PE20240363A1 - Anticuerpos anti-ccr8 y usos de los mismos - Google Patents
Anticuerpos anti-ccr8 y usos de los mismosInfo
- Publication number
- PE20240363A1 PE20240363A1 PE2023003211A PE2023003211A PE20240363A1 PE 20240363 A1 PE20240363 A1 PE 20240363A1 PE 2023003211 A PE2023003211 A PE 2023003211A PE 2023003211 A PE2023003211 A PE 2023003211A PE 20240363 A1 PE20240363 A1 PE 20240363A1
- Authority
- PE
- Peru
- Prior art keywords
- seq
- amino acid
- acid sequence
- ccr8
- antigen
- Prior art date
Links
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 6
- 108010047041 Complementarity Determining Regions Proteins 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 239000012634 fragment Substances 0.000 abstract 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 1
- 101000716063 Homo sapiens C-C chemokine receptor type 8 Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Referida a un anticuerpo que se une al receptor de quimiocina C-C de tipo 8 (CCR8) humano, o un fragmento de union a antigeno del mismo, en donde dicho anticuerpo o fragmento de union a antigeno del mismo comprende: una secuencia de aminoacidos de la region determinante de la complementariedad de cadena pesada (HCDR) 1 de la SEQ ID NO: 1; una secuencia de aminoacidos de HCDR2 de la SEQ ID NO: 2; una secuencia de aminoacidos de HCDR3 de la SEQ ID NO: 3; una secuencia de aminoacidos de la region determinante de la complementariedad de cadena ligera (LCDR) 1 de KSSQSVLYSSNNX1NYLA (SEQ ID NO: 1235), en donde X1 es K o R; una secuencia de aminoacidos de LCDR2 de la SEQ ID NO: 5; y una secuencia de aminoacidos de LCDR3 de la SEQ ID NO: 6. Dichos compuestos anti-CCR8 tienen actividad ADCC y son utiles en el tratamiento de cancer.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163197271P | 2021-06-04 | 2021-06-04 | |
| US202163236551P | 2021-08-24 | 2021-08-24 | |
| PCT/US2022/032011 WO2022256563A1 (en) | 2021-06-04 | 2022-06-02 | Anti-ccr8 antibodies and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20240363A1 true PE20240363A1 (es) | 2024-03-04 |
Family
ID=82358418
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2023003211A PE20240363A1 (es) | 2021-06-04 | 2022-06-02 | Anticuerpos anti-ccr8 y usos de los mismos |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20220403037A1 (es) |
| EP (1) | EP4347655A1 (es) |
| KR (1) | KR20240017912A (es) |
| AU (1) | AU2022285741A1 (es) |
| BR (1) | BR112023025433A2 (es) |
| CA (1) | CA3222764A1 (es) |
| CO (1) | CO2023018064A2 (es) |
| CR (1) | CR20230581A (es) |
| IL (1) | IL308808A (es) |
| PE (1) | PE20240363A1 (es) |
| TW (1) | TW202313684A (es) |
| UY (1) | UY39798A (es) |
| WO (1) | WO2022256563A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20240363A1 (es) * | 2021-06-04 | 2024-03-04 | Amgen Inc | Anticuerpos anti-ccr8 y usos de los mismos |
| WO2024097741A1 (en) * | 2022-11-04 | 2024-05-10 | Gilead Sciences, Inc. | Anticancer therapies using anti-ccr8 antibody, chemo and immunotherapy combinations |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4331647A (en) | 1980-03-03 | 1982-05-25 | Goldenberg Milton David | Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| MX2007002856A (es) | 2004-09-02 | 2007-09-25 | Genentech Inc | Metodos para el uso de ligandos receptores de muerte y anticuerpos c20. |
