PL3170834T3 - Krystaliczne postacie (1s,3’r,4’s,5’s,6’r)-6-[(4-etylofenylo)metylo]-3’,4’,5’,6’-tetrahydro-6’-(hydroksymetylo)spiro[izobenzofurano-1(3h) 2’-[2h]pirano]-3’,4’,5’-triolu - Google Patents
Krystaliczne postacie (1s,3’r,4’s,5’s,6’r)-6-[(4-etylofenylo)metylo]-3’,4’,5’,6’-tetrahydro-6’-(hydroksymetylo)spiro[izobenzofurano-1(3h) 2’-[2h]pirano]-3’,4’,5’-trioluInfo
- Publication number
- PL3170834T3 PL3170834T3 PL16202285T PL16202285T PL3170834T3 PL 3170834 T3 PL3170834 T3 PL 3170834T3 PL 16202285 T PL16202285 T PL 16202285T PL 16202285 T PL16202285 T PL 16202285T PL 3170834 T3 PL3170834 T3 PL 3170834T3
- Authority
- PL
- Poland
- Prior art keywords
- isobenzofuran
- triol
- ethylphenyl
- pyran
- spiro
- Prior art date
Links
- MGADZUXDNSDTHW-UHFFFAOYSA-N 2H-pyran Chemical compound C1OC=CC=C1 MGADZUXDNSDTHW-UHFFFAOYSA-N 0.000 title 1
- 125000004860 4-ethylphenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])C([H])([H])[H] 0.000 title 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 title 1
- 125000003003 spiro group Chemical group 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/04—Carbocyclic radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008162073 | 2008-06-20 | ||
| EP09766724.0A EP2308886B1 (en) | 2008-06-20 | 2009-06-19 | Process for the production of a spiroketal derivative |
| PCT/JP2009/061226 WO2009154276A1 (ja) | 2008-06-20 | 2009-06-19 | スピロケタール誘導体の結晶およびその製造方法 |
| EP16202285.9A EP3170834B8 (en) | 2008-06-20 | 2009-06-19 | Crystalline forms of (1s,3'r,4's,5's,6'r)-6-[(4-ethylphenyl)methyl]-3',4',5',6'-tetrahydro-6'-(hydroxymethyl)spiro[isobenzofuran-1(3h) 2'-[2h]pyran]-3',4',5'-triol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3170834T3 true PL3170834T3 (pl) | 2022-05-02 |
Family
ID=41434188
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL16202285T PL3170834T3 (pl) | 2008-06-20 | 2009-06-19 | Krystaliczne postacie (1s,3’r,4’s,5’s,6’r)-6-[(4-etylofenylo)metylo]-3’,4’,5’,6’-tetrahydro-6’-(hydroksymetylo)spiro[izobenzofurano-1(3h) 2’-[2h]pirano]-3’,4’,5’-triolu |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US8569520B2 (pl) |
| EP (3) | EP4036100A1 (pl) |
| JP (2) | JP4823385B2 (pl) |
| KR (1) | KR101856784B1 (pl) |
| CN (1) | CN102046645B (pl) |
| AR (1) | AR072211A1 (pl) |
| AU (1) | AU2009261129A1 (pl) |
| CA (1) | CA2727923A1 (pl) |
| CL (1) | CL2010001485A1 (pl) |
| CO (1) | CO6351798A2 (pl) |
| CR (1) | CR20110033A (pl) |
| EC (1) | ECSP11010773A (pl) |
| ES (1) | ES2907611T3 (pl) |
| IL (1) | IL210098A0 (pl) |
| MA (1) | MA32530B1 (pl) |
| MX (1) | MX2010014023A (pl) |
| NZ (1) | NZ589961A (pl) |
| PE (1) | PE20110115A1 (pl) |
| PL (1) | PL3170834T3 (pl) |
| RU (1) | RU2011101972A (pl) |
| SG (1) | SG193795A1 (pl) |
| TW (1) | TW201011043A (pl) |
| WO (1) | WO2009154276A1 (pl) |
| ZA (1) | ZA201100016B (pl) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5711669B2 (ja) * | 2009-12-18 | 2015-05-07 | 中外製薬株式会社 | スピロケタール誘導体の製造方法 |
| JP6294665B2 (ja) * | 2011-02-25 | 2018-03-14 | 中外製薬株式会社 | スピロケタール誘導体の結晶 |
| UA114490C2 (uk) * | 2011-10-06 | 2017-06-26 | Байєр Інтеллектуал Проперті Гмбх | Гетероциклілпіри(mі)динілпіразоли як фунгіциди |
| BR112016013164B1 (pt) | 2013-12-27 | 2022-07-26 | Chugai Seiyaku Kabushiki Kaisha | Preparações sólidas contendo tofoglifozina e processos para produzir a mesma |
| CN106188190B (zh) * | 2016-07-28 | 2020-08-25 | 迪嘉药业集团有限公司 | 一种托格列净一水合物的制备方法 |
| EP3528800A1 (en) | 2016-10-19 | 2019-08-28 | Boehringer Ingelheim International GmbH | Combinations comprising an ssao/vap-1 inhibitor and a sglt2 inhibitor, uses thereof |
| CN108640958B (zh) * | 2017-05-05 | 2021-03-30 | 镇江圣安医药有限公司 | 异苯并呋喃衍生物、其药物组合物和制剂以及用途 |
| AU2019254371A1 (en) | 2018-04-17 | 2020-10-08 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| CN112955214B (zh) | 2018-10-29 | 2024-05-07 | 勃林格殷格翰国际有限公司 | 吡啶基磺酰胺衍生物、药物组合物及其用途 |
