MA28396B1 - Dérivés de quinoléine nouveaux - Google Patents

Dérivés de quinoléine nouveaux

Info

Publication number
MA28396B1
MA28396B1 MA29132A MA29132A MA28396B1 MA 28396 B1 MA28396 B1 MA 28396B1 MA 29132 A MA29132 A MA 29132A MA 29132 A MA29132 A MA 29132A MA 28396 B1 MA28396 B1 MA 28396B1
Authority
MA
Morocco
Prior art keywords
quinoline derivatives
new quinoline
new
derivatives
quinoline
Prior art date
Application number
MA29132A
Other languages
English (en)
Inventor
Yufeng Hong
Robert Steven Kania
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34738830&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA28396(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of MA28396B1 publication Critical patent/MA28396B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
MA29132A 2003-12-23 2006-06-23 Dérivés de quinoléine nouveaux MA28396B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53272503P 2003-12-23 2003-12-23

Publications (1)

Publication Number Publication Date
MA28396B1 true MA28396B1 (fr) 2007-01-02

Family

ID=34738830

Family Applications (1)

Application Number Title Priority Date Filing Date
MA29132A MA28396B1 (fr) 2003-12-23 2006-06-23 Dérivés de quinoléine nouveaux

Country Status (33)

Country Link
US (2) US7381824B2 (fr)
EP (1) EP1699780A1 (fr)
JP (1) JP4503022B2 (fr)
KR (1) KR100807920B1 (fr)
CN (1) CN1890234A (fr)
AP (1) AP2006003619A0 (fr)
AR (1) AR048292A1 (fr)
AU (1) AU2004309166B2 (fr)
BR (1) BRPI0418102A (fr)
CA (1) CA2551508C (fr)
CR (1) CR8482A (fr)
EA (1) EA009994B1 (fr)
EC (1) ECSP066671A (fr)
GE (1) GEP20084572B (fr)
GT (1) GT200400274A (fr)
HN (1) HN2004000544A (fr)
IL (1) IL175947A (fr)
IS (1) IS8439A (fr)
MA (1) MA28396B1 (fr)
MX (1) MXPA06007242A (fr)
MY (1) MY139446A (fr)
NL (1) NL1027847C2 (fr)
NO (1) NO20063382L (fr)
NZ (1) NZ547009A (fr)
OA (1) OA13349A (fr)
PE (1) PE20050757A1 (fr)
SG (1) SG141459A1 (fr)
TN (1) TNSN06200A1 (fr)
TW (1) TWI331148B (fr)
UA (1) UA82577C2 (fr)
UY (1) UY28692A1 (fr)
WO (1) WO2005063739A1 (fr)
ZA (1) ZA200603657B (fr)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0418102A (pt) * 2003-12-23 2007-04-27 Pfizer derivados de quinolina
WO2005073224A2 (fr) * 2004-01-23 2005-08-11 Amgen Inc Composes et methodes d'utilisation de ces derniers
BRPI0614115A2 (pt) 2005-08-08 2011-03-09 Pfizer sais e polimofos de um inibidor de vergf-r, composição farmacêutica e cápsula contendo os mesmos, bem como seu uso
JP2009518382A (ja) * 2005-12-05 2009-05-07 ファイザー・プロダクツ・インク Ｖｅｇｆ−ｒ阻害剤を調製する方法
GB0604937D0 (en) * 2006-03-10 2006-04-19 Novartis Ag Organic compounds
WO2008020302A2 (fr) * 2006-08-17 2008-02-21 Pfizer Products Inc. Composés hétéro-aromatiques à base de quinoline
US8163923B2 (en) 2007-03-14 2012-04-24 Advenchen Laboratories, Llc Spiro substituted compounds as angiogenesis inhibitors
US8148532B2 (en) * 2007-03-14 2012-04-03 Guoqing Paul Chen Spiro substituted compounds as angiogenesis inhibitors
US8642067B2 (en) 2007-04-02 2014-02-04 Allergen, Inc. Methods and compositions for intraocular administration to treat ocular conditions
EP2154967B9 (fr) 2007-04-16 2014-07-23 Hutchison Medipharma Enterprises Limited Dérivés de pyrimidine
US7829574B2 (en) * 2008-05-09 2010-11-09 Hutchison Medipharma Enterprises Limited Substituted quinazoline compounds and their use in treating angiogenesis-related diseases
CN101584696A (zh) * 2008-05-21 2009-11-25 上海艾力斯医药科技有限公司 包含喹唑啉衍生物的组合物及制备方法、用途
US8426430B2 (en) 2008-06-30 2013-04-23 Hutchison Medipharma Enterprises Limited Quinazoline derivatives
US8211911B2 (en) 2008-08-19 2012-07-03 Guoqing Paul Chen Compounds as kinase inhibitors
