MA53226A - Sel et formes cristallines d'omecamtiv mecarbil - Google Patents
Sel et formes cristallines d'omecamtiv mecarbilInfo
- Publication number
- MA53226A MA53226A MA053226A MA53226A MA53226A MA 53226 A MA53226 A MA 53226A MA 053226 A MA053226 A MA 053226A MA 53226 A MA53226 A MA 53226A MA 53226 A MA53226 A MA 53226A
- Authority
- MA
- Morocco
- Prior art keywords
- salt
- crystalline forms
- omecamtiv mecarbil
- mecarbil
- omecamtiv
- Prior art date
Links
- RFUBTTPMWSKEIW-UHFFFAOYSA-N omecamtiv mecarbil Chemical compound C1CN(C(=O)OC)CCN1CC1=CC=CC(NC(=O)NC=2C=NC(C)=CC=2)=C1F RFUBTTPMWSKEIW-UHFFFAOYSA-N 0.000 title 1
- 229950001617 omecamtiv mecarbil Drugs 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C309/07—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton
- C07C309/08—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton containing hydroxy groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/33—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of six-membered aromatic rings being part of condensed ring systems
- C07C309/34—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of six-membered aromatic rings being part of condensed ring systems formed by two rings
- C07C309/35—Naphthalene sulfonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
- C07C55/02—Dicarboxylic acids
- C07C55/06—Oxalic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
- C07C55/02—Dicarboxylic acids
- C07C55/08—Malonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
- C07C57/145—Maleic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
- C07C57/15—Fumaric acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
- C07C59/255—Tartaric acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
- C07C65/03—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
- C07C65/05—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring o-Hydroxy carboxylic acids
- C07C65/10—Salicylic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862765090P | 2018-08-17 | 2018-08-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA53226A true MA53226A (fr) | 2021-11-24 |
Family
ID=67809688
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA053226A MA53226A (fr) | 2018-08-17 | 2019-08-16 | Sel et formes cristallines d'omecamtiv mecarbil |
Country Status (8)
Country | Link |
---|---|
US (3) | US11465969B2 (fr) |
EP (1) | EP3837009A1 (fr) |
JP (2) | JP2021534138A (fr) |
AU (1) | AU2019321573A1 (fr) |
CA (1) | CA3108800A1 (fr) |
MA (1) | MA53226A (fr) |
MX (2) | MX2021001792A (fr) |
WO (1) | WO2020037164A1 (fr) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LT2970123T (lt) | 2013-03-14 | 2019-11-11 | Amgen Inc | Omekamtivo mekarbilo druska ir jos gamybos būdas |
PT3645518T (pt) | 2017-06-30 | 2021-08-23 | Amgen Inc | Síntese de omecamtiv mecarbil |
US11576910B2 (en) | 2017-06-30 | 2023-02-14 | Amgen Inc. | Methods of treating heart failure with cardiac sarcomere activators |
IL272573B2 (en) | 2017-09-13 | 2023-10-01 | Amgen Inc | Sarcomere activating bisamide compounds and their uses |
CA3108800A1 (fr) * | 2018-08-17 | 2020-02-20 | Amgen Inc. | Sel et formes cristallines d'omecamtiv mecarbil |
US20220340542A1 (en) * | 2019-09-19 | 2022-10-27 | Synthon B.V. | Salts of omecamtiv mecarbil and solid forms thereof |
US20220348543A1 (en) * | 2019-09-19 | 2022-11-03 | Synthon B.V. | Salts of omecamtiv mecarbil and solid forms thereof |
WO2022177927A1 (fr) | 2021-02-16 | 2022-08-25 | Assia Chemical Industries Ltd | Forme cristalline non hydratée de sel de dihydrobromure d'omecamtiv mecarbil |
AU2022232919A1 (en) | 2021-03-10 | 2023-10-19 | Amgen Inc. | Synthesis of omecamtiv mecarbil |
US11986474B1 (en) | 2023-06-27 | 2024-05-21 | Cytokinetics, Incorporated | Methods for treating heart failure by administering cardiac sarcomere activators |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
