MA33938B1 - 5-alcynyl-pyrimidines - Google Patents

5-alcynyl-pyrimidines

Info

Publication number
MA33938B1
MA33938B1 MA35082A MA35082A MA33938B1 MA 33938 B1 MA33938 B1 MA 33938B1 MA 35082 A MA35082 A MA 35082A MA 35082 A MA35082 A MA 35082A MA 33938 B1 MA33938 B1 MA 33938B1
Authority
MA
Morocco
Prior art keywords
pyrimidine
alkynyl
medicament
excessive
preparing
Prior art date
Application number
MA35082A
Other languages
Arabic (ar)
English (en)
Inventor
Siegfried Schneider
Dirk Kessler
Der Veen Lars Van
Tobias Wunberg
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42140100&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA33938(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of MA33938B1 publication Critical patent/MA33938B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention englobe des composés de formule générale (1), r1 à r4 r3 étant définis comme dans la revendication 1, qui conviennent au traitement de maladies caractérisées par une prolifération cellulaire excessive ou anormale, et leur utilisation pour préparer un médicament ayant les propriétés ci-dessus mentionnées.
MA35082A 2010-01-26 2012-07-18 5-alcynyl-pyrimidines MA33938B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10151722 2010-01-26
PCT/EP2011/051060 WO2011092197A1 (fr) 2010-01-26 2011-01-26 5-alcynyl pyrimidines et leur utilisation comme inhibiteurs de kinases

Publications (1)

Publication Number Publication Date
MA33938B1 true MA33938B1 (fr) 2013-01-02

Family

ID=42140100

Family Applications (1)

Application Number Title Priority Date Filing Date
MA35082A MA33938B1 (fr) 2010-01-26 2012-07-18 5-alcynyl-pyrimidines

Country Status (23)

Country Link
US (1) US8618111B2 (fr)
EP (1) EP2528910B1 (fr)
JP (1) JP5670479B2 (fr)
KR (1) KR20130030742A (fr)
CN (1) CN102781931A (fr)
AP (1) AP2012006361A0 (fr)
AR (1) AR080019A1 (fr)
AU (1) AU2011209343A1 (fr)
BR (1) BR112012018454A2 (fr)
CA (1) CA2787396A1 (fr)
CL (1) CL2012001926A1 (fr)
CO (1) CO6592046A2 (fr)
EA (1) EA201201049A1 (fr)
EC (1) ECSP12012110A (fr)
IN (1) IN2012DN06600A (fr)
MA (1) MA33938B1 (fr)
MX (1) MX2012008359A (fr)
PE (1) PE20121527A1 (fr)
SG (1) SG182676A1 (fr)
TN (1) TN2012000370A1 (fr)
TW (1) TW201139412A (fr)
UY (1) UY33198A (fr)
WO (1) WO2011092197A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8633183B2 (en) * 2010-01-26 2014-01-21 Boehringer Ingelheim International Gmbh 5-alkynyl-pyrimidines
US8466162B2 (en) * 2011-01-26 2013-06-18 Boehringer Ingelheim International Gmbh 5-alkynyl-pyridines

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3832570A1 (de) * 1988-09-24 1990-03-29 Hoechst Ag 7-substituierte derivate der 3,5-dihydroxyhept-6-insaeure, verfahren zur ihrer herstellung, ihre verwendung als arzneimittel, sowie zwischenprodukte
WO1994014780A1 (fr) 1992-12-18 1994-07-07 The Wellcome Foundation Limited Derives de pyrimidine, de pyridine, de pteridinone et d'indazole utilises comme inhibiteurs enzymatiques
US5622954A (en) 1994-05-11 1997-04-22 Fmc Corporation 5[W(substituted aryl)alkenylene and alkynylene]-2,4-diaminopyrimidines as pesticides
EP1303495B1 (fr) * 2000-07-24 2010-05-26 Krenitsky Pharmaceuticals, Inc. 5-alkynyle pyrimidines substituees avec activite neurotrophique
JP4960085B2 (ja) * 2003-03-19 2012-06-27 エクセリクシス， インク． Ｔｉｅ−２モジュレータと使用方法
JP2007502298A (ja) * 2003-08-14 2007-02-08 スミスクライン ビーチャム コーポレーション 化合物
JP2007517006A (ja) * 2003-12-24 2007-06-28 アストラゼネカ アクチボラグ Ｔｉｅ２（ｔｅｋ）活性のあるピリミジン
US7776869B2 (en) 2004-10-18 2010-08-17 Amgen Inc. Heteroaryl-substituted alkyne compounds and method of use
US20100048543A1 (en) 2005-02-01 2010-02-25 Astrazeneca Ab Pyrimidine compounds having ties (tek) inhibitory activity
EP1846399A1 (fr) 2005-02-01 2007-10-24 AstraZeneca AB Dérivés de pyrimidine présentant une activité inhibitrice de tie2 (tek)
GB0502418D0 (en) * 2005-02-05 2005-03-16 Astrazeneca Ab Compounds
US20070135437A1 (en) 2005-03-04 2007-06-14 Alsgen, Inc. Modulation of neurodegenerative diseases
WO2006106721A1 (fr) * 2005-03-30 2006-10-12 Shionogi & Co., Ltd. Dérivé de pyrimidine ayant un effet d'inhibition de la tyrosine kinase
JP2008534565A (ja) 2005-03-31 2008-08-28 アストラゼネカ アクチボラグ Ｔｉｅ２阻害活性のあるアミノピリミジン誘導体
WO2007080382A1 (fr) * 2006-01-11 2007-07-19 Astrazeneca Ab Dérivés de morpholinopyrimidine et leur utilisation thérapeutique
GB0616747D0 (en) * 2006-08-24 2006-10-04 Astrazeneca Ab Novel compounds
EP2057129A1 (fr) 2006-08-24 2009-05-13 AstraZeneca AB Dérivés de morpholino pyrimidine utiles dans le traitement de désordres prolifératifs
AU2007341228B2 (en) 2006-12-29 2013-04-18 Janssen Sciences Ireland Uc HIV inhibiting 5,6-substituted pyrimidines
EP2022785A1 (fr) 2007-06-20 2009-02-11 Bayer Schering Pharma Aktiengesellschaft Alkynylpyrimidines comme inhibiteurs de la kinase Tie2
TW201010984A (en) 2008-07-29 2010-03-16 Boehringer Ingelheim Int 5-alkynyl-pyrimidines
JP2010018601A (ja) * 2009-02-16 2010-01-28 Tetsuya Nishio 複素環化合物、その製造法および用途
US8633183B2 (en) * 2010-01-26 2014-01-21 Boehringer Ingelheim International Gmbh 5-alkynyl-pyrimidines

