MA28673B1 - Derives de pyrazole, compositions contenant lesdits composes et methodes d'utilisation - Google Patents

Derives de pyrazole, compositions contenant lesdits composes et methodes d'utilisation

Info

Publication number
MA28673B1
MA28673B1 MA29545A MA29545A MA28673B1 MA 28673 B1 MA28673 B1 MA 28673B1 MA 29545 A MA29545 A MA 29545A MA 29545 A MA29545 A MA 29545A MA 28673 B1 MA28673 B1 MA 28673B1
Authority
MA
Morocco
Prior art keywords
methods
same
compositions containing
pyrazole derivatives
pyrazoles
Prior art date
Application number
MA29545A
Other languages
English (en)
Inventor
Emma R Parmee
Yusheng Xiong
Jian Guo
Rui Liang
Linda Brockunier
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of MA28673B1 publication Critical patent/MA28673B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Des pyrazoles ayant un groupement naphtyle attaché sont décrits. Les composés sont utiles pour traiter le diabète de type 2 et les pathologies y relatives. Des compositions pharmaceutiques et méthodes de traitement sont aussi comprises.
MA29545A 2004-06-04 2006-12-20 Derives de pyrazole, compositions contenant lesdits composes et methodes d'utilisation MA28673B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57711604P 2004-06-04 2004-06-04

Publications (1)

Publication Number Publication Date
MA28673B1 true MA28673B1 (fr) 2007-06-01

Family

ID=35335786

Family Applications (1)

Application Number Title Priority Date Filing Date
MA29545A MA28673B1 (fr) 2004-06-04 2006-12-20 Derives de pyrazole, compositions contenant lesdits composes et methodes d'utilisation

Country Status (34)

