MA39481A - Thérapies ciblées - Google Patents
Thérapies cibléesInfo
- Publication number
- MA39481A MA39481A MA039481A MA39481A MA39481A MA 39481 A MA39481 A MA 39481A MA 039481 A MA039481 A MA 039481A MA 39481 A MA39481 A MA 39481A MA 39481 A MA39481 A MA 39481A
- Authority
- MA
- Morocco
- Prior art keywords
- targeted therapies
- therapies
- targeted
- Prior art date
Links
- 238000002626 targeted therapy Methods 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/545—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Immunology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461947108P | 2014-03-03 | 2014-03-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA39481A true MA39481A (fr) | 2015-09-11 |
Family
ID=54055980
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA039481A MA39481A (fr) | 2014-03-03 | 2015-03-03 | Thérapies ciblées |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US10232049B2 (enExample) |
| EP (1) | EP3129064B1 (enExample) |
| JP (2) | JP6576942B6 (enExample) |
| KR (1) | KR20160126078A (enExample) |
| CN (1) | CN106456795A (enExample) |
| AU (1) | AU2015224576A1 (enExample) |
| CA (1) | CA2941618A1 (enExample) |
| IL (1) | IL247624A0 (enExample) |
| MA (1) | MA39481A (enExample) |
| WO (1) | WO2015134464A2 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3131586A4 (en) | 2014-03-18 | 2017-10-25 | Madrigal Pharmaceuticals, Inc. | Targeted therapeutics |
| PL3660004T3 (pl) * | 2016-10-11 | 2023-10-02 | Arvinas Operations, Inc. | Związki i sposoby do ukierunkowanej degradacji receptora androgenowego |
| EP3641767A4 (en) * | 2017-06-20 | 2021-03-10 | Tarveda Therapeutics, Inc. | COMBINATION THERAPIES WITH TARGETED THERAPEUTICS |
| US11491145B2 (en) * | 2017-06-20 | 2022-11-08 | Madrigal Pharmaceuticals, Inc. | Combination therapies comprising targeted therapeutics |
| EP3641647A4 (en) * | 2017-06-20 | 2021-05-05 | Madrigal Pharmaceuticals, Inc. | TARGETED THERAPEUTICS |
| CN109512821B (zh) * | 2017-09-18 | 2021-06-08 | 无锡富泽药业有限公司 | 一种克唑替尼与17-aag复合聚合物纳米胶束注射剂、其制备方法及其应用 |
| TW201936179A (zh) * | 2017-12-14 | 2019-09-16 | 美商塔維達治療公司 | Hsp90-靶定之共軛物及其調配物 |
| CN112566666A (zh) | 2018-05-14 | 2021-03-26 | 努瓦申生物公司 | 靶向抗癌核激素受体的化合物 |
| JP2021525766A (ja) * | 2018-06-01 | 2021-09-27 | ターベダ セラピューティクス インコーポレイテッドTarveda Therapeutics,Inc. | 併用療法 |
| CN109575044A (zh) * | 2018-12-21 | 2019-04-05 | 西安交通大学 | 2-(喜树碱-10-氧基)乙酰胺类化合物和应用 |
| CA3131034A1 (en) | 2019-03-06 | 2020-09-10 | Matthew J. Sharp | Abiraterone prodrugs |
| WO2020210451A1 (en) * | 2019-04-10 | 2020-10-15 | Dana-Farber Cancer Institute, Inc. | Degraders of fibroblast growth factor receptor 2 (fgfr2) |
| AU2020274113A1 (en) | 2019-05-14 | 2021-11-11 | Nuvation Bio Inc. | Anti-cancer nuclear hormone receptor-targeting compounds |
| CN110003181B (zh) * | 2019-05-22 | 2020-08-28 | 北京凯恩梅格医药科技有限公司 | 一种基于克唑替尼结构的c-Met/HDAC双靶点抑制剂及其合成方法与应用 |
| WO2021191219A1 (en) * | 2020-03-23 | 2021-09-30 | Helmholtz-Zentrum für Infektionsforschung GmbH | N-phenyl-3-mercaptopropanamide derivatives as metallo-beta-lactamase inhibitors for the treatment of bacterial infections |
