MA53186B2 - Anticorps monoclonal qui se lie spécifiquement à cd20 - Google Patents
Anticorps monoclonal qui se lie spécifiquement à cd20Info
- Publication number
- MA53186B2 MA53186B2 MA53186A MA53186A MA53186B2 MA 53186 B2 MA53186 B2 MA 53186B2 MA 53186 A MA53186 A MA 53186A MA 53186 A MA53186 A MA 53186A MA 53186 B2 MA53186 B2 MA 53186B2
- Authority
- MA
- Morocco
- Prior art keywords
- monoclonal antibody
- specifically binds
- relates
- antibodies
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La présente invention concerne le domaine de la biotechnologie et porte sur un anticorps monoclonal qui se lie spécifiquement à cd20. L'invention concerne des adn qui codent pour ledit anticorps, qui correspondent aux vecteurs d'expression, et des procédés de production ainsi que des méthodes de traitement utilisant ces anticorps.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2018138510A RU2724469C2 (ru) | 2018-10-31 | 2018-10-31 | Моноклональное антитело, которое специфически связывается с cd20 |
PCT/RU2019/050205 WO2020091634A1 (fr) | 2018-10-31 | 2019-10-30 | Anticorps monoclonal qui se lie spécifiquement à cd20 |
Publications (2)
Publication Number | Publication Date |
---|---|
MA53186A1 MA53186A1 (fr) | 2022-02-28 |
MA53186B2 true MA53186B2 (fr) | 2023-05-31 |
Family
ID=70462324
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA53186A MA53186B2 (fr) | 2018-10-31 | 2019-10-30 | Anticorps monoclonal qui se lie spécifiquement à cd20 |
Country Status (25)
Country | Link |
---|---|
US (1) | US20220089761A1 (fr) |
EP (1) | EP3875486A4 (fr) |
JP (1) | JP2022506430A (fr) |
KR (1) | KR20210084604A (fr) |
CN (1) | CN113272329A (fr) |
AR (1) | AR116937A1 (fr) |
AU (1) | AU2019373999A1 (fr) |
BR (1) | BR112021008326A2 (fr) |
CA (1) | CA3117486A1 (fr) |
CL (1) | CL2021001104A1 (fr) |
CO (1) | CO2021005178A2 (fr) |
EA (1) | EA202191173A1 (fr) |
EC (1) | ECSP21028958A (fr) |
IL (1) | IL282742A (fr) |
JO (1) | JOP20210100A1 (fr) |
MA (1) | MA53186B2 (fr) |
MX (1) | MX2021005033A (fr) |
PE (1) | PE20211731A1 (fr) |
PH (1) | PH12021550991A1 (fr) |
RU (1) | RU2724469C2 (fr) |
SG (1) | SG11202104248UA (fr) |
TW (1) | TW202031682A (fr) |
UY (1) | UY38432A (fr) |
WO (1) | WO2020091634A1 (fr) |
ZA (1) | ZA202102874B (fr) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2024025440A1 (fr) * | 2022-07-26 | 2024-02-01 | Joint Stock Company "Biocad" | Composition pharmaceutique d'anticorps anti-cd20 et son utilisation |
Family Cites Families (46)
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IL47062A (en) | 1975-04-10 | 1979-07-25 | Yeda Res & Dev | Process for diminishing antigenicity of tissues to be usedas transplants by treatment with glutaraldehyde |
US4665077A (en) | 1979-03-19 | 1987-05-12 | The Upjohn Company | Method for treating rejection of organ or skin grafts with 6-aryl pyrimidine compounds |
US4634665A (en) | 1980-02-25 | 1987-01-06 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
US5179017A (en) | 1980-02-25 | 1993-01-12 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
US4510245A (en) | 1982-11-18 | 1985-04-09 | Chiron Corporation | Adenovirus promoter system |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4740461A (en) | 1983-12-27 | 1988-04-26 | Genetics Institute, Inc. | Vectors and methods for transformation of eucaryotic cells |
US5168062A (en) | 1985-01-30 | 1992-12-01 | University Of Iowa Research Foundation | Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence |
CA1319120C (fr) | 1985-04-01 | 1993-06-15 | John Henry Kenten | Lignee cellulaire myelomateuse transformee et expression d'un gene codant pour un polypeptide d'eucaryote a l'aide de cette lignee |
US4968615A (en) | 1985-12-18 | 1990-11-06 | Ciba-Geigy Corporation | Deoxyribonucleic acid segment from a virus |
GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
US4959455A (en) | 1986-07-14 | 1990-09-25 | Genetics Institute, Inc. | Primate hematopoietic growth factors IL-3 and pharmaceutical compositions |
US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
US4912040A (en) | 1986-11-14 | 1990-03-27 | Genetics Institute, Inc. | Eucaryotic expression system |
IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
GB8717430D0 (en) | 1987-07-23 | 1987-08-26 | Celltech Ltd | Recombinant dna product |
IL85746A (en) | 1988-03-15 | 1994-05-30 | Yeda Res & Dev | Preparations comprising t-lymphocyte cells treated with 8-methoxypsoralen or cell membranes separated therefrom for preventing or treating autoimmune diseases |
GB8809129D0 (en) | 1988-04-18 | 1988-05-18 | Celltech Ltd | Recombinant dna methods vectors and host cells |
FI891226A (fi) | 1988-04-28 | 1989-10-29 | Univ Leland Stanford Junior | Reseptordeterminanter i anti-t-celler foer behandling av autoimmunsjukdom. |
US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
WO1990008187A1 (fr) | 1989-01-19 | 1990-07-26 | Dana Farber Cancer Institute | Proteine cd2 soluble a deux domaines |
RU2138512C1 (ru) | 1989-03-21 | 1999-09-27 | Дзе Иммюн Риспонз Корпорейшн | Вакцина для профилактики или лечения опосредованной т-клетками патологии или нерегулируемой репликации клонами т-клеток, способ выделения вакцины, способ диагностирования или прогнозирования восприимчивости к ревматоидному артриту или рассеянному склерозу, способ профилактики или лечения ревматоидного артрита или рассеянного склероза и содержащий последовательность sgdqggne пептид, являющийся агентом для обнаружения, профилактики или лечения рассеянного склероза |
ES2112838T5 (es) | 1989-07-19 | 2004-09-01 | Connetics Corporation | Peptidos receptores de celulas t como agentes terapeuticos para enfermedades autoinmunitarias y malignas. |
US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
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DE69334255D1 (de) | 1992-02-06 | 2009-02-12 | Novartis Vaccines & Diagnostic | Marker für Krebs und biosynthetisches Bindeprotein dafür |
EP0752248B1 (fr) | 1992-11-13 | 2000-09-27 | Idec Pharmaceuticals Corporation | Application thérapeutique d'anticorps chimériques et radio-marqués contre l'antigène à differentiation restreinte des lymphocytes B humains pour le traitement du lymphome des cellules B |
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US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
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DE19544393A1 (de) | 1995-11-15 | 1997-05-22 | Hoechst Schering Agrevo Gmbh | Synergistische herbizide Mischungen |
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WO2003068821A2 (fr) * | 2002-02-14 | 2003-08-21 | Immunomedics, Inc. | Anticorps anti-cd20 et proteines hybrides desdits anticorps, et methodes d'utilisation |
EP1572744B1 (fr) | 2002-12-16 | 2010-06-09 | Genentech, Inc. | Variants d'immunoglobuline et utilisations |
