LV12991B - Use of strains of the parapox ovis virus against organ fibrosis - Google Patents
Use of strains of the parapox ovis virus against organ fibrosis Download PDFInfo
- Publication number
- LV12991B LV12991B LVP-03-13A LV030013A LV12991B LV 12991 B LV12991 B LV 12991B LV 030013 A LV030013 A LV 030013A LV 12991 B LV12991 B LV 12991B
- Authority
- LV
- Latvia
- Prior art keywords
- der
- die
- von
- manufacture
- organ fibrosis
- Prior art date
Links
- 210000000056 organ Anatomy 0.000 title claims abstract 10
- 241000283898 Ovis Species 0.000 title claims description 18
- 206010016654 Fibrosis Diseases 0.000 title claims description 15
- 241000700605 Viruses Species 0.000 title claims description 5
- 230000004761 fibrosis Effects 0.000 title claims 9
- 241000282414 Homo sapiens Species 0.000 claims abstract description 21
- 241000700639 Parapoxvirus Species 0.000 claims abstract description 17
- 238000011321 prophylaxis Methods 0.000 claims abstract description 3
- 238000011282 treatment Methods 0.000 claims abstract description 3
- 230000000694 effects Effects 0.000 claims description 9
- 238000004519 manufacturing process Methods 0.000 claims description 9
- 230000006978 adaptation Effects 0.000 claims description 6
- 210000004027 cell Anatomy 0.000 claims description 5
- 239000012634 fragment Substances 0.000 claims description 5
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- 206010046865 Vaccinia virus infection Diseases 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 208000007089 vaccinia Diseases 0.000 claims description 3
- 108091027544 Subgenomic mRNA Proteins 0.000 claims description 2
- 238000004113 cell culture Methods 0.000 claims description 2
- 238000004587 chromatography analysis Methods 0.000 claims description 2
- 239000013598 vector Substances 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 10
- 230000000069 prophylactic effect Effects 0.000 claims 7
- 230000001225 therapeutic effect Effects 0.000 claims 4
- 230000003510 anti-fibrotic effect Effects 0.000 claims 2
- 241001494479 Pecora Species 0.000 claims 1
- 244000309464 bull Species 0.000 claims 1
- 238000011156 evaluation Methods 0.000 claims 1
- 210000002950 fibroblast Anatomy 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 7
- 208000019425 cirrhosis of liver Diseases 0.000 abstract description 4
- 102000008186 Collagen Human genes 0.000 abstract description 3
- 108010035532 Collagen Proteins 0.000 abstract description 3
- 201000003883 Cystic fibrosis Diseases 0.000 abstract description 3
- 206010019799 Hepatitis viral Diseases 0.000 abstract description 3
- 229920001436 collagen Polymers 0.000 abstract description 3
- 230000008021 deposition Effects 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
- 208000019423 liver disease Diseases 0.000 abstract 1
- 201000001862 viral hepatitis Diseases 0.000 abstract 1
- 238000007912 intraperitoneal administration Methods 0.000 description 22
- 206010019668 Hepatic fibrosis Diseases 0.000 description 18
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 14
- 210000002966 serum Anatomy 0.000 description 13
- 241000700159 Rattus Species 0.000 description 9
- 239000000243 solution Substances 0.000 description 7
- 239000002775 capsule Substances 0.000 description 5
- 230000009466 transformation Effects 0.000 description 5
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 5
- 239000006145 Eagle's minimal essential medium Substances 0.000 description 4
- 239000002609 medium Substances 0.000 description 4
- 241000283690 Bos taurus Species 0.000 description 3
- 238000003556 assay Methods 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 235000012054 meals Nutrition 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 238000012453 sprague-dawley rat model Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000002054 transplantation Methods 0.000 description 3
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 2
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 2
- MJNIWUJSIGSWKK-UHFFFAOYSA-N Riboflavine 2',3',4',5'-tetrabutanoate Chemical compound CCCC(=O)OCC(OC(=O)CCC)C(OC(=O)CCC)C(OC(=O)CCC)CN1C2=CC(C)=C(C)C=C2N=C2C1=NC(=O)NC2=O MJNIWUJSIGSWKK-UHFFFAOYSA-N 0.000 description 2
