MA56074B1 - Anticorps contre le sars-cov-2 - Google Patents

Anticorps contre le sars-cov-2

Info

Publication number
MA56074B1
MA56074B1 MA56074A MA56074A MA56074B1 MA 56074 B1 MA56074 B1 MA 56074B1 MA 56074 A MA56074 A MA 56074A MA 56074 A MA56074 A MA 56074A MA 56074 B1 MA56074 B1 MA 56074B1
Authority
MA
Morocco
Prior art keywords
cov
antibodies against
formula
compound represented
against sars
Prior art date
Application number
MA56074A
Other languages
English (en)
Other versions
MA56074A (fr
Inventor
Davide Corti
Florian A Lempp
Amalio Telenti
Katja Fink
Martina Beltramello
Elisabetta Cameroni
Dora Pinto
Gyorgy Snell
Original Assignee
Vir Biotechnology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vir Biotechnology Inc filed Critical Vir Biotechnology Inc
Publication of MA56074A publication Critical patent/MA56074A/fr
Publication of MA56074B1 publication Critical patent/MA56074B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1002—Coronaviridae
    • C07K16/1003—Severe acute respiratory syndrome coronavirus 2 [SARS‐CoV‐2 or Covid-19]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1002—Coronaviridae
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/165—Coronaviridae, e.g. avian infectious bronchitis virus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne l'utilisation d'un composé représenté par la formule (i) ou de ses sels pharmaceutiquement acceptables dans la préparation de médicaments pour prévenir ou traiter les maladies infectieuses à coronavirus. Le composé représenté par la formule (i) est utilisé pour traiter les patients atteints d'une pneumonie causée par un nouveau coronavirus, et présente des avantages évidents en ce qui concerne le rapport de conversion négative du test d'acide nucléique viral, le cours de conversion négative et le temps de guérison et de sortie de l'hôpital.
MA56074A 2020-02-26 2021-02-25 Anticorps contre le sars-cov-2 MA56074B1 (fr)

Applications Claiming Priority (19)

Application Number Priority Date Filing Date Title
US202062981984P 2020-02-26 2020-02-26
US202062982661P 2020-02-27 2020-02-27
US202062987298P 2020-03-09 2020-03-09
US202062989522P 2020-03-13 2020-03-13
US202062990369P 2020-03-16 2020-03-16
US202062992082P 2020-03-19 2020-03-19
US202062994235P 2020-03-24 2020-03-24
US202063001204P 2020-03-27 2020-03-27
US202063003214P 2020-03-31 2020-03-31
US202063005206P 2020-04-03 2020-04-03
US202063010589P 2020-04-15 2020-04-15
US202063011971P 2020-04-17 2020-04-17
US202063014024P 2020-04-22 2020-04-22
US202063023788P 2020-05-12 2020-05-12
US202063025133P 2020-05-14 2020-05-14
US202063039813P 2020-06-16 2020-06-16
US202063043653P 2020-06-24 2020-06-24
US202063050331P 2020-07-10 2020-07-10
US202063052810P 2020-07-16 2020-07-16

Publications (2)

Publication Number Publication Date
MA56074A MA56074A (fr) 2022-04-06
MA56074B1 true MA56074B1 (fr) 2023-11-30

Family

ID=74758682

Family Applications (1)

Application Number Title Priority Date Filing Date
MA56074A MA56074B1 (fr) 2020-02-26 2021-02-25 Anticorps contre le sars-cov-2

Country Status (26)