TW201008933A (en) 2008-08-29 2010-03-01 Hutchison Medipharma Entpr Ltd Pyrimidine compounds
AU2009303602B2 (en) 2008-10-14 2012-06-14 Sunshine Lake Pharma Co., Ltd. Compounds and methods of use
IT1393351B1 (it) * 2009-03-16 2012-04-20 Eos Ethical Oncology Science Spa In Forma Abbreviata Eos Spa Procedimento per la preparazione della 6-(7-((1-amminociclopropil)metossi)-6-metossichinolin-4-ilossi)-n-metil-1-naftammide e suoi intermedi di sintesi
EP2408300B1 (fr) * 2009-03-21 2016-05-11 Sunshine Lake Pharma Co., Ltd. Dérivés d'ester d'amino, sels de ceux-ci et procédés d'utilisation
CN106866667B (zh) 2009-11-05 2019-11-15 圣母大学 咪唑并[1,2-a]吡啶类化合物及其合成及使用方法
WO2012042421A1 (fr) 2010-09-29 2012-04-05 Pfizer Inc. Procédé de traitement de la croissance cellulaire anormale
AU2012225735B2 (en) 2011-03-04 2016-03-10 Glaxosmithkline Intellectual Property Development Limited Amino-quinolines as kinase inhibitors
FR2973703A1 (fr) * 2011-04-08 2012-10-12 Univ Provence Aix Marseille 1 Derives de 4-arylcoumarine et de 4-arylquinoleine, leurs utilisations therapeutiques et leur procede de synthese
TWI547494B (zh) 2011-08-18 2016-09-01 葛蘭素史克智慧財產發展有限公司 作為激酶抑制劑之胺基喹唑啉類
UY34305A (es) 2011-09-01 2013-04-30 Novartis Ag Derivados de heterociclos bicíclicos para el tratamiento de la hipertensión arterial pulmonar
AR092529A1 (es) 2012-09-13 2015-04-22 Glaxosmithkline Llc Compuesto de aminoquinazolina, composicion farmaceutica que lo comprende y uso de dicho compuesto para la preparacion de un medicamento
TW201425307A (zh) 2012-09-13 2014-07-01 Glaxosmithkline Llc 作為激酶抑制劑之胺基－喹啉類
AU2014219024B2 (en) 2013-02-20 2018-04-05 KALA BIO, Inc. Therapeutic compounds and uses thereof
ES2654100T3 (es) 2013-02-21 2018-02-12 Glaxosmithkline Intellectual Property Development Limited Quinazolinas como inhibidores de quinasa
US9073921B2 (en) 2013-03-01 2015-07-07 Novartis Ag Salt forms of bicyclic heterocyclic derivatives
CN103524409B (zh) * 2013-09-26 2015-09-02 上海仁力医药科技有限公司 喹啉类化合物及其制备方法与应用
CN105311029A (zh) * 2014-06-06 2016-02-10 正大天晴药业集团股份有限公司 抗肿瘤活性的喹啉衍生物
CN105213394B (zh) * 2014-06-06 2019-04-09 正大天晴药业集团股份有限公司 具有抗肿瘤活性的喹啉衍生物
EP2974729A1 (fr) * 2014-07-17 2016-01-20 Abivax Dérivés de quinoléine utilisés dans le traitement de maladies inflammatoires
CN104628686A (zh) * 2015-01-27 2015-05-20 南通恒盛精细化工有限公司 一种带酰胺侧链的苯并呋喃制备工艺
US10654808B2 (en) 2015-04-07 2020-05-19 Guangdong Raynovent Biotech Co., Ltd. Tyrosine kinase inhibitor and pharmaceutical composition comprising same
US9890187B2 (en) 2015-06-26 2018-02-13 Epos-Iasis Research And Development, Ltd. Prototype systems of theranostic biomarkers for in vivo molecular management of cancer
CA2998375A1 (fr) 2015-09-17 2017-03-23 Marvin J. Miller Composes heterocycliques contenant de la benzylamine et compositions utiles contre une infection mycobacterienne
AU2016333987A1 (en) 2015-10-05 2018-05-10 Ny State Psychiatric Institute Activators of autophagic flux and phospholipase D and clearance of protein aggregates including tau and treatment of proteinopathies
EP3521276B1 (fr) * 2016-09-30 2021-03-10 Guangdong Raynovent Biotech Co., Ltd. Forme cristalline, forme de sel, et procédé de préparation d'inhibiteur de tyrosine kinase
CN107337634B (zh) * 2017-08-28 2019-07-09 新发药业有限公司 一种阿贝西利中间体化合物的制备方法
FR3080620B1 (fr) 2018-04-27 2021-11-12 Univ Paris Sud Composes a activite inhibitrice de la polymerisation de la tubuline et aux proprietes immunomodulatrices
WO2023138674A1 (fr) * 2022-01-21 2023-07-27 默达药物（香港）有限公司 Composé n-hydroxyquinoléine carboxamide et son utilisation

