MD3645002T2 - Metode pentru tratarea insuficienței cardiace cu activatori ai sarcomerului cardiac - Google Patents

Metode pentru tratarea insuficienței cardiace cu activatori ai sarcomerului cardiac Download PDF

Info

Publication number
MD3645002T2
MD3645002T2 MDE20200488T MDE20200488T MD3645002T2 MD 3645002 T2 MD3645002 T2 MD 3645002T2 MD E20200488 T MDE20200488 T MD E20200488T MD E20200488 T MDE20200488 T MD E20200488T MD 3645002 T2 MD3645002 T2 MD 3645002T2
Authority
MD
Moldova
Prior art keywords
subject
dose
csa
initial
weeks
Prior art date
Application number
MDE20200488T
Other languages
English (en)
Romanian (ro)
Inventor
Narimon Honarpour
Fady Malik
Original Assignee
Amgen Inc
Cytokinetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc, Cytokinetics Inc filed Critical Amgen Inc
Publication of MD3645002T2 publication Critical patent/MD3645002T2/ro

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
MDE20200488T 2017-06-30 2018-06-29 Metode pentru tratarea insuficienței cardiace cu activatori ai sarcomerului cardiac MD3645002T2 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762527983P 2017-06-30 2017-06-30
PCT/US2018/040181 WO2019006235A1 (en) 2017-06-30 2018-06-29 METHODS OF TREATING CARDIAC INSUFFICIENCY WITH CARDIAC SARCOMER ACTIVATORS

Publications (1)

Publication Number Publication Date
MD3645002T2 true MD3645002T2 (ro) 2025-04-30

Family

ID=63013097

Family Applications (1)

Application Number Title Priority Date Filing Date
MDE20200488T MD3645002T2 (ro) 2017-06-30 2018-06-29 Metode pentru tratarea insuficienței cardiace cu activatori ai sarcomerului cardiac

Country Status (22)

Country Link
US (4) US11576910B2 (https=)
EP (2) EP3645002B1 (https=)
JP (3) JP2020526483A (https=)
CN (1) CN110996953A (https=)
AU (2) AU2018290983B2 (https=)
BR (1) BR112019028046A2 (https=)
CA (1) CA3068588A1 (https=)
DK (1) DK3645002T3 (https=)
ES (1) ES3008457T3 (https=)
FI (1) FI3645002T3 (https=)
HR (1) HRP20241729T1 (https=)
HU (1) HUE069805T2 (https=)
LT (1) LT3645002T (https=)
MA (1) MA49508B1 (https=)
MD (1) MD3645002T2 (https=)
MX (2) MX2020000190A (https=)
PL (1) PL3645002T3 (https=)
PT (1) PT3645002T (https=)
RS (1) RS66581B1 (https=)
SI (1) SI3645002T1 (https=)
SM (1) SMT202500067T1 (https=)
WO (1) WO2019006235A1 (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201507258PA (en) 2013-03-14 2015-10-29 Amgen Inc Heterocyclic compounds and their uses
AU2018294254C1 (en) 2017-06-30 2022-10-13 Amgen Inc. Synthesis of omecamtiv mecarbil
DK3645002T3 (da) * 2017-06-30 2024-12-16 Amgen Inc Fremgangsmåder til behandling af hjertesvigt med hjerte-sarkomer-aktivatorer
PT3594199T (pt) 2018-07-09 2020-09-04 Amgen Inc 2-fluoro-3-nitrotolueno cristalino e processo para a sua preparação
MA53226A (fr) 2018-08-17 2021-11-24 Amgen Inc Sel et formes cristallines d'omecamtiv mecarbil
KR20220009440A (ko) * 2019-05-19 2022-01-24 미요카디아, 인크. 화합물 (r)-4-(1-((3-(디플루오로메틸)-1-메틸-1h-피라졸-4-일)술포닐)-1-플루오로에틸)-n-(이속사졸-3-일)피페리딘-1-카르복스아미드를 사용한 수축기 기능장애 및 감소된 박출 계수를 가진 심부전의 치료
US20230090391A1 (en) * 2020-02-10 2023-03-23 Amgen Inc. Omecamtiv mecarbil tablet
WO2021257456A1 (en) * 2020-06-15 2021-12-23 MyoKardia, Inc. Treatment of atrial dysfunction
DK4243825T3 (da) * 2020-11-12 2025-12-01 Amgen Inc Omecamtiv mecarbil til behandling af hjerteinsattsvigt hos udvalgte patientgrupper
CN116710139A (zh) * 2020-11-12 2023-09-05 安进股份有限公司 通过施用奥美卡替莫卡必尔治疗心力衰竭的方法
IL305751A (en) 2021-03-10 2023-11-01 Amgen Inc SYNTHESIS OF OMECAMTIV MECARBIL
US20250161298A1 (en) * 2022-02-22 2025-05-22 Yale University Methods of treating, ameliorating, or preventing heart failure, and methods of promoting heart muscle growth
JP2025534288A (ja) 2022-09-26 2025-10-15 エッジワイズ セラピューティクス, インコーポレイテッド 1,4-ジヒドロキナゾリノン化合物およびその使用
WO2024081611A1 (en) * 2022-10-11 2024-04-18 Cytokinetics, Incorporated Methods for treating heart failure by administering cardiac sarcomere activators
EP4688756A1 (en) 2023-03-27 2026-02-11 Edgewise Therapeutics, Inc. Quinazoline dione compounds and uses thereof
WO2024206339A1 (en) 2023-03-27 2024-10-03 Edgewise Therapeutics, Inc. Quinolinone amide compounds and uses thereof
US11986474B1 (en) 2023-06-27 2024-05-21 Cytokinetics, Incorporated Methods for treating heart failure by administering cardiac sarcomere activators
WO2026050494A1 (en) 2024-08-29 2026-03-05 Cytokinetics, Incorporated Omecamtiv mecarbil for use in treating heart failure by activating cardiac sarcomere