- 229940087168 alpha tocopherol Drugs 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 230000000937 inactivator Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 229960000984 tocofersolan Drugs 0.000 description 2
- 239000002076 α-tocopherol Substances 0.000 description 2
- 235000004835 α-tocopherol Nutrition 0.000 description 2
- BGNGWHSBYQYVRX-UHFFFAOYSA-N 4-(dimethylamino)benzaldehyde Chemical compound CN(C)C1=CC=C(C=O)C=C1 BGNGWHSBYQYVRX-UHFFFAOYSA-N 0.000 description 1
- 101000950981 Bacillus subtilis (strain 168) Catabolic NAD-specific glutamate dehydrogenase RocG Proteins 0.000 description 1
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 108050006400 Cyclin Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000283070 Equus zebra Species 0.000 description 1
- 208000010228 Erectile Dysfunction Diseases 0.000 description 1
- RZSYLLSAWYUBPE-UHFFFAOYSA-L Fast green FCF Chemical compound [Na+].[Na+].C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C(=CC(O)=CC=2)S([O-])(=O)=O)C=CC=1N(CC)CC1=CC=CC(S([O-])(=O)=O)=C1 RZSYLLSAWYUBPE-UHFFFAOYSA-L 0.000 description 1
- 108020004206 Gamma-glutamyltransferase Proteins 0.000 description 1
- 102000016901 Glutamate dehydrogenase Human genes 0.000 description 1
- 206010019669 Hepatic fibrosis and cirrhosis Diseases 0.000 description 1
- 206010067125 Liver injury Diseases 0.000 description 1
- 102000009339 Proliferating Cell Nuclear Antigen Human genes 0.000 description 1
- 102000004357 Transferases Human genes 0.000 description 1
- 108090000992 Transferases Proteins 0.000 description 1
- 239000005862 Whey Substances 0.000 description 1
- 102000007544 Whey Proteins Human genes 0.000 description 1
- 108010046377 Whey Proteins Proteins 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 231100000439 acute liver injury Toxicity 0.000 description 1
- 210000004100 adrenal gland Anatomy 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- VDQQXEISLMTGAB-UHFFFAOYSA-N chloramine T Chemical compound [Na+].CC1=CC=C(S(=O)(=O)[N-]Cl)C=C1 VDQQXEISLMTGAB-UHFFFAOYSA-N 0.000 description 1
- 230000007882 cirrhosis Effects 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 230000008029 eradication Effects 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 102000006640 gamma-Glutamyltransferase Human genes 0.000 description 1
- 230000036046 immunoreaction Effects 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000001524 infective effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 230000035987 intoxication Effects 0.000 description 1
- 231100000566 intoxication Toxicity 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 229960003350 isoniazid Drugs 0.000 description 1
- QRXWMOHMRWLFEY-UHFFFAOYSA-N isoniazide Chemical compound NNC(=O)C1=CC=NC=C1 QRXWMOHMRWLFEY-UHFFFAOYSA-N 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000003228 microsomal effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 238000010865 video microscopy Methods 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24211—Parapoxvirus, e.g. Orf virus
- C12N2710/24232—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Psychiatry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10033581 | 2000-07-11 | ||
| DE10122233A DE10122233A1 (de) | 2000-07-11 | 2001-05-08 | Verwendung von Stämmen des Parapoxvirus ovis gegen Organfibrosen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LV12991B true LV12991B (en) | 2003-08-20 |
Family
ID=26006334
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LVP-03-13A LV12991B (en) | 2000-07-11 | 2003-02-11 | Use of strains of the parapox ovis virus against organ fibrosis |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6632647B2 (hu) |
| EP (1) | EP1303302B1 (hu) |
| JP (1) | JP5106736B2 (hu) |
| CN (1) | CN1452496B (hu) |
| AR (1) | AR028800A1 (hu) |
| AU (2) | AU8582701A (hu) |
| BG (1) | BG107447A (hu) |
| CA (1) | CA2415399C (hu) |
| CZ (1) | CZ200372A3 (hu) |
| DK (1) | DK200300014A (hu) |
| EE (1) | EE200300019A (hu) |
| FI (1) | FI20030038A (hu) |
| GB (1) | GB2383752B (hu) |
| HK (1) | HK1054330B (hu) |
| HR (1) | HRP20030097A2 (hu) |
| HU (1) | HU227668B1 (hu) |
| IL (1) | IL153826A0 (hu) |
| LT (1) | LT5064B (hu) |
| LU (1) | LU90996B1 (hu) |
| LV (1) | LV12991B (hu) |
