DK200300014A - Anvendelse af stammer af Parapoxvirus ovis mod organfibroser - Google Patents
Anvendelse af stammer af Parapoxvirus ovis mod organfibroser Download PDFInfo
- Publication number
- DK200300014A DK200300014A DK200300014A DKPA200300014A DK200300014A DK 200300014 A DK200300014 A DK 200300014A DK 200300014 A DK200300014 A DK 200300014A DK PA200300014 A DKPA200300014 A DK PA200300014A DK 200300014 A DK200300014 A DK 200300014A
- Authority
- DK
- Denmark
- Prior art keywords
- parapoxvirus ovis
- organ fibrosis
- drugs
- fibrosis
- strains against
- Prior art date
Links
- 206010016654 Fibrosis Diseases 0.000 title description 9
- 230000004761 fibrosis Effects 0.000 title description 9
- 241000700639 Parapoxvirus Species 0.000 title description 6
- 241000283898 Ovis Species 0.000 title description 4
- 210000000056 organ Anatomy 0.000 title description 3
- 239000003814 drug Substances 0.000 description 10
- 229940079593 drug Drugs 0.000 description 10
- 230000009982 effect on human Effects 0.000 description 8
- 238000004519 manufacturing process Methods 0.000 description 8
- 230000003449 preventive effect Effects 0.000 description 8
- 210000004027 cell Anatomy 0.000 description 4
- 230000006978 adaptation Effects 0.000 description 3
- 239000012634 fragment Substances 0.000 description 3
- 230000003510 anti-fibrotic effect Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 241000282414 Homo sapiens Species 0.000 description 1
- 108091027544 Subgenomic mRNA Proteins 0.000 description 1
- 241000700618 Vaccinia virus Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24211—Parapoxvirus, e.g. Orf virus
- C12N2710/24232—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Psychiatry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
PATENTKRAV 1. Anvendelse af isolater af Parapoxvira til fremstilling af lægemidler med forebyggende eller helbredende virkning på organfibroser hos mennesket. 2. Anvendelse af isolater af Parapoxvira, f.eks. af stammerne D 1701, orf-11, Greek orf stamme 176, Greek orf stamme 155 samt New Zealand (NZ) stammerne til fremstilling af lægemidler med forebyggende eller helbredende virkning på organfibroser hos mennesket. 3. Anvendelse af isolater af Parapoxvira ifølge krav 1 til 2, idet der som New Zealand (NZ) stammer anvendes stammerne NZ2, NZ7 og NZ10 til fremstilling af lægemidler med forebyggende eller helbredende virkning på organfibroser hos mennesket. 4. Anvendelse af ved passage på eller tilpasning til egnede celler modificerede Parapoxvira ifølge krav 1-3 til fremstilling af lægemidler med forebyggende eller helbredende virkning på organfibroser hos mennesket. 4. Anvendelse af ved passage på eller tilpasning til egnede celler modificerede Parapoxvira ifølge krav 1-3 til fremstilling af lægemidler med forebyggende eller helbredende virkning på organfibroser hos mennesket, idet der til passage eller tilpasning anvendes humane celler som WI-38, MRC-5, bovine celler, såsom BK-KI3A47/Reg eller MDBK, og ovine celler, såsom MDOK. 6. Anvendelse af dele eller brudstykker af vira ifølge krav 1-5 til fremstilling af lægemidler med forebyggende eller helbredende virkning på organfibroser hos mennesket, idet der ved dele forstås ved hjælp af egnede vektorer, såsom vacciniavira, i egnede systemer, såsom fibroblastcellekulturer, eksprimerede genomiske eller subgenomiske fragmenter, og ved brudstykker forstås de ved biokemisk oprensning, såsom chromatografi, fremkomne fraktioner af de eksprimerede eller fysisk oplukkede virale partikler. 7. Anvendelse af et af isolaterne ifølge krav 1-6 i kombination med andre midler til fremstilling af lægemidler og farmaceutiske præparater med forebyggende eller helbredende virkning på organfibroser hos mennesket. 