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE317376B (fr) * 1961-07-10 1969-11-17 Roussel Uclaf
FR2077455A1 (en) 1969-09-03 1971-10-29 Aries Robert 5-haloveratryl-4-aminoquinoles - antimalarials amoebicides anthelmintics anticoccidials
US3755332A (en) * 1971-07-01 1973-08-28 Ciba Geigy Corp Substituted 4 indazolaminoquinolines
US3936461A (en) * 1973-09-24 1976-02-03 Warner-Lambert Company Substituted 4-benzylquinolines
FR2498187A1 (fr) * 1981-01-16 1982-07-23 Rhone Poulenc Sante Procede de preparation d'amino-4 chloro-7 quinoleines
JPS62168137A (ja) * 1985-12-20 1987-07-24 Fuji Photo Film Co Ltd ハロゲン化銀カラ−写真感光材料およびその処理方法
IL89029A (en) 1988-01-29 1993-01-31 Lilly Co Eli Fungicidal quinoline and cinnoline derivatives, compositions containing them, and fungicidal methods of using them
US5710158A (en) 1991-05-10 1998-01-20 Rhone-Poulenc Rorer Pharmaceuticals Inc. Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
CA2108889A1 (fr) 1991-05-29 1992-11-30 Robert Lee Dow Inhibiteurs tricycliques et polyhydroxyliques de la tyrosine kinase
WO1993003030A1 (fr) 1991-08-02 1993-02-18 Pfizer Inc. Derives de quinoline utilises comme immunostimulants____________
GB9127252D0 (en) 1991-12-23 1992-02-19 Boots Co Plc Therapeutic agents
US6177401B1 (en) 1992-11-13 2001-01-23 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis
GB9323290D0 (en) 1992-12-10 1994-01-05 Zeneca Ltd Quinazoline derivatives
IL112248A0 (en) 1994-01-25 1995-03-30 Warner Lambert Co Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
AU686843B2 (en) 1994-02-23 1998-02-12 Pfizer Inc. 4-heterocyclyl-substituted quinazoline derivatives, processes for their preparation and their use as anti-cancer agents
GB9510757D0 (en) 1994-09-19 1995-07-19 Wellcome Found Therapeuticaly active compounds
TW321649B (fr) 1994-11-12 1997-12-01 Zeneca Ltd
EP0817775B1 (fr) 1995-03-30 2001-09-12 Pfizer Inc. Derives de quinazoline
US5880141A (en) * 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
MX9709867A (es) 1995-06-07 1998-03-31 Pfizer Derivados de pirimidina condensados con un anillo heterociclico, composiciones que contienen los mismos, y uso de los mismos.
GB9514265D0 (en) 1995-07-13 1995-09-13 Wellcome Found Hetrocyclic compounds
AR004010A1 (es) 1995-10-11 1998-09-30 Glaxo Group Ltd Compuestos heterociclicos
US6143764A (en) * 1995-11-07 2000-11-07 Kirin Beer Kabushiki Kaisha Quinoline and quinazoline derivatives inhibiting platelet-derived growth factor receptor autophosphorylation and pharmaceutical compositions containing the same
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