TWI359812B (en) | 2004-06-17 | 2012-03-11 | Cytokinetics Inc | Compounds, compositions and methods |
WO2007070683A2 (fr) | 2005-12-15 | 2007-06-21 | Cytokinetics, Inc. | Entites chimiques, compositions et procedes |
US20090192168A1 (en) | 2008-01-04 | 2009-07-30 | Alex Muci | Compounds, Compositions and Methods |
LT2970123T (lt) * | 2013-03-14 | 2019-11-11 | Amgen Inc | Omekamtivo mekarbilo druska ir jos gamybos būdas |
AU2014240104B2 (en) | 2013-03-14 | 2018-11-08 | Amgen Inc. | Heterocyclic compounds and their uses |
CA2975260C (fr) | 2015-01-29 | 2024-05-21 | Signal Pharmaceuticals Llc | Isotopologues de 2-(tert-butylamino)-4-((1r,3r,4r) -3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide |
JP6858716B2 (ja) | 2015-06-26 | 2021-04-14 | アムジエン・インコーポレーテツド | 心筋ミオシン活性化剤と洞房結節If電流阻害剤の併用療法 |
US11576910B2 (en) | 2017-06-30 | 2023-02-14 | Amgen Inc. | Methods of treating heart failure with cardiac sarcomere activators |
PT3645518T (pt) | 2017-06-30 | 2021-08-23 | Amgen Inc | Síntese de omecamtiv mecarbil |
PT3594199T (pt) | 2018-07-09 | 2020-09-04 | Amgen Inc | 2-fluoro-3-nitrotolueno cristalino e processo para a sua preparação |
US11608318B2 (en) | 2018-07-12 | 2023-03-21 | Assia Chemical Industries Ltd. | Solid state forms of Omecamtiv mecarbil and Omecamtiv mecarbil diHCl |
CA3108800A1 (fr) * | 2018-08-17 | 2020-02-20 | Amgen Inc. | Sel et formes cristallines d'omecamtiv mecarbil |
WO2020131574A1 (fr) | 2018-12-18 | 2020-06-25 | Amgen Inc. | Procédé de réduction de composés nitro aromatiques |
US20220348543A1 (en) | 2019-09-19 | 2022-11-03 | Synthon B.V. | Salts of omecamtiv mecarbil and solid forms thereof |
US20220340542A1 (en) | 2019-09-19 | 2022-10-27 | Synthon B.V. | Salts of omecamtiv mecarbil and solid forms thereof |
WO2021070124A1 (fr) | 2019-10-09 | 2021-04-15 | Dr. Reddy’S Laboratories Limited | Nouveaux procédés destinés à la préparation de l'omécamtiv mécarbil |
EP4041198A4 (fr) | 2019-10-09 | 2023-08-16 | Dr. Reddy's Laboratories Limited | Formes solides de dichlorhydrate d'omecamtiv mecarbil et procédés associés |
CN114929671B (zh) | 2020-01-03 | 2024-04-16 | 苏州科睿思制药有限公司 | 化合物i二盐酸盐的共晶及其制备方法和用途 |
BR112022015457A2 (pt) | 2020-02-10 | 2022-10-04 | Amgen Inc | Formulação de comprimido, método para tratar insuficiência cardíaca, uso de uma formulação de comprimido, e, processo para fazer uma formulação de comprimido |
AU2021380754A1 (en) | 2020-11-12 | 2023-06-22 | Amgen Inc. | Methods of treating heart failure by administering omecamtiv mecarbil |
AU2022232919A1 (en) | 2021-03-10 | 2023-10-19 | Amgen Inc. | Synthesis of omecamtiv mecarbil |
-
2019
- 2019-08-16 CA CA3108800A patent/CA3108800A1/fr active Pending
- 2019-08-16 JP JP2021507456A patent/JP2021534138A/ja active Pending
- 2019-08-16 EP EP19762026.3A patent/EP3837009A1/fr active Pending
- 2019-08-16 WO PCT/US2019/046726 patent/WO2020037164A1/fr unknown
- 2019-08-16 MX MX2021001792A patent/MX2021001792A/es unknown
- 2019-08-16 AU AU2019321573A patent/AU2019321573A1/en active Pending
- 2019-08-16 MA MA053226A patent/MA53226A/fr unknown
- 2019-08-16 US US17/263,224 patent/US11465969B2/en active Active
-
2021
- 2021-02-12 MX MX2023013372A patent/MX2023013372A/es unknown
-
2022
- 2022-09-02 US US17/929,645 patent/US11926592B2/en active Active
-
2024
- 2024-01-18 US US18/416,741 patent/US20240199550A1/en active Pending
- 2024-06-04 JP JP2024090471A patent/JP2024123028A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US20210221771A1 (en) | 2021-07-22 |
JP2021534138A (ja) | 2021-12-09 |
US11465969B2 (en) | 2022-10-11 |
MX2023013372A (es) | 2023-11-27 |
CA3108800A1 (fr) | 2020-02-20 |
EP3837009A1 (fr) | 2021-06-23 |
MX2021001792A (es) | 2021-05-27 |
WO2020037164A1 (fr) | 2020-02-20 |
JP2024123028A (ja) | 2024-09-10 |
AU2019321573A1 (en) | 2021-03-04 |
US11926592B2 (en) | 2024-03-12 |
US20240199550A1 (en) | 2024-06-20 |
US20230108971A1 (en) | 2023-04-06 |
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