JP2020526483A - 心筋節活性化剤で心不全を治療する方法 - Google Patents

心筋節活性化剤で心不全を治療する方法 Download PDF

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JP2020526483A
JP2020526483A JP2019570045A JP2019570045A JP2020526483A JP 2020526483 A JP2020526483 A JP 2020526483A JP 2019570045 A JP2019570045 A JP 2019570045A JP 2019570045 A JP2019570045 A JP 2019570045A JP 2020526483 A JP2020526483 A JP 2020526483A
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JP2020526483A5 (https=
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オナールプール，ナリモン
ファディ，マリク
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Cytokinetics Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

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  • Health & Medical Sciences (AREA)
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  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2019570045A 2017-06-30 2018-06-29 心筋節活性化剤で心不全を治療する方法 Pending JP2020526483A (ja)

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JP2023040600A JP2023088944A (ja) 2017-06-30 2023-03-15 心筋節活性化剤で心不全を治療する方法
JP2025121073A JP2025165979A (ja) 2017-06-30 2025-07-18 心筋節活性化剤で心不全を治療する方法

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US201762527983P 2017-06-30 2017-06-30
US62/527,983 2017-06-30
PCT/US2018/040181 WO2019006235A1 (en) 2017-06-30 2018-06-29 METHODS OF TREATING CARDIAC INSUFFICIENCY WITH CARDIAC SARCOMER ACTIVATORS

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JP2025121073A Pending JP2025165979A (ja) 2017-06-30 2025-07-18 心筋節活性化剤で心不全を治療する方法

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Cited By (3)

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JP2022535195A (ja) * 2019-05-19 2022-08-05 マイオカーディア，インク 収縮不全の処置
JP2023088944A (ja) * 2017-06-30 2023-06-27 アムジエン・インコーポレーテツド 心筋節活性化剤で心不全を治療する方法
JP2024500616A (ja) * 2020-11-12 2024-01-10 アムジェン インコーポレイテッド オメカムチブメカルビルの投与により心不全を処置する方法

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MA53226A (fr) 2018-08-17 2021-11-24 Amgen Inc Sel et formes cristallines d'omecamtiv mecarbil
US20230090391A1 (en) * 2020-02-10 2023-03-23 Amgen Inc. Omecamtiv mecarbil tablet
WO2021257456A1 (en) * 2020-06-15 2021-12-23 MyoKardia, Inc. Treatment of atrial dysfunction
CN116710139A (zh) * 2020-11-12 2023-09-05 安进股份有限公司 通过施用奥美卡替莫卡必尔治疗心力衰竭的方法
IL305751A (en) 2021-03-10 2023-11-01 Amgen Inc SYNTHESIS OF OMECAMTIV MECARBIL
US20250161298A1 (en) * 2022-02-22 2025-05-22 Yale University Methods of treating, ameliorating, or preventing heart failure, and methods of promoting heart muscle growth
JP2025534288A (ja) 2022-09-26 2025-10-15 エッジワイズ セラピューティクス， インコーポレイテッド １，４－ジヒドロキナゾリノン化合物およびその使用
WO2024081611A1 (en) * 2022-10-11 2024-04-18 Cytokinetics, Incorporated Methods for treating heart failure by administering cardiac sarcomere activators
EP4688756A1 (en) 2023-03-27 2026-02-11 Edgewise Therapeutics, Inc. Quinazoline dione compounds and uses thereof
WO2024206339A1 (en) 2023-03-27 2024-10-03 Edgewise Therapeutics, Inc. Quinolinone amide compounds and uses thereof
US11986474B1 (en) 2023-06-27 2024-05-21 Cytokinetics, Incorporated Methods for treating heart failure by administering cardiac sarcomere activators
WO2026050494A1 (en) 2024-08-29 2026-03-05 Cytokinetics, Incorporated Omecamtiv mecarbil for use in treating heart failure by activating cardiac sarcomere

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023088944A (ja) * 2017-06-30 2023-06-27 アムジエン・インコーポレーテツド 心筋節活性化剤で心不全を治療する方法
US12295952B2 (en) 2017-06-30 2025-05-13 Cytokinetics, Inc. Methods of treating heart failure with cardiac sarcomere activators
JP2022535195A (ja) * 2019-05-19 2022-08-05 マイオカーディア，インク 収縮不全の処置
JP2024500616A (ja) * 2020-11-12 2024-01-10 アムジェン インコーポレイテッド オメカムチブメカルビルの投与により心不全を処置する方法
US12194039B2 (en) 2020-11-12 2025-01-14 Amgen Inc Methods of treating heart failure by administering omecamtiv mecarbil

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EP4512470A3 (en) 2025-04-23
US11576910B2 (en) 2023-02-14
HUE069805T2 (hu) 2025-04-28
MX2020000190A (es) 2020-07-22
EP3645002A1 (en) 2020-05-06
SMT202500067T1 (it) 2025-03-12
CA3068588A1 (en) 2019-01-03
EP3645002B1 (en) 2024-10-30
US20250255862A1 (en) 2025-08-14
US20200155547A1 (en) 2020-05-21
AU2024200991B2 (en) 2025-04-10
AU2024200991A1 (en) 2024-03-07
US11931358B2 (en) 2024-03-19
AU2018290983A1 (en) 2020-01-23
BR112019028046A2 (pt) 2020-07-07
RS66581B1 (sr) 2025-04-30
MA49508A (fr) 2020-05-06
PT3645002T (pt) 2025-01-24
AU2018290983B2 (en) 2023-11-23
WO2019006235A1 (en) 2019-01-03
MA49508B1 (fr) 2024-12-31
HRP20241729T1 (hr) 2025-03-14
MX2022015115A (es) 2023-01-18
PL3645002T3 (pl) 2025-03-24
JP2025165979A (ja) 2025-11-05
FI3645002T3 (fi) 2025-01-29
MD3645002T2 (ro) 2025-04-30
DK3645002T3 (da) 2024-12-16
ES3008457T3 (en) 2025-03-24
CN110996953A (zh) 2020-04-10
US12295952B2 (en) 2025-05-13
EP4512470A2 (en) 2025-02-26
LT3645002T (lt) 2025-02-10
SI3645002T1 (sl) 2025-03-31
JP2023088944A (ja) 2023-06-27
US20230149394A1 (en) 2023-05-18
US20230355615A1 (en) 2023-11-09

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