MA32530B1 - Dérivés de spirocétals cristallins et procédé pour la préparation de dérivés de spirocétals - Google Patents
Dérivés de spirocétals cristallins et procédé pour la préparation de dérivés de spirocétalsInfo
- Publication number
- MA32530B1 MA32530B1 MA33442A MA33442A MA32530B1 MA 32530 B1 MA32530 B1 MA 32530B1 MA 33442 A MA33442 A MA 33442A MA 33442 A MA33442 A MA 33442A MA 32530 B1 MA32530 B1 MA 32530B1
- Authority
- MA
- Morocco
- Prior art keywords
- spirocital
- derivatives
- crystalline
- preparation
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/04—Carbocyclic radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
Abstract
L'invention porte sur un procédé de fabrication d'un dérivé de spirocétal par l'intermédiaire d'un composé représenté par la formule (vi) [dans laquelle les groupes variables et les nombres variables sont tels que définis dans la description] qui peut être obtenu à partir d'un dérivé d'alcool dihalobenzylique par une réaction monotope.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2008162073 | 2008-06-20 | ||
PCT/JP2009/061226 WO2009154276A1 (fr) | 2008-06-20 | 2009-06-19 | Cristaux de dérivé de spirocétal et leur procédé de fabrication |
Publications (1)
Publication Number | Publication Date |
---|---|
MA32530B1 true MA32530B1 (fr) | 2011-08-01 |
Family
ID=41434188
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA33442A MA32530B1 (fr) | 2008-06-20 | 2010-12-20 | Dérivés de spirocétals cristallins et procédé pour la préparation de dérivés de spirocétals |
Country Status (25)
Country | Link |
---|---|
US (2) | US8569520B2 (fr) |
EP (3) | EP4036100A1 (fr) |
JP (2) | JP4823385B2 (fr) |
KR (1) | KR101856784B1 (fr) |
CN (1) | CN102046645B (fr) |
AR (1) | AR072211A1 (fr) |
AU (1) | AU2009261129A1 (fr) |
CA (1) | CA2727923A1 (fr) |
CL (1) | CL2010001485A1 (fr) |
CO (1) | CO6351798A2 (fr) |
CR (1) | CR20110033A (fr) |
EC (1) | ECSP11010773A (fr) |
ES (1) | ES2907611T3 (fr) |
HK (1) | HK1154589A1 (fr) |
IL (1) | IL210098A0 (fr) |
MA (1) | MA32530B1 (fr) |
MX (1) | MX2010014023A (fr) |
NZ (1) | NZ589961A (fr) |
PE (1) | PE20110115A1 (fr) |
PL (1) | PL3170834T3 (fr) |
RU (1) | RU2011101972A (fr) |
SG (1) | SG193795A1 (fr) |
TW (1) | TW201011043A (fr) |
WO (1) | WO2009154276A1 (fr) |
ZA (1) | ZA201100016B (fr) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011074675A1 (fr) * | 2009-12-18 | 2011-06-23 | 中外製薬株式会社 | Procédé de préparation d'un dérivé spirocétal |
WO2012115249A1 (fr) * | 2011-02-25 | 2012-08-30 | 中外製薬株式会社 | Cristal de dérivé de spirocétal |
AU2012320581B2 (en) * | 2011-10-06 | 2017-03-30 | Bayer Intellectual Property Gmbh | Heterocyclylpyri (mi) dinylpyrazole as fungicidals |
KR102395687B1 (ko) | 2013-12-27 | 2022-05-06 | 추가이 세이야쿠 가부시키가이샤 | 토포글리플로진을 함유하는 고형 제제 및 그 제조 방법 |
CN106188190B (zh) * | 2016-07-28 | 2020-08-25 | 迪嘉药业集团有限公司 | 一种托格列净一水合物的制备方法 |
BR112019005930A2 (pt) | 2016-10-19 | 2019-06-11 | Boehringer Ingelheim Int | combinações compreendendo um inibidor de ssao/vap-1 e um inibidor de sglt2, e usos das mesmas |
CN108640958B (zh) * | 2017-05-05 | 2021-03-30 | 镇江圣安医药有限公司 | 异苯并呋喃衍生物、其药物组合物和制剂以及用途 |
WO2019201752A1 (fr) | 2018-04-17 | 2019-10-24 | Boehringer Ingelheim International Gmbh | Composition pharmaceutique, méthodes de traitement et utilisations associées |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL63968A (en) | 1980-10-01 | 1985-10-31 | Glaxo Group Ltd | Form 2 ranitidine hydrochloride,its preparation and pharmaceutical compositions containing it |