| CN112955215B (zh) | 2018-10-29 | 2024-05-17 | 勃林格殷格翰国际有限公司 | 吡啶基磺酰胺衍生物、药物组合物及其用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL63968A (en) * | 1980-10-01 | 1985-10-31 | Glaxo Group Ltd | Form 2 ranitidine hydrochloride,its preparation and pharmaceutical compositions containing it |
| HU196775B (en) * | 1986-08-05 | 1989-01-30 | Richter Gedeon Vegyeszet | Process for production of morfologically unique new modifications of famotidin and medical compositions containing such substances |
| PT98344B (pt) | 1991-07-17 | 1999-04-30 | Lneti Lab Nac De Eng Tec Ind D | Processo para a obtencao de espirocetais labdanicos do tipo ambar cinzento |
| GB9426103D0 (en) | 1994-12-23 | 1995-02-22 | Merck Sharp & Dohme | Therapeutic agents |
| JP2000044534A (ja) * | 1998-07-28 | 2000-02-15 | Mitsui Chemicals Inc | Ｎ保護基アミノ酸の製造法 |
| ATE447578T1 (de) | 2000-02-02 | 2009-11-15 | Banyu Pharma Co Ltd | Verfahren zur verwandlung einer funktionellen gruppe durch halogen-metal-austausch |
| JP3849024B2 (ja) | 2003-03-26 | 2006-11-22 | 国立大学法人 東京大学 | 有機亜鉛錯体およびその製造方法 |
| TW200637869A (en) * | 2005-01-28 | 2006-11-01 | Chugai Pharmaceutical Co Ltd | The spiroketal derivatives and the use as therapeutical agent for diabetes of the same |
| WO2007070984A1 (en) | 2005-12-23 | 2007-06-28 | Ecobiotics Limited | Spiroketals |
| US7803778B2 (en) | 2006-05-23 | 2010-09-28 | Theracos, Inc. | Glucose transport inhibitors and methods of use |
| TWI403516B (zh) | 2006-07-27 | 2013-08-01 | Chugai Pharmaceutical Co Ltd | To replace spirocyclic alcohol derivatives, and its use as a therapeutic agent for diabetes |
-
2009
- 2009-06-18 TW TW098120460A patent/TW201011043A/zh unknown
- 2009-06-19 CA CA2727923A patent/CA2727923A1/en not_active Abandoned
- 2009-06-19 EP EP22155547.7A patent/EP4036100A1/en not_active Withdrawn
- 2009-06-19 ES ES16202285T patent/ES2907611T3/es active Active
- 2009-06-19 MX MX2010014023A patent/MX2010014023A/es not_active Application Discontinuation
- 2009-06-19 CN CN200980119081.4A patent/CN102046645B/zh active Active
- 2009-06-19 KR KR1020117000778A patent/KR101856784B1/ko not_active Expired - Fee Related
- 2009-06-19 JP JP2010517979A patent/JP4823385B2/ja active Active
- 2009-06-19 EP EP09766724.0A patent/EP2308886B1/en active Active
- 2009-06-19 PL PL16202285T patent/PL3170834T3/pl unknown
- 2009-06-19 SG SG2013061510A patent/SG193795A1/en unknown
- 2009-06-19 WO PCT/JP2009/061226 patent/WO2009154276A1/ja not_active Ceased
- 2009-06-19 US US13/000,208 patent/US8569520B2/en not_active Expired - Fee Related
- 2009-06-19 EP EP16202285.9A patent/EP3170834B8/en active Active
- 2009-06-19 RU RU2011101972/04A patent/RU2011101972A/ru not_active Application Discontinuation
- 2009-06-19 NZ NZ589961A patent/NZ589961A/xx not_active IP Right Cessation
- 2009-06-19 AR ARP090102252A patent/AR072211A1/es not_active Application Discontinuation
- 2009-06-19 AU AU2009261129A patent/AU2009261129A1/en not_active Abandoned
- 2009-06-19 PE PE2010001159A patent/PE20110115A1/es not_active Application Discontinuation
-
2010
- 2010-12-19 IL IL210098A patent/IL210098A0/en unknown
- 2010-12-20 CL CL2010001485A patent/CL2010001485A1/es unknown
- 2010-12-20 MA MA33442A patent/MA32530B1/fr unknown
-
2011
- 2011-01-03 ZA ZA2011/00016A patent/ZA201100016B/en unknown
- 2011-01-19 CR CR20110033A patent/CR20110033A/es not_active Application Discontinuation
- 2011-01-20 CO CO11005627A patent/CO6351798A2/es not_active Application Discontinuation
- 2011-01-20 EC EC2011010773A patent/ECSP11010773A/es unknown
- 2011-09-05 JP JP2011193271A patent/JP5485237B2/ja active Active
-
2013
- 2013-09-24 US US14/034,880 patent/US9163051B2/en active Active
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