Country Link
US (3) US11168128B2 (fr)
EP (2) EP4245373A3 (fr)
JP (2) JP7275405B2 (fr)
KR (1) KR20220164465A (fr)
AU (2) AU2021227687B2 (fr)
BR (1) BR112022017048A2 (fr)
CA (1) CA3158752C (fr)
CL (1) CL2022002335A1 (fr)
CO (1) CO2022013525A2 (fr)
DK (1) DK3872091T5 (fr)
ES (1) ES2954629T3 (fr)
FI (1) FI3872091T3 (fr)
HR (1) HRP20231031T1 (fr)
HU (1) HUE062777T2 (fr)
IL (1) IL295801A (fr)
LT (1) LT3872091T (fr)
MA (1) MA56074B1 (fr)
MX (1) MX2022010537A (fr)
PL (1) PL3872091T3 (fr)
PT (1) PT3872091T (fr)
RS (1) RS64645B1 (fr)
SG (1) SG11202110145SA (fr)
SI (1) SI3872091T1 (fr)
SM (1) SMT202300397T1 (fr)
TW (1) TWI859420B (fr)
WO (1) WO2021173753A1 (fr)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018138297A1 (fr) 2017-01-27 2018-08-02 Kymab Limited Anticorps anti-opg
CN115066275A (zh) * 2019-09-25 2022-09-16 斯图加特大学 包含修饰的ehd2结构域的结合模块
RS65199B1 (sr) * 2020-03-26 2024-03-29 Univ Vanderbilt Humana monoklonska antitela na teški akutni respiratorni sindrom koronavirus 2 (sars-cov-2)
WO2021045836A1 (fr) 2020-04-02 2021-03-11 Regeneron Pharmaceuticals, Inc. Anticorps anti-glycoprotéine spike du sars-cov 2 et fragments de liaison à l'antigène de ceux-ci
EP4132579A4 (fr) 2020-04-10 2024-05-22 Invivyd, Inc. Composés spécifiques à la protéine s du coronavirus et leurs utilisations
WO2021247779A1 (fr) 2020-06-03 2021-12-09 Regeneron Pharmaceuticals, Inc. Méthodes de traitement ou de prévention d'infections au sars-cov-2 et de la covid-19 à l'aide d'anticorps de glycoprotéine de spicule anti-sars-cov-2
AU2021288203A1 (en) * 2020-06-12 2023-01-19 Vir Biotechnology, Inc. Antibody therapies for SARS-CoV-2 infection
AU2021305067A1 (en) 2020-07-06 2023-02-09 Flagship Pioneering Innovations Vi, Llc Antigen binding molecules targeting SARS-CoV-2
IL299630A (en) * 2020-07-06 2023-03-01 Flagship Pioneering Innovations Vi Llc Antigen binding molecules targeting SARS Cov2
CN116528897A (zh) 2020-08-26 2023-08-01 旗舰开拓创新六世公司 靶向SARS-CoV-2的抗原结合分子
WO2022054068A1 (fr) * 2020-09-14 2022-03-17 Ramot At Tel-Aviv University Ltd. Anticorps pour la prévention, le traitement et la détection d'une infection à coronavirus
CN116157685A (zh) * 2020-09-22 2023-05-23 贝克顿·迪金森公司 用于检测样品中抗体的基于细胞的分析
US11440952B2 (en) 2020-10-16 2022-09-13 Invisishield Technologies Ltd. Compositions for preventing or treating viral and other microbial infections
US12109237B2 (en) * 2020-12-15 2024-10-08 Rutgers, The State University Of New Jersey S309 chimeric antigen receptors and methods of use
WO2023001736A1 (fr) 2021-07-19 2023-01-26 Universität Für Bodenkultur Wien Anticorps igg3 anti-sars-cov-2 modifiés
US20240400652A1 (en) * 2021-09-01 2024-12-05 Vir Biotechnology, Inc. Antibody therapies for sars-cov-2 infection in pediatric subjects
WO2023034871A1 (fr) * 2021-09-01 2023-03-09 Vir Biotechnology, Inc. Thérapies par anticorps à haute concentration contre infection par sars-cov-2
WO2023039442A1 (fr) * 2021-09-08 2023-03-16 Vir Biotechnology, Inc. Polythérapies à base d'anticorps à large spectre de neutralisation pour infection par sars-cov-2
