MA44146A - Combinaison d'anticorps anti-pd-1 et d'anticorps bispécifiques anti-cd20/anti-cd3 pour traiter le cancer - Google Patents

Combinaison d'anticorps anti-pd-1 et d'anticorps bispécifiques anti-cd20/anti-cd3 pour traiter le cancer

Info

Publication number
MA44146A
MA44146A MA044146A MA44146A MA44146A MA 44146 A MA44146 A MA 44146A MA 044146 A MA044146 A MA 044146A MA 44146 A MA44146 A MA 44146A MA 44146 A MA44146 A MA 44146A
Authority
MA
Morocco
Prior art keywords
antibodies
combination
treat cancer
bispecific
bispecific anti
Prior art date
Application number
MA044146A
Other languages
English (en)
Other versions
MA44146B1 (fr
Inventor
Carrie Brownstein
Israel Lowy
Gavin Thurston
Bindu Varghese
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MA44146A publication Critical patent/MA44146A/fr
Publication of MA44146B1 publication Critical patent/MA44146B1/fr

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061Blood cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
MA44146A 2015-12-22 2016-12-21 Combinaison d'anticorps anti-pd-1 et d'anticorps bispécifiques anti-cd20/anti-cd3 pour traiter le cancer MA44146B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562270749P 2015-12-22 2015-12-22
PCT/US2016/068030 WO2017112775A1 (fr) 2015-12-22 2016-12-21 Combinaison d'anticorps anti-pd-1 et d'anticorps bispécifiques anti-cd20/anti-cd3 pour traiter le cancer

Publications (2)

Publication Number Publication Date
MA44146A true MA44146A (fr) 2018-10-31
MA44146B1 MA44146B1 (fr) 2023-10-31

Family

ID=57799835

Family Applications (1)

Application Number Title Priority Date Filing Date
MA44146A MA44146B1 (fr) 2015-12-22 2016-12-21 Combinaison d'anticorps anti-pd-1 et d'anticorps bispécifiques anti-cd20/anti-cd3 pour traiter le cancer

Country Status (27)

Country Link
US (2) US20170174779A1 (fr)
EP (1) EP3394103B1 (fr)
JP (1) JP7126941B2 (fr)
KR (1) KR20180089444A (fr)
CN (1) CN108473578A (fr)
AU (1) AU2016378721B2 (fr)
BR (1) BR112018012801B1 (fr)
CA (1) CA3009161A1 (fr)
DK (1) DK3394103T3 (fr)
EA (1) EA201891428A1 (fr)
ES (1) ES2954153T3 (fr)
FI (1) FI3394103T3 (fr)
HK (1) HK1255040A1 (fr)
HR (1) HRP20231156T1 (fr)
HU (1) HUE063377T2 (fr)
IL (1) IL259924A (fr)
LT (1) LT3394103T (fr)
MA (1) MA44146B1 (fr)
MD (1) MD3394103T2 (fr)
MX (1) MX2018007613A (fr)
PL (1) PL3394103T3 (fr)
PT (1) PT3394103T (fr)
RS (1) RS64588B1 (fr)
SG (2) SG11201804765UA (fr)
SI (1) SI3394103T1 (fr)
WO (1) WO2017112775A1 (fr)
ZA (1) ZA201804681B (fr)

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Also Published As

Publication number Publication date
AU2016378721B2 (en) 2024-01-11
AU2016378721A1 (en) 2018-07-19
EP3394103A1 (fr) 2018-10-31
ES2954153T3 (es) 2023-11-20
PL3394103T3 (pl) 2023-11-20
JP2019503361A (ja) 2019-02-07
PT3394103T (pt) 2023-09-04
HK1255040A1 (zh) 2019-08-02
IL259924A (en) 2018-07-31
BR112018012801A2 (pt) 2018-12-04
SG10202005670TA (en) 2020-07-29
MX2018007613A (es) 2018-09-21
SG11201804765UA (en) 2018-07-30
MD3394103T2 (ro) 2023-11-30
US20210214457A1 (en) 2021-07-15
FI3394103T3 (fi) 2023-08-30
RS64588B1 (sr) 2023-10-31
US20170174779A1 (en) 2017-06-22
MA44146B1 (fr) 2023-10-31
HUE063377T2 (hu) 2024-01-28
SI3394103T1 (sl) 2023-10-30
CA3009161A1 (fr) 2017-06-29
KR20180089444A (ko) 2018-08-08
HRP20231156T1 (hr) 2024-01-05
ZA201804681B (en) 2019-04-24
EP3394103B1 (fr) 2023-06-28
CN108473578A (zh) 2018-08-31
EA201891428A1 (ru) 2018-12-28
DK3394103T3 (da) 2023-09-04
WO2017112775A1 (fr) 2017-06-29
BR112018012801B1 (pt) 2024-03-12
LT3394103T (lt) 2023-09-11
JP7126941B2 (ja) 2022-08-29

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