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4450150A (en) 1973-05-17 1984-05-22 Arthur D. Little, Inc. Biodegradable, implantable drug delivery depots, and method for preparing and using the same
EP1053752A1 (en) 1998-02-10 2000-11-22 Yoshitomi Pharmaceutical Industries, Ltd. Preparations with controlled release
GB2344287A (en) 1998-12-03 2000-06-07 Ferring Bv Controlled release pharmaceutical formulation
AU2003279842A1 (en) 2002-10-04 2004-05-04 Microchips, Inc. Medical device for controlled drug delivery and cardiac monitoring and/or stimulation
ES2522579T3 (es) 2004-06-17 2014-11-17 Cytokinetics, Inc. Compuestos, composiciones y métodos
ES2419007T3 (es) 2005-12-15 2013-08-19 Cytokinetics, Inc. Ciertas entidades químicas, composiciones y procedimientos
US20080031957A1 (en) 2006-05-15 2008-02-07 Deluca Hector F Pulmonary delivery of 1alpha,25-dihydroxyvitamin D3 and co-administration of parathyroid hormone or calcitonin
FR2902092B1 (fr) 2006-06-07 2008-09-05 Sapelem Soc Par Actions Simpli Appareil de manutention de charge
WO2008130158A1 (en) 2007-04-19 2008-10-30 Dong-A Pharmaceutical. Co., Ltd A biodegradable microsphere composition suitable for the controlled release of glucose controlling peptide and formulation thereof
US9895308B2 (en) * 2013-03-14 2018-02-20 Amgen Inc. Heterocyclic compounds and their uses
SG11201507258PA (en) 2013-03-14 2015-10-29 Amgen Inc Heterocyclic compounds and their uses
EP3250557B1 (en) 2015-01-29 2024-11-20 Signal Pharmaceuticals, LLC Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide
US10543215B2 (en) 2015-06-26 2020-01-28 Amgen Inc. Combination therapy of cardiac myosin activator and sinus node if current inhibitor
CA3052625A1 (en) 2017-02-06 2018-08-09 Acceleron Pharma Inc. Compositions and methods for treating heart failure
AU2018294254C1 (en) 2017-06-30 2022-10-13 Amgen Inc. Synthesis of omecamtiv mecarbil
DK3645002T3 (da) 2017-06-30 2024-12-16 Amgen Inc Fremgangsmåder til behandling af hjertesvigt med hjerte-sarkomer-aktivatorer
PT3594199T (pt) 2018-07-09 2020-09-04 Amgen Inc 2-fluoro-3-nitrotolueno cristalino e processo para a sua preparação
EP3820851A1 (en) 2018-07-12 2021-05-19 Assia Chemical Industries Ltd Solid state forms of omecamtiv mecarbil & omecamtiv mecarbil dihcl
FI3599243T3 (fi) 2018-07-26 2023-06-22 Cvie Therapeutics Ltd 17beeta-heterosyklyylidigitaliksen kaltaisia yhdisteitä sydämen vajaatoiminnan hoitoon
MA53226A (fr) 2018-08-17 2021-11-24 Amgen Inc Sel et formes cristallines d'omecamtiv mecarbil
WO2020131574A1 (en) 2018-12-18 2020-06-25 Amgen Inc. Method of reducing aromatic nitro compounds
MX2021010483A (es) 2019-03-05 2021-10-01 Windtree Therapeutics Inc Formulacion intravenosa que contiene istaroxima para el tratamiento de insuficiencia cardiaca aguda (ahf).
WO2021053175A1 (en) 2019-09-19 2021-03-25 Synthon B.V. Salts of omecamtiv mecarbil and solid forms thereof
EP4031541A1 (en) 2019-09-19 2022-07-27 Synthon B.V. Salts of omecamtiv mecarbil and solid forms thereof
EP4041710A1 (en) 2019-10-09 2022-08-17 Dr. Reddy's Laboratories Limited Alternate processes for the preparation of omecamtiv mecarbil
WO2021070123A1 (en) 2019-10-09 2021-04-15 Dr. Reddy’S Laboratories Limited Solid forms of omecamtiv mecarbil dihydrochloride and processes thereof
EP4054588A4 (en) 2019-11-10 2023-12-13 MyoKardia, Inc. Methods of treatment with myosin modulator
GB201918853D0 (en) 2019-12-19 2020-02-05 Lund Lars H Methods of treatment
CN114929671B (zh) 2020-01-03 2024-04-16 苏州科睿思制药有限公司 化合物i二盐酸盐的共晶及其制备方法和用途
US20230090391A1 (en) 2020-02-10 2023-03-23 Amgen Inc. Omecamtiv mecarbil tablet
DK4243825T3 (da) 2020-11-12 2025-12-01 Amgen Inc Omecamtiv mecarbil til behandling af hjerteinsattsvigt hos udvalgte patientgrupper
IL305751A (en) 2021-03-10 2023-11-01 Amgen Inc SYNTHESIS OF OMECAMTIV MECARBIL
WO2023205291A2 (en) 2022-04-21 2023-10-26 The Board Of Regents Of The University Of Oklahoma Targeting myocardial tissue for delivery of therapeutic and imaging agents
WO2024081611A1 (en) 2022-10-11 2024-04-18 Cytokinetics, Incorporated Methods for treating heart failure by administering cardiac sarcomere activators
US11986474B1 (en) * 2023-06-27 2024-05-21 Cytokinetics, Incorporated Methods for treating heart failure by administering cardiac sarcomere activators