US20240385189A1 (en) * 2021-09-10 2024-11-21 Jacobs Technion-Cornell Institute Compositions and methods for determining humoral immune responses against seasonal coronaviruses and predicting efficiency of sars-cov-2 spike targeting, covid-19 disease severity, and providing interventions
EP4401832A4 (fr) * 2021-09-15 2025-08-13 Univ Illinois Récepteurs modifiés et anticorps monoclonaux contre les coronavirus et leurs utilisations
WO2023046057A1 (fr) * 2021-09-24 2023-03-30 南京金斯瑞生物科技有限公司 Anticorps monoclonal dirigé contre le mutant l452r de protéine de spicule de sars-cov-2 et son utilisation
EP4413034A4 (fr) * 2021-10-07 2025-10-29 Seqirus Pty Ltd Anticorps anti-sars-cov-2 et leurs utilisations ii
WO2023086827A1 (fr) * 2021-11-09 2023-05-19 Rhode Island Hospital Prédiction d'anticorps contre la covid-19 parmi des survivants avec séquençage d'arn profond
WO2023086635A1 (fr) 2021-11-15 2023-05-19 Vir Biotechnology, Inc. Substituts virologiques et moléculaires de réponse à l'anticorps neutralisant le sars-cov-2 sotrovimab
WO2023094980A1 (fr) * 2021-11-23 2023-06-01 Fondazione Toscana Life Sciences Anticorps contre le coronavirus
CN114107223B (zh) * 2021-11-25 2024-03-26 湖北省疾病预防控制中心（湖北省预防医学科学院） 利用TPCK胰酶提高SARS-CoV-2病毒细胞培养滴度的方法
WO2023122211A2 (fr) * 2021-12-21 2023-06-29 Duke University Anticorps du coronavirus et leurs utilisations
WO2023130123A2 (fr) * 2022-01-03 2023-07-06 Twist Bioscience Corporation Anticorps bispécifiques du sars-cov-2 et procédés d'utilisation
EP4460564A2 (fr) * 2022-01-08 2024-11-13 Carogen Corporation Vaccins thérapeutiques à antigènes multiples pour traiter ou prévenir une infection chronique par le virus de l'hépatite b
CN116444656B (zh) * 2022-01-10 2023-09-22 东莞市朋志生物科技有限公司 一种鉴别新冠突变型抗原的抗体、试剂及方法
TWI868567B (zh) * 2022-01-26 2025-01-01 中央研究院 冠狀病毒之特異性抗體及其用途
WO2023150307A2 (fr) * 2022-02-03 2023-08-10 Abpro Corporation Compositions et méthodes contre un virus
TW202342510A (zh) 2022-02-18 2023-11-01 英商Ｒｑ生物科技有限公司 抗體
WO2023201256A1 (fr) * 2022-04-12 2023-10-19 Vir Biotechnology, Inc. Thérapies par anticorps à haute dose contre une infection par le sars-cov-2
EP4507729A2 (fr) 2022-04-14 2025-02-19 Invisishield Technologies Ltd. Compositions pour prévenir ou traiter des infections à coronavirus
WO2023201306A1 (fr) 2022-04-14 2023-10-19 Invisishield Technologies Ltd. Compositions pour prévenir ou traiter des infections par la grippe
EP4519310A1 (fr) 2022-05-06 2025-03-12 Generate Biomedicines, Inc. Molécules de liaison à l'antigène ciblant le sars-cov-2
WO2023224714A1 (fr) * 2022-05-16 2023-11-23 Lawrence Livermore National Security, Llc Anticorps thérapeutiques et prophylactiques réparés contre des variants du sars-cov-2
KR20240008997A (ko) * 2022-07-12 2024-01-22 (재) 스크립스코리아항체연구원 사스-코로나 바이러스 2 중화 항체
WO2024058987A2 (fr) * 2022-09-14 2024-03-21 Merck Sharp & Dohme Llc Polypeptides efficaces contre de multiples coronavirus
WO2024102674A1 (fr) 2022-11-13 2024-05-16 Generate Biomedicines, Inc. Molécules de liaison à l'antigène ciblant sars-cov-2
WO2024112818A1 (fr) * 2022-11-22 2024-05-30 Humabs Biomed Sa Anticorps anti-sars-cov-2 modifiés et leurs utilisations

