MC1596A1 - Composes utiles pour le traitement des etats allergiques - Google Patents

Composes utiles pour le traitement des etats allergiques

Info

Publication number
MC1596A1
MC1596A1 MC841711A MC1711A MC1596A1 MC 1596 A1 MC1596 A1 MC 1596A1 MC 841711 A MC841711 A MC 841711A MC 1711 A MC1711 A MC 1711A MC 1596 A1 MC1596 A1 MC 1596A1
Authority
MC
Monaco
Prior art keywords
hydrogen
formula
lower alkyl
treatment
allergic conditions
Prior art date
Application number
MC841711A
Other languages
English (en)
French (fr)
Inventor
Noel Cohen
Giuseppe Weber
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MC1596A1 publication Critical patent/MC1596A1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/66Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Feeding And Controlling Fuel (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Discharging, Photosensitive Material Shape In Electrophotography (AREA)
  • Transformer Cooling (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
MC841711A 1983-06-24 1984-06-22 Composes utiles pour le traitement des etats allergiques MC1596A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50738383A 1983-06-24 1983-06-24
US67419385A 1985-01-18 1985-01-18

Publications (1)

Publication Number Publication Date
MC1596A1 true MC1596A1 (fr) 1985-05-09

Family

ID=37102508

Family Applications (1)

Application Number Title Priority Date Filing Date
MC841711A MC1596A1 (fr) 1983-06-24 1984-06-22 Composes utiles pour le traitement des etats allergiques

Country Status (22)

Country Link
US (1) US4650812A (pt)
EP (2) EP0129906B1 (pt)
JP (2) JPS6019782A (pt)
KR (1) KR920001776B1 (pt)
AT (1) ATE34981T1 (pt)
AU (2) AU565490B2 (pt)
BR (1) BR8403068A (pt)
CS (1) CS246085B2 (pt)
DE (1) DE3471933D1 (pt)
DK (1) DK304784A (pt)
ES (2) ES533678A0 (pt)
FI (1) FI87207C (pt)
GR (1) GR82135B (pt)
HU (1) HU202512B (pt)
IL (1) IL72187A (pt)
MC (1) MC1596A1 (pt)
NO (1) NO168643C (pt)
NZ (1) NZ208610A (pt)
PH (1) PH20806A (pt)
PT (1) PT78779A (pt)
ZA (1) ZA844519B (pt)
ZW (1) ZW9884A1 (pt)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU548450B2 (en) * 1983-08-08 1985-12-12 G.D. Searle & Co. Substituted dihydrobenzopyrans
US4565882A (en) * 1984-01-06 1986-01-21 G. D. Searle & Co. Substituted dihydrobenzopyran-2-carboxylates
US4885309A (en) * 1986-08-01 1989-12-05 Hoffmann-La Roche Inc. Therapeutic treatment of leukotriene-mediated dermal inflammation by topical administration of 3,4-dihydro-2H-1-benzopyran derivatives
ZA875319B (en) * 1986-08-15 1988-02-15 F. Hoffmann-La Roche & Co. Aktiengesellschaft Use of dihydro benzopyran derivatives
US4874777A (en) * 1987-04-10 1989-10-17 Eli Lilly And Company Leukotriene antagonists
US4853398A (en) * 1987-04-13 1989-08-01 Eli Lilly And Company Leukotriene antagonists and use thereas
US4889871A (en) * 1987-05-29 1989-12-26 G. D. Searle & Co. Alkoxy-substituted dihydrobenzopyran-2-carboxylate derivatives
AT392902B (de) * 1987-10-08 1991-07-10 Hoffmann La Roche Pharmazeutische verwendung von phenoxypentyloxy-3,4-dihydro-2h-1-benzopyran- derivaten
US5037747A (en) * 1988-01-26 1991-08-06 Hoffmann-La Roche Inc. Production of benzopyran-2-carboxylic acids and esters by enzymatic hydrolysis
EP0336068A1 (en) * 1988-02-11 1989-10-11 F. Hoffmann-La Roche Ag Phenoxyalkoxy-3,4-dihydro-2H-1-benzopyran derivatives
US5219883A (en) * 1988-05-20 1993-06-15 G. D. Searle & Co. 2,2-di-substituted benzopyran leukotriene-D4 antagonists
US4950684A (en) * 1988-05-20 1990-08-21 G. D. Searle & Co. 2,2-di-substituted benzopyran leukotriene-D4 antagonists
US5093353A (en) * 1988-05-20 1992-03-03 G. D. Searle & Co. 2,2-di-substituted benzopyran leukotriene-D4 antagonists
US4931574A (en) * 1988-08-23 1990-06-05 Hoffmann-La Roche Inc. Process for the preparation of benzopyrans
JPH0366669A (ja) * 1989-08-03 1991-03-22 Shionogi & Co Ltd 複素環式化合物
US5192782A (en) * 1990-05-10 1993-03-09 G. D. Searle & Co. Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof
US5073562A (en) * 1990-05-10 1991-12-17 G. D. Searle & Co. Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof
US5212198A (en) * 1990-05-10 1993-05-18 G. D. Searle & Co. Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof
US5124350A (en) * 1990-06-28 1992-06-23 G. D. Searle & Co. Leukotriene b4 antagonists
US5273999A (en) * 1991-09-10 1993-12-28 Hoffmann-La Roche Inc. Carboxylic acid leukotriene B4 antagonists
PH30449A (en) * 1991-11-25 1997-05-28 Lilly Co Eli Substituted phenyl phenol leukotriene antagonists
US5380740A (en) * 1993-04-28 1995-01-10 G. D. Searle & Co. Anti-inflammatory compounds, compositions and method of use thereof
US5527827A (en) * 1994-10-27 1996-06-18 Merck Frosst Canada, Inc. Bisarylcarbinol cinnamic acids as inhibitors of leukotriene biosynthesis
US6051586A (en) * 1997-12-19 2000-04-18 Bayer Corporation Sulfonamide substituted chroman derivatives useful as beta 3 adrenoreceptor agonists
US6469031B1 (en) 1998-12-18 2002-10-22 Bayer Corporation Carboxyl substituted chroman derivatives useful as beta 3 adrenoreceptor agonists
AU9287401A (en) 2000-09-27 2002-04-08 Merck & Co Inc Benzopyrancarboxylic acid derivatives for the treatment of diabetes and lipid disorders
CA2427610A1 (en) 2000-10-31 2002-08-08 Merck & Co., Inc. Benzopyrancarboxylic acid derivatives for the treatment of diabetes and lipid disorders
AR035605A1 (es) 2000-12-11 2004-06-16 Bayer Corp Derivados de aminometil cromano di-sustituidos, un metodo para su preparacion, composiciones farmaceuticas y el uso de dichos derivados para la manufactura de medicamentos utiles como agonistas beta-3-adreno-receptores
AR035858A1 (es) 2001-04-23 2004-07-21 Bayer Corp Derivados de cromano 2,6-sustituidos,composiciones farmaceuticas,uso de dichos derivados para la manufactura de medicamentos utiles como agonistas adrenorreceptores beta-3
MXPA04001785A (es) 2001-09-14 2004-07-08 Bayer Ag Benzofurano y derivados de dihidrobenzofurano utiles como agonistas de beta-3 adrenoreceptores.
KR101233223B1 (ko) * 2004-12-21 2013-02-14 제이엔씨 석유 화학 주식회사 크로만환을 가지는 액정 화합물, 액정 조성물 및 이 액정조성물을 함유하는 액정 표시소자