Also Published As

Publication number Publication date
EP4512470A3 (en) 2025-04-23
US11576910B2 (en) 2023-02-14
HUE069805T2 (hu) 2025-04-28
MX2020000190A (es) 2020-07-22
EP3645002A1 (en) 2020-05-06
SMT202500067T1 (it) 2025-03-12
CA3068588A1 (en) 2019-01-03
EP3645002B1 (en) 2024-10-30
US20250255862A1 (en) 2025-08-14
US20200155547A1 (en) 2020-05-21
AU2024200991B2 (en) 2025-04-10
AU2024200991A1 (en) 2024-03-07
US11931358B2 (en) 2024-03-19
AU2018290983A1 (en) 2020-01-23
BR112019028046A2 (pt) 2020-07-07
RS66581B1 (sr) 2025-04-30
MA49508A (fr) 2020-05-06
PT3645002T (pt) 2025-01-24
AU2018290983B2 (en) 2023-11-23
WO2019006235A1 (en) 2019-01-03
MA49508B1 (fr) 2024-12-31
HRP20241729T1 (hr) 2025-03-14
MX2022015115A (es) 2023-01-18
PL3645002T3 (pl) 2025-03-24
JP2025165979A (ja) 2025-11-05
FI3645002T3 (fi) 2025-01-29
JP2020526483A (ja) 2020-08-31
DK3645002T3 (da) 2024-12-16
ES3008457T3 (en) 2025-03-24
CN110996953A (zh) 2020-04-10
US12295952B2 (en) 2025-05-13
EP4512470A2 (en) 2025-02-26
LT3645002T (lt) 2025-02-10
SI3645002T1 (sl) 2025-03-31
JP2023088944A (ja) 2023-06-27
US20230149394A1 (en) 2023-05-18
US20230355615A1 (en) 2023-11-09

Similar Documents

Publication Publication Date Title
US12295952B2 (en) Methods of treating heart failure with cardiac sarcomere activators
Sayin et al. Left ventricular hypertrophy: etiology-based therapeutic options
Sezai et al. Feasibility of landiolol and bisoprolol for prevention of atrial fibrillation after coronary artery bypass grafting: a pilot study
EP3038654B1 (en) New use
JP2024500616A (ja) オメカムチブメカルビルの投与により心不全を処置する方法
Yuyun et al. Are arrhythmias the drivers of sudden cardiac death in heart failure with preserved ejection fraction? A review
JP2002128696A (ja) 肺高血圧の治療
JP2020520948A (ja) 心不全の治療用のホルミルペプチド受容体2/リポキシンa4受容体(fpr2/alx)アゴニストの新規な使用
Cada et al. Sacubitril/valsartan
US20260041679A1 (en) Method of treating hypertension with the aldosterone synthase inhibitor baxdrostat
JP2002538172A (ja) 循環器疾患治療のためのアンギオテンシン変換酵素阻害薬およびエポキシ−ステロイドアルドステロン拮抗薬の組合せ療法
HK40028258B (en) Methods of treating heart failure with cardiac sarcomere activators
HK40028258A (en) Methods of treating heart failure with cardiac sarcomere activators
Kowalczyk et al. Levosimendan–a calcium sensitising agent with potential anti‐arrhythmic properties
HK40027649A (en) Methods of treating heart failure with cardiac sarcomere activators
JP2021525791A (ja) 新たな心不全治療用医薬の使用
Ahmed et al. Sacubitril/Valsartan: A Novel Approach in the Treatment of Heart Failure with Reduced Ejection Fraction
US20240058350A1 (en) Methods of Treatment
SINDONE et al. How to optimise therapy
Sojitra et al. A review on Nifedipine co-administered with Metoprolol succinate for the treatment of hypertension
Cokkinos and Therapeutic Approaches
Gibler New Drug Evaluation: sacubitril/valsartan tablet, oral