MA22858A1 - Procede pour la preparation de nouveaux composes . - Google Patents

Procede pour la preparation de nouveaux composes .

Info

Publication number
MA22858A1
MA22858A1 MA23147A MA23147A MA22858A1 MA 22858 A1 MA22858 A1 MA 22858A1 MA 23147 A MA23147 A MA 23147A MA 23147 A MA23147 A MA 23147A MA 22858 A1 MA22858 A1 MA 22858A1
Authority
MA
Morocco
Prior art keywords
preparation
new compounds
useful
image
production
Prior art date
Application number
MA23147A
Other languages
English (en)
Inventor
Jutta Forster Cornelia
Elliot Bender Paul
Benjamin Christensen Siegrfied
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1993/002325 external-priority patent/WO1993019750A1/fr
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of MA22858A1 publication Critical patent/MA22858A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C255/46—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/56—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having carbon atoms of carboxamide groups bound to carbon atoms of carboxyl groups, e.g. oxamides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/82—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/44—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reduction and hydrolysis of nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/515—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being an acetalised, ketalised hemi-acetalised, or hemi-ketalised hydroxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/38—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings
    • C07C47/47—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/757—Unsaturated compounds containing a keto groups being part of a ring containing —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • External Artificial Organs (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
MA23147A 1992-04-02 1993-04-01 Procede pour la preparation de nouveaux composes . MA22858A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US86208392A 1992-04-02 1992-04-02
US96875392A 1992-10-30 1992-10-30
US9302045 1993-03-05
PCT/US1993/002325 WO1993019750A1 (fr) 1992-04-02 1993-03-12 Composes efficaces dans le traitement de maladies allergiques ou inflammatoires

Publications (1)

Publication Number Publication Date
MA22858A1 true MA22858A1 (fr) 1993-12-31

Family

ID=27127666

Family Applications (2)

Application Number Title Priority Date Filing Date
MA23147A MA22858A1 (fr) 1992-04-02 1993-04-01 Procede pour la preparation de nouveaux composes .
MA23146A MA22857A1 (fr) 1992-04-02 1993-04-01 Procede pour la preparation de nouveaux composes .

Family Applications After (1)

Application Number Title Priority Date Filing Date
MA23146A MA22857A1 (fr) 1992-04-02 1993-04-01 Procede pour la preparation de nouveaux composes .

Country Status (21)

Country Link
US (3) US5449686A (fr)
EP (2) EP0633775B1 (fr)
JP (1) JP3195353B2 (fr)
CN (2) CN1146536C (fr)
AT (1) ATE203159T1 (fr)
AU (2) AU3738393A (fr)
CA (1) CA2133337C (fr)
CY (1) CY2311B1 (fr)
DE (2) DE69328778T2 (fr)
DK (1) DK0636025T3 (fr)
ES (1) ES2158860T3 (fr)
GR (1) GR3036853T3 (fr)
HK (1) HK1012262A1 (fr)
IL (1) IL105219A0 (fr)
MA (2) MA22858A1 (fr)
MX (1) MX9301904A (fr)
NZ (1) NZ251176A (fr)
PT (1) PT636025E (fr)
SA (1) SA93140227B1 (fr)
SI (1) SI9300171A (fr)
WO (1) WO1993019748A1 (fr)

