufficiency
DE3431541A1 (en) * 1984-08-28 1986-03-06 Hoechst Ag Cis, endo-2-azabicycloalkane-3-carboxylic acid derivatives, to processes for their preparation, their use, and intermediates in their preparation
GB8422165D0 (en) * 1984-09-01 1984-10-03 Wellcome Found Compounds
US5231080A (en) * 1985-10-15 1993-07-27 Hoechst Aktiengesellschaft Method for the treatment of atherosclerosis, thrombosis, and peripheral vessel disease
US4693996A (en) * 1985-12-23 1987-09-15 Warner-Lambert Company Method of treating heart failure and medicaments therefor
US5231084A (en) * 1986-03-27 1993-07-27 Hoechst Aktiengesellschaft Compounds having a cognition adjuvant action, agents containing them, and the use thereof for the treatment and prophylaxis of cognitive dysfuncitons
DE3633496A1 (en) * 1986-10-02 1988-04-14 Hoechst Ag Combination of angiotensin-converting-enzyme-inhibitors with calcium antagonists and their use in medicinal products
DE3639879A1 (en) * 1986-11-21 1988-06-01 Hoechst Ag A process for the preparation of mono-, bi-, tricyclic and amino acids, this procedure intermediates and a process for their preparation
DE3722007A1 (en) * 1987-07-03 1989-01-12 Hoechst Ag A process for producing bicyclic aminocarboxylic acids, between products of this process and the use thereof
FR2620703B1 (en) * 1987-09-17 1991-10-04 Adir Process for the industrial synthesis of the carboxylic acid perhydroindole - 2 (2s, 3as, 7aS). application to the synthesis of carboxyalkyl dipeptides
FR2620699B1 (en) * 1987-09-17 1990-06-01 Adir A method of synthesizing alpha amino acids and n alkyl esters thereof. application to the synthesis of carboxyalkyl dipeptides
FR2620700B1 (en) * 1987-09-17 1990-06-01 Adir A method of synthesizing alpha amino acids and their alkyl esters n. application to the synthesis of carboxyalkyl dipeptides
FR2620709B1 (en) * 1987-09-17 1990-09-07 Adir Process for the industrial synthesis of perindopril and its key intermediate of synthesis
US4902695A (en) * 1989-02-13 1990-02-20 Eli Lilly And Company Excitatory amino acid receptor antagonists
TW197945B (en) * 1990-11-27 1993-01-11 Hoechst Ag
LT3872B (en) 1993-12-06 1996-04-25 Hoechst Ag Novel peptides and pharmaceutical compositions containing them
FR2746394B1 (en) 1996-03-20 1998-05-29 Roussel Uclaf Novel tricyclic compounds, their preparation process, and intermediates thereof, their application as medicaments and the pharmaceutical compositions containing them
PT796855E (en) 1996-03-20 2002-07-31 Hoechst Ag Inhibition of reabsorcao in bones and antagonists of vitronectin
DE19653647A1 (en) 1996-12-20 1998-06-25 Hoechst Ag Vitronectin receptor antagonists, their preparation and their use
DE19741873A1 (en) * 1997-09-23 1999-03-25 Hoechst Marion Roussel De Gmbh Novel 5-membered ring heterocycles, their preparation, their use and pharmaceutical compositions containing them
DE19751251A1 (en) 1997-11-19 1999-05-20 Hoechst Marion Roussel De Gmbh Substituted imidazolidine derivatives, their preparation, their use and pharmezeutische preparations containing them
DE19821483A1 (en) 1998-05-14 1999-11-18 Hoechst Marion Roussel De Gmbh New imidazolidine derivatives useful as leukocyte adhesion and migration inhibitors and/or VLA-4 receptor antagonists for treating E.G. inflammatory and allergic disorders
FR2807431B1 (en) * 2000-04-06 2002-07-19 Adir Novel process for the synthesis of perindopril and its pharmaceutically acceptable salts
FR2807430B1 (en) * 2000-04-11 2002-05-17 Adir Novel process for the synthesis of n - [(s) -1- carboxybutyl] - (s) -alanine esters and application to the synthesis of perindopril
FR2811320B1 (en) * 2000-07-06 2002-08-23 Adir Novel alpha crystalline form of tert-butylamine salt of perindopril, preparation method thereof and pharmaceutical compositions containing the same