| CN111499623B (zh) * | 2020-04-01 | 2022-07-08 | 南京缘聚医药科技有限公司 | 一类非核苷抗肿瘤药物的噻唑酮脲衍生物及其药物用途 |
| JP2023524599A (ja) | 2020-05-09 | 2023-06-12 | アルビナス・オペレーションズ・インコーポレイテッド | 二官能性化合物を製造する方法、二官能性化合物の超高純度形態、及びそれらを含む剤形 |
| JP2024504932A (ja) | 2021-01-13 | 2024-02-02 | モンテ ローザ セラピューティクス, インコーポレイテッド | イソインドリノン化合物 |
| US11957696B2 (en) | 2021-02-15 | 2024-04-16 | Propella Therapeutics, Inc. | Abiraterone prodrugs |
| IL306010A (en) | 2021-03-23 | 2023-11-01 | Nuvation Bio Inc | Anticancer compounds against the nuclear hormone receptor |
| CA3218577A1 (en) | 2021-05-03 | 2022-11-10 | Nuvation Bio Inc. | Anti-cancer nuclear hormone receptor-targeting compounds |
| CN114933584B (zh) * | 2021-08-09 | 2022-12-27 | 上海贵之言医药科技有限公司 | 一种二氢-2h-异吲哚酯类化合物 |
| CN116354933B (zh) * | 2021-12-27 | 2025-06-20 | 青岛普泰科生物医药科技有限公司 | 作为雄激素受体调节剂的杂环化合物及其应用 |
| CN115650975B (zh) * | 2022-08-23 | 2024-07-02 | 四川大学华西医院 | 一种靶向降解人表皮生长因子受体2的蛋白降解靶向嵌合体化合物及其应用 |
| WO2024197429A1 (zh) * | 2023-03-24 | 2024-10-03 | 青岛普泰科生物医药科技有限公司 | 作为雄激素受体调节剂的杂环化合物及其应用 |
| WO2024199473A1 (en) * | 2023-03-31 | 2024-10-03 | Ranok Therapeutics (Hangzhou) Co. Ltd. | Methods and compositions for targeted protein degradation |
| US12496301B2 (en) | 2023-12-08 | 2025-12-16 | Arvinas Operations, Inc. | Use of androgen receptor degrader for the treatment of spinal and bulbar muscular atrophy |
| WO2025199665A1 (en) * | 2024-03-23 | 2025-10-02 | Ranok Therapeutics (Hangzhou) Co. Ltd. | Methods and compositions for targeted protein degradation |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6214345B1 (en) | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
| DE69942578D1 (de) | 1998-05-22 | 2010-08-26 | Univ R | Bifunktionelle moleküle sowie darauf basierende therapien. |
| US8617514B2 (en) | 1999-02-22 | 2013-12-31 | Georgetown University | Tumor-targeted nanodelivery systems to improve early MRI detection of cancer |
| AU769235B2 (en) | 1999-04-09 | 2004-01-22 | Sloan-Kettering Institute For Cancer Research | Methods and compositions for degradation and/or inhibition of her-family tyrosine kinases |
| WO2002036171A1 (en) | 2000-11-02 | 2002-05-10 | Sloan Kettering Institute For Cancer Research | Methods for enhancing the efficacy of cytotoxic agents through the use of hsp90 inhibitors |
| US7671010B2 (en) | 2002-08-30 | 2010-03-02 | The Board Of Regents Of The University Of Texas System | Compositions and methods of use of targeting peptides for diagnosis and therapy of human cancer |
| EP1519735A4 (en) | 2001-12-12 | 2006-01-11 | Conforma Therapeutic Corp | ASSAYS AND DEVICES FOR DETERMINING AND MODULATING HSP90 BINDING ACTIVITY |
| GB0211578D0 (en) | 2002-05-21 | 2002-06-26 | Univ Belfast | Medicaments |
| US6759416B2 (en) | 2002-08-06 | 2004-07-06 | Panorama Research, Inc. | Anticancer conjugates of camptothecin and unsaturated fatty acids |
| US7769423B2 (en) | 2002-09-11 | 2010-08-03 | Duke University | MRI imageable liposomes for the evaluation of treatment efficacy, thermal distribution, and demonstration of dose painting |
| EP1581261A4 (en) | 2002-12-12 | 2009-10-21 | Conforma Therapeutics Corp | CYTOTOXINS AND DIAGNOSTIC IMAGING AGENTS COMPRISING HSP90 LIGANDS |
