PE20091351A1 - Anticuerpos humanizados especificos para el factor von willebrand - Google Patents
Anticuerpos humanizados especificos para el factor von willebrandInfo
- Publication number
- PE20091351A1 PE20091351A1 PE2009000068A PE2009000068A PE20091351A1 PE 20091351 A1 PE20091351 A1 PE 20091351A1 PE 2009000068 A PE2009000068 A PE 2009000068A PE 2009000068 A PE2009000068 A PE 2009000068A PE 20091351 A1 PE20091351 A1 PE 20091351A1
- Authority
- PE
- Peru
- Prior art keywords
- seq
- von willebrand
- willebrand factor
- antibody
- humanized antibodies
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
SE REFIERE A UN ANTICUERPO HUMANIZADO O FRAGMENTO DE UNION DEL MISMO ESPECIFICO PARA EL FACTOR VON WILLEBRAND (vWF) QUE COMPRENDE: A) UNA SECUENCIA DE REGION VARIABLE DE CADENA PESADA COMO LA EXPUESTA EN LA SEC ID NO:19; Y B) UNA SECUENCIA DE REGION VARIABLE DE CADENA LIVIANA COMO LA EXPUESTA EN LA SEC ID NO:28. DONDE DICHO ANTICUERPO TAMBIEN COMPRENDE: i) REGIONES DETERMINANTES DE COMPLEMENTARIEDAD (CDR) DE CADENA PESADA TALES COMO a) HCDR1 (SEC ID NO:7); b) HCDR2 (SEC ID NO:8) Y c) HCDR3 (SEC ID NO:9); E ii) REGIONES DETERMINANTES DE COMPLEMENTARIEDAD (CDR) DE CADENA LIGERA TALES COMO a) LCDR1 (SEC ID NO:10); b) LCDR2 (SEC ID NO:11) Y c) LCDR3 (SEC ID NO:12). SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN METODO DE PREPARACION DE DICHO ANTICUERPO QUE ES UTIL EN EL TRATAMIENTO DE ATEROSCLEROSIS, ANGINA, INFARTO AGUDO DE MIOCARDIO, TROMBOSIS VENOSA, ENFERMEDAD VASCULAR PERIFERICA
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2302508P | 2008-01-23 | 2008-01-23 | |
US4478708P | 2008-04-14 | 2008-04-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20091351A1 true PE20091351A1 (es) | 2009-09-16 |
Family
ID=40613108
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2009000068A PE20091351A1 (es) | 2008-01-23 | 2009-01-21 | Anticuerpos humanizados especificos para el factor von willebrand |
Country Status (21)
Country | Link |
---|---|
US (1) | US8236315B2 (es) |
EP (1) | EP2245069B1 (es) |
JP (1) | JP2011510622A (es) |
KR (1) | KR20100113589A (es) |
CN (1) | CN101932606A (es) |
AP (1) | AP2010005332A0 (es) |
AR (1) | AR070141A1 (es) |
AU (1) | AU2009207340A1 (es) |
BR (1) | BRPI0905761A2 (es) |
CA (1) | CA2712221A1 (es) |
CL (1) | CL2009000123A1 (es) |
CO (1) | CO6280500A2 (es) |
DK (1) | DK2245069T3 (es) |
EA (1) | EA201070730A1 (es) |
ES (1) | ES2495092T3 (es) |
IL (1) | IL207134A0 (es) |
MX (1) | MX2010008060A (es) |
PE (1) | PE20091351A1 (es) |
TW (1) | TW200938630A (es) |
WO (1) | WO2009093138A1 (es) |
ZA (1) | ZA201005373B (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
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AR079944A1 (es) * | 2010-01-20 | 2012-02-29 | Boehringer Ingelheim Int | Anticuerpo neutralizante de la actividad de un anticoagulante |
US9597379B1 (en) | 2010-02-09 | 2017-03-21 | David Gordon Bermudes | Protease inhibitor combination with therapeutic proteins including antibodies |
US8771669B1 (en) | 2010-02-09 | 2014-07-08 | David Gordon Bermudes | Immunization and/or treatment of parasites and infectious agents by live bacteria |
US8524220B1 (en) | 2010-02-09 | 2013-09-03 | David Gordon Bermudes | Protease inhibitor: protease sensitivity expression system composition and methods improving the therapeutic activity and specificity of proteins delivered by bacteria |
WO2012097313A2 (en) | 2011-01-14 | 2012-07-19 | The Regents Of The University Of California | Therapeutic antibodies against ror-1 protein and methods for use of same |
US20150183885A1 (en) * | 2012-06-08 | 2015-07-02 | Glenmark Pharmaceuticals S.A. | Anti-trka antibodies with enhanced inhibitory properties and derivatives thereof |
TW201922795A (zh) | 2012-09-10 | 2019-06-16 | 愛爾蘭商尼歐托普生物科學公司 | 抗mcam抗體及相關使用方法 |
WO2014205487A2 (en) * | 2013-06-26 | 2014-12-31 | Elashwah Mohammed | System and method for detecting prescription, transcription and administration errors in drug administration |