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4751180A (en) 1985-03-28 1988-06-14 Chiron Corporation Expression using fused genes providing for protein product
US4935233A (en) 1985-12-02 1990-06-19 G. D. Searle And Company Covalently linked polypeptide cell modulators
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5959177A (en) 1989-10-27 1999-09-28 The Scripps Research Institute Transgenic plants expressing assembled secretory antibodies
US5283173A (en) 1990-01-24 1994-02-01 The Research Foundation Of State University Of New York System to detect protein-protein interactions
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
WO1993006217A1 (fr) 1991-09-19 1993-04-01 Genentech, Inc. EXPRESSION DANS L'E. COLI DE FRAGMENTS D'ANTICORPS POSSEDANT AU MOINS UNE CYSTEINE PRESENTE SOUS FORME D'UN THIOL LIBRE, ET LEUR UTILISATION DANS LA PRODUCTION D'ANTICORPS BIFONCTIONNELS F(ab')¿2?
US5789199A (en) 1994-11-03 1998-08-04 Genentech, Inc. Process for bacterial production of polypeptides
US5840523A (en) 1995-03-01 1998-11-24 Genetech, Inc. Methods and compositions for secretion of heterologous polypeptides
US6040498A (en) 1998-08-11 2000-03-21 North Caroline State University Genetically engineered duckweed
US6833268B1 (en) 1999-06-10 2004-12-21 Abgenix, Inc. Transgenic animals for producing specific isotypes of human antibodies via non-cognate switch regions
MXPA02003456A (es) 1999-10-04 2002-10-23 Medicago Inc Metodo para regular la transcripcion de genes foraneos.
US7125978B1 (en) 1999-10-04 2006-10-24 Medicago Inc. Promoter for regulating expression of foreign genes
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
WO2004024750A2 (fr) 2002-09-13 2004-03-25 Dyax Corporation Ligands liant cd44
EP1597280B2 (fr) 2003-02-26 2016-08-24 Institute for Research in Biomedicine Production d'anticorps monoclonaux par transformation de lymphocytes b par le virus d'epstein barr
JP2007528700A (ja) 2003-04-08 2007-10-18 コロノヴァティブ ビー．ブイ． Ｓａｒｓ
KR101206206B1 (ko) 2003-07-22 2012-11-29 크루셀 홀란드 비.브이. 사스-코로나바이러스에 대한 결합분자 및 그것의 용도
EP1644414B1 (fr) 2003-07-22 2015-01-14 Crucell Holland B.V. Molecules de liaison dirigees contre le coronavirus du syndrome respiratoire aigu severe et applications de celles-ci
US7396914B2 (en) 2003-08-04 2008-07-08 University Of Massachusetts SARS nucleic acids, proteins, antibodies, and uses thereof
ATE492562T1 (de) 2003-09-24 2011-01-15 Kyowa Hakko Kirin Co Ltd Rekombinanter antikörper gegen humanen insulin- like growth factor
WO2005060520A2 (fr) 2003-11-25 2005-07-07 Dana-Farber Cancer Institute, Inc. Anticorps diriges contre sras-cov et methodes d'utilisation de ceux-ci
US7553944B2 (en) 2004-07-21 2009-06-30 The University Of Hong Kong Human virus causing respiratory tract infection and uses thereof
AU2005303758B2 (en) 2004-11-11 2011-04-28 Crucell Holland B.V. Compositions against SARS-coronavirus and uses thereof
US7612181B2 (en) 2005-08-19 2009-11-03 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
EP2035454A2 (fr) 2006-05-19 2009-03-18 Amgen, Inc. Anticorps au coronavirus sras
SI2511301T1 (en) 2006-08-04 2018-05-31 MedImmune Limited, Human antibodies to ERBB 2
US8119772B2 (en) 2006-09-29 2012-02-21 California Institute Of Technology MART-1 T cell receptors
BRPI0808673A2 (pt) 2007-03-06 2014-08-12 Symphogen As Anticorpos recombinantes para tratamento de infecções com vírus sinciciais respiratórios.
US20110159001A1 (en) 2008-01-17 2011-06-30 Institute For Research In Biomedicine CROSS-NEUTRALIZING HUMAN MONOCLONAL ANTIBODIES TO SARS-CoV AND METHODS OF USE THEREOF
US20110004955A1 (en) 2008-01-30 2011-01-06 Monsanto Technology Llc Transgenic plants with enhanced agronomic traits
MX357213B (es) 2009-03-20 2018-06-29 Amgen Inc Anticuerpo de antagonista especifico de heterodimero alfa-4-beta-7.
US20120316071A1 (en) 2009-11-04 2012-12-13 Vaughn Smider Methods for affinity maturation-based antibody optimization