| US20070297980A1 (en) | 2004-03-26 | 2007-12-27 | Qian Xie | Geldanamycin and Derivatives Inhibit Cancer Invasion and Identify Novel Targets |
| NZ555158A (en) | 2004-11-18 | 2010-09-30 | Synta Pharmaceuticals Corp | Triazole compounds that modulate Hsp90 activity |
| WO2006084030A2 (en) | 2005-02-01 | 2006-08-10 | Sloan-Kettering Institute For Cancer Research | Small-molecule hsp90 inhibitors |
| WO2007053792A2 (en) | 2005-11-05 | 2007-05-10 | Amplyx Pharmaceuticals, Inc. | Improving the pharmacokinetics of protease inhibitors and other drugs |
| US8293726B2 (en) | 2005-12-02 | 2012-10-23 | Vianova Labs, Inc. | Treatment of cancer and other diseases |
| GB0526615D0 (en) | 2005-12-30 | 2006-02-08 | Novartis Ag | Organic compounds |
| CA2653332A1 (en) | 2006-05-25 | 2007-12-06 | Synta Pharmaceuticals Corp. | Triazole compounds that modulate hsp90 activity |
| ES2645095T3 (es) | 2006-06-30 | 2017-12-04 | Sloan-Kettering Institute For Cancer Research | Tratamiento de enfermedades neurodegenerativas a través de la inhibición de Hsp90 |
| JP5721949B2 (ja) | 2006-10-12 | 2015-05-20 | アステックス、セラピューティックス、リミテッドAstex Therapeutics Limited | 複合薬剤 |
| US20100280032A1 (en) | 2006-10-26 | 2010-11-04 | Synta Pharmaceuticals Corp. | Method for treating inflammatory disorders |
| WO2008108386A1 (ja) * | 2007-03-05 | 2008-09-12 | Kyowa Hakko Kirin Co., Ltd. | 医薬組成物 |
| US20120003160A1 (en) | 2007-06-29 | 2012-01-05 | Amag Pharmaceuticals, Inc. | Macrophage-Enhanced MRI (MEMRI) in a Single Imaging Session |
| WO2009009067A2 (en) | 2007-07-09 | 2009-01-15 | Kwon Glen S | Micelle encapsulation of theropeutic agents |
| US8466140B2 (en) | 2007-09-10 | 2013-06-18 | University Of Massachusetts | Mitochondria-targeted anti-tumor agents |
| WO2010028389A1 (en) | 2008-09-08 | 2010-03-11 | The Methodist Hospital Research Institute | Image-guided energy deposition for targeted drug delivery |
| WO2011116181A1 (en) | 2010-03-17 | 2011-09-22 | Caris Life Sciences, Inc. | Theranostic and diagnostic methods using sparc and hsp90 |
| PL2349274T3 (pl) | 2008-09-17 | 2025-09-22 | Endocyte, Inc. | Koniugaty antyfolianów wiążące się z receptorem folianów |
| US20110217241A1 (en) | 2008-11-14 | 2011-09-08 | University Of Maryland, Baltimore | Conjugates of 19f mr imaging tracers for use in multi-chromic mri imaging |
| KR20120053042A (ko) * | 2009-08-17 | 2012-05-24 | 로슈 글리카트 아게 | 표적화된 면역접합체 |
| WO2011133879A2 (en) | 2010-04-22 | 2011-10-27 | University Of Massachusetts | Combination therapies with mitochondrial-targeted anti-tumor agents |
| RU2013122898A (ru) | 2010-10-22 | 2014-11-27 | Университы До Страсбур | Похоксимовые конъюгаты, применимые для лечения связанных с hsp90 патологий, композиция и способ лечения с их помощью |
| WO2012096919A1 (en) * | 2011-01-11 | 2012-07-19 | Synta Pharmaceuticals Corp. | Combination therapy of hsp90 inhibitory compounds with proteasome inhibitors |
| GB201106814D0 (en) * | 2011-04-21 | 2011-06-01 | Astex Therapeutics Ltd | New compounds |
