MA38898A1 - Combinaison de facteurs épigénétiques et de composés bispécifiques ciblant cd33 et cd3 dans le traitement de la leucémie myéloïde - Google Patents
Combinaison de facteurs épigénétiques et de composés bispécifiques ciblant cd33 et cd3 dans le traitement de la leucémie myéloïdeInfo
- Publication number
- MA38898A1 MA38898A1 MA38898A MA38898A MA38898A1 MA 38898 A1 MA38898 A1 MA 38898A1 MA 38898 A MA38898 A MA 38898A MA 38898 A MA38898 A MA 38898A MA 38898 A1 MA38898 A1 MA 38898A1
- Authority
- MA
- Morocco
- Prior art keywords
- myeloid leukemia
- treatment
- epigenetic
- targeting
- factor
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La présente invention concerne une composition de facteurs épigénétiques et de composés bispécifiques ciblant cd33 et cd3 dans le traitement de la leucémie myéloïde, le facteur épigénétique étant sélectionné parmi les inhibiteurs d'histone désacétylase (hdac), les inhibiteurs d'adn méthyltransférase (dnmt) i, l'hydroxyurée, le facteur de croissance des granulocytes (g-csf), les inhibiteurs d'histone déméthylase et l'atra (acide rétinoïque totalement trans). L'invention concerne donc une composition pharmaceutique contenant un composé ciblant cd33 et au moins un facteur épigénétique, la composition pharmaceutique servant à améliorer et/ou à traiter une leucémie myéloïde, le facteur épigénétique augmentant la sensibilité d'un patient à un composé ciblant cd33. De plus, l'invention concerne l'utilisation d'au moins un facteur épigénétique pour augmenter la sensibilité d'un patient souffrant d'une leucémie myéloïde à un traitement avec un composé ciblant cd33, un procédé de traitement d'une leucémie myéloïde, le procédé comprenant l'administration d'au moins un facteur épigénétique et d'un composé ciblant cd33 à un patient ayant besoin d'un tel traitement et un kit comprenant une composition pharmaceutique de l'invention ou un facteur épigénétique de l'invention et un composé bispécifique ciblant cd33.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361877714P | 2013-09-13 | 2013-09-13 | |
PCT/EP2014/069575 WO2015036583A2 (fr) | 2013-09-13 | 2014-09-15 | Combinaison de facteurs épigénétiques et de composés bispécifiques ciblant cd33 et cd3 dans le traitement de la leucémie myéloïde |
Publications (1)
Publication Number | Publication Date |
---|---|
MA38898A1 true MA38898A1 (fr) | 2018-01-31 |
Family
ID=51690351
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA46164A MA46164B1 (fr) | 2013-09-13 | 2014-09-15 | Combinaison de facteurs epignetique et de composes bispecifiques ciblant cd33 et cd3 dans le traitement de la leucémie myéloïde |
MA38898A MA38898A1 (fr) | 2013-09-13 | 2016-03-09 | Combinaison de facteurs épigénétiques et de composés bispécifiques ciblant cd33 et cd3 dans le traitement de la leucémie myéloïde |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA46164A MA46164B1 (fr) | 2013-09-13 | 2014-09-15 | Combinaison de facteurs epignetique et de composes bispecifiques ciblant cd33 et cd3 dans le traitement de la leucémie myéloïde |
Country Status (28)
Country | Link |
---|---|
US (1) | US10933132B2 (fr) |
EP (1) | EP3043794B1 (fr) |
JP (1) | JP6530409B2 (fr) |
KR (1) | KR102366470B1 (fr) |
CN (2) | CN111888474A (fr) |
AP (1) | AP2016009132A0 (fr) |
AR (1) | AR097648A1 (fr) |
AU (2) | AU2014320246B2 (fr) |
CA (1) | CA2923354C (fr) |
CL (1) | CL2016000564A1 (fr) |
DK (1) | DK3043794T3 (fr) |
EA (1) | EA036476B1 (fr) |
HK (1) | HK1225975A1 (fr) |
HU (1) | HUE056867T2 (fr) |