DK2504364T3 (da) 2009-11-24 2017-11-06 Medimmune Ltd Målrettede bindemidler mod b7-h1
JO3274B1 (ar) 2009-12-24 2018-09-16 Regeneron Pharma أجسام مضادة بشرية للبروتين 4 المشابه لأجيوبيوتين البشري
KR101299753B1 (ko) 2010-11-19 2013-08-23 주식회사 단바이오텍 소 코로나바이러스 항원 결정기를 포함하는 스파이크 재조합 단백질 및 이에 대한 항체
SG10201700735PA (en) 2012-01-20 2017-02-27 Genzyme Corp Anti-cxcr3 antibodies
AR090244A1 (es) 2012-03-08 2014-10-29 Hoffmann La Roche Formulacion de anticuerpo anti-selectina p
BR112014028764A2 (pt) 2012-05-18 2017-06-27 Novozymes As mutante isolado, métodos para a obtenção do mutante isolado e de um lactobacillus transformante, e, lactobacillus transformante.
TW201843172A (zh) 2012-06-25 2018-12-16 美商再生元醫藥公司 抗－ｅｇｆｒ抗體及其用途
MX2016008667A (es) 2013-12-30 2017-02-02 Epimab Biotherapeutics Inc Inmunoglobulina con fab en tandem y usos de esta.
JO3701B1 (ar) 2014-05-23 2021-01-31 Regeneron Pharma مضادات حيوية بشرية لمتلازمة الشرق الأوسط التنفسية - بروتين كورونا فيروس الشوكي
AR101669A1 (es) 2014-07-31 2017-01-04 Amgen Res Munich Gmbh Constructos de anticuerpos para cdh19 y cd3
WO2016073906A2 (fr) 2014-11-06 2016-05-12 Scholar Rock, Inc. Immunoessais liés à des facteurs de croissance transformants
TWI710573B (zh) 2015-01-26 2020-11-21 美商再生元醫藥公司 抗伊波拉病毒醣蛋白之人類抗體
WO2016138160A1 (fr) 2015-02-24 2016-09-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Immunogènes du coronavirus du syndrome respiratoire du moyen-orient, anticorps et leur utilisation
MX2017012966A (es) 2015-04-10 2018-06-06 Amgen Inc Muteinas de interleuquina 2 para la expansion de celulas t regulatorias.
CN107847570A (zh) 2015-05-08 2018-03-27 优瑞科生物技术公司 靶向hpv16‑e7肽/mhc复合体的构建体及其用途
US11267899B2 (en) 2015-05-13 2022-03-08 Zumutor Biologics Inc. Afucosylated protein, cell expressing said protein and associated methods
AU2016332900C1 (en) 2015-09-29 2024-07-04 Amgen Inc. ASGR inhibitors
JP7270379B2 (ja) 2016-03-08 2023-05-10 イナート・ファルマ・ソシエテ・アノニム Ｓｉｇｌｅｃ中和抗体
NZ789594A (en) 2016-06-20 2025-07-25 Kymab Ltd Anti-PD-L1 antibodies
US10759855B2 (en) 2016-12-02 2020-09-01 Rigel Pharmaceuticals, Inc. Antigen binding molecules to TIGIT
KR20190097128A (ko) 2016-12-16 2019-08-20 메르크 파텐트 게엠베하 루푸스 신염의 중증도 및 진행을 모니터링하기 위한 소변에서 검출된 갈렉틴 3 결합 단백질의 사용 방법
WO2018138297A1 (fr) 2017-01-27 2018-08-02 Kymab Limited Anticorps anti-opg
EP3645562A1 (fr) 2017-06-28 2020-05-06 Regeneron Pharmaceuticals, Inc. Protéines de liaison à l'antigène anti-papillomavirus humain et leurs méthodés d'utilisation
WO2019024979A1 (fr) 2017-07-31 2019-02-07 Institute For Research In Biomedicine Anticorps à domaines fonctionnels dans la région de coude
US11390686B2 (en) 2017-08-09 2022-07-19 University Of Saskatchewan HER3 binding agents and uses thereof
KR101895228B1 (ko) 2017-08-23 2018-10-30 대한민국 중동호흡기증후군 코로나바이러스의 스파이크 단백질에 대한 단일클론항체 및 이의 용도
KR20250114570A (ko) 2017-09-22 2025-07-29 우시 바이올로직스 아일랜드 리미티드 신규한 이중특이적 폴리펩티드 복합체
GB201721338D0 (en) 2017-12-19 2018-01-31 Kymab Ltd Anti-icos Antibodies
WO2021045836A1 (fr) 2020-04-02 2021-03-11 Regeneron Pharmaceuticals, Inc. Anticorps anti-glycoprotéine spike du sars-cov 2 et fragments de liaison à l'antigène de ceux-ci
WO2021203053A1 (fr) * 2020-04-03 2021-10-07 Vir Biotechnology, Inc. Immunothérapie ciblant une région conservée dans des coronavirus sras
US20240059757A1 (en) * 2020-04-14 2024-02-22 Vir Biotechnology, Inc. Antibodies against sars-cov-2 and methods of using the same
BR112022022523A2 (pt) * 2020-05-08 2023-01-10 Vir Biotechnology Inc Anticorpos contra sars-cov-2
WO2021247925A1 (fr) * 2020-06-03 2021-12-09 Vir Biotechnology, Inc. Immunothérapie guidée par une structure dirigée contre le sars-cov-2
AU2021288203A1 (en) * 2020-06-12 2023-01-19 Vir Biotechnology, Inc. Antibody therapies for SARS-CoV-2 infection
CN112062859B (zh) 2020-07-24 2022-08-09 沣潮医药科技（上海）有限公司 用于病原体清除的嵌合抗原受体及其应用

