MA31516B1 - Modification de la production de glycoprotéine dans des plantes - Google Patents
Modification de la production de glycoprotéine dans des plantesInfo
- Publication number
- MA31516B1 MA31516B1 MA32504A MA32504A MA31516B1 MA 31516 B1 MA31516 B1 MA 31516B1 MA 32504 A MA32504 A MA 32504A MA 32504 A MA32504 A MA 32504A MA 31516 B1 MA31516 B1 MA 31516B1
- Authority
- MA
- Morocco
- Prior art keywords
- plant
- nucleotide sequence
- protein
- interest
- gnt1
- Prior art date
Links
- 102000003886 Glycoproteins Human genes 0.000 title 1
- 108090000288 Glycoproteins Proteins 0.000 title 1
- 230000004048 modification Effects 0.000 title 1
- 238000012986 modification Methods 0.000 title 1
- 239000002773 nucleotide Substances 0.000 abstract 4
- 125000003729 nucleotide group Chemical group 0.000 abstract 4
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 102000004169 proteins and genes Human genes 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 2
- 230000001105 regulatory effect Effects 0.000 abstract 2
- 101150112732 GNT1 gene Proteins 0.000 abstract 1
- 108010046068 N-Acetyllactosamine Synthase Proteins 0.000 abstract 1
- 102100023315 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase Human genes 0.000 abstract 1
- 108010056664 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase Proteins 0.000 abstract 1
- 230000004988 N-glycosylation Effects 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 230000003197 catalytic effect Effects 0.000 abstract 1
- 230000004186 co-expression Effects 0.000 abstract 1
- 230000005021 gait Effects 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
- C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8245—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified carbohydrate or sugar alcohol metabolism, e.g. starch biosynthesis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
- C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nutrition Science (AREA)
- Immunology (AREA)
- Virology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Cultivation Of Plants (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94434407P | 2007-06-15 | 2007-06-15 | |
| PCT/CA2008/001139 WO2008151440A1 (en) | 2007-06-15 | 2008-06-13 | Modifying glycoprotein production in plants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA31516B1 true MA31516B1 (fr) | 2010-07-01 |
Family
ID=40129187
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA32504A MA31516B1 (fr) | 2007-06-15 | 2010-01-12 | Modification de la production de glycoprotéine dans des plantes |
Country Status (24)
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2615372A1 (en) | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
| KR20100120157A (ko) | 2007-11-27 | 2010-11-12 | 메디카고 인코포레이티드 | 헤마글루티닌을 발현하는 트랜스제닉 식물에서 생산된 재조합 인플루엔자 바이러스-유사 입자(ＶＬＰｓ) |
| CN102089432A (zh) | 2008-07-08 | 2011-06-08 | 麦迪卡格公司 | 可溶性重组流感抗原 |
| AU2009270404B2 (en) | 2008-07-18 | 2015-01-29 | Medicago Inc. | New influenza virus immunizing epitope |
| HRP20180706T1 (hr) | 2009-06-24 | 2018-06-01 | Medicago Inc. | Kimerna gripa nalik čestici koja sadrži hemaglutinin |
| JP5551780B2 (ja) | 2009-09-22 | 2014-07-16 | メディカゴ インコーポレイテッド | 植物由来のタンパク質を調製する方法 |
| TWI620816B (zh) | 2011-03-23 | 2018-04-11 | 苜蓿股份有限公司 | 植物衍生蛋白回收方法 |
