NO160780C - ANALOGY PROCEDURE FOR THE PREPARATION OF SUBSTITUTED IMINODIC ACIDS. - Google Patents

ANALOGY PROCEDURE FOR THE PREPARATION OF SUBSTITUTED IMINODIC ACIDS.

Info

Publication number
NO160780C
NO160780C NO813339A NO813339A NO160780C NO 160780 C NO160780 C NO 160780C NO 813339 A NO813339 A NO 813339A NO 813339 A NO813339 A NO 813339A NO 160780 C NO160780 C NO 160780C
Authority
NO
Norway
Prior art keywords
iminodic
acids
substituted
preparation
analogy procedure
Prior art date
Application number
NO813339A
Other languages
Norwegian (no)
Other versions
NO813339L (en
NO160780B (en
Inventor
Michel Vincent
Georges Remond
Michel Laubie
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26222007&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO160780(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from FR8021095A external-priority patent/FR2491469A1/en
Application filed by Adir filed Critical Adir
Publication of NO813339L publication Critical patent/NO813339L/en
Publication of NO160780B publication Critical patent/NO160780B/en
Publication of NO160780C publication Critical patent/NO160780C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/08—Six-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
NO813339A 1980-10-02 1981-10-01 ANALOGY PROCEDURE FOR THE PREPARATION OF SUBSTITUTED IMINODIC ACIDS. NO160780C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8021095A FR2491469A1 (en) 1980-10-02 1980-10-02 2-Carboxy-per:hydro-indole(s) and per or tetra:hydro-isoquinoline(s) - having a carboxy-substd. amino-acyl N-gp., inhibit carboxy:poly:peptidase(s), and kininase II and control hypertension
FR8106916A FR2503155A2 (en) 1980-10-02 1981-04-07 NOVEL SUBSTITUTED IMINO DIACIDES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS AN ENZYME INHIBITOR

Publications (3)

Publication Number Publication Date
NO813339L NO813339L (en) 1982-04-05
NO160780B NO160780B (en) 1989-02-20
NO160780C true NO160780C (en) 1989-05-31

Family

ID=26222007

Family Applications (1)

Application Number Title Priority Date Filing Date
NO813339A NO160780C (en) 1980-10-02 1981-10-01 ANALOGY PROCEDURE FOR THE PREPARATION OF SUBSTITUTED IMINODIC ACIDS.

Country Status (29)