HU196775B (en) * | 1986-08-05 | 1989-01-30 | Richter Gedeon Vegyeszet | Process for production of morfologically unique new modifications of famotidin and medical compositions containing such substances |
PT98344B (pt) | 1991-07-17 | 1999-04-30 | Lneti Lab Nac De Eng Tec Ind D | Processo para a obtencao de espirocetais labdanicos do tipo ambar cinzento |
GB9426103D0 (en) | 1994-12-23 | 1995-02-22 | Merck Sharp & Dohme | Therapeutic agents |
JP2000044534A (ja) * | 1998-07-28 | 2000-02-15 | Mitsui Chemicals Inc | N保護基アミノ酸の製造法 |
DE60140348D1 (de) | 2000-02-02 | 2009-12-17 | Banyu Pharma Co Ltd | Verfahren zur verwandlung einer funktionellen gruppe durch halogen-metal-austausch |
JP3849024B2 (ja) | 2003-03-26 | 2006-11-22 | 国立大学法人 東京大学 | 有機亜鉛錯体およびその製造方法 |
TW200637869A (en) | 2005-01-28 | 2006-11-01 | Chugai Pharmaceutical Co Ltd | The spiroketal derivatives and the use as therapeutical agent for diabetes of the same |
CN101389632B (zh) | 2005-12-23 | 2013-02-06 | 生态生物有限公司 | 螺缩酮 |
US7803778B2 (en) | 2006-05-23 | 2010-09-28 | Theracos, Inc. | Glucose transport inhibitors and methods of use |
TWI403516B (zh) | 2006-07-27 | 2013-08-01 | Chugai Pharmaceutical Co Ltd | To replace spirocyclic alcohol derivatives, and its use as a therapeutic agent for diabetes |
JP5791983B2 (ja) | 2011-07-07 | 2015-10-07 | 三井化学株式会社 | 樹脂組成物、これを用いたポリイミド金属積層体、及び電子回路用基板 |
-
2009
- 2009-06-18 TW TW098120460A patent/TW201011043A/zh unknown
- 2009-06-19 KR KR1020117000778A patent/KR101856784B1/ko active IP Right Grant
- 2009-06-19 EP EP22155547.7A patent/EP4036100A1/fr not_active Withdrawn
- 2009-06-19 EP EP16202285.9A patent/EP3170834B8/fr active Active
- 2009-06-19 JP JP2010517979A patent/JP4823385B2/ja active Active
- 2009-06-19 RU RU2011101972/04A patent/RU2011101972A/ru not_active Application Discontinuation
- 2009-06-19 WO PCT/JP2009/061226 patent/WO2009154276A1/fr active Application Filing
- 2009-06-19 PE PE2010001159A patent/PE20110115A1/es not_active Application Discontinuation
- 2009-06-19 SG SG2013061510A patent/SG193795A1/en unknown
- 2009-06-19 CA CA2727923A patent/CA2727923A1/fr not_active Abandoned
- 2009-06-19 PL PL16202285T patent/PL3170834T3/pl unknown
- 2009-06-19 ES ES16202285T patent/ES2907611T3/es active Active
- 2009-06-19 AR ARP090102252A patent/AR072211A1/es not_active Application Discontinuation
- 2009-06-19 CN CN200980119081.4A patent/CN102046645B/zh active Active
- 2009-06-19 MX MX2010014023A patent/MX2010014023A/es not_active Application Discontinuation
- 2009-06-19 EP EP09766724.0A patent/EP2308886B1/fr active Active
- 2009-06-19 AU AU2009261129A patent/AU2009261129A1/en not_active Abandoned
- 2009-06-19 US US13/000,208 patent/US8569520B2/en active Active
- 2009-06-19 NZ NZ589961A patent/NZ589961A/xx not_active IP Right Cessation
-
2010
- 2010-12-19 IL IL210098A patent/IL210098A0/en unknown
- 2010-12-20 MA MA33442A patent/MA32530B1/fr unknown
- 2010-12-20 CL CL2010001485A patent/CL2010001485A1/es unknown
-
2011
- 2011-01-03 ZA ZA2011/00016A patent/ZA201100016B/en unknown
- 2011-01-19 CR CR20110033A patent/CR20110033A/es not_active Application Discontinuation
- 2011-01-20 CO CO11005627A patent/CO6351798A2/es not_active Application Discontinuation
- 2011-01-20 EC EC2011010773A patent/ECSP11010773A/es unknown
- 2011-08-17 HK HK11108698.5A patent/HK1154589A1/xx unknown
- 2011-09-05 JP JP2011193271A patent/JP5485237B2/ja active Active
-
2013
- 2013-09-24 US US14/034,880 patent/US9163051B2/en active Active
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