MA39193A1 - Modulateurs du gpr6 à base de tétrahydropyridopyrazines - Google Patents

Modulateurs du gpr6 à base de tétrahydropyridopyrazines

Info

Publication number
MA39193A1
MA39193A1 MA39193A MA39193A MA39193A1 MA 39193 A1 MA39193 A1 MA 39193A1 MA 39193 A MA39193 A MA 39193A MA 39193 A MA39193 A MA 39193A MA 39193 A1 MA39193 A1 MA 39193A1
Authority
MA
Morocco
Prior art keywords
tetrahydropyridopyrazines
gpr6
modulators based
gpr6 modulators
compounds
Prior art date
Application number
MA39193A
Other languages
English (en)
Other versions
MA39193B1 (fr
Inventor
Stephen Hitchcock
Holger Monenschein
Holly Reichard
Shota Kikuchi
Todd Macklin
Maria Hopkins
Jason Brown
Kristin Schleicher
Hukai Sun
Original Assignee
Takeda Pharmaceuticals Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52440811&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA39193(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceuticals Co filed Critical Takeda Pharmaceuticals Co
Publication of MA39193A1 publication Critical patent/MA39193A1/fr
Publication of MA39193B1 publication Critical patent/MA39193B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La présente invention concerne des composés de formule (i) : qui sont utiles comme modulateurs du gpr6, des compositions pharmaceutiques les contenant, des procédés de traitement de maladies associées au gpr6, et des procédé de fabrication des composés et de leurs intermédiaires.
MA39193A 2013-12-20 2014-12-19 Modulateurs du gpr6 à base de tétrahydropyridopyrazines MA39193B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361919661P 2013-12-20 2013-12-20
PCT/US2014/071543 WO2015095728A1 (fr) 2013-12-20 2014-12-19 Modulateurs du gpr6 à base de tétrahydropyridopyrazines

Publications (2)

Publication Number Publication Date
MA39193A1 true MA39193A1 (fr) 2017-06-30
MA39193B1 MA39193B1 (fr) 2018-04-30

Family

ID=52440811

Family Applications (1)

Application Number Title Priority Date Filing Date
MA39193A MA39193B1 (fr) 2013-12-20 2014-12-19 Modulateurs du gpr6 à base de tétrahydropyridopyrazines

Country Status (41)