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SK279958B6 (sk) * 1992-04-02 1999-06-11 Smithkline Beecham Corporation Zlúčeniny s protialergickým a protizápalovým účink
GB9222253D0 (en) * 1992-10-23 1992-12-09 Celltech Ltd Chemical compounds
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GB9304920D0 (en) * 1993-03-10 1993-04-28 Celltech Ltd Chemical compounds
GB9304919D0 (en) * 1993-03-10 1993-04-28 Celltech Ltd Chemical compounds
US6323041B1 (en) * 1993-06-11 2001-11-27 Pfizer Inc. Screening novel human phosphodiesterase IV isozymes for compounds which modify their enzymatic activity
GB9312853D0 (en) 1993-06-22 1993-08-04 Euro Celtique Sa Chemical compounds
AU8011194A (en) * 1993-10-01 1995-05-01 Smithkline Beecham Corporation Compounds, compositions and treatment of allergies and inflammation
DE69433594T2 (de) * 1993-12-22 2004-08-05 Celltech R&D Ltd., Slough Trisubstituierte phenyl-derivate, verfahren zu deren herstellung und deren verwendung als phosphodiesterase (typ iv) hemmstoffe
GB9326173D0 (en) * 1993-12-22 1994-02-23 Celltech Ltd Chemical compounds and process
US6245774B1 (en) 1994-06-21 2001-06-12 Celltech Therapeutics Limited Tri-substituted phenyl or pyridine derivatives
US5786354A (en) * 1994-06-21 1998-07-28 Celltech Therapeutics, Limited Tri-substituted phenyl derivatives and processes for their preparation
GB9412573D0 (en) * 1994-06-22 1994-08-10 Celltech Ltd Chemical compounds
GB9412571D0 (en) 1994-06-22 1994-08-10 Celltech Ltd Chemical compounds
GB9412672D0 (en) * 1994-06-23 1994-08-10 Celltech Ltd Chemical compounds
US5922751A (en) * 1994-06-24 1999-07-13 Euro-Celtique, S.A. Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
US5591776A (en) * 1994-06-24 1997-01-07 Euro-Celtique, S.A. Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
JPH10512552A (ja) * 1994-12-23 1998-12-02 スミスクライン・ビーチャム・コーポレイション ４，４−（二置換）シクロヘキサン−１−オン二量体および関連化合物
EP0802791A4 (fr) * 1994-12-23 1998-03-25 Smithkline Beecham Corp Dimeres de 3,3-(disubstitues)cyclohexan-1-ylidine acetate et composes correspondants
EP0799182A4 (fr) * 1994-12-23 1998-03-25 Smithkline Beecham Corp Dimeres 3,3-(disubstitue)cyclohexan-1-ol et composes apparentes
JPH10511394A (ja) * 1994-12-23 1998-11-04 スミスクライン・ビーチャム・コーポレイション ４，４−（二置換）シクロヘキサン−１−イリジンアセテート単量体および関連化合物
WO1996020175A1 (fr) * 1994-12-23 1996-07-04 Smithkline Beecham Corporation Monomeres de 1,4,4-(trisubstitue)cyclohex-1-ene utilises comme inhibiteurs de pde iv et tnf
EP0799036A4 (fr) * 1994-12-23 1998-03-25 Smithkline Beecham Corp Dimeres d'acetate 4,4-(disubstitue)cyclohexane-1-ylidine et composes associes
US6166041A (en) 1995-10-11 2000-12-26 Euro-Celtique, S.A. 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
GB9523675D0 (en) 1995-11-20 1996-01-24 Celltech Therapeutics Ltd Chemical compounds
US5767151A (en) * 1995-12-21 1998-06-16 Smithkline Beecham Corporation 3,3-(disubstituted) cyclohexan-1-ylidine acetate dimers and related compounds
GB9526246D0 (en) * 1995-12-21 1996-02-21 Celltech Therapeutics Ltd Chemical compounds
US5900417A (en) * 1995-12-21 1999-05-04 Smithkline Beecham Corporation 1,3,3-(Trisubstituted)cyclohexanemonomers and related compounds
GB9526245D0 (en) * 1995-12-21 1996-02-21 Celltech Therapeutics Ltd Chemical compounds
US6075016A (en) 1996-04-10 2000-06-13 Euro-Celtique S.A. 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity
GB9608435D0 (en) * 1996-04-24 1996-06-26 Celltech Therapeutics Ltd Chemical compounds
EP2223920A3 (fr) 1996-06-19 2011-09-28 Aventis Pharma Limited Composes azabicycliques substitues
GB9619284D0 (en) * 1996-09-16 1996-10-30 Celltech Therapeutics Ltd Chemical compounds
GB9622363D0 (en) * 1996-10-28 1997-01-08 Celltech Therapeutics Ltd Chemical compounds
GB9625184D0 (en) * 1996-12-04 1997-01-22 Celltech Therapeutics Ltd Chemical compounds
WO1998028281A1 (fr) 1996-12-23 1998-07-02 Celltech Therapeutics Limited Derives polycyclique fondus de 2-aminopyrimidine, leur preparation et leur utilisation comme inhibiteurs de proteine tyrosine-kinase
GB9705361D0 (en) 1997-03-14 1997-04-30 Celltech Therapeutics Ltd Chemical compounds
GB9713087D0 (en) * 1997-06-20 1997-08-27 Celltech Therapeutics Ltd Chemical compounds
GB9914258D0 (en) 1999-06-18 1999-08-18 Celltech Therapeutics Ltd Chemical compounds
MXPA02001471A (es) * 1999-08-10 2002-07-02 Smithkline Beecham Corp 4,4-diaril ciclohexanos 1,4-substituidos.
GB9924862D0 (en) 1999-10-20 1999-12-22 Celltech Therapeutics Ltd Chemical compounds
US6872382B1 (en) 2001-05-21 2005-03-29 Alcon, Inc. Use of selective PDE IV inhibitors to treat dry eye disorders
WO2002096888A1 (fr) 2001-05-29 2002-12-05 Schering Aktiengesellschaft Pyrimidine inhibitrice de la cdk, sa production et son utilisation comme medicament
US6811777B2 (en) * 2002-04-13 2004-11-02 Allan Mishra Compositions and minimally invasive methods for treating incomplete connective tissue repair
US20090274676A1 (en) * 2003-07-31 2009-11-05 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a pde-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20050085430A1 (en) * 2003-07-31 2005-04-21 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a PDE-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20050026883A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a PDE-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease
KR100879423B1 (ko) * 2004-12-02 2009-01-19 (주)아모레퍼시픽 Ｔｎｆ-알파의 생산을 저해하는 2-사이클로펜텐-1-온 옥심유도체
AU2007236115A1 (en) * 2006-04-11 2007-10-18 Novartis Ag Organic compounds
KR20090096636A (ko) * 2006-12-22 2009-09-11 노파르티스 아게 Ｄｄｐ-ｉｖ 억제제로서의 1-아미노메틸-ｌ-페닐-시클로헥산 유도체
US20090182035A1 (en) * 2007-04-11 2009-07-16 Alcon Research, Ltd. Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis
AR066016A1 (es) * 2007-04-11 2009-07-15 Alcon Res Ltd Uso de un inhibidor del tnf alfa junto con una antihistamina para tratar la rinitis alergica y la conjuntivitis alergica
US7943658B2 (en) * 2007-07-23 2011-05-17 Bristol-Myers Squibb Company Indole indane amide compounds useful as CB2 agonists and method
EP2196465A1 (fr) 2008-12-15 2010-06-16 Almirall, S.A. Dérivés de (3-oxo)pyridazin-4-ylurée comme inhibiteurs de PDE4
EP2226323A1 (fr) 2009-02-27 2010-09-08 Almirall, S.A. Nouveaux dérivés de tétrahydropyrazolo [3,4-c]isoquinoléine-5-amine
CA2773483A1 (fr) * 2009-10-01 2011-04-07 Alcon Research, Ltd. Compositions d'olopatadine et leurs utilisations
EP2380890A1 (fr) 2010-04-23 2011-10-26 Almirall, S.A. Nouveaux dérivés de 7,8-dihydro-1,6-naphthyridin-5(6h)-one comme PDE4 inhibiteurs
EP2394998A1 (fr) 2010-05-31 2011-12-14 Almirall, S.A. Dérivés de 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl en tant qu'inhibiteurs de la PDE4
CN102336704B (zh) * 2011-10-19 2013-04-17 丁克 一种制备罗氟司特的方法
EP2776395A2 (fr) 2011-11-09 2014-09-17 Mylan Laboratories, Limited Procédé pour la préparation de roflumilast
GB201515921D0 (en) * 2015-09-08 2015-10-21 Parker Hannifin Mfg Uk Ltd Method
EP3541777B1 (fr) 2016-11-18 2023-01-11 Golden Biotechnology Corporation Compositions pour le traitement de la dermatite atopique

