MA24354A1 - Pyrroles substitues - Google Patents

Pyrroles substitues

Info

Publication number
MA24354A1
MA24354A1 MA24743A MA24743A MA24354A1 MA 24354 A1 MA24354 A1 MA 24354A1 MA 24743 A MA24743 A MA 24743A MA 24743 A MA24743 A MA 24743A MA 24354 A1 MA24354 A1 MA 24354A1
Authority
MA
Morocco
Prior art keywords
substituted pyrroles
pyrroles
substituted
Prior art date
Application number
MA24743A
Other languages
English (en)
French (fr)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA24354A1 publication Critical patent/MA24354A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
MA24743A 1996-07-29 1997-07-29 Pyrroles substitues MA24354A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2207896P 1996-07-29 1996-07-29
US4849697P 1997-06-03 1997-06-03

Publications (1)

Publication Number Publication Date
MA24354A1 true MA24354A1 (fr) 1998-07-01

Family

ID=26695475

Family Applications (1)

Application Number Title Priority Date Filing Date
MA24743A MA24354A1 (fr) 1996-07-29 1997-07-29 Pyrroles substitues

Country Status (20)

Country Link
US (1) US6228877B1 (cg-RX-API-DMAC10.html)
EP (1) EP0915870B1 (cg-RX-API-DMAC10.html)
JP (1) JP2000516588A (cg-RX-API-DMAC10.html)
KR (1) KR20000029640A (cg-RX-API-DMAC10.html)
CN (1) CN1077571C (cg-RX-API-DMAC10.html)
AR (1) AR007969A1 (cg-RX-API-DMAC10.html)
AT (1) ATE224889T1 (cg-RX-API-DMAC10.html)
AU (1) AU740011B2 (cg-RX-API-DMAC10.html)
BR (1) BR9711607A (cg-RX-API-DMAC10.html)
CA (1) CA2262089A1 (cg-RX-API-DMAC10.html)
CO (1) CO4900054A1 (cg-RX-API-DMAC10.html)
DE (1) DE69715870T2 (cg-RX-API-DMAC10.html)
DK (1) DK0915870T3 (cg-RX-API-DMAC10.html)
ES (1) ES2183163T3 (cg-RX-API-DMAC10.html)
HR (1) HRP970415A2 (cg-RX-API-DMAC10.html)
MA (1) MA24354A1 (cg-RX-API-DMAC10.html)
PE (1) PE91598A1 (cg-RX-API-DMAC10.html)
PT (1) PT915870E (cg-RX-API-DMAC10.html)
TR (1) TR199900186T2 (cg-RX-API-DMAC10.html)
WO (1) WO1998004551A1 (cg-RX-API-DMAC10.html)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1064279B1 (en) * 1998-03-17 2003-06-25 F.Hoffmann-La Roche Ag Substituted bisindolylmaleimides for the inhibition of cell proliferation
US6350786B1 (en) * 1998-09-22 2002-02-26 Hoffmann-La Roche Inc. Stable complexes of poorly soluble compounds in ionic polymers
EP1224181B1 (en) * 1999-10-12 2003-12-03 F. Hoffmann-La Roche Ag Substituted pyrroles as antiproliferative agents for the treatment of cancer
US6559164B1 (en) 1999-10-12 2003-05-06 Hoffmann-La Roche Inc. Substituted pyrroles suitable for continuous infusion
US6313143B1 (en) * 1999-12-16 2001-11-06 Hoffmann-La Roche Inc. Substituted pyrroles
US6281356B1 (en) 1999-12-22 2001-08-28 Hoffmann-La Roche Inc. Substituted pyrroles
US6326501B1 (en) * 2000-04-19 2001-12-04 Hoffmann-La Roche Inc. Methylation of indole compounds using dimethyl carbonate
US7129250B2 (en) * 2000-05-19 2006-10-31 Aegera Therapeutics Inc. Neuroprotective and anti-proliferative compounds
CA2308994A1 (en) * 2000-05-19 2001-11-19 Aegera Therapeutics Inc. Neuroprotective compounds