AU2007203451B2 (en) * 2000-07-06 2010-09-02 Les Laboratoires Servier Pharmaceutical composition containing a crystalline form of perindopril tert-butylamine salt
FR2811318B1 (en) * 2000-07-06 2002-08-23 Adir Novel gamma crystalline form of tert-butylamine salt of perindopril, preparation method thereof and pharmaceutical compositions containing the same
FR2827860B1 (en) * 2001-07-24 2004-12-10 Servier Lab Novel process for synthesis of acid derivatives (2s, 3as, 7as) -1 - [(s) -alanyl] -octahydro-1h-indole-2-carboxyline and application to the synthesis of perindopril
AT365714T (en) * 2002-01-30 2007-07-15 Servier Lab Process for preparing high-purity perindopril and intermediates useful in synthesis
FR2838648B1 (en) * 2002-04-18 2004-05-21 Servier Lab New perindopril salt and the pharmaceutical compositions containing it
GB2395195A (en) * 2002-11-18 2004-05-19 Cipla Ltd Preparation of perindopril from carboxy-protected precursor, & perindopril monohydrates for use as angiotensin converting enzyme (ACE) inhibitors
JP2007507418A (en) 2003-06-24 2007-03-29 レ・ラボラトワール・セルヴィエLes Laboratoires Servier A new crystal form of perindopril erbumine.
SI1367061T1 (en) * 2003-06-30 2006-04-30 Servier Lab Method for synthesis of perindopril and its pharmaceutically acceptable salts
AT338766T (en) * 2003-08-29 2006-09-15 Servier Lab Process for the synthesis of perindopril and its pharmaceutically acceptable salts
AT445588T (en) * 2003-09-01 2009-10-15 Servier Lab A new method for the production of esters of n- ((s) -1-carboxybutyl) - (s) -alanine and its use in the synthesis of perindopril
SI21703A (en) 2004-01-14 2005-08-31 Lek Farmacevtska Druzba Dd Inclusion complexes of perindopril, procedure of their preparation, pharmaceutical compositions containing these complexes and their application in treatment of hypertensia
GB2413128A (en) * 2004-04-13 2005-10-19 Neopharma Ltd Process for the preparation of perindopril
SI21800A (en) 2004-05-14 2005-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto New procedure of synthesis of perindopril
SI21881A (en) 2004-10-15 2006-04-30 Diagen, Smartno Pri Ljubljani, D.O.O. New crystal forms of perindopril erbumine hydrates, procedure of their preparation and pharmaceutical forms containing these compounds
EP1679072B9 (en) 2005-01-06 2009-09-02 IPCA Laboratories Limited Process for for synthesis of (2S,3aS,7aS)-1-(S)-alanyl-octahydro-1H-indole-2- carboxylic acid derivatives and use in the synthesis of perindopril
EP1815857A1 (en) 2006-02-02 2007-08-08 LEK Pharmaceuticals D.D. A pharmaceutical composition comprising perindopril
FR2897866B1 (en) * 2006-02-28 2008-04-18 Servier Lab Alpha crystalline form of perinopril arginine salt, process for preparing the same, and pharmaceutical compositions containing the same
SI22543A (en) 2007-06-27 2008-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto New salts of perindopril
GB0910692D0 (en) 2009-06-20 2009-08-05 Teva Pharma Compound
PT105315B (en) 2010-09-29 2013-01-16 Inst Superior Tecnico A new crystalin hydrate form of perindopril erbumine, methods for preparation and use in pharmaceutical preparations
FR2985511B1 (en) 2012-01-05 2014-01-03 Servier Lab Crystalline delta form of perinopril arginine salt, process for preparing the same, and pharmaceutical compositions containing the same
FR2985512B1 (en) 2012-01-05 2014-06-20 Servier Lab Process for the preparation of l-arginine salt of perindopril
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
FR3050380A1 (en) 2016-04-20 2017-10-27 Servier Lab Pharmaceutical composition comprising a betabloquant, a conversion enzyme inhibitor and an antihyperteness or a nsaid.