DE69709319T2 (de) 1996-03-05 2002-08-14 Astrazeneca Ab 4-anilinochinazolin derivate
CA2258548C (fr) 1996-06-24 2005-07-26 Pfizer Inc. Derives tricycliques substitues par phenylamino, destines au traitement des maladies hyperproliferatives
JPH11512750A (ja) * 1996-06-27 1999-11-02 ファイザー インク． ２―（２―オキソ―エチリデン）―イミダゾリジン―４―オンの誘導体およびファルネシル蛋白質トランスフェラーゼ阻害物質としてのそれらの使用法
EA199900021A1 (ru) 1996-07-13 1999-08-26 Глаксо, Груп Лимитед Бициклические гетероароматические соединения в качестве ингибиторов протеинтирозинкиназы
HRP970371A2 (en) 1996-07-13 1998-08-31 Kathryn Jane Smith Heterocyclic compounds
JP2001500890A (ja) 1996-09-25 2001-01-23 ゼネカ リミテッド Ｖｅｇｆのような成長因子の作用を阻害するキノリン誘導体
US6225318B1 (en) * 1996-10-17 2001-05-01 Pfizer Inc 4-aminoquinazolone derivatives
BR9713552A (pt) 1996-11-27 2000-01-25 Pfizer Derivados de pirimidina bicìclicos condensados
JP4495257B2 (ja) 1997-02-19 2010-06-30 バーレツクス ラボラトリーズ インコーポレーテツド Ｎｏｓ抑制剤としてのｎ−複素環誘導体
ES2239393T3 (es) 1997-05-07 2005-09-16 Sugen, Inc. Derivados de 2-indolinona utilizados como moduladores de la actividad de la proteina-quinasa.
AU7345798A (en) 1997-05-12 1998-12-08 Kennedy Institute Of Rheumatology, The Suppression of tumor necrosis factor alpha and vascular endothelial growth factor in therapy
JP2002501532A (ja) 1997-05-30 2002-01-15 メルク エンド カンパニー インコーポレーテッド 新規血管形成阻害薬
DE69838172T2 (de) 1997-08-22 2008-04-10 Astrazeneca Ab Oxindolylchinazolinderivate als angiogenesehemmer
EP1017682A4 (fr) 1997-09-26 2000-11-08 Merck & Co Inc Nouveaux inhibiteurs de l'angiogenese
CN101328186A (zh) 1997-11-11 2008-12-24 辉瑞产品公司 用作抗癌药的噻吩并嘧啶和噻吩并吡啶衍生物
JP4194678B2 (ja) 1997-11-28 2008-12-10 キリンファーマ株式会社 キノリン誘導体およびそれを含む医薬組成物
AU3850299A (en) 1998-05-20 1999-12-06 Kyowa Hakko Kogyo Co. Ltd. Vegf activity inhibitors
US6395734B1 (en) 1998-05-29 2002-05-28 Sugen, Inc. Pyrrole substituted 2-indolinone protein kinase inhibitors
AU763669B2 (en) * 1998-09-29 2003-07-31 Wyeth Holdings Corporation Substituted 3-cyanoquinolines as protein tyrosine kinases inhibitors
GB9827882D0 (en) 1998-12-17 1999-02-10 Smithkline Beecham Plc Novel compounds
IL143901A0 (en) 1998-12-23 2002-04-21 Searle & Co Use of cyclooxygenase-2- inhibitor, a matrix metallaproteinase inhibitor, an antineoplastic agent and optionally radiation as a combination treatment of neoplasia
NZ513006A (en) 1999-01-22 2003-10-31 Kirin Brewery Quinoline derivatives and quinazoline derivatives
KR20080015482A (ko) 1999-02-10 2008-02-19 아스트라제네카 아베 혈관형성 억제제로서의 퀴나졸린 유도체
GB9904103D0 (en) 1999-02-24 1999-04-14 Zeneca Ltd Quinoline derivatives