AU2011226858B2 (en) * | 2002-12-16 | 2015-01-22 | Genentech, Inc. | Immunoglobulin variants and uses thereof |
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DOP2006000029A (es) * | 2005-02-07 | 2006-08-15 | Genentech Inc | Antibody variants and uses thereof. (variantes de un anticuerpo y usos de las mismas) |
MY149159A (en) | 2005-11-15 | 2013-07-31 | Hoffmann La Roche | Method for treating joint damage |
RU2489166C2 (ru) | 2006-04-09 | 2013-08-10 | Джинентех, Инк. | Применение антитела для лечения аутоиммунных заболеваний у пациента с неадекватным ответом на ингибитор tnf-альфа |
US9175086B2 (en) * | 2010-02-10 | 2015-11-03 | Immunogen, Inc. | CD20 antibodies and uses thereof |
CN102190728B (zh) * | 2010-03-17 | 2014-07-02 | 永卓博济(上海)生物医药技术有限公司 | 一种人源化抗cd20单克隆抗体 |
-
2018
- 2018-10-31 RU RU2018138510A patent/RU2724469C2/ru active
-
2019
- 2019-10-29 TW TW108139053A patent/TW202031682A/zh unknown
- 2019-10-30 US US17/288,234 patent/US20220089761A1/en active Pending
- 2019-10-30 CN CN201980087511.2A patent/CN113272329A/zh active Pending
- 2019-10-30 BR BR112021008326-0A patent/BR112021008326A2/pt unknown
- 2019-10-30 JP JP2021523796A patent/JP2022506430A/ja active Pending
- 2019-10-30 UY UY0001038432A patent/UY38432A/es unknown
- 2019-10-30 SG SG11202104248UA patent/SG11202104248UA/en unknown
- 2019-10-30 WO PCT/RU2019/050205 patent/WO2020091634A1/fr unknown
- 2019-10-30 MA MA53186A patent/MA53186B2/fr unknown
- 2019-10-30 CA CA3117486A patent/CA3117486A1/fr active Pending
- 2019-10-30 EP EP19880700.0A patent/EP3875486A4/fr active Pending
- 2019-10-30 PE PE2021000556A patent/PE20211731A1/es unknown
- 2019-10-30 AU AU2019373999A patent/AU2019373999A1/en active Pending
- 2019-10-30 MX MX2021005033A patent/MX2021005033A/es unknown
- 2019-10-30 JO JOP/2021/0100A patent/JOP20210100A1/ar unknown
- 2019-10-30 EA EA202191173A patent/EA202191173A1/ru unknown
- 2019-10-30 KR KR1020217016587A patent/KR20210084604A/ko active Search and Examination
- 2019-10-31 AR ARP190103167A patent/AR116937A1/es unknown
-
2021
- 2021-04-22 CO CONC2021/0005178A patent/CO2021005178A2/es unknown
- 2021-04-22 EC ECSENADI202128958A patent/ECSP21028958A/es unknown
- 2021-04-28 CL CL2021001104A patent/CL2021001104A1/es unknown
- 2021-04-28 IL IL282742A patent/IL282742A/en unknown
- 2021-04-29 ZA ZA2021/02874A patent/ZA202102874B/en unknown
- 2021-04-30 PH PH12021550991A patent/PH12021550991A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2020091634A1 (fr) | 2020-05-07 |
PE20211731A1 (es) | 2021-09-06 |
UY38432A (es) | 2020-05-29 |
PH12021550991A1 (en) | 2021-10-04 |
RU2018138510A (ru) | 2020-04-30 |
KR20210084604A (ko) | 2021-07-07 |
SG11202104248UA (en) | 2021-05-28 |
EP3875486A1 (fr) | 2021-09-08 |
IL282742A (en) | 2021-06-30 |
US20220089761A1 (en) | 2022-03-24 |
AU2019373999A1 (en) | 2021-05-27 |
CA3117486A1 (fr) | 2020-05-07 |
JP2022506430A (ja) | 2022-01-17 |
MX2021005033A (es) | 2021-06-15 |
RU2018138510A3 (fr) | 2020-04-30 |
EP3875486A4 (fr) | 2022-08-03 |
AR116937A1 (es) | 2021-06-30 |
RU2724469C2 (ru) | 2020-06-23 |
CL2021001104A1 (es) | 2021-12-03 |
TW202031682A (zh) | 2020-09-01 |
ECSP21028958A (es) | 2021-05-31 |
EA202191173A1 (ru) | 2021-07-28 |
CO2021005178A2 (es) | 2021-04-30 |
CN113272329A (zh) | 2021-08-17 |
BR112021008326A2 (pt) | 2021-08-31 |
ZA202102874B (en) | 2022-06-29 |
MA53186A1 (fr) | 2022-02-28 |
JOP20210100A1 (ar) | 2023-01-30 |
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