FI915379A0 - Tnf-muteiner. - Google Patents

Tnf-muteiner.

Info

Publication number
FI915379A0
FI915379A0 FI915379A FI915379A FI915379A0 FI 915379 A0 FI915379 A0 FI 915379A0 FI 915379 A FI915379 A FI 915379A FI 915379 A FI915379 A FI 915379A FI 915379 A0 FI915379 A0 FI 915379A0
Authority
FI
Finland
Prior art keywords
muteiner
tnf
Prior art date
Application number
FI915379A
Other languages
English (en)
Other versions
FI915379A (fi
Inventor
Walter Fiers
Jan Tavernier
Ostade Xaveer Van
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of FI915379A0 publication Critical patent/FI915379A0/fi
Publication of FI915379A publication Critical patent/FI915379A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
FI915379A 1990-11-21 1991-11-14 Tnf-muteiner. FI915379A (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP90810901 1990-11-21

Publications (2)

Publication Number Publication Date
FI915379A0 true FI915379A0 (fi) 1991-11-14
FI915379A FI915379A (fi) 1992-05-22

Family

ID=8205969

Family Applications (1)

Application Number Title Priority Date Filing Date
FI915379A FI915379A (fi) 1990-11-21 1991-11-14 Tnf-muteiner.

Country Status (17)

Country Link
US (2) US5422104A (fi)
EP (1) EP0486908A3 (fi)
JP (1) JPH06256395A (fi)
AR (1) AR245783A1 (fi)
AU (1) AU655948B2 (fi)
CA (1) CA2055168A1 (fi)
FI (1) FI915379A (fi)
HU (1) HUT62034A (fi)
IE (1) IE914035A1 (fi)
IL (1) IL100062A0 (fi)
MC (1) MC2300A1 (fi)
MX (1) MX9102110A (fi)
NO (1) NO914541L (fi)
NZ (1) NZ240595A (fi)
PT (1) PT99560A (fi)
UY (1) UY23327A1 (fi)
ZA (1) ZA919035B (fi)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK376492A3 (en) * 1992-04-02 1995-06-07 Hoffmann La Roche Tnf - muteins and method of their production
CA2119089A1 (en) * 1993-03-29 1994-09-30 David Banner Tumor necrosis factor muteins
US7070771B1 (en) 1996-12-09 2006-07-04 Regents Of The University Of California Methods of expressing chimeric mouse and human CD40 ligand in human CD40+ cells
CA2324138A1 (en) * 1998-03-20 1999-09-23 Charles A. Nicolette Novel complementing receptor-ligand pairs and adoptive immunotherapy using same
ES2267593T3 (es) * 2000-02-16 2007-03-16 Genentech, Inc. Anticuerpos anti-april y celulas hibridomas.
US7244823B2 (en) * 2000-03-02 2007-07-17 Xencor TNF-alpha variants proteins for the treatment of TNF-alpha related disorders
US7687461B2 (en) * 2000-03-02 2010-03-30 Xencor, Inc. Treatment of TNF-α related disorders with TNF-α variant proteins
US7101974B2 (en) 2000-03-02 2006-09-05 Xencor TNF-αvariants
US7446174B2 (en) 2001-03-02 2008-11-04 Xencor, Inc. Protein based TNF-α variants for the treatment of TNF-α related disorders
US20070172449A1 (en) * 2000-03-02 2007-07-26 Xencor, Inc. TNF-alpha VARIANT FORMULATIONS FOR THE TREATMENT OF TNF-alpha RELATED DISORDERS
US7662367B2 (en) 2000-03-02 2010-02-16 Xencor, Inc. Pharmaceutical compositions for the treatment of TNF-α related disorders
US7056695B2 (en) 2000-03-02 2006-06-06 Xencor TNF-α variants
US6579522B1 (en) 2000-06-27 2003-06-17 Genvec, Inc. Replication deficient adenoviral TNF vector
MXPA04001050A (es) * 2001-08-03 2004-07-08 Genentech Inc Polipeptidos tacis y br3 y usos de los mismos.
US20030086903A1 (en) * 2001-11-02 2003-05-08 Genvec, Inc. Therapeutic regimen for treating cancer
US7786282B2 (en) * 2001-12-06 2010-08-31 The Regents Of The University Of California Nucleic acid molecules encoding TNF-α ligand polypeptides having a CD154 domain
CA2492447A1 (en) * 2002-07-25 2004-02-05 Genentech, Inc. Taci antibodies and uses thereof
MXPA05005921A (es) * 2002-12-02 2005-10-19 Abgenix Inc Anticuerpos dirigidos a factor de necrosis tumoral y sus usos.
US20050163775A1 (en) * 2003-06-05 2005-07-28 Genentech, Inc. Combination therapy for B cell disorders
BRPI0411276A (pt) * 2003-06-05 2006-08-01 Genentech Inc métodos de esgotamento de células b, método de tratamento de neoplasma de células b ou malignidade, método de alìvio de disfunção autoimunológica regulada por células b, composição e artigo industrializado
ATE458500T1 (de) * 2003-11-14 2010-03-15 Genvec Inc Pharmazeutische verbindung zur behandlung von lokal fortgeschrittenem primär inoperablen pankreaskarzinom (lapc).
TW201122103A (en) * 2004-01-06 2011-07-01 Hayashibara Biochem Lab Tnf antagonists and tnf inhibitors comprising the same as the active ingredient
EP1598075A1 (en) * 2004-05-21 2005-11-23 LEK Pharmaceuticals d.d. Process for the isolation and / or purification of proteins
GB0425972D0 (en) 2004-11-25 2004-12-29 Celltech R&D Ltd Biological products
WO2006074451A2 (en) * 2005-01-10 2006-07-13 Research Development Foundation Targeted chimeric molecules for cancer therapy
JP6088723B2 (ja) * 2005-11-23 2017-03-01 ジェネンテック， インコーポレイテッド Ｂ細胞アッセイに関する組成物及び方法。
WO2008127515A1 (en) * 2007-03-01 2008-10-23 Cytologic, Inc. Compositions and method for enhancing immune responses in mammals
WO2008124086A2 (en) * 2007-04-05 2008-10-16 President And Fellows Of Harvard College Chimeric activators: quantitatively designed protein therapeutics and uses thereof
US9605844B2 (en) * 2009-09-01 2017-03-28 Cree, Inc. Lighting device with heat dissipation elements
PT2953634T (pt) 2013-02-07 2021-09-02 Massachusetts Gen Hospital Métodos de expansão ou depleção das células t reguladoras
WO2015168474A1 (en) 2014-04-30 2015-11-05 President And Fellows Of Harvard College Fusion proteins for treating cancer and related methods
JP6925431B2 (ja) 2016-11-09 2021-08-25 フィロジェン エッセ．ピー．アー． Ｉｌ２及びｔｎｆ突然変異体のイムノコンジュゲート
IL300930A (en) 2020-08-27 2023-04-01 Enosi Therapeutics Corp Methods and compositions for the treatment of autoimmune diseases and cancer