CA2395414A1 (fr) 1999-12-24 2001-07-05 Kyowa Hakko Kogyo Co., Ltd Derives de purine condense
EP1243582A4 (fr) 1999-12-24 2003-06-04 Kirin Brewery Quinoline, derives de la quinazoline et medicaments contenant ces substances
EP1265635A1 (fr) 2000-03-22 2002-12-18 Glaxo Group Limited Produit pharmaceutique comprenant un agent bloquant le cycle cellulaire et anticorps
WO2001074296A2 (fr) 2000-03-31 2001-10-11 Imclone Systems Incorporated Traitement de tumeurs non solides chez des mammiferes au moyen d'antagonistes de recepteur de facteur de croissance endothelial vasculaire
GB0008269D0 (en) * 2000-04-05 2000-05-24 Astrazeneca Ab Combination chemotherapy
EP1297016B1 (fr) 2000-05-12 2006-03-22 Vlaams Interuniversitair Instituut voor Biotechnologie vzw. Utilisation d'inhibiteurs du facteur de croissance placentaire pour le traitement de l'angiogenese pathologique, de l'arteriogenese pathologique, de l'inflammation, de la formation tumorale et/ou de la fuite vasculaire
AU2001276536B2 (en) * 2000-08-09 2007-01-04 Astrazeneca Ab Quinoline derivatives having vegf inhibiting activity
KR100389127B1 (ko) 2000-10-09 2003-06-25 동부한농화학 주식회사 벤조피라닐 헤테로고리 유도체, 그의 제조방법 및 그를포함하는 약학적 조성물
WO2002030453A1 (fr) 2000-10-12 2002-04-18 Beth Israel Deaconess Medical Center, Inc. Procedes d'inhibition de l'angiogenese utilisant des inhibiteurs de la nadph-oxydase
EP1415987B1 (fr) * 2000-10-20 2007-02-28 Eisai R&D Management Co., Ltd. Composes heteroaromatiques azotes pour le traitement des maladies de cancer
EP1339458B1 (fr) 2000-11-22 2007-08-15 Novartis AG Combinaison comprenant un agent diminuant l'activite du facteur de croissance endotelial vasculaire et un agent diminuant l'activite du facteur de croissance de l'epiderme
WO2002064170A1 (fr) 2001-02-09 2002-08-22 Children's Medical Center Corporation Methode pour traiter le cancer et augmenter le taux d'hematocrite
US20040241160A1 (en) 2001-07-13 2004-12-02 Yan Wu Vegfr-1 antibodies to treat breast cancer
WO2003033472A1 (fr) 2001-10-17 2003-04-24 Kirin Beer Kabushiki Kaisha Derives de quinoline ou de quinazoline inhibant l'autophosphorylation de recepteurs du facteur de croissance des fibroblastes
CN100506224C (zh) 2001-10-25 2009-07-01 诺瓦提斯公司 包含选择性环加氧酶-2抑制剂的组合
JP2005527511A (ja) * 2002-03-01 2005-09-15 ファイザー インコーポレイテッド 抗血管形成剤として有用なチエノピリジンのインドリル−尿素誘導体およびその使用法
JPWO2004018430A1 (ja) 2002-08-23 2005-12-08 麒麟麦酒株式会社 ＴＧＦβ阻害活性を有する化合物およびそれを含んでなる医薬組成物
WO2004020434A1 (fr) 2002-08-30 2004-03-11 Eisai Co., Ltd. Derives d'azaarene
BRPI0418102A (pt) * 2003-12-23 2007-04-27 Pfizer derivados de quinolina