IL (1) | IL278527B (fr) |
JO (1) | JO3597B1 (fr) |
LT (1) | LT3043794T (fr) |
MA (2) | MA46164B1 (fr) |
MX (1) | MX2016003197A (fr) |
MY (1) | MY185611A (fr) |
NZ (1) | NZ716448A (fr) |
PH (1) | PH12016500434B1 (fr) |
SG (2) | SG10201801777YA (fr) |
SI (1) | SI3043794T1 (fr) |
TW (1) | TWI688401B (fr) |
UA (1) | UA123199C2 (fr) |
WO (1) | WO2015036583A2 (fr) |
ZA (1) | ZA201600528B (fr) |
Families Citing this family (32)
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US9212225B1 (en) * | 2014-07-01 | 2015-12-15 | Amphivena Therapeutics, Inc. | Bispecific CD33 and CD3 binding proteins |
CN108289949B (zh) * | 2015-05-29 | 2022-04-12 | 安普希韦纳治疗公司 | 双特异性cd33和cd3结合蛋白质的使用方法 |
TWI796283B (zh) | 2015-07-31 | 2023-03-21 | 德商安美基研究(慕尼黑)公司 | Msln及cd3抗體構築體 |
TWI829617B (zh) | 2015-07-31 | 2024-01-21 | 德商安美基研究(慕尼黑)公司 | Flt3及cd3抗體構築體 |
JO3620B1 (ar) | 2015-08-05 | 2020-08-27 | Amgen Res Munich Gmbh | مثبطات نقطة فحص مناعية للاستخدام في علاج سرطانات محمولة عبر الدم |
JP6945532B2 (ja) * | 2015-12-16 | 2021-10-06 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 改善された組換え体作製方法 |
TWI797073B (zh) * | 2016-01-25 | 2023-04-01 | 德商安美基研究(慕尼黑)公司 | 包含雙特異性抗體建構物之醫藥組合物 |
EA039859B1 (ru) | 2016-02-03 | 2022-03-21 | Эмджен Рисерч (Мюник) Гмбх | Биспецифические конструкты антител, связывающие egfrviii и cd3 |
JOP20170091B1 (ar) * | 2016-04-19 | 2021-08-17 | Amgen Res Munich Gmbh | إعطاء تركيبة ثنائية النوعية ترتبط بـ cd33 وcd3 للاستخدام في طريقة لعلاج اللوكيميا النخاعية |
DK3600419T5 (en) * | 2017-03-20 | 2024-05-27 | Vaccinex Inc | Treatment of cancer with a semaphorin-4d antibody in combination with an epigenetic modulating agent |
WO2019103531A1 (fr) * | 2017-11-24 | 2019-05-31 | 충북대학교 산학협력단 | Anticorps anti-icam4 et composition pour le diagnostic et le traitement d'une maladie associée à une cellule d'expression d'icam4 |
KR102090407B1 (ko) * | 2017-11-24 | 2020-03-17 | 충북대학교 산학협력단 | 항-icam4 항체 및 icam4 발현 세포와 관련된 질병의 진단 및 치료용 조성물 |
WO2019108789A1 (fr) | 2017-11-29 | 2019-06-06 | The Trustees Of Columbia University In The City Of New York | Polythérapie contre un lymphome |
JOP20190116A1 (ar) | 2018-05-24 | 2019-11-24 | Janssen Biotech Inc | الأجسام المضادة لتكتل التمايز 33 (cd33)، والأجسام المضادة ثنائية النوعية لتكتل التمايز 33 (cd33)/تكتل التمايز 3 (cd3) واستخداماتها |
AU2019313444A1 (en) * | 2018-07-30 | 2021-02-18 | Amgen Inc. | Prolonged administration of a bispecific antibody construct binding to CD33 and CD3 |
WO2020056170A1 (fr) | 2018-09-12 | 2020-03-19 | Fred Hutchinson Cancer Research Center | Réduction de l'expression de cd33 pour protéger sélectivement des cellules thérapeutiques |
CN113045664B (zh) | 2019-11-28 | 2023-05-12 | 尚健单抗(北京)生物技术有限公司 | 一种分离的结合抗原axl的蛋白及其用途 |
EP4268895A3 (fr) | 2019-12-09 | 2024-01-10 | Chigenovo Co., Ltd. | Utilisations de cyp4v2 et rdcvf dans la préparation de médicaments |
CN112079934B (zh) | 2019-12-17 | 2021-01-29 | 合源生物科技(天津)有限公司 | 一种靶向cd19的嵌合抗原受体及其用途 |
WO2021136263A1 (fr) | 2020-01-02 | 2021-07-08 | 江苏茂行科技有限公司 | Cellule effectrice immunitaire modifiée et son procédé de préparation |
CN113481165B (zh) * | 2020-07-16 | 2022-06-03 | 山东博安生物技术股份有限公司 | 分泌双特异性t细胞衔接子的car-t及治疗实体肿瘤的应用 |
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CN112630438B (zh) * | 2021-03-08 | 2021-06-22 | 信纳克(北京)生化标志物检测医学研究有限责任公司 | 抗体组合物及其筛查髓系疾病及检测免疫检查点的应用 |
KR20230162797A (ko) | 2021-03-22 | 2023-11-28 | 스타맵 바이오로직스 (쑤저우) 씨오., 엘티디 | 뉴몰리신을 표적으로 하는 항원 결합 단백질 및 이의 용도 |
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