Country Link
EP (1) EP0049658B1 (en)
JP (1) JPS5791974A (en)
KR (1) KR860001875B1 (en)
AR (1) AR242949A1 (en)
AT (1) ATE7910T1 (en)
AU (1) AU542611B2 (en)
CA (1) CA1341196C (en)
DD (1) DD201783A5 (en)
DE (1) DE3164201D1 (en)
DK (1) DK157011C (en)
EG (1) EG15361A (en)
ES (1) ES505999A0 (en)
FI (1) FI77230C (en)
FR (1) FR2503155A2 (en)
GE (1) GEP19970943B (en)
GR (1) GR75016B (en)
HU (1) HU185147B (en)
IE (1) IE51821B1 (en)
IL (1) IL63940A (en)
LU (1) LU88262I2 (en)
MD (1) MD381C2 (en)
NL (1) NL930046I2 (en)
NO (1) NO160780C (en)
NZ (1) NZ198535A (en)
OA (1) OA06914A (en)
PH (1) PH17516A (en)
PT (1) PT73755B (en)
SU (1) SU1153827A3 (en)
UA (1) UA6308A1 (en)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0046953B1 (en) * 1980-08-30 1989-12-06 Hoechst Aktiengesellschaft Amino acid derivatives, processes for their preparation, compositions containing them and their use
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
ATE20469T1 (en) * 1980-10-23 1986-07-15 Schering Corp CARBOXYALKYL DIPEPTIDES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICALS CONTAINING THEM.
ZA817261B (en) * 1980-10-23 1982-09-29 Schering Corp Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them
US4479963A (en) * 1981-02-17 1984-10-30 Ciba-Geigy Corporation 1-Carboxyalkanoylindoline-2-carboxylic acids
US4532342A (en) * 1981-02-20 1985-07-30 Warner-Lambert Company N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
IN156096B (en) * 1981-03-19 1985-05-11 Usv Pharma Corp
EP0065301A1 (en) * 1981-05-18 1982-11-24 Merck & Co. Inc. Isoquinoline carboxylic acid derivates, process for preparing and pharmaceutical composition containing the same
DE3226768A1 (en) * 1981-11-05 1983-05-26 Hoechst Ag, 6230 Frankfurt DERIVATIVES OF CIS, ENDO-2-AZABICYCLO- (3.3.0) -OCTAN-3-CARBONIC ACID, METHOD FOR THE PRODUCTION THEREOF, THE MEANS CONTAINING THEM AND THE USE THEREOF
SU1327787A3 (en) * 1981-11-05 1987-07-30 Хехст Аг (Фирма) Method of producing cis,endo-2-azabicyclo-(3,3,0)-octane-3-carboxylic acids or acid-additive salts thereof
GR78413B (en) * 1981-12-29 1984-09-27 Hoechst Ag
ATE25244T1 (en) * 1981-12-29 1987-02-15 Hoechst Ag NEW DERIVATIVES OF BICYCLIC AMINO ACIDS, PROCESS FOR THEIR PREPARATION, COMPOSITIONS CONTAINING THEM AND THEIR USE, AS WELL AS NEW BICYCLIC AMINO ACIDS AS INTERMEDIATE STAGES AND PROCESS FOR THEIR PREPARATION.
DE3210496A1 (en) * 1982-03-23 1983-10-06 Hoechst Ag NEW DERIVATIVES OF BICYCLIC AMINO ACIDS, METHOD FOR THE PRODUCTION THEREOF, THE MEANS CONTAINING THEM AND THE USE THEREOF, AND NEW BICYCLIC AMINO ACIDS AS INTERMEDIATE STAGES AND METHOD FOR THE PRODUCTION THEREOF
DE3302125A1 (en) * 1983-01-22 1984-07-26 Boehringer Ingelheim KG, 6507 Ingelheim AMINO ACID DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF
HU191120B (en) * 1983-01-31 1987-01-28 Hoechts Ag,De Process for raceme separation of optically active byciclic imino-alpha-carbonic acid esthers
US5175306A (en) * 1983-01-31 1992-12-29 Hoechst Aktiengesellschaft Process for the resolution of racemates of optically active bicyclic imino-α-carboxylic esters
DE3303344A1 (en) 1983-02-02 1984-08-02 Hoechst Ag, 6230 Frankfurt METHOD FOR PRODUCING N-ALKYLATED AMINO ACIDS AND THEIR ESTERS
DE3333455A1 (en) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt METHOD FOR PRODUCING N-ALKYLATED DIPEPTIDES AND THEIR ESTERS
DE3333454A1 (en) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt METHOD FOR PRODUCING N-ALKYLATED DIPEPTIDES AND THEIR ESTERS
DE3408923A1 (en) * 1984-03-12 1985-09-26 Hoechst Ag, 6230 Frankfurt CARBOXYALKYLDIPEPTIDE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THE AGENTS CONTAINING THEM AND THE USE THEREOF
DE3413710A1 (en) * 1984-04-12 1985-10-24 Hoechst Ag, 6230 Frankfurt METHOD FOR TREATING HEART INSUFFICIENCY
US5684016A (en) * 1984-04-12 1997-11-04 Hoechst Aktiengesellschaft Method of treating cardiac insufficiency
DE3431541A1 (en) * 1984-08-28 1986-03-06 Hoechst Ag, 6230 Frankfurt CIS, ENDO-2-AZABICYCLOALKAN-3-CARBONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AND INTERMEDIATE PRODUCTS IN THEIR PRODUCTION
GB8422165D0 (en) * 1984-09-01 1984-10-03 Wellcome Found Compounds
US5231080A (en) * 1985-10-15 1993-07-27 Hoechst Aktiengesellschaft Method for the treatment of atherosclerosis, thrombosis, and peripheral vessel disease
US4693996A (en) * 1985-12-23 1987-09-15 Warner-Lambert Company Method of treating heart failure and medicaments therefor
US5231084A (en) * 1986-03-27 1993-07-27 Hoechst Aktiengesellschaft Compounds having a cognition adjuvant action, agents containing them, and the use thereof for the treatment and prophylaxis of cognitive dysfuncitons
DE3633496A1 (en) * 1986-10-02 1988-04-14 Hoechst Ag COMBINATION OF ANGIOTENSIN CONVERTING ENZYME INHIBITORS WITH CALCIUMANTAGONISTS AND THEIR USE IN MEDICINAL PRODUCTS
DE3639879A1 (en) * 1986-11-21 1988-06-01 Hoechst Ag METHOD FOR PRODUCING MONO, BI AND TRICYCLIC AMINO ACIDS, INTERMEDIATE PRODUCTS OF THIS METHOD, AND A METHOD FOR PRODUCING THE SAME
DE3722007A1 (en) * 1987-07-03 1989-01-12 Hoechst Ag METHOD FOR PRODUCING BICYCLIC AMINOCARBONIC ACIDS, INTERMEDIATE PRODUCTS OF THIS METHOD AND THE USE THEREOF
FR2620709B1 (en) * 1987-09-17 1990-09-07 Adir PROCESS FOR THE INDUSTRIAL SYNTHESIS OF PERINDOPRIL AND ITS MAIN INTERMEDIATE SYNTHESIS
FR2620700B1 (en) * 1987-09-17 1990-06-01 Adir PROCESS FOR THE SYNTHESIS OF ALPHA AMINO ACIDS N ALKYLS AND THEIR ESTERS. APPLICATION TO THE SYNTHESIS OF CARBOXYALKYL DIPEPTIDES
FR2620699B1 (en) * 1987-09-17 1990-06-01 Adir PROCESS FOR THE SYNTHESIS OF ALPHA AMINO N ALKYL ACIDS AND THEIR ESTERS. APPLICATION TO THE SYNTHESIS OF CARBOXYALKYL DIPEPTIDES