Country Link
US (2) US7598285B2 (fr)
EP (1) EP1756064B1 (fr)
JP (2) JP4108739B2 (fr)
CN (1) CN1964947A (fr)
AR (2) AR049291A1 (fr)
AT (1) ATE395338T1 (fr)
AU (2) AU2005252183B2 (fr)
BR (1) BRPI0511703B8 (fr)
CA (1) CA2566945C (fr)
CR (1) CR8766A (fr)
CY (1) CY1108544T1 (fr)
DE (1) DE602005006806D1 (fr)
DK (1) DK1756064T3 (fr)
EA (1) EA012431B1 (fr)
EC (1) ECSP067062A (fr)
ES (1) ES2306165T3 (fr)
GE (1) GEP20094605B (fr)
HR (1) HRP20080311T3 (fr)
IL (1) IL179754A (fr)
MA (1) MA28673B1 (fr)
MX (1) MXPA06014084A (fr)
MY (1) MY143599A (fr)
NI (1) NI200600290A (fr)
NO (1) NO339149B1 (fr)
NZ (1) NZ551405A (fr)
PE (1) PE20060427A1 (fr)
PL (1) PL1756064T3 (fr)
PT (1) PT1756064E (fr)
SI (1) SI1756064T1 (fr)
TN (1) TNSN06397A1 (fr)
TW (1) TWI293952B (fr)
UA (1) UA85884C2 (fr)
WO (1) WO2005121097A2 (fr)
ZA (1) ZA200609489B (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004210127B2 (en) 2003-01-27 2009-10-01 Merck Sharp & Dohme Corp. Substituted pyrazoles, compositions containing such compounds and methods of use
PT1756064E (pt) 2004-06-04 2008-07-22 Merck & Co Inc Derivados de pirazole, composições contendo tais compostos e métodos de utilização
JP2008507528A (ja) * 2004-07-22 2008-03-13 メルク　エンド　カムパニー　インコーポレーテッド 置換ピラゾール、このような化合物を含有する組成物及び使用方法
AU2006276072A1 (en) * 2005-07-26 2007-02-08 Merck Sharp & Dohme Corp. Process for synthesizing a substituted pyrazole
AR056574A1 (es) * 2005-10-19 2007-10-10 Merck & Co Inc Derivados de pirazol, composiciones que contienen dichos compuestos y procedimientos de uso
US20100099712A1 (en) * 2007-01-17 2010-04-22 Laboratorios Del Dr. Esteve, S.A. Substituted pyrazoline compounds with acat inhibition activity
MX2009008534A (es) 2007-02-09 2009-11-23 Metabasis Therapeutics Inc Antagonistas novedosos del receptor de glucagon.
WO2009005675A1 (fr) * 2007-06-28 2009-01-08 Abbott Laboratories Nouvelles triazolopyridazines
US8232413B2 (en) * 2007-09-12 2012-07-31 Merck Sharp & Dohme Corp. Process for the production of a crystalline glucagon receptor antagonist compound
GEP20135844B (en) 2008-03-05 2013-06-10 Takeda Pharmaceutical Heterocyclic compound
JP5437232B2 (ja) 2008-03-11 2014-03-12 あすか製薬株式会社 固体分散体とその医薬組成物、並びにそれらの製造方法
US8623818B2 (en) 2008-05-16 2014-01-07 Merck Sharp & Dohme Corp. Glucagon receptor antagonists, compositions, and methods for their use
PT2799428T (pt) 2008-08-13 2017-02-17 Metabasis Therapeutics Inc Antagonistas de glicagina
RU2008135294A (ru) * 2008-08-29 2010-03-10 Дик Корпорейшн (Jp) Нафталиновые производные
WO2010030722A1 (fr) * 2008-09-15 2010-03-18 Merck Sharp & Dohme Corp. Composés antagonistes du récepteur du glucagon, compositions contenant ces composés et méthodes d'utilisation
US8361959B2 (en) * 2008-10-03 2013-01-29 Merck Sharp & Dohme Corp. Spiro-imidazolone derivatives as glucagon receptor antagonists
WO2010093535A1 (fr) 2009-02-12 2010-08-19 Merck Sharp & Dohme Corp. Composés antagonistes de récepteur de glucagon, compositions contenant ces composés et procédés d'utilisation
WO2010098994A1 (fr) 2009-02-25 2010-09-02 Merck Sharp & Dohme Corp. Composés antagonistes du récepteur du glucagon, compositions contenant de tels composés et procédés d'utilisation
EP2440553B1 (fr) 2009-06-12 2017-08-23 Merck Sharp & Dohme Corp. Thiophènes en tant qu'antagonistes du récepteur du glucagon, compositions, et leurs procédés d'utilisation
WO2011037815A1 (fr) 2009-09-22 2011-03-31 Schering Corporation Pyrrolidines inédites utilisées en tant qu'antagonistes des récepteurs au glucagon, compositions en contenant et leurs procédés d'utilisation
MX2013006768A (es) 2010-12-23 2013-07-22 Pfizer Moduladores de receptor de glucagon.
EA023517B1 (ru) 2011-02-08 2016-06-30 Пфайзер Инк. Модуляторы глюкагонового рецептора
US8927577B2 (en) 2011-07-22 2015-01-06 Pfizer Inc. Quinolinyl glucagon receptor modulators
TW201427658A (zh) 2012-12-10 2014-07-16 Merck Sharp & Dohme 藉由投予升糖素受體拮抗劑及膽固醇吸收抑制劑治療糖尿病之方法
WO2015066252A1 (fr) 2013-11-04 2015-05-07 Merck Sharp & Dohme Corp. Composés antagonistes du récepteur du glucagon, compositions correspodantes et méthodes d'utilisation
CN103933032B (zh) * 2013-12-30 2019-08-23 北京赛林泰医药技术有限公司 作为抗癌药物的吡唑类衍生物的使用方法和用途
US10076504B2 (en) 2014-06-12 2018-09-18 Ligand Pharmaceuticals, Inc. Glucagon antagonists
MX2019002437A (es) 2016-08-30 2019-10-09 Regeneron Pharma Metodos para tratar la resistencia severa a la insulina interfiriendo con la señalizacion del receptor de glucagon.
TWI763705B (zh) * 2016-09-06 2022-05-11 比利時商健生藥品公司 可作為升糖素受體拮抗劑之吲哚衍生物
EP3529278A1 (fr) 2016-10-20 2019-08-28 Regeneron Pharmaceuticals, Inc. Méthodes d'abaissement de niveaux de glycémie
US20210130480A1 (en) 2017-08-22 2021-05-06 Regeneron Pharmaceuticals, Inc. Methods of treating urea cycle disorders by interfering with glucagon receptor signaling
WO2019160940A1 (fr) 2018-02-13 2019-08-22 Ligand Pharmaceuticals Incorporated Antagonistes de récepteur de glucagon