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4133889A (en) * 1971-07-29 1979-01-09 Fisons, Ltd. 2(5-Tetrazolyl)chromones
GB1384530A (en) * 1971-07-29 1975-02-19 Fisons Ltd Chromone derivatives
SU469247A3 (ru) * 1972-01-14 1975-04-30 Майлз Лабораториз Инк (Фирма) Способ получени производных хромона
ZA739471B (en) * 1972-12-22 1974-08-28 Hoffmann La Roche Chromane derivatives
US4150050A (en) * 1978-01-30 1979-04-17 Hoffmann-La Roche Inc. 3,6-Dioxo-1,4-cyclohexadien-1-yl-butandate esters
EP0061800B1 (en) * 1981-03-24 1985-08-28 FISONS plc Anti srs-a carboxylic acid derivatives, processes for their production and pharmaceutical formulations containing them
ATE25251T1 (de) * 1981-11-12 1987-02-15 Fisons Plc Anti srs-a carbonsaeure-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische formulierungen.
AU548450B2 (en) * 1983-08-08 1985-12-12 G.D. Searle & Co. Substituted dihydrobenzopyrans
US4546194A (en) * 1984-05-29 1985-10-08 G. D. Searle & Co. Substituted chromanon-2-yl alkanols and derivatives thereof

Also Published As

Publication number Publication date
PH20806A (en) 1987-04-21
AU565490B2 (en) 1987-09-17
NO168643B (no) 1991-12-09
PT78779A (en) 1984-07-01
US4650812A (en) 1987-03-17
AU6301386A (en) 1988-03-24
DK304784D0 (da) 1984-06-21
HUT36816A (en) 1985-10-28
GR82135B (pt) 1984-12-13
IL72187A0 (en) 1984-10-31
NO842549L (no) 1984-12-27
EP0261254B1 (en) 1990-02-07
HU202512B (en) 1991-03-28
BR8403068A (pt) 1985-05-28
EP0129906B1 (de) 1988-06-08
FI87207C (fi) 1992-12-10
ES8602741A1 (es) 1985-12-01
ES8507534A1 (es) 1985-10-01
ZA844519B (en) 1985-02-27
NZ208610A (en) 1987-05-29
FI842497A0 (fi) 1984-06-20
ATE34981T1 (de) 1988-06-15
CS246085B2 (en) 1986-10-16
IL72187A (en) 1990-02-09
ZW9884A1 (en) 1985-04-17
JPS6391381A (ja) 1988-04-22
KR850000426A (ko) 1985-02-27
FI87207B (fi) 1992-08-31
AU2978584A (en) 1985-01-03
JPS6019782A (ja) 1985-01-31
JPH0469153B2 (pt) 1992-11-05
DE3471933D1 (de) 1988-07-14
EP0261254A1 (en) 1988-03-30
ES533678A0 (es) 1985-10-01
EP0129906A1 (de) 1985-01-02
NO168643C (no) 1992-03-18
DK304784A (da) 1984-12-25
ES541709A0 (es) 1985-12-01
KR920001776B1 (ko) 1992-03-02
AU590798B2 (en) 1989-11-16
FI842497A (fi) 1984-12-25

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