AR116937A1 - Anticuerpo monoclonal que se une específicamente al antígeno cd20 - Google Patents

Anticuerpo monoclonal que se une específicamente al antígeno cd20

Info

Publication number
AR116937A1
AR116937A1 ARP190103167A ARP190103167A AR116937A1 AR 116937 A1 AR116937 A1 AR 116937A1 AR P190103167 A ARP190103167 A AR P190103167A AR P190103167 A ARP190103167 A AR P190103167A AR 116937 A1 AR116937 A1 AR 116937A1
Authority
AR
Argentina
Prior art keywords
antigen
antibody
binding fragment
seq
nucleic acid
Prior art date
Application number
ARP190103167A
Other languages
English (en)
Inventor
Sergei Vasilyevich Diduk
Alexey Konstantinovich Misorin
Valery Vladimirovich Solovyev
Nina Grachyaevna Kharatian
Mariia Aleksandrovna Shchemeleva
Anna Alexandrovna Trudovishnikova
Arina Vitalevna Anikina
Natalia Eugenievna Pestova
Pavel Andreevich Iakovlev
Dmitry Valentinovich Morozov
Roman Alekseevich Ivanov
Svetlana Vladimirovna Koskova
Iana Andreevna Smirnova
Aleksei Aleksandrovich Aleksandrov
Elena Andreevna Krendeleva
Veronika Sergeevna Usatova
Iakov Iurevich Ustiugov
Anna Vladimirovna Eroshova
Original Assignee
Joint Stock Company “Biocad”
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Joint Stock Company “Biocad” filed Critical Joint Stock Company “Biocad”
Publication of AR116937A1 publication Critical patent/AR116937A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Cell Biology (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente se refiere a la biotecnología y proporciona un anticuerpo monoclonal que se une específicamente al antígeno CD20. La presente también se refiere a ADN que codifica dicho anticuerpo, los correspondientes vectores de expresión y métodos para su producción, al igual que métodos de tratamiento para emplear dicho anticuerpo. Reivindicación 1: Un anticuerpo monoclonal o fragmento de unión al antígeno de este que se une específicamente a CD20 que comprende: a) un dominio variable de la cadena pesada que comprende una secuencia de aminoácidos que se muestra en la SEQ ID Nº 2 o SEQ ID Nº 6; b) un dominio variable de la cadena ligera que comprende una secuencia de aminoácidos que se muestra en la SEQ ID Nº 4 o SEQ ID Nº 8. Reivindicación 10: Un ácido nucleico que codifica un anticuerpo o fragmento de unión al antígeno de este según cualquiera de las reivindicaciones 1 - 9. Reivindicación 12: Un vector de expresión que comprende un ácido nucleico según cualquiera de las reivindicaciones 10 - 11. Reivindicación 13: Un método para la producción de una célula hospedante para producir un anticuerpo o fragmento de unión al antígeno de este según cualquiera de las reivindicaciones 1 - 9 que comprende la transformación de una célula con un vector según la reivindicación 12. Reivindicación 14: Una célula hospedante para producir un anticuerpo o fragmento de unión al antígeno de este según cualquiera de las reivindicaciones 1 - 9, que comprende un ácido nucleico según cualquiera de las reivindicaciones 10 - 11. Reivindicación 15: Un método para la producción de un anticuerpo o fragmento de unión al antígeno de este según cualquiera de las reivindicaciones 1 - 9, que comprende cultivar una célula hospedante según la reivindicación 14 en un medio de cultivo en condiciones suficientes para producir dicho anticuerpo o fragmento de unión al antígeno de este, si es necesario, seguido del aislamiento y la purificación del anticuerpo producido o de un fragmento de unión al antígeno de este. Reivindicación 16: Una composición farmacéutica para la profilaxis o el tratamiento de una enfermedad o un trastorno mediado por CD20, que comprende un anticuerpo o fragmento de unión al antígeno de este según cualquiera de las reivindicaciones 1 - 9 en combinación con uno o más excipientes farmacéuticamente aceptables.
ARP190103167A 2018-10-31 2019-10-31 Anticuerpo monoclonal que se une específicamente al antígeno cd20 AR116937A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2018138510A RU2724469C2 (ru) 2018-10-31 2018-10-31 Моноклональное антитело, которое специфически связывается с cd20

Publications (1)

Publication Number Publication Date
AR116937A1 true AR116937A1 (es) 2021-06-30

Family

ID=70462324

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP190103167A AR116937A1 (es) 2018-10-31 2019-10-31 Anticuerpo monoclonal que se une específicamente al antígeno cd20

Country Status (24)

Country Link
US (1) US20220089761A1 (es)
EP (1) EP3875486A4 (es)
JP (1) JP2022506430A (es)
KR (1) KR20210084604A (es)
CN (1) CN113272329A (es)
AR (1) AR116937A1 (es)
AU (1) AU2019373999A1 (es)
BR (1) BR112021008326A2 (es)
CA (1) CA3117486A1 (es)
CL (1) CL2021001104A1 (es)
CO (1) CO2021005178A2 (es)
EA (1) EA202191173A1 (es)
EC (1) ECSP21028958A (es)
IL (1) IL282742A (es)
JO (1) JOP20210100A1 (es)
MA (1) MA53186B2 (es)
MX (1) MX2021005033A (es)
PE (1) PE20211731A1 (es)
PH (1) PH12021550991A1 (es)
RU (1) RU2724469C2 (es)
SG (1) SG11202104248UA (es)
UY (1) UY38432A (es)
WO (1) WO2020091634A1 (es)
ZA (1) ZA202102874B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024025440A1 (en) * 2022-07-26 2024-02-01 Joint Stock Company "Biocad" Pharmaceutical composition of anti-cd20 antibody and use thereof

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Also Published As

Publication number Publication date
EP3875486A4 (en) 2022-08-03
IL282742A (en) 2021-06-30
ECSP21028958A (es) 2021-05-31
UY38432A (es) 2020-05-29
ZA202102874B (en) 2022-06-29
SG11202104248UA (en) 2021-05-28
TW202031682A (zh) 2020-09-01
BR112021008326A2 (pt) 2021-08-31
WO2020091634A1 (ru) 2020-05-07
RU2724469C2 (ru) 2020-06-23
PH12021550991A1 (en) 2021-10-04
CA3117486A1 (en) 2020-05-07
JOP20210100A1 (ar) 2023-01-30
RU2018138510A (ru) 2020-04-30
US20220089761A1 (en) 2022-03-24
PE20211731A1 (es) 2021-09-06
KR20210084604A (ko) 2021-07-07
AU2019373999A1 (en) 2021-05-27
EA202191173A1 (ru) 2021-07-28
EP3875486A1 (en) 2021-09-08
CL2021001104A1 (es) 2021-12-03
CO2021005178A2 (es) 2021-04-30
RU2018138510A3 (es) 2020-04-30
MA53186A1 (fr) 2022-02-28
CN113272329A (zh) 2021-08-17
MX2021005033A (es) 2021-06-15
JP2022506430A (ja) 2022-01-17
MA53186B2 (fr) 2023-05-31

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