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9303993D0 (en) 1993-02-26 1993-04-14 Fujisawa Pharmaceutical Co New heterocyclic derivatives
AU702887B2 (en) 1995-10-31 1999-03-11 Merck & Co., Inc. Substituted pyridyl pyrroles, compositions containing such compounds and methods of use
AR008789A1 (es) * 1996-07-31 2000-02-23 Bayer Corp Piridinas y bifenilos substituidos
US5776954A (en) * 1996-10-30 1998-07-07 Merck & Co., Inc. Substituted pyridyl pyrroles, compositions containing such compounds and methods of use
JP2000514088A (ja) 1996-11-20 2000-10-24 メルク エンド カンパニー インコーポレーテッド グルカゴンアンタゴニストとしてのトリアリール置換イミダゾール
WO1998021957A1 (fr) 1996-11-20 1998-05-28 Merck & Co., Inc. Imidazoles a substitution triaryle, compositions renfermant de tels composes et modes d'utilisation
CA2271941A1 (fr) 1996-11-20 1998-05-28 Merck & Co., Inc. Imidazoles a substitution triaryle et leurs procedes d'utilisation
EP0945438B1 (fr) * 1996-12-12 2003-03-05 Banyu Pharmaceutical Co., Ltd. Derives de pyrazole
NZ500141A (en) 1997-04-18 2002-05-31 G Method of using cyclooxygenase-2 inhibitors in the prevention of cardiovascular disorders
US6613942B1 (en) 1997-07-01 2003-09-02 Novo Nordisk A/S Glucagon antagonists/inverse agonists
US6420427B1 (en) * 1997-10-09 2002-07-16 Ono Pharmaceutical Co., Ltd. Aminobutyric acid derivatives
HUP0101099A3 (en) 1997-12-19 2002-09-30 Amgen Inc Thousand Oaks Substituted pyridine and pyridazine compounds and their pharmaceutical use
EP1113801A4 (fr) 1998-09-17 2002-10-02 Bristol Myers Squibb Co PROCEDE POUR TRAITER L'ATHEROSCLEROSE AU MOYEN D'UN INHIBITEUR D'aP2 OU D'UNE COMBINAISON CORRESPONDANTE
US6503949B1 (en) * 1999-05-17 2003-01-07 Noro Nordisk A/S Glucagon antagonists/inverse agonists
AU5841400A (en) * 1999-08-10 2001-03-05 Nihon Bayer Agrochem K.K. Herbicidal tetrazolinone derivatives
ES2225252T3 (es) * 1999-11-10 2005-03-16 Takeda Chemical Industries, Ltd. Compuestos n-heterociclicos de 5 miembros con actividad hipoglucemica e hipolipidemica.
US6562807B2 (en) * 2000-06-23 2003-05-13 Novo Nordisk A/S Glucagon antagonists/inverse agonists
DE60128475T2 (de) * 2000-07-25 2008-02-07 Merck & Co., Inc. N-substituierte indole mit anwendung in der behandlung von diabetes
US20030203946A1 (en) 2000-11-17 2003-10-30 Carsten Behrens Glucagon antagonists/inverse agonists
AU2002223501A1 (en) 2000-11-17 2002-05-27 Agouron Pharmaceuticals, Inc. Glucagon antagonists/inverse agonists
ITMI20010733A1 (it) * 2001-04-05 2002-10-05 Recordati Chem Pharm Uso di inibitori dell'isoenzina cox-2 per il trattamento dell'incontinenza urinaria
US6762318B2 (en) * 2001-12-03 2004-07-13 Novo Nordisk A/S Glucagon antagonists
US6881746B2 (en) * 2001-12-03 2005-04-19 Novo Nordick A/S Glucagon antagonists/inverse agonists
WO2003051357A1 (fr) 2001-12-19 2003-06-26 Novo Nordisk A/S Antagonistes/agonistes inverses du recepteur du glucagon
WO2003053938A1 (fr) 2001-12-20 2003-07-03 Novo Nordisk A/S Nouveaux antagonistes/agonistes inverses du recepteur du glucagon
JP4415216B2 (ja) * 2002-02-01 2010-02-17 大日本住友製薬株式会社 ２−フランカルボン酸ヒドラジド化合物及びそれを含有する医薬組成物
WO2004009158A2 (fr) 2002-07-19 2004-01-29 Baxter International Inc. Systemes et methodes de dialyse peritoneale
EP1400243A1 (fr) 2002-09-19 2004-03-24 Tanabe Seiyaku Co., Ltd. Activateur de canaux potassiques dependants du calcium
AU2003298889A1 (en) * 2002-12-04 2004-06-23 Merck & Co., Inc. Spirocyclic ureas, compositions containing such compounds and methods of use
AU2004210127B2 (en) * 2003-01-27 2009-10-01 Merck Sharp & Dohme Corp. Substituted pyrazoles, compositions containing such compounds and methods of use
BRPI0409447A (pt) * 2003-04-14 2006-04-18 Inst For Pharm Discovery Inc ácidos fenilalcanóicos substituìdos
JP2006528687A (ja) * 2003-05-09 2006-12-21 メルク　エンド　カムパニー　インコーポレーテッド ベンズイミダゾール、こうした化合物を含有する組成物および使用方法
PT1756064E (pt) 2004-06-04 2008-07-22 Merck & Co Inc Derivados de pirazole, composições contendo tais compostos e métodos de utilização
JP2008507528A (ja) * 2004-07-22 2008-03-13 メルク　エンド　カムパニー　インコーポレーテッド 置換ピラゾール、このような化合物を含有する組成物及び使用方法
AR056574A1 (es) * 2005-10-19 2007-10-10 Merck & Co Inc Derivados de pirazol, composiciones que contienen dichos compuestos y procedimientos de uso