| MA (1) | MA25765A1 (hu) |
| MX (1) | MXPA03000278A (hu) |
| NO (1) | NO20030081D0 (hu) |
| NZ (1) | NZ523535A (hu) |
| PL (1) | PL360839A1 (hu) |
| RU (1) | RU2003104522A (hu) |
| SE (1) | SE0300033L (hu) |
| SI (1) | SI21171A (hu) |
| SK (1) | SK382003A3 (hu) |
| WO (1) | WO2002004019A2 (hu) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19922407A1 (de) * | 1999-05-14 | 2000-11-16 | Bayer Ag | Organ-, gewebs- und zellspezifisches Immuntherapeutikum für chronische virale Infektionen, sowie entzündliche, degenerative und proliferative Erkrankungen insbesondere der Leber sowie Krebs auf der Basis von rekombinantem Parapoxvirus |
| AU2002362072A1 (en) | 2001-12-07 | 2003-06-23 | Board Of Regents The University Of Texas System | Use a parapox b2l protein to modify immune responses to administered antigens |
| US6752995B2 (en) | 2002-04-15 | 2004-06-22 | Board Of Regents, The University Of Texas System | Nucleic acid and polypeptide sequences useful as adjuvants |
| EP1574211A1 (en) | 2004-03-09 | 2005-09-14 | Inserm | Use of antagonists of the CB1 receptor for the manufacture of a composition useful for the treatment of hepatic diseases |
| WO2012045473A1 (en) * | 2010-10-07 | 2012-04-12 | Technische Universität München | Viruses for the treatment of fibrosis |
| US11077157B2 (en) | 2016-02-16 | 2021-08-03 | Osaka University | Medicinal composition for treating fibrosis |
| TW201919675A (zh) * | 2017-09-07 | 2019-06-01 | 德商艾庫瑞斯公司 | 使用羊副痘疹病毒(Parapoxvirus ovis；PPVO)及至少一種額外抗病毒藥之經B型肝炎病毒(HBV)感染之個體之組合療法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2714665A1 (de) * | 1977-04-01 | 1978-10-05 | Mayr Anton | Praeparat zur behandlung von herpes zoster und anderen herpes-infektionen, sowie verfahren zu seiner herstellung |
| US4360510A (en) * | 1979-11-30 | 1982-11-23 | Proctor Julian W | Method for screening anti-tumor agents of the reticulo-endothelial stimulant class |
| US4663306A (en) * | 1983-09-23 | 1987-05-05 | Ribi Immunochem Research, Inc. | Pyridine-soluble extract-refined detoxified endotoxin composition and use |
| DE3504940C2 (de) | 1984-02-17 | 1997-11-06 | Bayer Ag | Multipotente Paramunitätsmediatoren, Verfahren zu ihrer Herstellung und diese Mediatoren enthaltende Arzneimittel |
| DE3816139A1 (de) * | 1987-10-17 | 1989-04-27 | Bayer Ag | Verfahren zur herstellung von paramunitaetsinducern |
| DE4405841C1 (de) * | 1994-02-23 | 1995-01-05 | Mayr Anton Prof Dr Med Vet Dr | Multipotente Paramunitätsinducer auf der Basis von Kombinationen von Pockenviruskomponenten, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| KR100302994B1 (ko) * | 1996-04-15 | 2001-11-30 | 안톤 마이어 | 약독화된비면역원성폭스바이러스또는파라폭스바이러스로부터멀티포텐트파라폭스면역유발인자의약제로서이용하는새로운적용 |
| DE19922407A1 (de) * | 1999-05-14 | 2000-11-16 | Bayer Ag | Organ-, gewebs- und zellspezifisches Immuntherapeutikum für chronische virale Infektionen, sowie entzündliche, degenerative und proliferative Erkrankungen insbesondere der Leber sowie Krebs auf der Basis von rekombinantem Parapoxvirus |
| IL139593A (en) * | 2000-11-09 | 2010-12-30 | Biogem Optical Ltd | Method for the detection of viable microorganisms |
-
2001
- 2001-07-11 US US09/903,005 patent/US6632647B2/en not_active Expired - Lifetime
- 2001-07-11 EE EEP200300019A patent/EE200300019A/xx unknown
- 2001-07-11 CA CA2415399A patent/CA2415399C/en not_active Expired - Lifetime
- 2001-07-11 HU HU0303830A patent/HU227668B1/hu not_active IP Right Cessation
- 2001-07-11 JP JP2002508473A patent/JP5106736B2/ja not_active Expired - Lifetime
- 2001-07-11 LU LU90996A patent/LU90996B1/en active
- 2001-07-11 NZ NZ52353501A patent/NZ523535A/xx unknown
- 2001-07-11 IL IL15382601A patent/IL153826A0/xx active IP Right Grant
- 2001-07-11 EP EP01965110A patent/EP1303302B1/de not_active Expired - Lifetime
- 2001-07-11 SK SK38-2003A patent/SK382003A3/sk not_active Application Discontinuation
- 2001-07-11 WO PCT/EP2001/007978 patent/WO2002004019A2/de active IP Right Grant
- 2001-07-11 AU AU8582701A patent/AU8582701A/xx active Pending
- 2001-07-11 AR ARP010103291A patent/AR028800A1/es not_active Application Discontinuation
- 2001-07-11 PL PL36083901A patent/PL360839A1/xx not_active Application Discontinuation
- 2001-07-11 AU AU2001285827A patent/AU2001285827B2/en not_active Expired