Also Published As

Publication number Publication date
US8618111B2 (en) 2013-12-31
EA201201049A1 (ru) 2013-02-28
EP2528910A1 (fr) 2012-12-05
JP5670479B2 (ja) 2015-02-18
AU2011209343A1 (en) 2012-08-02
US20120028958A1 (en) 2012-02-02
BR112012018454A2 (pt) 2016-04-19
AR080019A1 (es) 2012-03-07
AP2012006361A0 (en) 2012-08-31
PE20121527A1 (es) 2012-11-21
IN2012DN06600A (fr) 2015-10-23
CA2787396A1 (fr) 2011-08-04
UY33198A (es) 2011-08-31
MX2012008359A (es) 2012-08-08
EP2528910B1 (fr) 2015-03-18
TN2012000370A1 (en) 2014-01-30
CO6592046A2 (es) 2013-01-02
CN102781931A (zh) 2012-11-14
ECSP12012110A (es) 2012-09-28
SG182676A1 (en) 2012-08-30
TW201139412A (en) 2011-11-16
KR20130030742A (ko) 2013-03-27
WO2011092197A1 (fr) 2011-08-04
JP2013518078A (ja) 2013-05-20
CL2012001926A1 (es) 2012-11-30

Similar Documents

Publication Publication Date Title
TN2009000551A1 (fr) Nouveaux composes chimiques
MA32351B1 (fr) Derives d'aminodihydrothiazine a titre d'inhibiteurs de bace pour le traitement de la maladie d'alzheimer
MA33492B1 (fr) Inhibiteurs de bace
TN2015000547A1 (fr) Composes heteroaromatiques et leur utilisation comme ligands de dopamine d1
MA33939B1 (fr) 5-alcynyl-pyrimidines
MA33302B1 (fr) 2, 4-diaminopyrimidines pour le traitement de maladies caracterisees par une proliferation cellulaire excessive ou anormale
MA38146B1 (fr) Nouveaux dérivés du benzimidazole comme antagonistes ep4
MA39211B1 (fr) Composés tricycliques comme agents anti-cancers
TN2009000324A1 (fr) Composes tricycliques et leur utilisation comme modulateurs du recepteur de glucocorticoides
MA31906B1 (fr) Inhibiteurs de la replication du virus de limmunodeficience humaine
MA39193A1 (fr) Modulateurs du gpr6 à base de tétrahydropyridopyrazines
MX2013000821A (es) Nuevas aminopirazoloquinazolinas.
MA32811B1 (fr) Nouveaux composés
EA201500175A1 (ru) Соединения и композиции в качестве ингибиторов протеинкиназ
MA32506B1 (fr) Nouveaux composes
MA33119B1 (fr) Derives de benzofuranyle utilises comme inhibiteurs de la glucokinase
MX2013004491A (es) Boronatos como inhibidores de arginasa.
MA33509B1 (fr) Dérivés de l'oxazine et leur utilisation dans le traitement de troubles neurologiques
MA31834B1 (fr) 5-[(3,3,3-trifluoro-2-hydroxy-1-arylpropyl)amino]-1h-quinolin-2-ones, leur procédé de production et leur utilisation comme anti-inflammatoires
MA35895B1 (fr) Inhibiteurs d'iap
MA32158B1 (fr) Thiazolyldihydroindazoles
MA34968B1 (fr) Urées asymétriques et utilisations médicales de celles-ci
MA35816B1 (fr) Dérivés d'aniline, leur préparation et leur application thérapeutique
MA31526B1 (fr) Nouveaux herbicides
MA33222B1 (fr) 5-alcynylpyridines