| EP2766723A4 (en) * | 2011-10-12 | 2015-06-10 | Univ North Carolina | MULTIPLEXED KINASE HEMMER BEADS AND THEIR USE |
| JP6286358B2 (ja) * | 2011-11-11 | 2018-02-28 | ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. | プロテアソーム阻害剤に応答するバイオマーカー |
| US9475815B2 (en) * | 2012-02-23 | 2016-10-25 | Bayer Intelletual Property Gmbh | Substituted benzothienyl-pyrrolotriazines and uses thereof |
| US20140079636A1 (en) * | 2012-04-16 | 2014-03-20 | Dinesh U. Chimmanamada | Targeted therapeutics |
| ES2734259T3 (es) | 2012-05-15 | 2019-12-05 | Concortis Biosystems Corp | Conjugados de fármacos, métodos de conjugación y usos de los mismos |
| AU2012395148B2 (en) | 2012-11-24 | 2016-10-27 | Hangzhou Dac Biotech Co., Ltd. | Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules |
| EP3035938B1 (en) | 2013-09-10 | 2020-08-19 | Madrigal Pharmaceuticals, Inc. | Targeted therapeutics |
| DK3054991T3 (da) | 2013-10-11 | 2019-05-06 | Mersana Therapeutics Inc | Protein-polymer-lægemiddelkonjugater |
| RU2016134258A (ru) | 2013-10-15 | 2018-02-28 | Сорренто Терапьютикс Инк. | Конъюгат лекарственного средства с направляющей молекулой и двумя различными лекарственными средствами |
| WO2015066053A2 (en) | 2013-10-28 | 2015-05-07 | Synta Pharmaceuticals Corp. | Targeted therapeutics |
| ES2918375T3 (es) | 2013-12-20 | 2022-07-15 | Biomed Valley Discoveries Inc | Tratamientos contra el cáncer usando combinaciones de inhibidores de la ruta de PI3K/Akt y ERK |
| JP2017505777A (ja) * | 2014-01-29 | 2017-02-23 | シンタ ファーマスーティカルズ コーポレーション | 標的化治療薬 |
-
2015
- 2015-03-03 AU AU2015224576A patent/AU2015224576A1/en not_active Abandoned
- 2015-03-03 KR KR1020167027259A patent/KR20160126078A/ko not_active Withdrawn
- 2015-03-03 EP EP15758717.1A patent/EP3129064B1/en active Active
- 2015-03-03 CA CA2941618A patent/CA2941618A1/en not_active Abandoned
- 2015-03-03 CN CN201580022696.0A patent/CN106456795A/zh active Pending
- 2015-03-03 MA MA039481A patent/MA39481A/fr unknown
- 2015-03-03 JP JP2016555457A patent/JP6576942B6/ja not_active Expired - Fee Related
- 2015-03-03 WO PCT/US2015/018442 patent/WO2015134464A2/en not_active Ceased
-
2016
- 2016-08-30 US US15/251,255 patent/US10232049B2/en active Active
- 2016-09-04 IL IL247624A patent/IL247624A0/en unknown
-
2018
- 2018-10-25 US US16/170,733 patent/US10675360B2/en not_active Expired - Fee Related
-
2019
- 2019-08-21 JP JP2019151197A patent/JP2019196406A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20170049899A1 (en) | 2017-02-23 |
| AU2015224576A1 (en) | 2016-09-22 |
| JP2017507150A (ja) | 2017-03-16 |
| JP2019196406A (ja) | 2019-11-14 |
| US10232049B2 (en) | 2019-03-19 |
| EP3129064A4 (en) | 2017-10-25 |
| CN106456795A (zh) | 2017-02-22 |
| US20190060478A1 (en) | 2019-02-28 |
| EP3129064B1 (en) | 2020-01-01 |
| KR20160126078A (ko) | 2016-11-01 |
| IL247624A0 (en) | 2016-11-30 |
| JP6576942B6 (ja) | 2019-11-27 |
| CA2941618A1 (en) | 2015-09-11 |
| WO2015134464A2 (en) | 2015-09-11 |
| JP6576942B2 (ja) | 2019-09-18 |
| EP3129064A2 (en) | 2017-02-15 |
| WO2015134464A3 (en) | 2015-10-29 |
| US10675360B2 (en) | 2020-06-09 |
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