- 2001-07-11 GB GB0302629A patent/GB2383752B/en not_active Expired - Lifetime
- 2001-07-11 CN CN018151272A patent/CN1452496B/zh not_active Expired - Lifetime
- 2001-07-11 SI SI200120047A patent/SI21171A/sl not_active IP Right Cessation
- 2001-07-11 RU RU2003104522/15A patent/RU2003104522A/ru not_active Application Discontinuation
- 2001-07-11 CZ CZ200372A patent/CZ200372A3/cs unknown
- 2001-07-11 MX MXPA03000278A patent/MXPA03000278A/es active IP Right Grant
-
2003
- 2003-01-08 NO NO20030081A patent/NO20030081D0/no not_active Application Discontinuation
- 2003-01-08 BG BG107447A patent/BG107447A/bg unknown
- 2003-01-10 SE SE0300033A patent/SE0300033L/xx not_active Application Discontinuation
- 2003-01-10 DK DK200300014A patent/DK200300014A/da not_active Application Discontinuation
- 2003-01-10 MA MA26995A patent/MA25765A1/fr unknown
- 2003-01-10 FI FI20030038A patent/FI20030038A/fi not_active IP Right Cessation
- 2003-02-03 LT LT2003008A patent/LT5064B/lt not_active IP Right Cessation
- 2003-02-10 HR HR20030097A patent/HRP20030097A2/xx not_active Application Discontinuation
- 2003-02-11 LV LVP-03-13A patent/LV12991B/lv unknown
- 2003-09-15 HK HK03106614.0A patent/HK1054330B/zh not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AT405939B (de) | Verfahren zur inaktivierung von lipidumhüllten viren | |
| DE60314823T3 (de) | Modifizierte variante des vaccinia ankara virus als impfstoff für neugeborene | |
| DE60113512T2 (de) | Veränderter stamm des modifizierten vaccinia-virus ankara (mva) | |
| Chauhan et al. | Vesicular stomatitis virus infects resident cells of the central nervous system and induces replication-dependent inflammatory responses | |
| DE69628838T2 (de) | Chemokin bindendes protein und verfahren zu seiner verwendung | |
| Kris et al. | Passive serum antibody causes temporary recovery from influenza virus infection of the nose, trachea and lung of nude mice. | |
| Bennett et al. | Studies on poxvirus infection in cats | |
| DE60205631T2 (de) | Methode zur gewinnung und reinigung von poxviren aus infizierten zellen | |
| LV12991B (en) | Use of strains of the parapox ovis virus against organ fibrosis | |
| DE69034052T2 (de) | Rekombinante vectoren , die für selbstzusammengesetzte, defekte, sich nichtselbstvermehrende viruspartikel kodieren | |
| Jayati et al. | In vitro antiviral potential of Ocimum sanctum leaves extract against New Castle Disease Virus of poultry | |
| CA2415397A1 (en) | Use of strains of parapoxvirus ovis for producing antiviral medicaments and medicaments against cancer | |
| AT406778B (de) | Verfahren zur desintegration von nucleinsäuren und herstellung von qualitätsgesicherten biologischen produkten | |
| Karagöz et al. | Antiviral activity of Sanicula europaea L. extracts on multiplication of human parainfluenza virus type 2 | |
| WO2005070453A1 (de) | Monoparamunitätsinducer basierend auf attenuierten myxomaviren des kaninchens | |
| JP5587950B2 (ja) | 臓器線維形成に対するパラポックスウイルスｏｖｉｓ株の使用 | |
| EP1181381B1 (de) | Organ-, gewebs- und zellspezifisches immuntherapeutikum für chronische virale infektionen, sowie entzündliche, degenerative und proliferative erkrankungen insbesondere der leber sowie krebs auf der basis von rekombinantem parapoxvirus | |
| Jortner et al. | Experimental Chandipura virus infection in mice: I. Virus assay and light microscopic studies with emphasis on neuropathologic observations | |
| Trefry et al. | Recombinant chimeric Horsepox Virus (TNX-801) is attenuated relative to Vaccinia Virus Strains in Human Primary Cell Lines and in Immunocompromised Mice | |
| Oh et al. | Different susceptibilities of skin to type 1 and type 2 herpes simplex viruses in newborn rabbits | |
| Izawa et al. | Herpesviral isolates related to Marek's disease virus from chicken and turkey kidney cell cultures | |
| Walder et al. | Cytomorphological changes during Nariva virus infection | |
| 本多英一 et al. | A comparison of polypeptides and restriction endonuclease sites of BHV-1 isolates and identification of IPV virus in Japan. | |
| Pfahler et al. | Influence of progesterone on orthopox viruses in vitro and in vivo | |
| Cheville et al. | Cytopathic Changes in Lesions of a Pox Disease in Monkeys |