MC2300A1 - Procede de preparation d'un facteur de necrose tumorale humaine - Google Patents

Procede de preparation d'un facteur de necrose tumorale humaine

Info

Publication number
MC2300A1
MC2300A1 MC912217A MC2217A MC2300A1 MC 2300 A1 MC2300 A1 MC 2300A1 MC 912217 A MC912217 A MC 912217A MC 2217 A MC2217 A MC 2217A MC 2300 A1 MC2300 A1 MC 2300A1
Authority
MC
Monaco
Prior art keywords
preparation
necrosis factor
tumor necrosis
human tumor
human
Prior art date
Application number
MC912217A
Other languages
English (en)
Inventor
Fiers Walter
Tavernier Jan
Van Ostade Xaveer
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MC2300A1 publication Critical patent/MC2300A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
MC912217A 1990-11-21 1991-11-18 Procede de preparation d'un facteur de necrose tumorale humaine MC2300A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP90810901 1990-11-21

Publications (1)

Publication Number Publication Date
MC2300A1 true MC2300A1 (fr) 1993-09-06

Family

ID=8205969

Family Applications (1)

Application Number Title Priority Date Filing Date
MC912217A MC2300A1 (fr) 1990-11-21 1991-11-18 Procede de preparation d'un facteur de necrose tumorale humaine

Country Status (17)

Country Link
US (2) US5422104A (fr)
EP (1) EP0486908A3 (fr)
JP (1) JPH06256395A (fr)
AR (1) AR245783A1 (fr)
AU (1) AU655948B2 (fr)
CA (1) CA2055168A1 (fr)
FI (1) FI915379A (fr)
HU (1) HUT62034A (fr)
IE (1) IE914035A1 (fr)
IL (1) IL100062A0 (fr)
MC (1) MC2300A1 (fr)
MX (1) MX9102110A (fr)
NO (1) NO914541L (fr)
NZ (1) NZ240595A (fr)
PT (1) PT99560A (fr)
UY (1) UY23327A1 (fr)
ZA (1) ZA919035B (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ283533B6 (cs) * 1992-04-02 1998-04-15 F. Hoffmann-La Roche Ag TNF - muteiny a způsob jejich výroby
CA2119089A1 (fr) * 1993-03-29 1994-09-30 David Banner Muteines du facteur de necrose tumoral
US7070771B1 (en) 1996-12-09 2006-07-04 Regents Of The University Of California Methods of expressing chimeric mouse and human CD40 ligand in human CD40+ cells
CA2324138A1 (fr) * 1998-03-20 1999-09-23 Charles A. Nicolette Nouvelles paires complementaires de recepteurs/ligands et immunotherapi e adoptive les utilisant
DE60028830T2 (de) * 2000-02-16 2007-01-18 Genentech, Inc., South San Francisco Anti-april antikörper und hybridomazellen
US7056695B2 (en) 2000-03-02 2006-06-06 Xencor TNF-α variants
US7101974B2 (en) 2000-03-02 2006-09-05 Xencor TNF-αvariants
US20070172449A1 (en) * 2000-03-02 2007-07-26 Xencor, Inc. TNF-alpha VARIANT FORMULATIONS FOR THE TREATMENT OF TNF-alpha RELATED DISORDERS
US7662367B2 (en) 2000-03-02 2010-02-16 Xencor, Inc. Pharmaceutical compositions for the treatment of TNF-α related disorders
US7244823B2 (en) 2000-03-02 2007-07-17 Xencor TNF-alpha variants proteins for the treatment of TNF-alpha related disorders
US7687461B2 (en) * 2000-03-02 2010-03-30 Xencor, Inc. Treatment of TNF-α related disorders with TNF-α variant proteins
US7446174B2 (en) 2001-03-02 2008-11-04 Xencor, Inc. Protein based TNF-α variants for the treatment of TNF-α related disorders
US6579522B1 (en) * 2000-06-27 2003-06-17 Genvec, Inc. Replication deficient adenoviral TNF vector
HUP0500992A3 (en) * 2001-08-03 2007-11-28 Genentech Inc Tacis and br3 polypeptides and uses thereof
US20030086903A1 (en) * 2001-11-02 2003-05-08 Genvec, Inc. Therapeutic regimen for treating cancer
US7786282B2 (en) * 2001-12-06 2010-08-31 The Regents Of The University Of California Nucleic acid molecules encoding TNF-α ligand polypeptides having a CD154 domain
US20050043516A1 (en) * 2002-07-25 2005-02-24 Genentech, Inc. TACI antibodies and uses thereof
WO2004050683A2 (fr) * 2002-12-02 2004-06-17 Abgenix, Inc. Anticorps agissant sur le facteur de necrose des tumeurs (tnf) et leurs utilisation
ES2537738T3 (es) * 2003-06-05 2015-06-11 Genentech, Inc. Terapia de combinación para trastornos de células B
US20050163775A1 (en) * 2003-06-05 2005-07-28 Genentech, Inc. Combination therapy for B cell disorders
ES2340038T3 (es) * 2003-11-14 2010-05-28 Genvec, Inc. Composicion farmaceutica para tratar cancer de pancreas localmente avanzado (cpla) no extirpable.
TW201122103A (en) * 2004-01-06 2011-07-01 Hayashibara Biochem Lab Tnf antagonists and tnf inhibitors comprising the same as the active ingredient
EP1598075A1 (fr) * 2004-05-21 2005-11-23 LEK Pharmaceuticals d.d. Procédé pour l'isolement et/ou la purification de protéines
GB0425972D0 (en) 2004-11-25 2004-12-29 Celltech R&D Ltd Biological products
CN101203247A (zh) * 2005-01-10 2008-06-18 研究发展基金会 用于癌症治疗的靶向嵌合分子
CA2629306A1 (fr) * 2005-11-23 2007-05-31 Genentech, Inc. Procedes et compositions lies a des analyses de lymphocytes b
WO2008127515A1 (fr) * 2007-03-01 2008-10-23 Cytologic, Inc. Compositions et procédé pour renforcer les réponses immunitaires des mammifères
WO2008124086A2 (fr) * 2007-04-05 2008-10-16 President And Fellows Of Harvard College Activateurs chimériques, thérapies protéiniques à conception quantitative et leurs utilisations
US9605844B2 (en) * 2009-09-01 2017-03-28 Cree, Inc. Lighting device with heat dissipation elements
DK2953634T3 (da) 2013-02-07 2021-08-30 Massachusetts Gen Hospital Fremgangsmåder til udvidelse eller udtømning af regulerende t-celler
EP3139955B1 (fr) 2014-04-30 2024-03-20 President and Fellows of Harvard College Protéines de fusion pour le traitement du cancer et procédés associés
CA3043146C (fr) 2016-11-09 2021-11-23 Philogen S.P.A. Immunoconjugues mutants d'il2 et de tnf
CA3193273A1 (fr) 2020-08-27 2022-03-03 Enosi Therapeutics Corporation Methodes et compositions pour traiter des maladies auto-immunes et un cancer