Also Published As

Publication number Publication date
JP4108739B2 (ja) 2008-06-25
EP1756064B1 (fr) 2008-05-14
MY143599A (en) 2011-06-15
CA2566945C (fr) 2010-09-21
EA200602196A1 (ru) 2007-06-29
ECSP067062A (es) 2007-01-26
SI1756064T1 (sl) 2008-12-31
AU2005252183A1 (en) 2005-12-22
US7799818B2 (en) 2010-09-21
WO2005121097A2 (fr) 2005-12-22
AR088919A2 (es) 2014-07-16
US20090176854A1 (en) 2009-07-09
BRPI0511703B1 (pt) 2018-07-17
BRPI0511703A (pt) 2008-01-08
ATE395338T1 (de) 2008-05-15
PE20060427A1 (es) 2006-06-19
IL179754A (en) 2013-12-31
ES2306165T3 (es) 2008-11-01
NO20070073L (no) 2007-03-05
TW200604179A (en) 2006-02-01
CN1964947A (zh) 2007-05-16
DE602005006806D1 (de) 2008-06-26
GEP20094605B (en) 2009-02-10
IL179754A0 (en) 2007-05-15
BRPI0511703B8 (pt) 2021-05-25
US20050272794A1 (en) 2005-12-08
HRP20080311T3 (en) 2008-07-31
JP2008505062A (ja) 2008-02-21
PT1756064E (pt) 2008-07-22
AU2005252183B2 (en) 2008-07-17
TWI293952B (en) 2008-03-01
US7598285B2 (en) 2009-10-06
JP4733153B2 (ja) 2011-07-27
WO2005121097A3 (fr) 2006-02-16
MXPA06014084A (es) 2007-02-15
TNSN06397A1 (en) 2008-02-22
AR049291A1 (es) 2006-07-12
EA012431B1 (ru) 2009-10-30
CR8766A (es) 2007-08-28
ZA200609489B (en) 2007-10-31
CY1108544T1 (el) 2014-04-09
AU2008229701B2 (en) 2010-03-04
NO339149B1 (no) 2016-11-14
UA85884C2 (uk) 2009-03-10
PL1756064T3 (pl) 2008-11-28
EP1756064A2 (fr) 2007-02-28
DK1756064T3 (da) 2008-09-22
AU2008229701C1 (en) 2010-07-29
JP2008150388A (ja) 2008-07-03
CA2566945A1 (fr) 2005-12-22
NZ551405A (en) 2009-06-26
AU2008229701A1 (en) 2008-10-30
NI200600290A (es) 2007-08-07

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