MA32734B1 - Antagonisme smoothened pour traitement de troubles lies a la voie de signalisation hedgehog - Google Patents

Antagonisme smoothened pour traitement de troubles lies a la voie de signalisation hedgehog

Info

Publication number
MA32734B1
MA32734B1 MA33801A MA33801A MA32734B1 MA 32734 B1 MA32734 B1 MA 32734B1 MA 33801 A MA33801 A MA 33801A MA 33801 A MA33801 A MA 33801A MA 32734 B1 MA32734 B1 MA 32734B1
Authority
MA
Morocco
Prior art keywords
smoothened
hedgehog signaling
disorders related
inhibitors
formula
Prior art date
Application number
MA33801A
Other languages
Arabic (ar)
English (en)
Inventor
Marion Dorsch
John E Monahan
Michael Patrick Morrissey
Shifeng Pan
Juliet Williams
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41314595&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA32734(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA32734B1 publication Critical patent/MA32734B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne des procédés qui permettent de moduler, par exemple, d'exercer un effet antagoniste sur l'activité de la voie de signalisation Hedgehog, et de traiter des troubles liées à la voie de signalisation Hedgehog tels que des cancers (par exemple, le médulloblastome). En particulier, l'invention concerne des procédés permettant d'inhiber des états de croissance aberrante résultant de phénotypes tels que la perte de fonction Ptch, le gain de fonction Hedgehog, le gain de fonction Smoothened ou le gain de fonction GIi par administration à un mammifère de combinaisons d'inhibiteurs Smoothened (par exemple, un composé de formule I, de formule II, ou de formule III, ou un quelconque des composés se trouvant dans la liste de référence incluse dans la description) et des inhibiteurs de la voie de signalisation de la biosynthèse du cholestérol (par exemple, des statines), des inhibiteurs GIi, et/ou des inhibiteurs de la Phosphatidylinositol 3-kinase (P13K).
MA33801A 2008-10-01 2011-04-29 Antagonisme smoothened pour traitement de troubles lies a la voie de signalisation hedgehog MA32734B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10185808P 2008-10-01 2008-10-01
US10185108P 2008-10-01 2008-10-01
PCT/EP2009/062537 WO2010037715A1 (fr) 2008-10-01 2009-09-28 Antagonisme smoothened pour le traitement de troubles liés à la voie de signalisation hedgehog

Publications (1)

Publication Number Publication Date
MA32734B1 true MA32734B1 (fr) 2011-10-02

Family

ID=41314595

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33801A MA32734B1 (fr) 2008-10-01 2011-04-29 Antagonisme smoothened pour traitement de troubles lies a la voie de signalisation hedgehog

Country Status (16)

Country Link
US (2) US8778927B2 (fr)
EP (3) EP2617414A3 (fr)
JP (2) JP5773873B2 (fr)
KR (1) KR101624000B1 (fr)
CN (2) CN102170873B (fr)
AU (1) AU2009299927B2 (fr)
BR (1) BRPI0920533A2 (fr)
CA (1) CA2738868C (fr)
CL (1) CL2011000710A1 (fr)
IL (1) IL211678A (fr)
MA (1) MA32734B1 (fr)
MX (1) MX340304B (fr)
RU (1) RU2519200C2 (fr)
TW (1) TWI478916B (fr)
WO (1) WO2010037715A1 (fr)
ZA (1) ZA201101725B (fr)

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ES2588981T3 (es) * 2010-10-05 2016-11-08 Genentech, Inc. Smoothened mutante y métodos de uso de la misma
TWI574687B (zh) * 2011-01-03 2017-03-21 古利斯股份有限公司 具有鋅結合部份之刺蝟拮抗劑
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CN104177363B (zh) * 2013-05-24 2018-06-05 江苏先声药业有限公司 双环杂环胺类Hedgehog信号通路抑制剂
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US9970935B2 (en) * 2014-02-06 2018-05-15 The Brigham And Women's Hospital, Inc. Uses of GLI1 in detecting tissue fibrosis
US20170290849A1 (en) * 2014-09-05 2017-10-12 The Trustees Of Columbia University In The City Of New York AKT and SHH Pathway Inhibitor Combination Therapy for Treating Basal Cell Carcinomas
EP3560924B1 (fr) 2015-04-02 2021-03-31 Merck Patent GmbH Imidazolonyl-quinoléines et leur utilisation comme inhibiteurs du atm kinase
WO2017007634A1 (fr) * 2015-07-06 2017-01-12 The Board Of Regents Of The University Of Texas System Composés benzamide ou benzamine à utiliser en tant qu'anticancéreux pour le traitement de cancers humains
WO2017156350A1 (fr) 2016-03-09 2017-09-14 K-Gen, Inc. Méthodes de traitement du cancer
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EP3624798A1 (fr) * 2017-05-18 2020-03-25 Institut National de la Sante et de la Recherche Medicale (INSERM) Méthodes et compositions pharmaceutiques pour le traitement de maladies mastocytaires
WO2018218114A1 (fr) * 2017-05-26 2018-11-29 Institute For Cancer Research D/B/A The Research Institute Of Fox Chase Cancer Center Utilisation du cholestérol pour favoriser la survie et la prolifération de cellules de médulloblastomes primaires
CN110856722A (zh) * 2018-08-26 2020-03-03 中国农业科学院上海兽医研究所(中国动物卫生与流行病学中心上海分中心) 环靶明或其衍生物的用途

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Also Published As

Publication number Publication date
ZA201101725B (en) 2011-12-28
US8778927B2 (en) 2014-07-15
MX340304B (es) 2016-07-05
AU2009299927A1 (en) 2010-04-08
IL211678A0 (en) 2011-06-30
RU2519200C2 (ru) 2014-06-10
JP2015180654A (ja) 2015-10-15
CL2011000710A1 (es) 2011-08-05
JP2012504573A (ja) 2012-02-23
CA2738868C (fr) 2017-01-17
BRPI0920533A2 (pt) 2020-12-15
US20140200217A1 (en) 2014-07-17
CN102170873B (zh) 2014-07-30
RU2011117059A (ru) 2012-11-10
WO2010037715A1 (fr) 2010-04-08
TW201018672A (en) 2010-05-16
EP2346499A1 (fr) 2011-07-27
CN103784457A (zh) 2014-05-14
EP3023097A1 (fr) 2016-05-25
CN102170873A (zh) 2011-08-31
EP2617414A3 (fr) 2013-11-06
JP5773873B2 (ja) 2015-09-02
KR20110066200A (ko) 2011-06-16
AU2009299927B2 (en) 2013-05-30
TWI478916B (zh) 2015-04-01
MX2011003468A (es) 2011-04-21
KR101624000B1 (ko) 2016-05-24
US20110183962A1 (en) 2011-07-28
CA2738868A1 (fr) 2010-04-08
EP2617414A2 (fr) 2013-07-24
IL211678A (en) 2016-12-29

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