8. Anvendelse af Parapoxvirus ovis D 1701 alene eller i kombination med andre midler til fremstilling af lægemidler og farmaceutiske præparater med forebyggende eller helbredende virkning på organfibroser hos mennesket. 9. Anvendelse af Parapoxvirus ovis D 1701 eller præparater af NZ2 som referencestandard til bedømmelse af antifibrotiske virkninger i analyser til søgning efter antifibrotiske stoffer. 10. Anvendelse af Parapoxvirus ovis D 1701 ifølge krav 8, ved hvilken de farmaceutiske præparater og lægemidler er egnede til oral indgivelse.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10033581 | 2000-07-11 | ||
| DE10122233A DE10122233A1 (de) | 2000-07-11 | 2001-05-08 | Verwendung von Stämmen des Parapoxvirus ovis gegen Organfibrosen |
| PCT/EP2001/007978 WO2002004019A2 (de) | 2000-07-11 | 2001-07-11 | Verwendung von stämmen des parapoxvirus ovis gegen organfibrosen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK200300014A true DK200300014A (da) | 2003-03-07 |
Family
ID=26006334
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK200300014A DK200300014A (da) | 2000-07-11 | 2003-01-10 | Anvendelse af stammer af Parapoxvirus ovis mod organfibroser |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6632647B2 (da) |
| EP (1) | EP1303302B1 (da) |
| JP (1) | JP5106736B2 (da) |
| CN (1) | CN1452496B (da) |
| AR (1) | AR028800A1 (da) |
| AU (2) | AU8582701A (da) |
| BG (1) | BG107447A (da) |
| CA (1) | CA2415399C (da) |
| CZ (1) | CZ200372A3 (da) |
| DK (1) | DK200300014A (da) |
| EE (1) | EE200300019A (da) |
| FI (1) | FI20030038A (da) |
| GB (1) | GB2383752B (da) |
| HK (1) | HK1054330B (da) |
| HR (1) | HRP20030097A2 (da) |
| HU (1) | HU227668B1 (da) |
| IL (1) | IL153826A0 (da) |
| LT (1) | LT5064B (da) |
| LU (1) | LU90996B1 (da) |
| LV (1) | LV12991B (da) |
| MA (1) | MA25765A1 (da) |
| MX (1) | MXPA03000278A (da) |
| NO (1) | NO20030081D0 (da) |
| NZ (1) | NZ523535A (da) |
| PL (1) | PL360839A1 (da) |
| RU (1) | RU2003104522A (da) |
| SE (1) | SE0300033L (da) |
| SI (1) | SI21171A (da) |
| SK (1) | SK382003A3 (da) |
| WO (1) | WO2002004019A2 (da) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19922407A1 (de) * | 1999-05-14 | 2000-11-16 | Bayer Ag | Organ-, gewebs- und zellspezifisches Immuntherapeutikum für chronische virale Infektionen, sowie entzündliche, degenerative und proliferative Erkrankungen insbesondere der Leber sowie Krebs auf der Basis von rekombinantem Parapoxvirus |
| AU2002362072A1 (en) | 2001-12-07 | 2003-06-23 | Board Of Regents The University Of Texas System | Use a parapox b2l protein to modify immune responses to administered antigens |
| US6752995B2 (en) | 2002-04-15 | 2004-06-22 | Board Of Regents, The University Of Texas System | Nucleic acid and polypeptide sequences useful as adjuvants |
| EP1574211A1 (en) | 2004-03-09 | 2005-09-14 | Inserm | Use of antagonists of the CB1 receptor for the manufacture of a composition useful for the treatment of hepatic diseases |
| WO2012045473A1 (en) * | 2010-10-07 | 2012-04-12 | Technische Universität München | Viruses for the treatment of fibrosis |
| US11077157B2 (en) | 2016-02-16 | 2021-08-03 | Osaka University | Medicinal composition for treating fibrosis |
| TW201919675A (zh) * | 2017-09-07 | 2019-06-01 | 德商艾庫瑞斯公司 | 使用羊副痘疹病毒(Parapoxvirus ovis；PPVO)及至少一種額外抗病毒藥之經B型肝炎病毒(HBV)感染之個體之組合療法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2714665A1 (de) * | 1977-04-01 | 1978-10-05 | Mayr Anton | Praeparat zur behandlung von herpes zoster und anderen herpes-infektionen, sowie verfahren zu seiner herstellung |
| US4360510A (en) * | 1979-11-30 | 1982-11-23 | Proctor Julian W | Method for screening anti-tumor agents of the reticulo-endothelial stimulant class |
