MC1475A1 - Procede de preparation de derives de la purine a action anti-virale - Google Patents

Procede de preparation de derives de la purine a action anti-virale

Info

Publication number
MC1475A1
MC1475A1 MC821601A MC1601A MC1475A1 MC 1475 A1 MC1475 A1 MC 1475A1 MC 821601 A MC821601 A MC 821601A MC 1601 A MC1601 A MC 1601A MC 1475 A1 MC1475 A1 MC 1475A1
Authority
MC
Monaco
Prior art keywords
preparation
compounds
purine derivatives
viral action
viral
Prior art date
Application number
MC821601A
Other languages
English (en)
French (fr)
Inventor
Howard John Schaeffer
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of MC1475A1 publication Critical patent/MC1475A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/16—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
MC821601A 1981-08-11 1982-08-10 Procede de preparation de derives de la purine a action anti-virale MC1475A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8124444 1981-08-11

Publications (1)

Publication Number Publication Date
MC1475A1 true MC1475A1 (fr) 1983-06-17

Family

ID=10523843

Family Applications (1)

Application Number Title Priority Date Filing Date
MC821601A MC1475A1 (fr) 1981-08-11 1982-08-10 Procede de preparation de derives de la purine a action anti-virale

Country Status (25)

Country Link
EP (1) EP0072027B1 (de)
JP (1) JPS5841879A (de)
KR (1) KR880002276B1 (de)
AT (2) ATE34393T1 (de)
AU (1) AU569462B2 (de)
CA (1) CA1305138C (de)
CS (1) CS594082A2 (de)
DD (1) DD202717A5 (de)
DE (1) DE3278501D1 (de)
DK (1) DK154561C (de)
ES (3) ES8403128A1 (de)
FI (1) FI76086C (de)
GB (1) GB2104070B (de)
GR (1) GR76891B (de)
HU (1) HU189609B (de)
IE (1) IE54148B1 (de)
MC (1) MC1475A1 (de)
NO (1) NO158539C (de)
NZ (1) NZ201547A (de)
PH (3) PH19940A (de)
PL (3) PL141198B1 (de)
PT (1) PT75406B (de)
ZA (1) ZA825792B (de)
ZM (1) ZM6082A1 (de)
ZW (1) ZW16882A1 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
US5157120A (en) * 1980-09-16 1992-10-20 Syntex (U.S.A.) Inc. Guanine derivatives
US4355032B2 (en) * 1981-05-21 1990-10-30 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent
NZ201662A (en) * 1981-08-26 1986-07-11 Merck & Co Inc 9-(1,3-(and 2,3)-dihydroxy-1-(and 2)-propoxy-methyl)guanine derivatives and methods for their preparation
IE830186L (en) * 1982-02-01 1983-08-01 Syntex Inc Purines
US5250535A (en) * 1982-02-01 1993-10-05 Syntex Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
EP0095813A3 (de) * 1982-06-01 1985-05-08 THE PROCTER & GAMBLE COMPANY Durchdringende topische pharmazeutische Präparate, die 9-(2-Hydroxyäthoxymethyl)-guanin enthalten
US4556659A (en) * 1982-08-09 1985-12-03 Syntex (U.S.A.) Inc. Substituted 9-(1-0- or 3-0-monosubstituted or 1,3-Di-0-substituted propoxymethyl)-purines as antiviral agents
US4462986A (en) * 1982-11-04 1984-07-31 Ens Bio Logicals, Inc. Synergistic anti-herpes compositions
HUT36464A (en) * 1983-05-24 1985-09-30 Newport Pharmaceuticals Process for producing erythro-4-amino-3-/2-hydroxy-3-alkyl/-imidazol-5-carboxamide
DE3485225D1 (de) * 1983-08-18 1991-12-05 Beecham Group Plc Antivirale guanin-derivate.
AU577303B2 (en) * 1983-08-18 1988-09-22 Novartis International Pharmaceutical Ltd 9-substituted-2-amino purines
US5684153A (en) 1984-08-16 1997-11-04 Beecham Group Plc Process for the preparation of purine derivatives
EP0138683A3 (de) * 1983-09-30 1988-01-20 Merck & Co. Inc. Purinderivate, ihre Verwendung in antiviralen Zubereitungen
US4897479A (en) * 1983-09-30 1990-01-30 Merck & Co., Inc. Arylsulfonyloxy purine intermediates
IL73682A (en) * 1983-12-20 1991-08-16 Medivir Ab Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation
EP0152316B1 (de) * 1984-01-26 1989-07-26 Merck & Co. Inc. Substituierte Butylguanine und ihre Verwendung in antiviralen Zusammensetzungen
US4621140A (en) * 1984-02-23 1986-11-04 Syntex (U.S.A.) Inc. Process for preparing 2,6-substituted-9-(1,3-dihydroxy-2-propoxymethyl)-purines and certain derivatives
US4579849A (en) * 1984-04-06 1986-04-01 Merck & Co., Inc. N-alkylguanine acyclonucleosides as antiviral agents
WO1986000901A1 (en) * 1984-07-20 1986-02-13 Gauntt Charles O Immunoregulatory and anti-viral compound
EP0203736B1 (de) 1985-05-02 1989-11-23 The Wellcome Foundation Limited Antivirale Verbindungen
IL78643A0 (en) * 1985-05-02 1986-08-31 Wellcome Found Purine derivatives,their preparation and pharmaceutical compositions containing them
DE3627024A1 (de) 1985-09-24 1987-04-02 Hoechst Ag In 6- und 9-stellung substituierte 2-aminopurine, ihre verwendung, diese purine enthaltende arzneimittel und verfahren zur herstellung der purine
GB8829571D0 (en) * 1988-12-19 1989-02-08 Wellcome Found Antiviral compounds
JP2788084B2 (ja) * 1988-12-19 1998-08-20 ザ ウエルカム フアウンデーシヨン リミテツド 抗ウイルス化合物
US4966895A (en) * 1989-02-02 1990-10-30 Merck & Co. Inc. Cyclic monophosphates of purine and pyrimidine acyclonucleosides as anti-retroviral agents
DE4020481A1 (de) * 1990-06-27 1992-01-02 Hoechst Ag Verfahren zur herstellung von substituierten acyclischen nukleosiden und dabei auftretende zwischenprodukte
US5068119A (en) * 1990-09-28 1991-11-26 Nabisco Brands, Inc. Acid-hydrolyzable ester derivatives as low calorie fat mimetics
CA2152863A1 (en) * 1994-07-26 1996-01-27 Yeun-Kwei Han Preparation of acyclovir
US5567816A (en) * 1994-07-26 1996-10-22 Syntex (U.S.A.) Inc. Preparation of acyclovir using 1,3 dioxolane
US5840891A (en) * 1994-07-28 1998-11-24 Syntex (U.S.A.) Inc. 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
US5543414A (en) * 1994-07-28 1996-08-06 Syntex (Usa) Inc. Achiral amino acid acyl esters of ganciclovir and its derivatives
US5565565A (en) * 1994-08-04 1996-10-15 Syntex (U.S.A.) Inc. Preparation of N-9 substituted guanine compounds
US5559114A (en) * 1994-12-16 1996-09-24 Exley; Ray W. Treatment of autoimmune disease using 2-amino purine derivatives
US5756736A (en) * 1996-01-26 1998-05-26 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US6040446A (en) 1996-01-26 2000-03-21 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
US5840890A (en) * 1996-01-26 1998-11-24 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5700936A (en) * 1996-01-26 1997-12-23 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
US4355032B2 (en) * 1981-05-21 1990-10-30 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent
NZ201662A (en) * 1981-08-26 1986-07-11 Merck & Co Inc 9-(1,3-(and 2,3)-dihydroxy-1-(and 2)-propoxy-methyl)guanine derivatives and methods for their preparation
US5250535A (en) * 1982-02-01 1993-10-05 Syntex Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent

Also Published As

Publication number Publication date
ES514877A0 (es) 1983-10-01
ZM6082A1 (en) 1984-04-23
ES521551A0 (es) 1984-12-16
NO158539B (no) 1988-06-20
PL237847A1 (en) 1984-09-10
DK154561C (da) 1989-04-24
IE54148B1 (en) 1989-07-05
FI822783L (fi) 1983-02-12
AU8702082A (en) 1983-05-05
DE3278501D1 (en) 1988-06-23
PL141281B1 (en) 1987-07-31
ATA306082A (de) 1985-09-15
FI76086C (fi) 1988-09-09
ZW16882A1 (en) 1984-03-14
DK359082A (da) 1983-02-12
ES8502117A1 (es) 1984-12-16
ES8403128A1 (es) 1983-10-01
PH20148A (en) 1986-10-08
EP0072027A1 (de) 1983-02-16
AT380252B (de) 1986-05-12
CA1305138C (en) 1992-07-14
NZ201547A (en) 1986-01-24
IE821921L (en) 1983-02-11
PT75406A (en) 1982-09-01
DK154561B (da) 1988-11-28
PH19940A (en) 1986-08-14
GR76891B (de) 1984-09-04
GB2104070A (en) 1983-03-02
JPS5841879A (ja) 1983-03-11
KR880002276B1 (ko) 1988-10-21
PL247393A1 (en) 1984-10-22
FI822783A0 (fi) 1982-08-10
FI76086B (fi) 1988-05-31
NO158539C (no) 1988-09-28
ES8504802A1 (es) 1985-04-16
JPH04989B2 (de) 1992-01-09
AU569462B2 (en) 1988-02-04
GB2104070B (en) 1985-08-14
CS594082A2 (en) 1989-08-14
NO822725L (no) 1983-02-14
ZA825792B (en) 1984-03-28
ATE34393T1 (de) 1988-06-15
EP0072027B1 (de) 1988-05-18
HU189609B (en) 1986-07-28
ES521550A0 (es) 1985-04-16
PT75406B (en) 1985-11-15
PL247394A1 (en) 1984-10-22
KR840001169A (ko) 1984-03-28
PH18814A (en) 1985-09-27
PL141198B1 (en) 1987-07-31
DD202717A5 (de) 1983-09-28

Similar Documents

Publication Publication Date Title
MC1475A1 (fr) Procede de preparation de derives de la purine a action anti-virale
ATE33653T1 (de) Antivirale purinderivate.
PT76903A (en) Process for preparing novel derivatives of guanine and of pharmaceutical compositions containing the same
GEP19970666B (en) Process for the preparation of purine derivatives

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