Country Link
US (4) US9181249B2 (fr)
EP (2) EP3083620B1 (fr)
JP (1) JP6538697B2 (fr)
KR (1) KR102441531B1 (fr)
CN (2) CN108658978A (fr)
AR (2) AR098872A1 (fr)
AU (1) AU2014368992C1 (fr)
BR (1) BR112016014020B1 (fr)
CA (1) CA2934247C (fr)
CL (1) CL2016001595A1 (fr)
CR (1) CR20160321A (fr)
CY (1) CY1121395T1 (fr)
DK (1) DK3083620T3 (fr)
DO (1) DOP2016000144A (fr)
EA (1) EA032443B1 (fr)
EC (1) ECSP16061758A (fr)
ES (1) ES2702187T3 (fr)
GE (1) GEP201706783B (fr)
HR (1) HRP20182004T1 (fr)
HU (1) HUE042443T2 (fr)
IL (1) IL246177B (fr)
JO (1) JO3466B1 (fr)
LT (1) LT3083620T (fr)
MA (1) MA39193B1 (fr)
MX (1) MX2016008188A (fr)
MY (1) MY177031A (fr)
NZ (1) NZ721723A (fr)
PE (1) PE20160751A1 (fr)
PH (1) PH12016501192A1 (fr)
PL (1) PL3083620T3 (fr)
PT (1) PT3083620T (fr)
RS (1) RS58092B1 (fr)
SG (1) SG11201604921TA (fr)
SI (1) SI3083620T1 (fr)
TN (1) TN2016000244A1 (fr)
TR (1) TR201900038T4 (fr)
TW (2) TWI730937B (fr)
UA (1) UA120427C2 (fr)
UY (1) UY35908A (fr)
WO (1) WO2015095728A1 (fr)
ZA (1) ZA201604703B (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA037918B1 (ru) 2011-12-21 2021-06-07 Новира Терапьютикс, Инк. Противовирусные агенты против гепатита в
WO2014028479A1 (fr) 2012-08-13 2014-02-20 Envoy Therapeutics, Inc. Dérivés de quinoxaline en tant que modulateurs du gpr6
UA123256C2 (uk) 2012-08-28 2021-03-10 ЯНССЕН САЙЄНСІЗ АЙРЛЕНД ЮСі Сульфамоїлариламіди та їх застосування як лікарських препаратів для лікування гепатиту b
HUE034820T2 (en) 2013-02-28 2018-02-28 Janssen Sciences Ireland Uc Sulphamoyl arylamides and their use as medicaments for the treatment of hepatitis B
ES2640063T3 (es) 2013-04-03 2017-10-31 Janssen Sciences Ireland Uc Derivados de n-fenil-carboxamida y su uso como medicamentos para el tratamiento de la hepatitis B
AU2014267235B2 (en) 2013-05-17 2017-10-05 Janssen Sciences Ireland Uc Sulphamoylthiophenamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
JO3603B1 (ar) 2013-05-17 2020-07-05 Janssen Sciences Ireland Uc مشتقات سلفامويل بيرولاميد واستخدامها كادوية لمعالجة التهاب الكبد نوع بي
JP6348978B2 (ja) 2013-07-25 2018-06-27 ヤンセン・サイエンシズ・アイルランド・ユーシー グリオキサミド置換ピロールアミド誘導体およびｂ型肝炎を処置するための医薬品としてのその使用
ES2655518T3 (es) 2013-10-23 2018-02-20 Janssen Sciences Ireland Uc Derivados de carboxamida y su uso como medicamentos para el tratamiento de la hepatitis B
JO3466B1 (ar) * 2013-12-20 2020-07-05 Takeda Pharmaceuticals Co مواد ضابطة لتترا هيدرو بيريدوبيرازينات من gpr6
US9169212B2 (en) 2014-01-16 2015-10-27 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
US10392349B2 (en) 2014-01-16 2019-08-27 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
KR20160128305A (ko) 2014-02-05 2016-11-07 노비라 테라퓨틱스, 인코포레이티드 Hbv 감염의 치료를 위한 병용 요법
CN110483484A (zh) 2014-02-06 2019-11-22 爱尔兰詹森科学公司 氨磺酰基吡咯酰胺衍生物及其作为药物用于治疗乙型肝炎的用途
JP6526034B2 (ja) * 2014-02-14 2019-06-05 武田薬品工業株式会社 Ｇｐｒ６のピリドピラジンモジュレーター
US9884831B2 (en) 2015-03-19 2018-02-06 Novira Therapeutics, Inc. Azocane and azonane derivatives and methods of treating hepatitis B infections
US10875876B2 (en) 2015-07-02 2020-12-29 Janssen Sciences Ireland Uc Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
EP3356328A1 (fr) 2015-09-29 2018-08-08 Novira Therapeutics, Inc. Formes cristallines d'un agent antiviral de l'hépatite b
KR20180129943A (ko) 2016-04-15 2018-12-05 노비라 테라퓨틱스, 인코포레이티드 캡시드 조립 억제제를 포함하는 배합물 및 방법
JOP20180057A1 (ar) * 2017-06-15 2019-01-30 Takeda Pharmaceuticals Co مركبات رابع هيدروبيريدو بيرازين والتي تعمل كمعدلات gpr6
CA3090125A1 (fr) 2018-03-14 2019-09-19 Janssen Sciences Ireland Unlimited Company Schema posologique de modulateur d'assemblage de capside
CN113454077A (zh) 2019-02-22 2021-09-28 爱尔兰詹森科学公司 用于治疗hbv感染或hbv诱发的疾病的酰胺衍生物
BR112021021454A2 (pt) 2019-05-06 2021-12-21 Janssen Sciences Ireland Unlimited Co Derivados de amida úteis no tratamento da infecção por hbv ou doenças induzidas por hbv