FR2620703B1 (en) * 1987-09-17 1991-10-04 Adir PROCESS FOR THE INDUSTRIAL SYNTHESIS OF PERHYDROINDOLE CARBOXYLIC ACID - 2 (2S, 3AS, 7AS). APPLICATION TO THE SYNTHESIS OF CARBOXYALKYL DIPEPTIDES
US4902695A (en) * 1989-02-13 1990-02-20 Eli Lilly And Company Excitatory amino acid receptor antagonists
TW197945B (en) * 1990-11-27 1993-01-11 Hoechst Ag
LT3872B (en) 1993-12-06 1996-04-25 Hoechst Ag Novel peptides and pharmaceutical compositions containing them
FR2746394B1 (en) 1996-03-20 1998-05-29 Roussel Uclaf NOVEL TRICYCLIC COMPOUNDS, THEIR PREPARATION PROCESS, AND INTERMEDIATES THEREOF, THEIR APPLICATION AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
PT796855E (en) 1996-03-20 2002-07-31 Hoechst Ag INHIBITION OF REABSORCAO IN BONES AND ANTAGONISTS OF VITRONECTIN
DE19653647A1 (en) 1996-12-20 1998-06-25 Hoechst Ag Vitronectin receptor antagonists, their preparation and their use
DE19741873A1 (en) * 1997-09-23 1999-03-25 Hoechst Marion Roussel De Gmbh New 5-ring heterocycles, their preparation, their use and pharmaceutical preparations containing them
DE19751251A1 (en) 1997-11-19 1999-05-20 Hoechst Marion Roussel De Gmbh Substituted imidazolidine derivatives, their manufacture, their use and pharmaceutical preparations containing them
DE19821483A1 (en) 1998-05-14 1999-11-18 Hoechst Marion Roussel De Gmbh New imidazolidine derivatives useful as leukocyte adhesion and migration inhibitors and/or VLA-4 receptor antagonists for treating E.G. inflammatory and allergic disorders
FR2807431B1 (en) * 2000-04-06 2002-07-19 Adir NOVEL PROCESS FOR THE SYNTHESIS OF PERINDOPRIL AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS
FR2807430B1 (en) * 2000-04-11 2002-05-17 Adir NOVEL PROCESS FOR THE SYNTHESIS OF N - [(S) -1- CARBOXYBUTYL] - (S) -ALANINE ESTERS AND APPLICATION TO THE SYNTHESIS OF PERINDOPRIL
AU2007203451B2 (en) * 2000-07-06 2010-09-02 Les Laboratoires Servier Pharmaceutical composition containing a crystalline form of perindopril tert-butylamine salt
FR2811320B1 (en) * 2000-07-06 2002-08-23 Adir NOVEL ALPHA CRYSTALLINE FORM OF TERT-BUTYLAMINE SALT OF PERINDOPRIL, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
FR2811318B1 (en) * 2000-07-06 2002-08-23 Adir NOVEL GAMMA CRYSTALLINE FORM OF TERT-BUTYLAMINE SALT OF PERINDOPRIL, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
FR2827860B1 (en) * 2001-07-24 2004-12-10 Servier Lab NOVEL PROCESS FOR SYNTHESIS OF ACID DERIVATIVES (2S, 3AS, 7AS) -1 - [(S) -ALANYL] -OCTAHYDRO-1H-INDOLE-2-CARBOXYLINE AND APPLICATION TO THE SYNTHESIS OF PERINDOPRIL
ATE365714T1 (en) * 2002-01-30 2007-07-15 Servier Lab METHOD FOR PRODUCING HIGH PURITY PERINDOPRIL AND INTERMEDIATE COMPOUNDS USEFUL IN SYNTHESIS
FR2838648B1 (en) * 2002-04-18 2004-05-21 Servier Lab NEW PERINDOPRIL SALT AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING IT
GB2395195A (en) * 2002-11-18 2004-05-19 Cipla Ltd Preparation of perindopril from carboxy-protected precursor, & perindopril monohydrates for use as angiotensin converting enzyme (ACE) inhibitors
SI1636185T1 (en) 2003-06-24 2012-06-29 Servier Lab Novel crystalline forms of perindopril erbumine
DE60303101T2 (en) * 2003-06-30 2006-09-28 Les Laboratoires Servier Process for the synthesis of perindopril and its pharmaceutically acceptable salts
PT1380590E (en) * 2003-08-29 2006-12-29 Servier Lab Method for synthesis of perindopril and its pharmaceutically acceptable salts
DE60329648D1 (en) * 2003-09-01 2009-11-26 Servier Lab A new process for preparing esters of N - ((S) -1-carboxybutyl) - (S) -alanine and its use in the synthesis of perindopril
SI21703A (en) 2004-01-14 2005-08-31 Lek Farmacevtska Druzba Dd Inclusion complexes of perindopril, procedure of their preparation, pharmaceutical compositions containing these complexes and their application in treatment of hypertensia
GB2413128A (en) * 2004-04-13 2005-10-19 Neopharma Ltd Process for the preparation of perindopril
SI21800A (en) 2004-05-14 2005-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto New procedure of synthesis of perindopril
SI21881A (en) 2004-10-15 2006-04-30 Diagen, Smartno Pri Ljubljani, D.O.O. New crystal forms of perindopril erbumine hydrates, procedure of their preparation and pharmaceutical forms containing these compounds
DE602005009918D1 (en) 2005-01-06 2008-11-06 Ipca Lab Ltd Process for the synthesis of (2S, 3aS, 7aS) -1- (S) -alanyl-octahydro-1H-2-carboxylic acid derivatives and use in the synthesis of perindopril
EP1815857A1 (en) 2006-02-02 2007-08-08 LEK Pharmaceuticals D.D. A pharmaceutical composition comprising perindopril
FR2897866B1 (en) 2006-02-28 2008-04-18 Servier Lab ALPHA CRYSTALLINE FORM OF PERINOPRIL ARGININE SALT, PROCESS FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
SI22543A (en) 2007-06-27 2008-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto New salts of perindopril
GB0910692D0 (en) 2009-06-20 2009-08-05 Teva Pharma Compound
PT105315B (en) 2010-09-29 2013-01-16 Inst Superior Tecnico A NEW CRYSTALIN HYDRATE FORM OF PERINDOPRIL ERBUMINE, METHODS FOR PREPARATION AND USE IN PHARMACEUTICAL PREPARATIONS
FR2985511B1 (en) 2012-01-05 2014-01-03 Servier Lab CRYSTALLINE DELTA FORM OF PERINOPRIL ARGININE SALT, PROCESS FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
FR2985512B1 (en) 2012-01-05 2014-06-20 Servier Lab PROCESS FOR THE PREPARATION OF L-ARGININE SALT OF PERINDOPRIL
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
FR3050380B1 (en) 2016-04-20 2020-07-10 Les Laboratoires Servier PHARMACEUTICAL COMPOSITION COMPRISING A BETA-BLOCKER, A CONVERSION ENZYME INHIBITOR AND AN ANTIHYPERTENSOR OR NSAID.
EP3842035A1 (en) 2019-12-23 2021-06-30 KRKA, d.d., Novo mesto Composition for the preparation of perindopril arginine granules, a method for their preparation and pharmaceutical composition comprising the granules