Family Cites Families (13)

* Cited by examiner, † Cited by third party
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JPS5751834B2 (en) * 1978-11-27 1982-11-04
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
US4461896A (en) * 1979-02-07 1984-07-24 Norwich Eaton Pharmaceuticals, Inc. 1-[Acylthio) and (mercapto)-1-oxoalkyl]-1,2,3,4-tetrahydroquinoline-2-carboxylic acids
DE3063420D1 (en) * 1979-03-26 1983-07-07 Takeda Chemical Industries Ltd Tetrahydroisoquinolines, their production and the compounds and pharmaceutical compositions containing them for use in the prevention or treatment of hypertension
US4294832A (en) * 1979-04-28 1981-10-13 Tanabe Seiyaku Co., Ltd. Tetrahydroisoquinoline compounds and a pharmaceutical composition thereof
GB2048863B (en) * 1979-05-16 1983-06-15 Morton Norwich Products Inc Tetrahydroisoquinoline-3-carboxylic acids
US4303583A (en) * 1979-08-13 1981-12-01 American Home Products Corporation 1H,5H-[1,4]Thiazepino[4,3-a]indole-1,5-diones
FR2470767B1 (en) * 1979-12-07 1982-04-30 Science Union & Cie
FR2487829B2 (en) * 1979-12-07 1983-11-25 Science Union & Cie
ZA8101493B (en) * 1980-04-02 1982-03-31 Warner Lambert Co Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids
US4251444A (en) * 1980-04-07 1981-02-17 American Home Products Corporation Thiazepino-[4,3-b]-isoquinoline-1,5-dione derivatives and precursors
EP0046953B1 (en) * 1980-08-30 1989-12-06 Hoechst Aktiengesellschaft Amino acid derivatives, processes for their preparation, compositions containing them and their use
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids

Also Published As

Publication number Publication date
NO160780C (en) 1989-05-31
AU542611B2 (en) 1985-02-28
FI813034A (en)
CA1341196C (en) 2001-03-06
NO813339L (en) 1982-04-05
EG15361A (en) 1987-04-30
NZ198535A (en) 1984-09-28
LU88262I2 (en) 1994-02-03
FR2503155B2 (en) 1983-07-01
PT73755A (en) 1981-11-01
DK434381A (en) 1982-04-03
IL63940A (en) 1985-06-30
NL930046I1 (en) 1993-09-01
AT7910T (en) 1984-06-15
DD201783A5 (en) 1983-08-10
DE3164201D1 (en) 1984-07-19
SU1153827A3 (en) 1985-04-30
HU185147B (en) 1984-12-28
FI813034L (en) 1982-04-03
EP0049658B1 (en) 1984-06-13
PT73755B (en) 1983-10-11
FI77230C (en) 1989-02-10
NO160780B (en) 1989-02-20
JPS5791974A (en) 1982-06-08
IE51821B1 (en) 1987-04-01
NL930046I2 (en) 1994-01-03
EP0049658A1 (en) 1982-04-14
ES8305723A1 (en) 1983-04-16
AR242949A1 (en) 1993-06-30
FR2503155A2 (en) 1982-10-08
OA6914A (en) 1983-05-31
IL63940D0 (en) 1981-12-31
MD381C2 (en) 1996-05-31
JPH0132239B2 (en) 1989-06-29
GR75016B (en) 1984-07-12
LU88262A9 (en)
DK157011B (en) 1989-10-30
ES505999A0 (en) 1983-04-16
KR830007564A (en) 1983-10-21
AU7594981A (en) 1982-04-08
FI77230B (en) 1988-10-31
PH17516A (en) 1984-09-13
KR860001875B1 (en) 1986-10-24
DK157011C (en) 1990-03-26
ES505999D0 (en)

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