| US11673926B2 (en) * | 2011-06-07 | 2023-06-13 | Ibio, Inc. | In vivo de-glycosylation of recombinant proteins by co-expression with PNGase F |
| US9181532B2 (en) | 2011-07-29 | 2015-11-10 | Icon Genetics Gmbh | Production of galactosylated N-glycans in plants |
| WO2013044390A1 (en) | 2011-09-30 | 2013-04-04 | Medicago Inc. | Increasing virus-like particle yield in plants |
| KR20130125337A (ko) * | 2012-05-08 | 2013-11-18 | 경상대학교산학협력단 | 고-만노오스형 n-글라이칸을 생산하는 식물체 및 이를 이용한 고-만노오스형 n-글라이칸의 생산방법 |
| EP2978848B1 (en) | 2013-03-28 | 2020-05-06 | Medicago Inc. | Influenza virus-like particle production in plants |
| US12467058B2 (en) | 2013-03-28 | 2025-11-11 | Aramis Biotechnologies Inc. | Influenza virus-like particle production in plants |
| RU2731295C2 (ru) | 2014-07-11 | 2020-09-01 | Медикаго Инк. | Модификация продуцирования белков в растениях |
| EP3221455B1 (en) | 2014-11-20 | 2020-08-12 | Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. | Compositions and methods for producing polypeptides with a modified glycosylation pattern in plant cells |
| EP3548612A4 (en) | 2016-12-01 | 2020-04-15 | Plantform Corporation | TRANSGENIC PLANT WITH REDUCED FUCOSYL TRANSFERASE AND XYLOSYL TRANSFERASE ACTIVITY |
| US11649465B2 (en) * | 2017-09-11 | 2023-05-16 | R.J. Reynolds Tobacco Company | Methods and compositions for increasing expression of genes of interest in a plant by co-expression with p21 |
| EP4265104A4 (en) * | 2021-01-15 | 2024-12-11 | Denka Company Limited | METHOD FOR DETERMINING CULTURE CONDITIONS, AND METHOD FOR PRODUCING DESIRED PROTEIN OR DESIRED PEPTIDE |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5312746A (en) * | 1993-01-08 | 1994-05-17 | Life Technologies, Inc. | Cloning and expressing restriction endonucleases and modification methylases from caryophanon |
| GB9524350D0 (en) * | 1995-11-29 | 1996-01-31 | Lynxvale Ltd | Enhancer-increased gene expression in plants |
| US5945326A (en) * | 1997-03-20 | 1999-08-31 | New England Biolabs, Inc. | Method for cloning and producing the Spel restriction endonuclease |
| IL143641A0 (en) * | 1998-12-09 | 2002-04-21 | A method for manufacturing glycoproteins having human-type glycosylation | |
| DE60024658T2 (de) * | 1999-10-04 | 2006-08-24 | Medicago Inc., Sainte Foy | Promotor zur regulierung von fremdgenexpression |
| US7125978B1 (en) * | 1999-10-04 | 2006-10-24 | Medicago Inc. | Promoter for regulating expression of foreign genes |
| BR0014945A (pt) * | 1999-10-21 | 2004-08-31 | Monsanto Co | Modificação pós-traducional de proteìnas recombinantes produzidas em plantas |
| DE60035285T2 (de) * | 1999-10-26 | 2008-02-21 | Plant Research International B.V. | Glykolisierung des säugetiertyps in pflanzen |
| AU1738301A (en) * | 1999-10-26 | 2001-05-08 | Id-Lelystad, Instituut Voor Dierhouderij En Diergezondheid B.V. | Gonadotrophins in plants |
| WO2002057468A2 (en) * | 2001-01-19 | 2002-07-25 | The Dow Chemical Company | Method for secretory production of glycoprotein having human-type sugar chain using plant cell |
| US20030035774A1 (en) | 2001-07-18 | 2003-02-20 | Adjei Akwete L. | Salt/ion pair medicinal aerosol formulation |
| HUP0700103A3 (en) * | 2001-08-03 | 2012-09-28 | Glycart Biotechnology Ag | Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity |
| ES2806412T3 (es) * | 2002-02-13 | 2021-02-17 | Wisconsin Alumni Res Found | Señal para el empaquetamiento de vectores del virus de la gripe |
| JP4532118B2 (ja) * | 2002-03-19 | 2010-08-25 | スティヒティング ディーンスト ランドバウクンディフ オンデルズーク | 植物体内のグリカンプロセシングの最適化 |
| EP2319934B1 (en) * | 2002-03-19 | 2015-09-02 | Stichting Dienst Landbouwkundig Onderzoek | GnTIII (UDP-N-acetylglucosamine:Beta -D mannoside Beta (1,4)-N-acetylglucosaminyltransferase III) expression in plants. |
| CN1761746B (zh) * | 2003-01-22 | 2016-03-23 | 罗氏格黎卡特股份公司 | 融合构建体及其用来生产Fc受体结合亲和性和效应子功能提高的抗体的用途 |
| ATE475708T1 (de) * | 2003-01-22 | 2010-08-15 | Glycart Biotechnology Ag | Fusionskonstrukte und deren verwendung zur produktion von antikörpern mit erhöhter fc rezeptor bindungsaffinität und effektorfunktion |
| ATE473271T1 (de) * | 2003-05-05 | 2010-07-15 | Thompson Boyce Plant Res | Vektoren und zellen zur herstellung von aus transgenen pflanzen gewonnenen immunprotektiven zusammensetzungen |
| JP2006212019A (ja) * | 2004-04-30 | 2006-08-17 | National Institute Of Agrobiological Sciences | 植物を用いたユビキノン−１０の製造方法 |
-
2008
- 2008-06-13 DK DK08772802.8T patent/DK2155880T3/en active
- 2008-06-13 AU AU2008261527A patent/AU2008261527C1/en not_active Ceased
- 2008-06-13 PT PT87728028T patent/PT2155880T/pt unknown
- 2008-06-13 KR KR1020137014893A patent/KR20130075787A/ko not_active Ceased
- 2008-06-13 MX MX2009013665A patent/MX2009013665A/es active IP Right Grant
- 2008-06-13 SG SG2012066486A patent/SG185249A1/en unknown
- 2008-06-13 WO PCT/CA2008/001139 patent/WO2008151440A1/en not_active Ceased
- 2008-06-13 CN CN2013101091944A patent/CN103382487A/zh active Pending
- 2008-06-13 KR KR1020107000811A patent/KR101385050B1/ko not_active Expired - Fee Related
- 2008-06-13 NZ NZ598417A patent/NZ598417A/xx not_active IP Right Cessation
- 2008-06-13 PL PL08772802T patent/PL2155880T3/pl unknown
- 2008-06-13 JP JP2010511461A patent/JP5783720B2/ja not_active Expired - Fee Related
- 2008-06-13 NZ NZ581944A patent/NZ581944A/en unknown
- 2008-06-13 US US12/664,567 patent/US20110008837A1/en not_active Abandoned
- 2008-06-13 CA CA2700180A patent/CA2700180C/en active Active
- 2008-06-13 HU HUE08772802A patent/HUE031698T2/en unknown
- 2008-06-13 BR BRPI0812538-4A patent/BRPI0812538B1/pt not_active IP Right Cessation
- 2008-06-13 CN CN2008801031743A patent/CN101918559A/zh active Pending
- 2008-06-13 CA CA2795379A patent/CA2795379A1/en not_active Abandoned
- 2008-06-13 SI SI200831699A patent/SI2155880T1/sl unknown
- 2008-06-13 ES ES08772802.8T patent/ES2624776T3/es active Active
- 2008-06-13 RU RU2010101024/10A patent/RU2499053C2/ru active
- 2008-06-13 EP EP08772802.8A patent/EP2155880B1/en active Active
- 2008-06-13 CN CN201510364867.XA patent/CN104962579A/zh active Pending
-
2009
- 2009-12-07 IL IL202568A patent/IL202568A/en active IP Right Grant
- 2009-12-10 TN TNP2009000512A patent/TN2009000512A1/fr unknown
- 2009-12-14 EG EG2009121826A patent/EG26600A/en active
-
2010
- 2010-01-12 ZA ZA2010/00207A patent/ZA201000207B/en unknown
- 2010-01-12 MA MA32504A patent/MA31516B1/fr unknown
-
2013
- 2013-08-08 RU RU2013137208/10A patent/RU2013137208A/ru not_active Application Discontinuation
Also Published As
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