AR122286A1 - Anticuerpos potenciadores del factor h y usos de estos - Google Patents
Anticuerpos potenciadores del factor h y usos de estosInfo
- Publication number
- AR122286A1 AR122286A1 ARP200102011A ARP200102011A AR122286A1 AR 122286 A1 AR122286 A1 AR 122286A1 AR P200102011 A ARP200102011 A AR P200102011A AR P200102011 A ARP200102011 A AR P200102011A AR 122286 A1 AR122286 A1 AR 122286A1
- Authority
- AR
- Argentina
- Prior art keywords
- sequence
- seq
- nucleic acid
- antibody
- heavy chain
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Abstract
Reivindicación 1: Un anticuerpo aislado, sintético o recombinante o un fragmento de unión al antígeno de este que se une específicamente al dominio de la proteína de control del complemento 18 (CCP18) del factor H (FH) que comprende lo siguiente: una secuencia de CDR1 de cadena ligera que comprende la secuencia SSVTY (SEQ ID nº 1) o la secuencia TSVTY (SEQ ID nº 13), una secuencia de CDR2 de cadena ligera que comprende la secuencia ATS (SEQ ID nº 2) o la secuencia ASS (SEQ ID nº 14), una secuencia de CDR3 de cadena ligera que comprende la secuencia QHRSSSNPLT (SEQ ID nº 3), una secuencia de CDR1 de cadena pesada que comprende la secuencia GFSLTNYG (SEQ ID nº 5), una secuencia de CDR2 de cadena pesada que comprende la secuencia VWSGGTT (SEQ ID nº 6) o la secuencia de IWSGGTT (SEQ ID nº 10) y una secuencia de CDR3 de cadena pesada que comprende la secuencia ARNFGNYAMDY (SEQ ID nº 7) o la secuencia ARNFGNYAMDF (SEQ ID nº 11). Reivindicación 21: Un ácido nucleico aislado, sintético o recombinante que comprende una secuencia de ácido nucleico que codifica el anticuerpo o fragmento según cualquiera de las reivindicaciones 1 a 20. Reivindicación 22: Un vector que comprende un ácido nucleico según la reivindicación 21. Reivindicación 25: Una célula recombinante que comprende el ácido nucleico según la reivindicación 21 o el vector según cualquiera de las reivindicaciones 22 - 24. Reivindicación 26: Una composición farmacéutica que comprende el anticuerpo o fragmento según cualquiera de las reivindicaciones 1 a 20, el ácido nucleico según la reivindicación 21, el vector según cualquiera de las reivindicaciones 22 - 24 o la célula recombinante según la reivindicación 25 y un portador, diluyente y/o excipiente farmacéuticamente aceptable.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962875309P | 2019-07-17 | 2019-07-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR122286A1 true AR122286A1 (es) | 2022-08-31 |
Family
ID=74211270
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP200102011A AR122286A1 (es) | 2019-07-17 | 2020-07-17 | Anticuerpos potenciadores del factor h y usos de estos |
Country Status (13)
Country | Link |
---|---|
US (1) | US11820814B2 (es) |
EP (1) | EP3999073A4 (es) |
JP (1) | JP2022541275A (es) |
KR (1) | KR20220057530A (es) |
CN (1) | CN114828886A (es) |
AR (1) | AR122286A1 (es) |
AU (1) | AU2020313981A1 (es) |
BR (1) | BR112022000739A2 (es) |
CA (1) | CA3147638A1 (es) |
IL (1) | IL289812A (es) |
MX (1) | MX2022000725A (es) |
TW (1) | TW202110893A (es) |
WO (1) | WO2021011903A1 (es) |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
WO2003080672A1 (en) | 2002-03-22 | 2003-10-02 | Aprogen, Inc. | Humanized antibody and process for preparing same |
US20090004183A1 (en) | 2004-07-23 | 2009-01-01 | Taylor Ronald P | Compositions and Methods for Regulating the Alternative Pathway of Complement |
KR20170002684A (ko) | 2005-11-04 | 2017-01-06 | 제넨테크, 인크. | 안질환 치료를 위한 보체 경로 억제제의 용도 |
FR2894145B1 (fr) | 2005-12-07 | 2008-10-17 | Lab Francais Du Fractionnement | Utilisation de facteur h du complement a titre de medicament |
KR20150029002A (ko) | 2007-06-07 | 2015-03-17 | 제넨테크, 인크. | 보체-관련 장애의 예방 및 치료를 위한 C3b 항체 및 방법 |