| US4663306A (en) * | 1983-09-23 | 1987-05-05 | Ribi Immunochem Research, Inc. | Pyridine-soluble extract-refined detoxified endotoxin composition and use |
| DE3504940C2 (de) | 1984-02-17 | 1997-11-06 | Bayer Ag | Multipotente Paramunitätsmediatoren, Verfahren zu ihrer Herstellung und diese Mediatoren enthaltende Arzneimittel |
| DE3816139A1 (de) * | 1987-10-17 | 1989-04-27 | Bayer Ag | Verfahren zur herstellung von paramunitaetsinducern |
| DE4405841C1 (de) * | 1994-02-23 | 1995-01-05 | Mayr Anton Prof Dr Med Vet Dr | Multipotente Paramunitätsinducer auf der Basis von Kombinationen von Pockenviruskomponenten, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| KR100302994B1 (ko) * | 1996-04-15 | 2001-11-30 | 안톤 마이어 | 약독화된비면역원성폭스바이러스또는파라폭스바이러스로부터멀티포텐트파라폭스면역유발인자의약제로서이용하는새로운적용 |
| DE19922407A1 (de) * | 1999-05-14 | 2000-11-16 | Bayer Ag | Organ-, gewebs- und zellspezifisches Immuntherapeutikum für chronische virale Infektionen, sowie entzündliche, degenerative und proliferative Erkrankungen insbesondere der Leber sowie Krebs auf der Basis von rekombinantem Parapoxvirus |
| IL139593A (en) * | 2000-11-09 | 2010-12-30 | Biogem Optical Ltd | Method for the detection of viable microorganisms |
-
2001
- 2001-07-11 US US09/903,005 patent/US6632647B2/en not_active Expired - Lifetime
- 2001-07-11 EE EEP200300019A patent/EE200300019A/xx unknown
- 2001-07-11 CA CA2415399A patent/CA2415399C/en not_active Expired - Lifetime
- 2001-07-11 HU HU0303830A patent/HU227668B1/hu not_active IP Right Cessation
- 2001-07-11 JP JP2002508473A patent/JP5106736B2/ja not_active Expired - Lifetime
- 2001-07-11 LU LU90996A patent/LU90996B1/en active
- 2001-07-11 NZ NZ52353501A patent/NZ523535A/xx unknown
- 2001-07-11 IL IL15382601A patent/IL153826A0/xx active IP Right Grant
- 2001-07-11 EP EP01965110A patent/EP1303302B1/de not_active Expired - Lifetime
- 2001-07-11 SK SK38-2003A patent/SK382003A3/sk not_active Application Discontinuation
- 2001-07-11 WO PCT/EP2001/007978 patent/WO2002004019A2/de active IP Right Grant
- 2001-07-11 AU AU8582701A patent/AU8582701A/xx active Pending
- 2001-07-11 AR ARP010103291A patent/AR028800A1/es not_active Application Discontinuation
- 2001-07-11 PL PL36083901A patent/PL360839A1/xx not_active Application Discontinuation
- 2001-07-11 AU AU2001285827A patent/AU2001285827B2/en not_active Expired
- 2001-07-11 GB GB0302629A patent/GB2383752B/en not_active Expired - Lifetime
- 2001-07-11 CN CN018151272A patent/CN1452496B/zh not_active Expired - Lifetime
- 2001-07-11 SI SI200120047A patent/SI21171A/sl not_active IP Right Cessation
- 2001-07-11 RU RU2003104522/15A patent/RU2003104522A/ru not_active Application Discontinuation
- 2001-07-11 CZ CZ200372A patent/CZ200372A3/cs unknown
- 2001-07-11 MX MXPA03000278A patent/MXPA03000278A/es active IP Right Grant
-
2003
- 2003-01-08 NO NO20030081A patent/NO20030081D0/no not_active Application Discontinuation
- 2003-01-08 BG BG107447A patent/BG107447A/bg unknown
- 2003-01-10 SE SE0300033A patent/SE0300033L/xx not_active Application Discontinuation
- 2003-01-10 DK DK200300014A patent/DK200300014A/da not_active Application Discontinuation
- 2003-01-10 MA MA26995A patent/MA25765A1/fr unknown
- 2003-01-10 FI FI20030038A patent/FI20030038A/fi not_active IP Right Cessation
- 2003-02-03 LT LT2003008A patent/LT5064B/lt not_active IP Right Cessation
- 2003-02-10 HR HR20030097A patent/HRP20030097A2/xx not_active Application Discontinuation
- 2003-02-11 LV LVP-03-13A patent/LV12991B/lv unknown
- 2003-09-15 HK HK03106614.0A patent/HK1054330B/zh not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHS | Application shelved for other reasons than non-payment |