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5572169A (en) * 1978-11-27 1980-05-30 Tanabe Seiyaku Co Ltd Isoquinoline derivative and its preparation
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
US4461896A (en) * 1979-02-07 1984-07-24 Norwich Eaton Pharmaceuticals, Inc. 1-[Acylthio) and (mercapto)-1-oxoalkyl]-1,2,3,4-tetrahydroquinoline-2-carboxylic acids
DE3063420D1 (en) * 1979-03-26 1983-07-07 Takeda Chemical Industries Ltd Tetrahydroisoquinolines, their production and the compounds and pharmaceutical compositions containing them for use in the prevention or treatment of hypertension
US4294832A (en) * 1979-04-28 1981-10-13 Tanabe Seiyaku Co., Ltd. Tetrahydroisoquinoline compounds and a pharmaceutical composition thereof
GB2048863B (en) * 1979-05-16 1983-06-15 Morton Norwich Products Inc Tetrahydroisoquinoline-3-carboxylic acids
US4303583A (en) * 1979-08-13 1981-12-01 American Home Products Corporation 1H,5H-[1,4]Thiazepino[4,3-a]indole-1,5-diones
FR2487829A2 (en) * 1979-12-07 1982-02-05 Science Union & Cie NOVEL SUBSTITUTED IMINO ACIDS, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS AN ENZYME INHIBITOR
FR2470767A1 (en) * 1979-12-07 1981-06-12 Science Union & Cie N-Acyl-2-carboxy fused ring heterocyclic cpds. - useful for inhibiting angiotensin converting enzyme and enkephalin(s)
ZA811493B (en) * 1980-04-02 1982-03-31 Warner Lambert Co Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids
US4251444A (en) * 1980-04-07 1981-02-17 American Home Products Corporation Thiazepino-[4,3-b]-isoquinoline-1,5-dione derivatives and precursors
EP0046953B1 (en) * 1980-08-30 1989-12-06 Hoechst Aktiengesellschaft Amino acid derivatives, processes for their preparation, compositions containing them and their use
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids

Also Published As

Publication number Publication date
AU542611B2 (en) 1985-02-28
PH17516A (en) 1984-09-13
JPS5791974A (en) 1982-06-08
NL930046I1 (en) 1993-09-01
DK157011B (en) 1989-10-30
IE812257L (en) 1983-03-29
NO813339L (en) 1982-04-05
AU7594981A (en) 1982-04-08
KR830007564A (en) 1983-10-21
FI77230B (en) 1988-10-31
NO160780B (en) 1989-02-20
AR242949A1 (en) 1993-06-30
GEP19970943B (en) 1997-04-18
UA6308A1 (en) 1994-12-29
CA1341196C (en) 2001-03-06
FR2503155A2 (en) 1982-10-08
JPH0132239B2 (en) 1989-06-29
IE51821B1 (en) 1987-04-01
MD381C2 (en) 1996-05-31
IL63940A0 (en) 1981-12-31
SU1153827A3 (en) 1985-04-30
ATE7910T1 (en) 1984-06-15
ES8305723A1 (en) 1983-04-16
ES505999A0 (en) 1983-04-16
NZ198535A (en) 1984-09-28
DK434381A (en) 1982-04-03
EP0049658B1 (en) 1984-06-13
DD201783A5 (en) 1983-08-10
DK157011C (en) 1990-03-26
NL930046I2 (en) 1994-01-03
KR860001875B1 (en) 1986-10-24
IL63940A (en) 1985-06-30
DE3164201D1 (en) 1984-07-19
EP0049658A1 (en) 1982-04-14
FI813034L (en) 1982-04-03
FR2503155B2 (en) 1983-07-01
LU88262I2 (en) 1994-02-03
FI77230C (en) 1989-02-10
PT73755A (en) 1981-11-01
EG15361A (en) 1987-04-30
PT73755B (en) 1983-10-11
GR75016B (en) 1984-07-12
HU185147B (en) 1984-12-28
OA06914A (en) 1983-05-31