GB0819633D0 (en) | 2008-10-25 | 2008-12-03 | Isis Innovation | Composition |
JP2013508287A (ja) | 2009-10-14 | 2013-03-07 | ヤンセン バイオテツク,インコーポレーテツド | 抗体を親和性成熟する方法 |
CA2780221A1 (en) | 2009-11-04 | 2011-05-12 | Fabrus Llc | Methods for affinity maturation-based antibody optimization |
US9295713B2 (en) | 2010-09-15 | 2016-03-29 | Celldex Therapeutics, Inc. | Treatment of chronic nephropathies using soluble complement receptor type I (sCR1) |
WO2013078223A1 (en) * | 2011-11-23 | 2013-05-30 | Children's Hospital & Research Center Oakland | Anti-factor h binding protein antibodies and methods of use thereof |
US9926366B2 (en) | 2012-10-04 | 2018-03-27 | Novelmed Therapeutics, Inc. | Methods of treating a hemolytic disorder comprising administering anti-properdin antibodies |
GB201318170D0 (en) * | 2013-10-14 | 2013-11-27 | Univ Edinburgh | Proteins with Diagnostic and Therapeutic Uses |
EP3066132A2 (en) | 2013-11-07 | 2016-09-14 | Novo Nordisk A/S | Novel methods and antibodies for treating coagulapathy |
US10357554B2 (en) | 2013-11-11 | 2019-07-23 | The United States Of America, As Represented By The Secretary Of The Army | AMA-1 epitopes, antibodies, compositions, and methods of making and using the same |
CN107074939B (zh) | 2014-08-20 | 2021-09-07 | 桑昆血液供给基金会 | H因子增强抗体及其用途 |
BR112017003582B1 (pt) | 2014-08-27 | 2024-01-09 | Memorial Sloan Kettering Cancer Center | Agente de anticorpo, uso do mesmo, composição farmacêutica e receptor de antígeno quimérico |
WO2017114401A1 (zh) * | 2015-12-31 | 2017-07-06 | 江苏匡亚生物医药科技有限公司 | 具有补体调节活性的重组补体因子h-免疫球蛋白融合蛋白及其制备方法与应用 |
CR20180529A (es) * | 2016-04-04 | 2019-03-21 | Bioverativ Usa Inc | Anticuerpos anti-factor bb del complemento y usos de estos referencia cruzada |
GB201608046D0 (en) * | 2016-05-09 | 2016-06-22 | Cambridge Entpr Ltd And Syndey Children S Hospitals Network Randwick And Westmead Incorporating The | Treatment of complement-mediated disorders |
US20190202878A1 (en) * | 2016-06-28 | 2019-07-04 | Universitat Ulm | Complement inhibitors and uses thereof |
US10865238B1 (en) * | 2017-05-05 | 2020-12-15 | Duke University | Complement factor H antibodies |
KR20200110688A (ko) * | 2018-01-15 | 2020-09-24 | 스티흐팅 산퀸 불드포르지닝 | 인자 h 강화 항체 및 이의 사용 |
-
2020
- 2020-07-17 AR ARP200102011A patent/AR122286A1/es unknown
- 2020-07-17 AU AU2020313981A patent/AU2020313981A1/en active Pending
- 2020-07-17 KR KR1020227005261A patent/KR20220057530A/ko unknown
- 2020-07-17 CA CA3147638A patent/CA3147638A1/en active Pending
- 2020-07-17 EP EP20840846.8A patent/EP3999073A4/en active Pending
- 2020-07-17 JP JP2022503450A patent/JP2022541275A/ja active Pending
- 2020-07-17 MX MX2022000725A patent/MX2022000725A/es unknown
- 2020-07-17 WO PCT/US2020/042627 patent/WO2021011903A1/en unknown
- 2020-07-17 BR BR112022000739A patent/BR112022000739A2/pt unknown
- 2020-07-17 TW TW109124345A patent/TW202110893A/zh unknown
- 2020-07-17 CN CN202080063736.7A patent/CN114828886A/zh active Pending
- 2020-07-17 US US17/627,503 patent/US11820814B2/en active Active
-
2022
- 2022-01-12 IL IL289812A patent/IL289812A/en unknown
Also Published As
Publication number | Publication date |
---|---|
US20220372120A1 (en) | 2022-11-24 |
IL289812A (en) | 2022-03-01 |
AU2020313981A8 (en) | 2024-05-30 |
EP3999073A4 (en) | 2023-07-26 |
BR112022000739A2 (pt) | 2022-04-12 |
JP2022541275A (ja) | 2022-09-22 |
CA3147638A1 (en) | 2021-01-21 |
KR20220057530A (ko) | 2022-05-09 |
AU2020313981A1 (en) | 2022-03-03 |
EP3999073A1 (en) | 2022-05-25 |
TW202110893A (zh) | 2021-03-16 |
US11820814B2 (en) | 2023-11-21 |
WO2021011903A1 (en) | 2021-01-21 |
CN114828886A (zh) | 2022-07-29 |
MX2022000725A (es) | 2022-04-26 |
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