Also Published As

Publication number Publication date
US20210371504A1 (en) 2021-12-02
HUE062777T2 (hu) 2023-12-28
RS64645B1 (sr) 2023-10-31
US20230331821A1 (en) 2023-10-19
EP3872091B1 (fr) 2023-06-14
US11168128B2 (en) 2021-11-09
SG11202110145SA (en) 2021-10-28
FI3872091T3 (fi) 2023-08-31
EP4245373A3 (fr) 2023-12-20
CL2022002335A1 (es) 2023-07-21
DK3872091T5 (da) 2024-08-12
JP2023505613A (ja) 2023-02-09
AU2021227687B2 (en) 2023-02-23
PL3872091T3 (pl) 2023-12-27
HRP20231031T1 (hr) 2023-12-22
TWI859420B (zh) 2024-10-21
IL295801A (en) 2022-10-01
AU2023203201A1 (en) 2023-06-15
JP7275405B2 (ja) 2023-05-17
JP2023009046A (ja) 2023-01-19
WO2021173753A1 (fr) 2021-09-02
ES2954629T3 (es) 2023-11-23
CO2022013525A2 (es) 2022-12-20
TW202146442A (zh) 2021-12-16
SI3872091T1 (sl) 2023-12-29
MA56074A (fr) 2022-04-06
EP3872091A1 (fr) 2021-09-01
KR20220164465A (ko) 2022-12-13
SMT202300397T1 (it) 2024-01-10
LT3872091T (lt) 2023-10-10
US20210261650A1 (en) 2021-08-26
MX2022010537A (es) 2022-09-21
CA3158752A1 (fr) 2021-09-02
PT3872091T (pt) 2023-09-19
AU2021227687A1 (en) 2022-10-20
US11479599B2 (en) 2022-10-25
DK3872091T3 (da) 2023-09-11
BR112022017048A2 (pt) 2022-11-16
CA3158752C (fr) 2023-08-08
EP4245373A2 (fr) 2023-09-20