| WO2007044756A2 (en) * | 2005-10-11 | 2007-04-19 | Icos Corporation | Monoclonal antibodies recognizing human ccr8 |
| WO2008119353A1 (en) | 2007-03-29 | 2008-10-09 | Genmab A/S | Bispecific antibodies and methods for production thereof |
| CN103097417B (zh) | 2010-04-20 | 2019-04-09 | 根马布股份公司 | 含异二聚体抗体fc的蛋白及其制备方法 |
| EP3539988A3 (en) | 2010-05-27 | 2019-12-04 | Genmab A/S | Monoclonal antibodies against her2 |
| PL2771364T3 (pl) | 2011-10-27 | 2020-01-31 | Genmab A/S | Wytwarzanie heterodimerycznych białek |
| MA41044A (fr) * | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
| EP4129327A1 (en) * | 2015-08-28 | 2023-02-08 | Amunix Pharmaceuticals, Inc. | Chimeric polypeptide assembly and methods of making and using the same |
| AU2018243020B2 (en) | 2017-03-29 | 2020-04-16 | Osaka University | Medicinal composition for treating cancer |
| PE20211270A1 (es) | 2018-01-12 | 2021-07-19 | Amgen Inc | Anticuerpos anti-pd-1 y metodos de tratamiento |
| US20220064312A1 (en) * | 2018-12-27 | 2022-03-03 | Shionogi & Co., Ltd. | Novel Anti-CCR8 Antibody |
| CA3160204A1 (en) * | 2020-01-06 | 2021-07-15 | Vaccinex, Inc. | Anti-ccr8 antibodies and uses thereof |
| TW202216771A (zh) * | 2020-06-26 | 2022-05-01 | 德商拜耳廠股份有限公司 | 用於治療應用之ccr8抗體 |
| US20230322955A1 (en) | 2020-08-20 | 2023-10-12 | Amgen Inc. | Antigen binding proteins with non-canonical disulfide in fab region |
| US20240132603A1 (en) * | 2020-08-27 | 2024-04-25 | Harbour Biomed US, Inc. | Ccr8 antibody and application thereof |
| WO2022081718A1 (en) * | 2020-10-14 | 2022-04-21 | Five Prime Therapeutics, Inc. | Anti-c-c chemokine receptor 8 (ccr8) antibodies and methods of use thereof |
| PE20240363A1 (es) * | 2021-06-04 | 2024-03-04 | Amgen Inc | Anticuerpos anti-ccr8 y usos de los mismos |
| IL308809A (en) * | 2021-06-04 | 2024-01-01 | Amgen Res Munich Gmbh | T cell binding compounds and their uses |
-
2022
- 2022-06-02 PE PE2023003211A patent/PE20240363A1/es unknown
- 2022-06-02 WO PCT/US2022/032011 patent/WO2022256563A1/en active Application Filing
- 2022-06-02 BR BR112023025433A patent/BR112023025433A2/pt unknown
- 2022-06-02 KR KR1020247000218A patent/KR20240017912A/ko unknown
- 2022-06-02 EP EP22736093.0A patent/EP4347655A1/en active Pending
- 2022-06-02 AU AU2022285741A patent/AU2022285741A1/en active Pending
- 2022-06-02 CA CA3222764A patent/CA3222764A1/en active Pending
- 2022-06-02 UY UY0001039798A patent/UY39798A/es unknown
- 2022-06-02 US US17/831,398 patent/US20220403037A1/en active Pending
- 2022-06-02 IL IL308808A patent/IL308808A/en unknown
- 2022-06-02 CR CR20230581A patent/CR20230581A/es unknown
- 2022-06-02 TW TW111120681A patent/TW202313684A/zh unknown
-
2023
- 2023-12-20 CO CONC2023/0018064A patent/CO2023018064A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA3222764A1 (en) | 2022-12-08 |
| CR20230581A (es) | 2024-02-13 |
| TW202313684A (zh) | 2023-04-01 |
| EP4347655A1 (en) | 2024-04-10 |
| BR112023025433A2 (pt) | 2024-02-27 |
| AU2022285741A1 (en) | 2023-12-14 |
| CO2023018064A2 (es) | 2024-01-15 |
| US20220403037A1 (en) | 2022-12-22 |
| WO2022256563A1 (en) | 2022-12-08 |
| UY39798A (es) | 2022-12-30 |
| IL308808A (en) | 2024-01-01 |
| KR20240017912A (ko) | 2024-02-08 |
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