Also Published As

Publication number Publication date
KR100807920B1 (ko) 2008-02-27
PE20050757A1 (es) 2005-10-31
TWI331148B (en) 2010-10-01
US7923457B2 (en) 2011-04-12
GT200400274A (es) 2005-09-20
NZ547009A (en) 2009-09-25
JP2007516273A (ja) 2007-06-21
EA009994B1 (ru) 2008-06-30
KR20060101548A (ko) 2006-09-25
UY28692A1 (es) 2005-07-29
NL1027847C2 (nl) 2006-04-19
NL1027847A1 (nl) 2005-06-27
GEP20084572B (en) 2008-12-25
UA82577C2 (en) 2008-04-25
US20050137395A1 (en) 2005-06-23
JP4503022B2 (ja) 2010-07-14
CA2551508C (fr) 2011-08-09
WO2005063739A1 (fr) 2005-07-14
MXPA06007242A (es) 2006-08-18
SG141459A1 (en) 2008-04-28
CN1890234A (zh) 2007-01-03
ECSP066671A (es) 2006-10-25
EP1699780A1 (fr) 2006-09-13
AP2006003619A0 (en) 2006-06-30
IL175947A (en) 2012-08-30
ZA200603657B (en) 2007-08-29
MY139446A (en) 2009-10-30
US20090069316A1 (en) 2009-03-12
IL175947A0 (en) 2006-10-05
CA2551508A1 (fr) 2005-07-14
TW200526218A (en) 2005-08-16
AU2004309166B2 (en) 2008-02-21
BRPI0418102A (pt) 2007-04-27
CR8482A (es) 2007-12-17
AU2004309166A1 (en) 2005-07-14
HN2004000544A (es) 2010-06-09
OA13349A (en) 2007-04-13
TNSN06200A1 (fr) 2007-11-15
NO20063382L (no) 2006-09-20
IS8439A (is) 2006-05-04
AR048292A1 (es) 2006-04-19
US7381824B2 (en) 2008-06-03
EA200600892A1 (ru) 2006-12-29

Similar Documents

Publication Publication Date Title
MA28396B1 (fr) Dérivés de quinoléine nouveaux
MA28347A1 (fr) Dérivés de quinoléine substitués
ATE340782T1 (de) Piperidinbenzolsulfonamidderivate
NO20054136D0 (no) Imidazol-4-yl-etynyl-pyridin-derivater
DE602004015724D1 (de) Diazepinoindolderivate als kinaseinhibitoren
DK1682493T3 (da) Amidoacetonitrilderivater
DE602004024420D1 (de) Chinazolinderivate als antitumormittel
IS8180A (is) Nýjar besímídasólafleiður
ATE352550T1 (de) Chinazolinderivate
DE602004031543D1 (de) Amidderivate
IS8364A (is) N-þíasól-2-ýl-bensamíð afleiður
MA28816B1 (fr) Nouveaux derives de 4-benzylidene-piperidine
IS8195A (is) Ásetnar pýrrólafleiður
IS8045A (is) Púrín-6-ón-afleiður
DK1652843T3 (da) Amidderivater
IS7924A (is) Setnar anilín afleiður
ATE449064T1 (de) Amidoacetonitrilderivate
ATE394372T1 (de) G-lactamderivate als prostaglandinagonisten
IS8235A (is) 2-amínóbensóýl afleiður
DK1633719T3 (da) Substituerede spirobenzazepiner
DE502004009935D1 (de) Substituierte dihydrochinazoline ii
UY28661A1 (es) Derivados de cromano
UA9443S (uk) Жакет
UA8266S (uk) Жакет
FR2858310B1 (fr) Licol ameliore