Similar Documents

Publication Publication Date Title
MA56074B1 (fr) Anticorps contre le sars-cov-2
MA57574A1 (fr) Utilisation d'un composé nucléoside dans le traitement des maladies infectieuses à coronavirus
Zhou et al. Small-molecule inhibition of human immunodeficiency virus type 1 replication by specific targeting of the final step of virion maturation
Staples Jr et al. Hepatitis C in the HIV (human immunodeficiency virus) Atlanta VA (Veterans Affairs Medical Center) Cohort Study (HAVACS): the effect of coinfection on survival
EA200200471A1 (ru) Конденсированные нафтиридины в качестве ингибиторов обратной транскриптазы вич
MA27348A1 (fr) Inhibiteurs de protease du vih, compositions les contenant, leurs utilisations pharmaceutiques et matieres pour leur synthese
RU2007119390A (ru) Соединения 4-метоксиметил-пирролидин-2-карбоновой кислоты и их производные - ингибиторы вируса гепатита с
NO20054264L (no) Ikke-Nukleoside Revers Transkriptase-Inhibitorer I for behandling av HIV-medierte sydommer
Ruprecht et al. Interferon-α and 3′-azido-3′-deoxythymidine are highly synergistic in mice and prevent viremia after acute retrovirus exposure
AR034312A1 (es) Composicion de vacuna que comprende al menos un antigeno del virus de la inmunodeficiencia humana (vih), kit de vacunacion que la comprende, uso de un antigeno de vph y vhs para la preparacion de la composicion de vacuna y procedimiento para la preparacion de dicha vacuna
WO2020114444A1 (fr) Utilisation de diacéréine dans la préparation de médicaments antiviraux et traitement d'infections virales
WO2021175295A1 (fr) Application d'un composé de myricétine dans la préparation de médicaments pour la prévention et le traitement de la pneumonie à nouveau coronavirus
WO2021164689A1 (fr) Application de nelfinavir dans la préparation d'un médicament pour la prévention et le traitement d'une nouvelle pneumonie à coronavirus
GB1334327A (en) Compositions for and method of combating virus infections
US5519028A (en) Antiviral preparations
CN113648313A (zh) 一种哌嗪取代-2-甲基苄腈类化合物zk-22在制备抗冠状病毒药物中的应用
JP2022104747A (ja) 抗ウイルス剤
BÖTTIGER et al. Prevention of HIV-2 and SIV infections in cynomolgus macaques by prophylactic treatment with 3′-fluorothymidine
BE903675Q (fr) Compositions contenant des 1,2,4-triazole-3-carboxamides et leur methode d'utilisation
US5036101A (en) Method for treating retroviral infections with aryl-(2-pyrryl) ketone compound
CA2433237A1 (fr) Utilisation de chloroquine, d'hydroxychloroquine et de derives 4-amino-quinoleiques pour produire un medicament antiretroviral pouvant agir sur des souches sensibles au vih et surdes souches de vih resistantes aux inhibiteurs nucleosidiques et non-nucleosidiques de la transcriptase inverse et aux inhibiteurs de proteases
US5164376A (en) Method for treating retroviral infections with aryl-(2-pyrryl) keytone compound
US20050059745A1 (en) Antiviral therapy
CA2028758A1 (fr) Utilisation d'une benzodiazepine et d'un derive de la phenylpyrrylcetone
SU1419706A1 (ru) Способ профилактики гриппа у беременных