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6114139A (en) * 1994-08-11 2000-09-05 Takeda Chemical Industries, Ltd. G-protein coupled receptor protein and a DNA encoding the receptor
MXPA01008618A (es) * 1999-02-26 2002-03-20 Arena Pharm Inc Moduladores de molecula pequena de receptor seis acoplado de proteina g.
WO2001070269A1 (fr) 2000-03-24 2001-09-27 Akzo Nobel N.V. Inhibiteurs de la croissance des keratinocytes et derives d'acide hydroxamique
WO2004038416A1 (fr) * 2002-10-24 2004-05-06 Bayer Healthcare Ag Diagnostic et therapeutique de maladies associees au recepteur 6 couple a la proteine g humain (gpr6)
EP1592689A4 (fr) 2003-01-31 2008-12-24 Merck & Co Inc Derives d'acide 3-amino-4-phenylbutanoique utilises comme inhibiteurs de dipeptidyle peptidase pour le traitement ou la prevention du diabete
SE0400285D0 (sv) * 2004-02-10 2004-02-10 Astrazeneca Ab Pyrroloquinoline and piperidoquinoline derivatives, preparation thereof, compositions containing them and uses thereof
US20070054916A1 (en) 2004-10-01 2007-03-08 Amgen Inc. Aryl nitrogen-containing bicyclic compounds and methods of use
BRPI0710658A2 (pt) * 2006-04-21 2011-08-16 Pfizer Prod Inc compostos de piridina[3,4-b] pirazinonas, seus usos na preparação de composições farmacêuticas e composições farmacêuticas compreendendo os mesmos
CA2651072A1 (fr) 2006-05-01 2007-11-08 Pfizer Products Inc. Composes heterocycliques 2-amino-substitues a cycles fusionnes
JP5390513B2 (ja) 2007-06-05 2014-01-15 アストリウム・リミテッド 遠隔検査システム及び方法
GB0710844D0 (en) 2007-06-06 2007-07-18 Lectus Therapeutics Ltd Potassium ion channel modulators & uses thereof
GB2449929A (en) 2007-06-08 2008-12-10 Snell & Wilcox Ltd Hierarchical spatial resolution building processes to fill holes in an interpolated image
RU2567752C2 (ru) 2009-06-12 2015-11-10 Абивакс Соединения, пригодные для лечения рака
WO2013087808A1 (fr) 2011-12-15 2013-06-20 Merz Pharma Gmbh & Co. Kgaa Composition pharmaceutique comprenant une pyrazolopyrimidine et une cyclodextrine
WO2013087815A1 (fr) 2011-12-15 2013-06-20 Merz Pharma Gmbh & Co. Kgaa Composition pharmaceutique liquide contenant un dérivé de pyrazolopyrimidine et utilisations pharmaceutiques de celle-ci
WO2013169964A1 (fr) 2012-05-09 2013-11-14 Sunovion Pharmaceuticals Inc. Composés hétéroaryles et leurs procédés d'utilisation
WO2014028479A1 (fr) * 2012-08-13 2014-02-20 Envoy Therapeutics, Inc. Dérivés de quinoxaline en tant que modulateurs du gpr6
FR2995937B1 (fr) 2012-09-21 2014-09-26 Exoes Ensemble de production d'electricite a moteur a pression de vapeur
JO3466B1 (ar) * 2013-12-20 2020-07-05 Takeda Pharmaceuticals Co مواد ضابطة لتترا هيدرو بيريدوبيرازينات من gpr6