Similar Documents

Publication Publication Date Title
NO160780C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF SUBSTITUTED IMINODIC ACIDS.
NO154229C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF ANTIHYPERCHOLESTEROLEMIC COMPOUNDS.
NO164712C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF METHYLENDYPHOSPHONIC ACID DERIVATIVES.
NO159667C (en) PROCEDURE FOR THE PREPARATION OF PICKHOST TOXIDE.
NO813541L (en) PROCEDURE FOR PREPARING AZA-BICYCLE-OCTANE CARBOXYL ACIDS.
NO814065L (en) PROCEDURE FOR THE PREPARATION OF IMIDAZOLYLPHENYLAMIDINES
NO163042C (en) PROCEDURES FOR THE PREPARATION OF STABILIZED POISTS.
NO152894C (en) PROCEDURE FOR PREPARING UREAPELLETS.
NO812519L (en) PROCEDURE FOR THE PREPARATION OF CHOLESTERASE.
NO157735C (en) PROCEDURE FOR THE PREPARATION OF ALFA-ARYLALIC ACIDS.
NO153431C (en) PROCEDURE FOR THE PREPARATION OF 6ALFA-HALOGEN-3-KETO-DELTA1,4-PREGNADIEN.
NO831673L (en) PROCEDURE FOR THE PREPARATION OF ROER COOKILLES.
NO153853C (en) PROCEDURE FOR THE PREPARATION OF 17BETA-HYDROXY-17ALFA-PREGN-5-EN-21-CARBOXYLIC ACID-GAMMA LAKTONS.
NO813814L (en) PROCEDURE FOR THE PREPARATION OF HYDROQINONE COMPOUNDS
NO157143C (en) PROCEDURE FOR THE PREPARATION OF CARBAPEN-2-EM DERIVATIVES.
NO824030L (en) PROCEDURE FOR THE PREPARATION OF ALKYLENIC CARBONATE.
NO812467L (en) PROCEDURE FOR THE PREPARATION OF AS-TRIAZINE DERIVATIVES
NO157652C (en) PROCEDURE FOR THE PREPARATION OF 3-PICOLINE.
NO152840C (en) PROCEDURE FOR THE PREPARATION OF DIBENZYLETERS.
NO810114L (en) PROCEDURE FOR THE PREPARATION OF KIJANIMICIN.
NO153100C (en) PROCEDURE FOR THE PREPARATION OF N- (HALOGENMETHYL) -ACYLAMIDES.
NO158656C (en) PROCEDURE FOR THE PREPARATION OF AN Aqueous SOLUTION OF SULSPHONAMIDE-POTENTIATOR-ALDEHYDE COMBINATIONS.
NO158024C (en) PROCEDURE FOR THE PREPARATION OF PROPYLENE POLYMERS.
NO791220L (en) PROCEDURES FOR THE PREPARATION OF 4-AZA-17-SUBSTITUTED-5ALFA-ANDROSTAN-3-ONERS
NO790328L (en) PROCEDURE FOR THE PREPARATION OF NAFTHYL-1-ACETIC ACID DERIVATIVES.

Legal Events

Date Code Title Description
MK1K Patent expired

Free format text: EXPIRED IN OCTOBER 2001