CN103760358A (zh) * | 2013-11-12 | 2014-04-30 | 赵铁铭 | 一种用于检测冯维勒布兰德因子的试剂及其制备方法和应用 |
US9737592B1 (en) | 2014-02-14 | 2017-08-22 | David Gordon Bermudes | Topical and orally administered protease inhibitors and bacterial vectors for the treatment of disorders and methods of treatment |
CA2938933A1 (en) | 2014-03-12 | 2015-09-17 | Prothena Biosciences Limited | Anti-laminin4 antibodies specific for lg4-5 |
WO2015136471A1 (en) * | 2014-03-12 | 2015-09-17 | Prothena Biosciences Limited | Anti-laminin4 antibodies specific for lg1-3 |
EP3116911B8 (en) | 2014-03-12 | 2019-10-23 | Prothena Biosciences Limited | Anti-mcam antibodies and associated methods of use |
WO2016000039A1 (en) * | 2014-07-02 | 2016-01-07 | Csl Limited | Modified von willebrand factor |
US11155615B2 (en) | 2015-05-18 | 2021-10-26 | Eureka Therapeutics, Inc. | Anti-ROR1 antibodies |
JP6941165B2 (ja) * | 2016-09-30 | 2021-09-29 | ノボ・ノルデイスク・エー/エス | 薬剤注射の分布の平均およびばらつきを表す用量履歴を通信するシステムおよび方法 |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
US11576840B1 (en) * | 2019-04-26 | 2023-02-14 | INMAR Rx SOLUTIONS, INC. | Medication inventory system including RFID based medication discrepancy determination and related methods |
GB202105625D0 (en) * | 2021-04-20 | 2021-06-02 | Ip2Ipo Innovations Ltd | Von willebrand factor (VWF) inhibitors |
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CA2682212C (en) * | 2007-03-20 | 2014-05-06 | Eli Lilly And Company | Anti-sclerostin antibodies |
-
2009
- 2009-01-09 AR ARP090100075A patent/AR070141A1/es unknown
- 2009-01-21 PE PE2009000068A patent/PE20091351A1/es not_active Application Discontinuation
- 2009-01-22 BR BRPI0905761-7A patent/BRPI0905761A2/pt not_active IP Right Cessation
- 2009-01-22 CN CN2009801028919A patent/CN101932606A/zh active Pending
- 2009-01-22 CL CL2009000123A patent/CL2009000123A1/es unknown
- 2009-01-22 CA CA2712221A patent/CA2712221A1/en not_active Abandoned
- 2009-01-22 DK DK09703856.6T patent/DK2245069T3/da active
- 2009-01-22 KR KR1020107018544A patent/KR20100113589A/ko not_active Application Discontinuation
- 2009-01-22 WO PCT/IB2009/000124 patent/WO2009093138A1/en active Application Filing
- 2009-01-22 EP EP09703856.6A patent/EP2245069B1/en not_active Not-in-force
- 2009-01-22 ES ES09703856.6T patent/ES2495092T3/es active Active
- 2009-01-22 AU AU2009207340A patent/AU2009207340A1/en not_active Abandoned
- 2009-01-22 MX MX2010008060A patent/MX2010008060A/es not_active Application Discontinuation
- 2009-01-22 AP AP2010005332A patent/AP2010005332A0/en unknown
- 2009-01-22 EA EA201070730A patent/EA201070730A1/ru unknown
- 2009-01-22 JP JP2010543586A patent/JP2011510622A/ja not_active Withdrawn
- 2009-01-23 US US12/358,682 patent/US8236315B2/en active Active
- 2009-01-23 TW TW098102855A patent/TW200938630A/zh unknown
-
2010
- 2010-07-21 IL IL207134A patent/IL207134A0/en unknown
- 2010-07-28 ZA ZA2010/05373A patent/ZA201005373B/en unknown
- 2010-08-02 CO CO10093896A patent/CO6280500A2/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AP2010005332A0 (en) | 2010-08-31 |
CL2009000123A1 (es) | 2010-02-05 |
IL207134A0 (en) | 2010-12-30 |
AR070141A1 (es) | 2010-03-17 |
KR20100113589A (ko) | 2010-10-21 |
US8236315B2 (en) | 2012-08-07 |
ZA201005373B (en) | 2011-06-29 |
BRPI0905761A2 (pt) | 2015-07-14 |
ES2495092T3 (es) | 2014-09-16 |
EP2245069A1 (en) | 2010-11-03 |
EP2245069B1 (en) | 2014-06-18 |
AU2009207340A1 (en) | 2009-07-30 |
CN101932606A (zh) | 2010-12-29 |
DK2245069T3 (da) | 2014-09-01 |
CO6280500A2 (es) | 2011-05-20 |
TW200938630A (en) | 2009-09-16 |
CA2712221A1 (en) | 2009-07-30 |
US20090232804A1 (en) | 2009-09-17 |
WO2009093138A1 (en) | 2009-07-30 |
JP2011510622A (ja) | 2011-04-07 |
MX2010008060A (es) | 2010-08-10 |
EA201070730A1 (ru) | 2011-04-29 |
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