TW201041580A (en) 2001-09-27 2010-12-01 Alcon Inc Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma
MXPA04004026A (es) * 2001-10-29 2004-07-08 Nektar Therapeutics Al Corp Conjugados polimericos de inhibidores de la proteina quinasa c.
CA2393720C (en) * 2002-07-12 2010-09-14 Eli Lilly And Company Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride
RS51826B (sr) 2005-02-09 2012-02-29 Arqule Inc. Maleimid derivati, farmaceutske kompozicije i postupak lečenja kancera
JP2010513386A (ja) * 2006-12-19 2010-04-30 ノバルティス アーゲー キナーゼ阻害剤としてのインドリルマレイミド誘導体
AU2008268613A1 (en) 2007-06-22 2008-12-31 Arqule, Inc. Quinazolinone compounds and methods of use thereof
EP2392574B1 (en) 2007-06-22 2013-12-18 ArQule, Inc. Indolyl pyrrolidines for the treatment of cancer
CA2690799C (en) * 2007-06-22 2015-06-16 Arqule, Inc. Pyrrolidinone, pyrrolidine-2,5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer
GB201111427D0 (en) * 2011-07-05 2011-08-17 Amakem Nv Novel bisindolylmaleimides, pan-pkc inhibitors
US20170209488A1 (en) 2014-07-17 2017-07-27 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods for treating neuromuscular junction-related diseases
WO2016207366A1 (en) 2015-06-26 2016-12-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of viral infections
CN105777751B (zh) * 2016-04-26 2018-12-11 浙江工业大学 一种双芳基马来酰亚胺类化合物及其药学上可接受的盐及其制备方法和应用
CN107973785B (zh) * 2017-11-27 2019-12-31 浙江工业大学上虞研究院有限公司 一种用于检测银离子的荧光探针及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ280738B6 (cs) 1988-02-10 1996-04-17 F. Hoffmann - La Roche And Co., Aktiengesellschaft Substituované pyrroly, jejich použití pro výrobu léčiv a léčiva na jejich bázi
US5380746A (en) 1989-05-05 1995-01-10 Goedecke Aktiengesellschaft Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
PT93947B (pt) * 1989-05-05 1996-11-29 Goedecke Ag Processo para a preparacao de novos derivados de maleinimidas e de composicoes farmaceuticas que os contem
JPH0539289A (ja) 1991-02-15 1993-02-19 Masahiro Irie 無水マレイン酸誘導体およびその製造方法
JPH07504673A (ja) 1992-03-20 1995-05-25 ザ・ウエルカム・ファウンデーション・リミテッド 抗ウイルス活性を有するインドール誘導体
DE4217964A1 (de) 1992-05-30 1993-12-02 Goedecke Ag Indolocarbazol-Imide und deren Verwendung

Also Published As

Publication number Publication date
PT915870E (pt) 2003-01-31
CN1077571C (zh) 2002-01-09
CN1226248A (zh) 1999-08-18
JP2000516588A (ja) 2000-12-12
DE69715870D1 (de) 2002-10-31
HRP970415A2 (en) 1998-08-31
PE91598A1 (es) 1998-12-24
EP0915870B1 (en) 2002-09-25
US6228877B1 (en) 2001-05-08
EP0915870A1 (en) 1999-05-19
AR007969A1 (es) 1999-11-24
DE69715870T2 (de) 2003-06-18
BR9711607A (pt) 1999-08-24
DK0915870T3 (da) 2003-02-03
ATE224889T1 (de) 2002-10-15
AU740011B2 (en) 2001-10-25
WO1998004551A1 (en) 1998-02-05
CA2262089A1 (en) 1998-02-05
KR20000029640A (ko) 2000-05-25
ES2183163T3 (es) 2003-03-16
TR199900186T2 (xx) 1999-03-22
CO4900054A1 (es) 2000-03-27
AU4296397A (en) 1998-02-20

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