Also Published As

Publication number Publication date
DOP2016000144A (es) 2016-08-15
EP3083620A1 (fr) 2016-10-26
UA120427C2 (uk) 2019-12-10
WO2015095728A1 (fr) 2015-06-25
UY35908A (es) 2015-07-31
KR102441531B1 (ko) 2022-09-07
IL246177A0 (en) 2016-08-02
ZA201604703B (en) 2018-11-28
AR129635A2 (es) 2024-09-11
TW201605854A (zh) 2016-02-16
EA201691272A1 (ru) 2017-05-31
GEP201706783B (en) 2017-11-27
BR112016014020B1 (pt) 2023-02-28
TR201900038T4 (tr) 2019-01-21
US20180346464A1 (en) 2018-12-06
HUE042443T2 (hu) 2019-06-28
PL3083620T4 (pl) 2019-09-30
PH12016501192B1 (en) 2016-08-15
JO3466B1 (ar) 2020-07-05
EP3453709A1 (fr) 2019-03-13
PH12016501192A1 (en) 2016-08-15
IL246177B (en) 2019-11-28
RS58092B1 (sr) 2019-02-28
PE20160751A1 (es) 2016-08-01
US20170283414A1 (en) 2017-10-05
US10738046B2 (en) 2020-08-11
CN105829309A (zh) 2016-08-03
BR112016014020A2 (pt) 2017-08-08
TW202202497A (zh) 2022-01-16
TN2016000244A1 (en) 2017-10-06
TWI809395B (zh) 2023-07-21
NZ721723A (en) 2021-07-30
CL2016001595A1 (es) 2017-01-13
CR20160321A (es) 2016-09-28
TWI730937B (zh) 2021-06-21
AU2014368992B2 (en) 2018-09-13
AR098872A1 (es) 2016-06-22
US20160031881A1 (en) 2016-02-04
US10077266B2 (en) 2018-09-18
EA032443B1 (ru) 2019-05-31
CN108658978A (zh) 2018-10-16
MX2016008188A (es) 2016-09-29
SI3083620T1 (sl) 2019-02-28
PT3083620T (pt) 2019-01-17
CY1121395T1 (el) 2020-05-29
US9181249B2 (en) 2015-11-10
JP2017502027A (ja) 2017-01-19
US20150175602A1 (en) 2015-06-25
CA2934247A1 (fr) 2015-06-25
AU2014368992C1 (en) 2019-02-21
MY177031A (en) 2020-09-02
PL3083620T3 (pl) 2019-09-30
US9708313B2 (en) 2017-07-18
ECSP16061758A (es) 2018-02-28
HRP20182004T1 (hr) 2019-02-08
DK3083620T3 (en) 2019-01-14
CN105829309B (zh) 2018-05-15
ES2702187T3 (es) 2019-02-27
CA2934247C (fr) 2023-01-17
EP3083620B1 (fr) 2018-10-03
LT3083620T (lt) 2019-02-11
BR112016014020A8 (pt) 2018-01-30
AU2014368992A1 (en) 2016-07-07
KR20160099705A (ko) 2016-08-22
JP6538697B2 (ja) 2019-07-03
SG11201604921TA (en) 2016-07-28
MA39193B1 (fr) 2018-04-30

Similar Documents

Publication Publication Date Title
MA39193A1 (fr) Modulateurs du gpr6 à base de tétrahydropyridopyrazines
MA42109A (fr) Amides hétérocycliques utilisés en tant qu'inhibiteurs de kinase
MA35920B1 (fr) Composés destinés au traitement de l'amyotrophie spinale
MD3464249T2 (ro) Derivați carbonucleozidici substituiţi utili în calitate de agenți anticanceroşi
MA37959A2 (fr) Dérivés de 5-phénoxy-3h-pyrimidin-4-one et leur utilisation en tant qu'inhibiteurs de la transcriptase inverse du vih
EA201690153A1 (ru) Замещенные бензофуранильные и бензоксазолильные соединения и их применения
EA201790273A1 (ru) Флагеллиновые композиции и их применение
EA201500926A1 (ru) Фумараты как пролекарства и их применение при лечении различных заболеваний
MA39211B1 (fr) Composés tricycliques comme agents anti-cancers
MA34968B1 (fr) Urées asymétriques et utilisations médicales de celles-ci
GEP20166438B (en) Imidazopyrrolidinone compounds
PH12019501362A1 (en) Polymorphs
EA201500403A1 (ru) Соединения, активирующие теломеразу, и способы их применения
EA201691141A1 (ru) Соединения против ccr6
MA39152B1 (fr) Cyclopentanes substitués en 1,2 utilisés comme antagonistes du récepteur d'orexine
EA201891379A1 (ru) Ингибиторы тирозинкиназы брутона и способы их применения
EA201790570A1 (ru) Модуляторы р2х7
MA40875A (fr) 2,4-diamino-quinoléine substituée servant de nouveaux agents anticancéreux
BR112014013138A2 (pt) anilinas substituídas como antagonistas de ccr(4)
EA201890898A1 (ru) Новые соединения и конъюгаты криптофицина, их получение и их терапевтическое применение
EA201790070A1 (ru) Бифениламиды, содержащие модифицированные простые эфирные группы, в качестве ингибиторов hsp90 и стимуляторов hsp70
EA201071367A1 (ru) Соли соединений ингибиторов вич
MA40366A (fr) Dérivés de tétrahydroquinoline à titre d'inhibiteurs des bromodomaines
PH12020550947A1 (en) Polymorphs
MA39337A1 (fr) Modulateurs de pyrazines de gpr6