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Also Published As

Publication number Publication date
DE69328778T2 (de) 2000-11-23
AU3807993A (en) 1993-11-08
ES2158860T3 (es) 2001-09-16
ATE203159T1 (de) 2001-08-15
AU708544B2 (en) 1999-08-05
EP0636025B1 (fr) 2001-07-18
US5449686A (en) 1995-09-12
EP0633775B1 (fr) 2000-05-31
CN1146536C (zh) 2004-04-21
MX9301904A (es) 1994-06-30
IL105219A0 (en) 1993-07-08
WO1993019748A1 (fr) 1993-10-14
EP0636025A1 (fr) 1995-02-01
AU7199996A (en) 1997-02-13
AU3738393A (en) 1993-11-08
AU675640B2 (en) 1997-02-13
NZ251176A (en) 1997-05-26
DE69328778D1 (de) 2000-07-06
US5631286A (en) 1997-05-20
SA93140227B1 (ar) 2005-12-26
CN1092407A (zh) 1994-09-21
MA22857A1 (fr) 1993-12-31
PT636025E (pt) 2001-12-28
CN1094710A (zh) 1994-11-09
HK1012262A1 (en) 1999-07-30
JP3195353B2 (ja) 2001-08-06
EP0636025A4 (en) 1995-02-22
EP0633775A4 (en) 1995-02-22
GR3036853T3 (en) 2002-01-31
DE69330459T2 (de) 2002-05-29
JPH07508262A (ja) 1995-09-14
DK0636025T3 (da) 2001-10-29
EP0633775A1 (fr) 1995-01-18
CA2133337A1 (fr) 1993-10-14
US5811455A (en) 1998-09-22
SI9300171A (en) 1993-12-31
DE69330459D1 (de) 2001-08-23
CY2311B1 (en) 2003-11-14
CA2133337C (fr) 2005-05-03

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