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4650674A (en) * 1984-07-05 1987-03-17 Genentech, Inc. Synergistic cytotoxic composition
GR851626B (fr) * 1984-07-05 1985-11-26 Genentech Inc
DE3750056T2 (de) * 1986-06-20 1995-04-06 Dainippon Pharmaceutical Co Polypeptid-Mutanten des menschlichen TNF und für diese Mutanten codierende DNS.
JPH07106158B2 (ja) * 1986-12-04 1995-11-15 サントリー株式会社 抗腫瘍活性を有する新規ポリペプチドおよびその製造法
AU1346488A (en) * 1987-02-26 1988-09-26 Cetus Corporation Arginine-depleted human tumor necrosis factor
JPS63291590A (ja) * 1987-05-25 1988-11-29 Teijin Ltd 新規生理活性ポリペプチド
DE3843534A1 (de) * 1988-12-23 1990-07-12 Basf Ag Neue tnf-polypeptide

Also Published As

Publication number Publication date
FI915379A0 (fi) 1991-11-14
NO914541L (no) 1992-05-22
NZ240595A (en) 1994-09-27
CA2055168A1 (fr) 1992-05-22
HUT62034A (en) 1993-03-29
EP0486908A2 (fr) 1992-05-27
MX9102110A (es) 1992-07-08
HU913595D0 (en) 1992-01-28
AR245783A1 (es) 1994-02-28
IE914035A1 (en) 1992-06-03
EP0486908A3 (en) 1992-11-19
PT99560A (pt) 1992-10-30
AU655948B2 (en) 1995-01-19
IL100062A0 (en) 1992-08-18
US5422104A (en) 1995-06-06
AU8791591A (en) 1992-05-28
ZA919035B (en) 1992-08-26
FI915379A (fi) 1992-05-22
NO914541D0 (no) 1991-11-20
JPH06256395A (ja) 1994-09-13
US5652353A (en) 1997-07-29
UY23327A1 (es) 1992-05-19

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