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4650674A (en) * 1984-07-05 1987-03-17 Genentech, Inc. Synergistic cytotoxic composition
GR851626B (fi) * 1984-07-05 1985-11-26 Genentech Inc
ATE107362T1 (de) * 1986-06-20 1994-07-15 Dainippon Pharmaceutical Co Polypeptid-mutanten des menschlichen tnf und für diese mutanten codierende dns.
JPH07106158B2 (ja) * 1986-12-04 1995-11-15 サントリー株式会社 抗腫瘍活性を有する新規ポリペプチドおよびその製造法
AU1346488A (en) * 1987-02-26 1988-09-26 Cetus Corporation Arginine-depleted human tumor necrosis factor
JPS63291590A (ja) * 1987-05-25 1988-11-29 Teijin Ltd 新規生理活性ポリペプチド
DE3843534A1 (de) * 1988-12-23 1990-07-12 Basf Ag Neue tnf-polypeptide

Also Published As

Publication number Publication date
HUT62034A (en) 1993-03-29
IE914035A1 (en) 1992-06-03
EP0486908A2 (en) 1992-05-27
MX9102110A (es) 1992-07-08
IL100062A0 (en) 1992-08-18
AR245783A1 (es) 1994-02-28
PT99560A (pt) 1992-10-30
NO914541D0 (no) 1991-11-20
UY23327A1 (es) 1992-05-19
NZ240595A (en) 1994-09-27
NO914541L (no) 1992-05-22
MC2300A1 (fr) 1993-09-06
CA2055168A1 (en) 1992-05-22
FI915379A (fi) 1992-05-22
EP0486908A3 (en) 1992-11-19
US5652353A (en) 1997-07-29
AU655948B2 (en) 1995-01-19
ZA919035B (en) 1992-08-26
AU8791591A (en) 1992-05-28
HU913595D0 (en) 1992-01-28
JPH06256395A (ja) 1994-09-13
US5422104A (en) 1995-06-06

Similar Documents

Publication Publication Date Title
DE69112037T2 (de) Waferträger.
FI923479A (fi) Svaellande brandskyddskompositioner.
FI910647A0 (fi) Foerbaettrad kakaofermentation.
DE69111876D1 (de) Ophthalmometer.
FI912282A0 (fi) Foerbraenningsmotor.
DE59104521D1 (de) Polkern.
FI905306A0 (fi) Bakugn-spisugnkombination.
FI915777A0 (fi) Spaenningsavlaegsning foer en isoleringsfoerskjutningskontakt.
NO911163D0 (no) Mikrosrimmelantenne.
FI912844A0 (fi) Inloppslaoda.
DE69100071D1 (de) Kaefigmutter.
DE69110728D1 (de) 8-Sulfamylmethylen-2-aminotetraline.
FI912928A0 (fi) Gasledningssystem.
FI902811A0 (fi) Ariadnetraoden.
DE59103525D1 (de) Honmachine.
DE69104797D1 (de) 2-Substituierte-1-Hydroxyindole.
DE59100113D1 (de) Rollcontainer.
FI900061A (fi) Spelanordning.
ES1013194Y (es) Porta-objetos.
ES1012467Y (es) Huevera.
ES1017193Y (es) Cubre-bidet.
DE59101556D1 (de) Propellane.
ES1015228Y (es) Kiosko.
ES1015089Y (es) Muneco caricatura titere.
ES1014067Y (es) Caja-expositor.

Legal Events

Date Code Title Description
FD Application lapsed